Lens Group Research Articles

Myopia control: short-term effect of 0.01% atropine vs. defocus incorporated multiple segment lenses—a retrospective study in European children

PurposeTo compare 0.01% atropine with DIMS spectacle lenses in the prevention of myopia progression in European children.MethodsThis was a retrospective study including data from pediatric European patients with myopia. From November 2021 to March 2022, only 0.01% atropine was prescribed because DIMS lenses were still not available in Portugal. From March to October 2022, only DIMS spectacle lenses were prescribed due to patients’ parents’ preference. Myopia progression endpoints were axial length (AL) and spherical equivalent (SE) differences between before and 6 months after treatment. AL and SE evolution were compared using a general linear model with repeated measures.ResultsThe study included 98 eyes from 50 patients: 47 in the atropine group and 51 in the DIMS group. There were no statistically significant differences between groups in terms of initial AL, initial SE, sex or age. The mean AL elongation at 6 months was 0.057 mm in the atropine group (SD = 0.118) and 0.002 mm (SD = 0.077) in the DIMS group. SE progression was − 0.098 (SD = 0.232) D in the atropine group and − 0.039 (SD = 0.105) D in the DIMS group. AL elongation was significantly lower in the DIMS lens group (p = 0.038, partial Eta2 = 0.045). There was no difference in SE progression between groups (p = 0.302, partial Eta2 = 0.011).ConclusionComparison between 0.01% atropine eyedrops and DIMS spectacle lenses for slowing the progression of myopia favored DIMS lenses in terms of AL elongation in a short-term follow-up. There was no difference in terms of SE between groups.

Defocus-induced spatial changes in choroidal thickness of chicks observed by wide-field swept-source OCT

Choroid has been claimed to be of importance during ocular development. However, how the choroid responds spatially to different visual cues has not been fully understood. The aim of this study was to investigate defocus-induced spatial changes in choroidal thickness (ChT) in chicks. Eight 10-day-old chicks were fitted monocularly with −10 D or +10 D lenses (day 0), which were removed seven days later (day 7). The ChT was measured on days 0, 7, 14, and 21 using wide-field swept-source optical coherence tomography (SS-OCT) and analyzed with custom-made software. Comparisons of the ChT in the central (1 mm), paracentral (1–3 mm), and peripheral (3–6 mm) ring areas and the ChT in the superior, inferior, nasal, and temporal regions were conducted. Axial lengths and refractions were also evaluated. In the negative lens group, the global ChT of the treated eyes was significantly less than that of the fellow eyes on day 7 (interocular difference: 179.28 ± 25.94 μm, P = 0.001), but thicker on day 21 (interocular difference: 241.80 ± 57.13 μm, P = 0.024). These changes were more pronounced in the central choroid. The superior-temporal choroid changed more during induction but less during recovery. In the positive lens group, the ChT of both eyes increased on day 7 and decreased on day 21, with most changes occurring in the central region, too. The inferior-nasal choroid of the treated eyes changed more during induction but less during recovery. These results provide evidence for regionally asymmetric characteristics of the choroidal response to visual cues and insights into the underlying mechanisms of emmetropization.

Optical system design of double-sided telecentric microscope with high numerical aperture and long working distance.

The working distance of the high numerical aperture visible video microscope is extremely short, which greatly limits its application scenarios. To solve this problem, this paper proposes an unobstructed design method of double-sided telecentric microscope with high numerical aperture and long working distance. First, aiming at the obstruction problem of the image-side telecentric catadioptric microscope objective, the structure of the catadioptric optical system is improved. Then, the aspheric design method based on the best aberration compensation is analyzed theoretically to better correct the primary aberration of the high-numerical aperture microscope objective. Finally, a double-sided telecentric microscope optical system with a numerical aperture (NA) of 0.8 and a working distance of 10.0 mm was designed, which is composed of a spherical reflector, a beam splitter plate, a collimating lens group, and an image-side telecentric eyepiece optical system. The design results show that the imaging resolution of this high numerical aperture video microscope is as high as 0.42 µm, and the microscope has a magnification of about 220× for the image with 1080P (1920 × 1080 pixels) resolution. This double-sided telecentric microscope has the advantages of a large field of view, compact structure, good stray light suppression ability, and manufacturability, and has high practical value in the field of high-precision measurement and detection.

