This research examines the evolution and renewal of Shanghai’s Huangpu River industrial zone after the 2010 Shanghai Expo, with a temporal focus on the profound changes and development philosophies driven by this mega-event. By investigating emblematic case studies along the Huangpu River, such as the transformative 80,000-ton silo, the Shanghai Museum of Contemporary Art, and the Long Museum, this research articulates how mega-events serve as pivotal moments for reimagining and repurposing industrial heritage. In the wake of the 2010 Shanghai Expo, these industrial relics emerged as focal points of urban regeneration, embodying the tensions and synergies between historical preservation and contemporary urban development. This study explores the temporal layers—from the event’s catalytic role to enduring legacies—and reveals how time influences the trajectory of urban spaces and the community’s connection to them. Through this temporal lens, the paper analyses the redevelopment process, assessing how these initiatives have reconfigured the industrial waterfront into a dynamic cultural landscape. The findings offer a dynamic perspective on the temporal dimensions that underpin the redevelopment of industrial heritage sites, providing insights into how such spaces can be continuously activated and symbiotically integrated into the fabric of the city. This paper aims to contribute to a broader understanding of the complexities involved in harnessing industrial heritage for mega-events, with implications for future urban planning and heritage conservation strategies.