Abstract
The posterior pituitary hormone, pituitrin, exerts some characteristic effects on fat-metabolism and seems to be an important factor in the consumption and distribution of body fat. These facts were demonstrated experimentally for the first time in 1925 by Coope and Chamberlain (6), who found a considerable accumulation of fatty acids within the liver under the influence of pituitrin and by Raab's (14) studies on the changes of blood fat and blood acetone bodies through various hormone preparations. Pituitrin was the only one that produced a marked and comparatively long lasting action on the blood fat level—a regular decrease during several hours. For obtaining this effect in fasting dogs large doses of pituitrin are needed if injected subcutaneously, while the same effect can be produced by very small doses (0.18 cc.) if injected into the third ventricle of the brain. The pituitrin effect is abolished by destruction of the tuber cinereum at the base of the mesencephalon, by paralyzing the mesencephalic ...
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