Development of vertical edge Thomson scattering diagnostic on HL-2M Tokamak

A vertical edge Thomson scattering diagnostic system on HL-2 M Tokamak has been developed recently. A Nd: YAG laser (1064 nm, 0.6–2.0 J, 30 Hz, 15 ns) is used as the probe beam. The laser beam propagates vertically through the plasma region and the scattered light is observed horizontally. The combination of a half-wave plate and a polarized beam splitter is used for stray light suppression. A group of in-vacuum collection lens is designed to image the 400 mm scattered region onto the rectangular fiber arrays. The laser beam waist and vertical spatial resolution are 2 mm and 10 mm, respectively. Scattered light is imaged on the 2.20 × 2.86 mm (10 × 13) fiber optic bundle. The development of collection optics with a special designed safety shutter ensures a reliable scattered signal, where the solid angle at central field of view (FOV) is 0.018 sr. A compact polychromator is developed to measure the scattered light. Relative calibration of the filter response (1060 nm, 1052 nm, 1029 nm and 982 nm) and absolute calibration by nitrogen Raman scattering have been completed. In the 2022 plasma campaign of HL-2M, the scattering signal is measured at E0 = 1.2 J, confirming the capability of the system for pedestal measurement in the future H-mode campaign.

A High-Precision Real-Time Pose Measurement Method for the Primary Lens of Large Aperture Space Telescope Based on Laser Ranging.

The aperture of space telescopes increases with their required resolution, and the transmission optical systems with long focal length and diffractive primary lens are becoming increasingly popular. In space, the changes in the pose of the primary lens relative to the rear lens group have a significant impact on the imaging performance of the telescope system. The measurement of the pose of the primary lens in real-time and with high-precision is one of the important techniques for a space telescope. In this paper, a high-precision real-time pose measurement method for the primary lens of a space telescope in orbit based on laser ranging is proposed, and a verification system is established. The pose change of the telescope's primary lens can be easily calculated through six high-precision laser distance changes. The measurement system can be installed freely, which solves the problems of complex system structure and low measurement accuracy in traditional pose measurement techniques. Analysis and experiments show that this method can accurately obtain the pose of the primary lens in real-time. The rotation error of the measurement system is 2 × 10-5 degrees (0.072 arcsecs), and the translation error is 0.2 μm. This study will provide a scientific basis for high-quality imaging of a space telescope.

Theoretical analysis of a multi-grating-based cross-dispersed spatial heterodyne spectrometer.

This paper presents a multi-grating-based cross-dispersed spatial heterodyne spectrometer (MGCDSHS). The principle of generation of two-dimensional interferograms for two cases, where the light beam is diffracted by one sub-grating or two sub-gratings, is given and equations for the interferogram parameters in these two cases are derived. An instrument design with numerical simulations is presented that demonstrates the spectrometer's ability to simultaneously record separate interferograms corresponding to different spectral features with high resolution over a broad spectral range. The design solves the mutual interference problem caused by overlapping of the interferograms, and also provides the high spectral resolution and broad spectral measurement range that cannot be achieved using conventional SHSs. Additionally, by introducing cylindrical lens groups, the MGCDSHS solves the throughput loss and light intensity reduction problems caused by direct use of multi-gratings. The MGCDSHS is compact, highly stable, and high-throughput. These advantages make the MGCDSHS suitable for high-sensitivity, high-resolution, and broadband spectral measurements.

Influence of isofocal intraocular lenses on objective refraction based on autorefraction and aberrometry.

