Abstract
Purpose: To investigate the effect of newly designed photochromic Senofilcon-A lens(PCL) on optical aberrations of the eye (total (TA) and high-order-aberrations (HOA)) under ambient illumination conditions.
 Methods: In this retrospective study, 40 eyes of 20 volunteers were fitted with a non-photochromic Senofilcon-A contact lens on the right eye, a PCL on left eye. Subjects were evaluated in terms of best-corrected visual-acuity. Aberrometric measurements were obtained at baseline(lens-free), with activated and deactivated PCL in 3 mm, 6 mm and maximum pupil size. 
 Results: In lens-free situation there was no difference in terms of TA and HOAs(for 3mm, 6mm and max-pupil-size, TA; P= .456; P= .687; P= .899 and HOA; P = .226; P = .259; P = .442 respectively).In all pupil diameters, in the PCL group compared to the standard lens group, there was a slight increase in total aberrations independent of lens activation, which was not statistically significant(for 3mm,6mm and max-pupil-size, activated lens situation;P = .523; P = .622; P = .244 and deactivated lens situation; P = .785; P = .357; P = .201,respectively). Contrary to total aberrations, higher order aberrations were non-significantly slightly decreased in the PCL group(for 3mm,6mm and max-pupil-size, activated lens situation; P = .235; P = .661; P = .841 and deactivated lens situation;P = .245; P = .071; P = .231,respectively).
 Conclusion: The PCL produces similar TA and HOAs with the non-photochromic soft contact lens in both activated and deactivated situation. PCLs can be preferred for those who need uninterrupted vision in variable light conditions.
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