Blood Fat Levels Research Articles

TOTAL AND FRACTIONAL BLOOD LIPID LEVELS IN THE NEPHROTIC SYNDROME

The blood chemistry of the nephrotic syndrome is characterized by abnormal plasma protein levels and by hyperlipemia. The latter, despite years of study, remains one of the more obscure features of this disease. I should like, therefore, to present and to comment on an example of unusually severe nephrotic hyperlipemia in a patient whose total plasma lipid and all significant fractions thereof have been followed over a nine month period beginning soon after the onset of his illness. In the following report the results have been summarized in relation to events of the patient's clinical course and I have indicated a few correlations which would seem to merit further study. These determinations are part of an extended survey, not yet complete, of abnormal blood fat levels in certain diseases of childhood. With the aid of the same modified Bloor technic 1 which is used in the present study, normal ranges

THE ACTION OF PITUITRIN, PITRESSIN AND PITOCIN ON THE BLOOD PHOSPHATIDES

The posterior pituitary hormone, pituitrin, exerts some characteristic effects on fat-metabolism and seems to be an important factor in the consumption and distribution of body fat. These facts were demonstrated experimentally for the first time in 1925 by Coope and Chamberlain (6), who found a considerable accumulation of fatty acids within the liver under the influence of pituitrin and by Raab's (14) studies on the changes of blood fat and blood acetone bodies through various hormone preparations. Pituitrin was the only one that produced a marked and comparatively long lasting action on the blood fat level—a regular decrease during several hours. For obtaining this effect in fasting dogs large doses of pituitrin are needed if injected subcutaneously, while the same effect can be produced by very small doses (0.18 cc.) if injected into the third ventricle of the brain. The pituitrin effect is abolished by destruction of the tuber cinereum at the base of the mesencephalon, by paralyzing the mesencephalic ...