To evaluate and compare the objective refractions obtained by autorefraction and aberrometry under different lighting conditions with an isofocal intraocular lens (Isopure, BVI medical, Liége, Belgium) compared to a monofocal control lens (Micropure, BVI medical, Liége, Belgium) with the same platform and material. Prospective, comparative and randomized study on patients undergoing cataract surgery and bilateral isofocal or monofocal IOL implantation. A total of 44 subjects were randomly assigned to either the isofocal group (n = 22) or the Micropure (n = 22). Manifest refraction (MR) was always performed under the same lighting conditions for all the patients. For objective refraction the autorefractor KR8800 and the aberrometer OPD-Scan III (Nidek Inc., Tokyo, Japan.) were used. For each eye included in the study, six result sets were collected: MR, AR (autorefraction measured with the autorefractor), WF-P and WF-M (Zernike-coefficients-based objective refraction, photopic and mesopic pupil size), OPD-C and OPD-M (autorefraction measured with the aberrometer in photopic and mesopic conditions). The mean sphere for MR was 0.03 ± 0.32D for the Isopure group and 0.24 ± 0.22D for the monofocal group (p = 0.013). For the Isopure group, Friedman analysis showed statistically significant differences for sphere measured with WF-P (p = 0.035), WF-M (p = 0.018) and OPD-M (p = 0.000), and SE measured with OPD-M (p = 0.004). In the Micropure lens group, the Friedman analysis showed differences for all values studied (p < 0.05). Correlation coefficients showed that AR is the objective method with the strongest correlation values for all components of refraction for both groups. The modification of the surfaces of the isofocal lens does not have a negative impact on the refraction obtained by AR compared to a standard monofocal intraocular lens.

Fotokromik Senofilcon A Kontakt Lensin Total Göz Aberasyonlarına Etkisi

Purpose: To investigate the effect of newly designed photochromic Senofilcon-A lens(PCL) on optical aberrations of the eye (total (TA) and high-order-aberrations (HOA)) under ambient illumination conditions.&#x0D; Methods: In this retrospective study, 40 eyes of 20 volunteers were fitted with a non-photochromic Senofilcon-A contact lens on the right eye, a PCL on left eye. Subjects were evaluated in terms of best-corrected visual-acuity. Aberrometric measurements were obtained at baseline(lens-free), with activated and deactivated PCL in 3 mm, 6 mm and maximum pupil size. &#x0D; Results: In lens-free situation there was no difference in terms of TA and HOAs(for 3mm, 6mm and max-pupil-size, TA; P= .456; P= .687; P= .899 and HOA; P = .226; P = .259; P = .442 respectively).In all pupil diameters, in the PCL group compared to the standard lens group, there was a slight increase in total aberrations independent of lens activation, which was not statistically significant(for 3mm,6mm and max-pupil-size, activated lens situation;P = .523; P = .622; P = .244 and deactivated lens situation; P = .785; P = .357; P = .201,respectively). Contrary to total aberrations, higher order aberrations were non-significantly slightly decreased in the PCL group(for 3mm,6mm and max-pupil-size, activated lens situation; P = .235; P = .661; P = .841 and deactivated lens situation;P = .245; P = .071; P = .231,respectively).&#x0D; Conclusion: The PCL produces similar TA and HOAs with the non-photochromic soft contact lens in both activated and deactivated situation. PCLs can be preferred for those who need uninterrupted vision in variable light conditions.

Optical centering method for lens assembly based on fiber point diffraction interferometry

Centering error in lens assembly reduces the image quality. We proposed an optical centering method based on fiber point diffraction interferometry (FPDI) in this paper. Two fiber point-light-sources (PLSs) interfere longitudinally. The intersection of the line connecting the two PLSs with an imaging plane occurs where the optical path difference (OPD) is an extremum. The line of these two PLSs defines a virtual reference axis. A lens group can be centered by mounting and adjusting lenses piece by piece between the two PLSs and keeping the OPD extremum point as unchanged as possible in this process. Introducing an auxiliary lens can enhance the sensitivity of this method to centering errors. We centered a lens group and showed the effectiveness of the proposed method. Compared with the autocollimation method, the FPDI method does not need to rotate lens elements and is always effective in testing centering errors. In contrast to the calculation of wavefront aberration in the computer-aided alignment (CAA) method, the FPDI method just determines the centering error through the coordinate offset of the OPD extremum point. It utilizes a reference axis that can be precisely positioned by interferometry. The theoretical assembly accuracy can reach micron and arcsec levels.

