Objective: As adipokines relates with increases sympathetic activity and hyperinsulinemia, we aimed to assess the relationship between blood pressure (BP) and plasma adiponectin, leptin and resistin levels in resistant hypertension (RHTN), comparing the groups with and without type 2 diabetes mellitus (T2D). Design and method: Forty four RHTN pts (mean age 56.2 ± 8.6 years; mean 24 h BP: 162/91 mmHg; 20 male (46%)) underwent ambulatory BP monitoring, evaluating body mass index (BMI), plasma adiponectin, leptin and resistin concentrations. Results: Similar values of adiponectin, leptin and resistin were found in the T2D group (n = 17) and the non-T2D (n = 27) (p > 0.05). There were positively correlations of leptin level with BMI in both groups (r = 0.75, p = 0.00 for non-T2D and r = 0.71, r = 0.02 for T2D). The non-T2D pts with obesity (n = 19) have higher plasma leptin levels than those without (n = 8) (50.8 ± 25.2 vs. 18.4 ± 16.5ng/ml, p = 0.003), whereas in the T2D group plasma leptin level had no significant difference in the pts with (n = 4) and without obesity (n = 13) (27.6 ± 17.9 vs. 46.9 ± 25.6 ng/dL, p = 0.19). Furthermore, pts with obesity have similar leptin level in the non-T2D and T2D groups (p > 0.5). Values of adiponectin and resistin were similar in pts with and without obesity in both groups. Plasma leptin positively correlated with variability of 24 h systolic BP (SBP) and diastolic BP (DBP) in the non-T2D group (r = 0.41, P = 0.04 and r = 0.40, p = 0.04) and negatively correlated with the nighttime drop in SBP and DBP in the T2D group (r = −0.62, P = 0.01 for SBP and r = −0.59, P = 0.02 for DBP). Plasma adiponectin negatively correlated with SBP-24 h (r = −54, p = 0.04), SBP-day (r = −0.57, h = 0.03), loads of SBP-24 h (r = −0.64, p = = 0.009) and loads of SBP-day (r = −0.57, p = 0.03) only in the T2D group, whereas plasma resistin positively correlated with BP only in the non-T2D group (r = 0.56, p = 0.02 for SBP-24 h, r = 0.67, p = 0.000 for DBP-24 h.). Conclusions: These findings suggests that RHTN pts with or without type 2 diabetes have similar values of adipokines, but those adipokines differently contribute to blood pressure abnormalities in these groups. Plasma leptin has close relationship with BMI, and obesity RHTN pts have similar plasma leptin level regardless of the presence of T2D.