Six years of wearer experience in children participating in a myopia control study of MiSight® 1 day

PurposeTo evaluate the experience of children wearing soft contact lenses (CLs) during a trial of MiSight® 1 day (omafilcon A, CooperVision, Inc.), a dual-focus myopia-control daily disposable CL. MethodsA 3-year, double-masked, randomised trial (Part 1) comparing experiences with MiSight 1 day and a single-vision control (Proclear® 1 day, omafilcon A, CooperVision, Inc.) of neophyte, myopic children (ages 8–12). Treatment (n = 65) and control (n = 70) participants received lenses at sites in Canada, Portugal, Singapore, and the UK. Successful participants completing Part 1 were invited to continue for a further 3 years wearing the dual-focus CL (Part 2), and 85 participants completed the 6-year study. Children and parent questionnaires were conducted at baseline, 1 week, 1 month, and every 6 months until the 60-month visit, with children only also completing questionnaires at 66 and 72 months. ResultsThroughout the study, children reported high satisfaction with handling (≥89% top 2 box [T2B]), comfort (≥94% T2B), vision (≥93% T2B for various activities), and overall satisfaction (≥97% T2B). Ratings for comfort and vision were not significantly different between lens groups, visits, or study parts and did not change when children switched to dual-focus CLs. Ratings for ‘really easy’ or ‘kind of easy’ application improved from the outset for the neophytes (57% at 1-week follow-up and 85% at 1-month follow-up) and remained high throughout the study (visit: P = 0.007; part: P = 0.0004). Overall satisfaction improved in Part 2 (P = 0.04). Wearing times increased in Part 2 (14 vs. 13 hrs/weekday; 13 vs. 12 hrs/day on weekends; P < 0.001); there were no differences between groups. ConclusionsChildren adapted rapidly to full-time wear, rated lenses highly, and rarely reported issues. The dual-focus optics included in the MiSight® 1 day lenses successfully achieved myopia control without lowering subjective ratings when fitted to neophytes or children refitted from single-vision CLs.

Miniature camera module with a hollow linear ultrasonic motor-based focus feature

The construction of a miniature camera module that can explore inside limited spaces is of great interest for the design of millimeter-scale devices, such as endoscopes. This article presents a miniature camera module with a focus feature using a hollow linear ultrasonic motor. The hollow stator, which is simplified by the expansion and thickness-shear piezoelectric effects, is suitable for the miniaturization of the camera module because it can contain a lens group. The linear slider, which is thin and cylindrical with a slit, is inserted into the stator’s hole and generates a preload that exploits optimal motor performance measures. The resultant camera module is 4.6 mm × 4.6 mm square, which is the smallest one of camera modules reported to date. The motion of the miniature camera module is demonstrated by the wire-driven mechanism and a visual feedback control system. The orientation of the camera module head is controlled by a wire-driven mechanism until the target object is set in the range of view. The lens group placed inside the slider is controlled by the hollow linear ultrasonic motor in a visual feedback-loop system.

Highly efficient and ultra‐compact micro‐LED pico‐projector based on a microlens array

AbstractPico‐projection displays are the main developing direction for future projection displays, but the balance between the optical efficiency and the system size is still a big concern. This paper presents a pico‐projector design based on micro‐LED (μLED) light sources. Firstly, based on the analysis of the characteristics of μLED, a highly integrated microlens array is designed to improve the system efficiency by reshaping the spatial light distribution. In addition, the matching relationship between the aperture angle of projection lens and the divergence angle of μLED is studied, and on this basis, a set of four‐piece spherical lens group is proposed to achieve compact size. Simulation results show that the μLED equipped with the microlens array can concentrate about 86% of the light energy within a dispersion angle of ±20°, thus increasing the light energy utilization by about 3.5 times and reducing the size of the pico‐projector to 30.18 mm3. The designed pico‐projector has high performance and compact size with great potential for future applications.

Is myopia accelerated in type 1 diabetes mellitus children? Analyses from the ocular parameters

BackgroundThis study compares the ocular biometry with or without myopia in children with type 1 diabetes mellitus (T1DM) and healthy children in China to analyse the difference between myopia in T1DM and healthy children.MethodsA case-control study was conducted at the Children’s Hospital of Fudan University. The children were divided into four subgroups depending on myopia or non-myopia, T1DM or non-DM. The participants were evaluated for anterior chamber depth (ACD), lens thickness (LT), axial length (AL), average keratometry (K) and lens power (P). Furthermore, cycloplegic refraction was performed and the spherical equivalent (SE) was acquired.ResultsOne hundred and ten patients with T1DM and 102 healthy subjects were included in this study. In the age-sex adjusted analysis, the myopia T1DM subgroup showed thicker LT (p = 0.001), larger P (p = 0.003) and similar ACD, AL, K and SE (all p > 0.05) compared to the myopia control subgroup. Additionally, the myopia T1DM subgroup showed longer AL (p < 0.001) and similar ACD, LT, K and P (all p > 0.05) as the non-myopia T1DM subgroup. In the multivariate linear regression, for T1DM patients, eyes with longer AL, shallower ACD, and larger P were associated with a decrease in SE (p < 0.001, p = 0.01, and p < 0.001, respectively). Meanwhile, for healthy controls, eyes with longer AL and larger P were associated with a decrease in SE (all p < 0.001).ConclusionsThe ACD and LT of myopia T1DM children remained unchanged compared to non-myopia T1DM children. This means that the lens in the former group could not lose power as compensation for AL growth, thus providing evidence for the acceleration of myopia in T1DM children.

Long-term myopia control effect and safety in children wearing DIMS spectacle lenses for 6 years

This study evaluated the long-term myopia control effect and safety in children wearing Defocus Incorporated Multiple Segments (DIMS) spectacle lenses. Participants who completed the 2-year RCT were followed for a total of 6 years; their cycloplegic refractions and axial length were measured. Group 1 (n = 36) wore DIMS spectacles for 6 years; Group 2 (n = 14) wore DIMS lens for the first 3.5 years and SV spectacles afterwards; Group 3 (n = 22) wore SV spectacles in the first 2 years and switched to DIMS; Group 4 (n = 18) wore SV spectacles in the first 2 years, switched to DIMS for 1.5 years and then SV spectacles again. Group 1 showed no significant differences in myopia progression (− 0.52 ± 0.66 vs. − 0.40 ± 0.72D) and axial elongation (0.32 ± 0.26 vs. 0.28 ± 0.28 mm, both p > 0.05) between the first and the later 3 years. In the last 2.5 years, DIMS lens groups (Groups 1 and 3) had less myopia progression and axial elongation than the single vision groups (Groups 2 and 4). There was no evidence of rebound after stopping the treatment. Post-wear visual functions in all groups were within norms. The results supported that DIMS lenses provided sustained myopia control without adverse effects over the 6-year study period.Trial registration: clinicaltrials.gov; NCT02206217.

Outcomes of Laser Retinopexy for Retinal Tears in Pseudophakic Eyes with Multifocal Versus Monofocal Intraocular Lenses: A Matched Cohort Study

Purpose Performing laser retinopexy through multifocal intraocular lenses may be challenging due to aberrations of the peripheral retinal view. This study investigated the influence of multifocal versus monofocal intraocular lenses on outcomes of laser retinopexy for retinal tears. Methods Pseudophakic eyes (multifocal and monofocal intraocular lenses) that underwent in-office laser retinopexy for retinal tears, with a minimum follow-up of 3 months, were retrospectively analyzed. Eyes with multifocal intraocular lenses were matched to controls with monofocal intraocular lenses in a 1:2 ratio for age, gender, number, and location of retinal tears. The main outcome measure was the rate of complications. Results We included 168 eyes in the study. Fifty-six eyes (51 patients) with multifocal intraocular lenses were matched with 112 eyes (112 patients) with monofocal intraocular lenses. The mean follow-up was 26 months. Baseline characteristics were similar between two groups. No significant differences were noted in the rate of successful laser retinopexy without additional procedures (91% vs. 86% at 3 months and 79% vs. 74% during follow-up, in the multifocal intraocular lens and monofocal intraocular lens group, respectively). No significant differences were observed in the rate of subsequent rhegmatogenous retinal detachment (multifocal, 4% vs. monofocal, 6%, p=.716) or need for additional laser retinopexy for new tears (14% vs. 15%; p=.939). The surgery rates for vitreous hemorrhage (0% vs. 3%; p=.537), epiretinal membrane (2% vs. 2%; p=.553), and vitreous floaters (5% vs. 2%, p=.422) were not significantly different. Visual outcomes were also similar. Conclusion Multifocal intraocular lenses did not appear to negatively impact the outcomes of in-office laser retinopexy for retinal tears.

Wide-spectrum laser beam shaping for full-color volume holographic optical element recording.

For homogeneous diffraction efficiency of the recorded volume holographic optical element (vHOE), a recording beam of uniform intensity is required. A multicolor vHOE is recorded by an RGB laser source with Gaussian intensity distribution; during equal exposure time, recording beams of different intensities would result in different diffraction efficiencies in different recording areas. In this paper, we present a wide-spectrum laser beam shaping system design method, by which the incident RGB laser beam can be controlled into uniform intensity distribution with a spherical wavefront. This beam shaping system can be added to any recording system to obtain uniform intensity distribution without altering the beam shaping effect of the original recording system. The proposed beam shaping system is composed of two aspherical lens groups, and the design method with an initial point design and optimization design method is given. An example is built to demonstrate the feasibility of the proposed beam shaping system.

Beam Shaping Technique for 5-mm Fiber-coupled Laser Diode Bars with Lens Group

In the last few years, fiber-coupled diode lasers have shown massive applications in many fields of communication and scientific research. Particularly, the pumping of solid-state lasers is a key application for more powerful diode lasers enabling good solutions in various laser micro methods like metal cutting, sintering, structuring as well as drilling. In this work, a simple beam shaping method is demonstrated for coupling a high-power semiconductor laser diode into multi-mode fiber optic using optical lenses. The optical lenses as beam transformation components are utilized to reshape the asymmetrical irradiation of the diode laser bar and to circularize the laser beam. Using this simple method, compact, high-output-power, and high-brightness fiber-coupled laser diode systems are achieved. The obtained results show that the entire optical coupling efficiency of the system is more than 65%.

Comparing children's, teenagers' and young adults' subjective responses to myopia control contact lenses.

Myopia control (MC) studies in children link efficacy with subjective performance. There is little MC research in teenagers and young adults. This study compared subjective experience of MC contact lenses in different age groups. Data were retrospectively reviewed from two double-masked, bilateral wear, crossover contact lens clinical trials (myopia -0.75D to -3.50D and <1.00 DC; 9-35 years). Participants wore two novel lenses (MC lenses with relative peripheral plus [+1.50D and +2.50D]) and a single-vision (SV) control lens (Clariti® 1day) for 1 week each. All lenses were made from Somofilcon A material. Data collected included visual acuity (VA), wearing time, subjective ratings of comfort, distance and near vision clarity and overall vision. Generalised estimating equations with subject random intercepts and identity link functions were used in the analysis. A total of 31 participants (10 children, 11 teenagers and 10 adults) were included, with no difference between the age groups for VA with the dispensed lenses (p > 0.05). All groups could discriminate between the SV and MC lenses for vision (distance, near and overall) after 1 week (p < 0.05). There was no difference between groups for comfort or distance and near vision. Children rated the overall vision quality higher than teenagers and adults for both SV and MC lenses (p < 0.05), but there was no difference relative to the SV lens between groups (p > 0.50). Daily wear time was lowest for children for all lens types (all p < 0.02). Wear time was positively associated with ratings of overall vision quality for children and young adults (both p < 0.05). All age groups rated SV lenses higher than MC lenses. Subjective ratings of MC lenses appear similar between age groups relative to SV lenses. Wear time was lowest in children and was correlated with overall vision quality ratings in children and young adults.

The effects of base curve aspheric orthokeratology lenses on corneal topography and peripheral refraction: A randomized prospective trial

BackgroundTo investigate the effects of orthokeratology (ortho-k) lenses with aspheric and spherical base curve designs on corneal refractive power (CRP) and peripheral refraction. MethodsChildren aged 8 to 12 years with myopia between −0.75 D to −4.00 D, astigmatism ≤1.00 D, and corneal astigmatism ≤1.50 D were randomly assigned to the base curve aspheric (BCA) and base curve spherical (BCS) ortho-k lens groups. CRP was assessed for the central 8 mm cornea along horizontal and vertical meridians, and peripheral refraction was measured at 10°, 20°, and 30° along the nasal and temporal retina. Primary measurements included relative corneal refractive power change (RCRPC) and relative peripheral refraction change (RPRC). ResultsThe 3-month results of the 33 and 29 subjects (right eye only) in the BCA and BCS groups, respectively, were obtained. Nonsignificant differences were found in the baseline data between the two groups (p > 0.05). At the 3-month follow-up visit, the mean RCRPC in the BCA group (2.08 ± 0.65 D) was significantly greater than that in the BCS group (1.32 ± 0.81 D) (F1,51 = 25.25, p < 0.001). The BCA group (-1.82 ± 0.65 D) exhibited a larger absolute RPRC than the BCS group (-0.98 ± 0.54 D) (F1,57 = 33.73, p < 0.001). ConclusionsIt was found that the BCA ortho-k lens resulted in a more aspheric treatment zone and a more myopic relative peripheral refraction (RPR) along the horizontal meridian. The more myopic RPR was contributed by a more hyperopic central refraction and a more myopic peripheral refraction in the BCA group.

The Analysis of Muscle Volume Measured by Bioelectrical Impedance in Patients with Hepatocellular Carcinoma Treated with First-Line Atezolizumab plus Bevacizumab Combination Therapy or First-Line Lenvatinib

Introduction: Measurements of body composition, such as the skeletal muscle index (SMI), are useful for predicting prognosis in hepatocellular carcinoma (HCC). This study aimed to analyze the relationship between skeletal muscle changes during therapy with atezolizumab plus bevacizumab (Atezo + Beva) or lenvatinib (Len) and the association between SMI and prognosis. Methods: Patients with advanced HCC and Child-Pugh A status received Atezo + Beva or Len as first-line systemic chemotherapy. We assessed prognosis and body composition obtained by bioelectrical impedance analysis. Results: A total of 109 patients received treatment (Atezo + Beva, n = 47; Len, n = 62). During treatment, the arm SMI was reduced in the Len group and maintained in the Atezo + Beva group. The extracellular water to total body water ratio (ECW/TBW) increased significantly in both groups during treatment. In the Atezo + Beva group, no factor was associated with prognosis. Multivariate analysis showed that in the Len group, the arm SMI (hazard ratio [HR], 0.5; 95% CI: 0.26–0.89; p = 0.02), ECW/TBW (HR: 2.7; 95% CI: 1.21–6.01; p = 0.01), and Child-Pugh score (HR: 2.3; 95% CI: 1.31–6.13; p = 0.004) were associated with progression-free survival. Conclusion: Assessing body composition with BIA before Atezo + Beva and Len treatment may be useful.