Objective: This review article explores solid dispersions (SDs) as one of the suitable approaches to formulate poorly water-soluble drugs. The objective of this review on SD techniques is to explore their utility as a feasible, simple, and economically viable method for augmentation of dissolution of hydrophobic drugs.
 Methods: Various types of SDs are classified and compared. Use of surfactants to stabilize the SDs and their potential advantages and disadvantages has been discussed. Different techniques for preparing and evaluating SDs are appraised along with discussions on scalability and industrial production. Review of the current research on SD along with future trends is also offered.
 Results: Based on the various researches, SDs offer an efficient means of improving bioavailability while concurrently contributing to lower toxicity and dose-reduction.
 Conclusion: Solid-dispersions have been and continue to be one of the key technologies for solving the issue of poor solubility for newer hydrophobic molecules which are being discovered. This would give a new lease of life for such drugs enabling them to be delivered in an effective way.

BackgroundTreating severe emotional dysregulation and co-occurring substance misuse is challenging. Dialectical behaviour therapy (DBT) is a comprehensive and evidence-based treatment for borderline personality disorder (BPD). It has been hypothesised that the skills training, which is a facet of the full DBT programme, might be effective for people with severe emotional dysregulation and other co-occurring conditions, but who do not meet the criteria for BPD. However, there is limited research on standalone DBT skills training for people with substance misuse and emotional dysregulation.MethodsA mixed methods study employing an explanatory sequential design was conducted where participants with a dual diagnosis (n = 64) were recruited from a community-based public addiction treatment service in Ireland between March 2015 and January 2018. DBT therapists screened potential participants against the study eligibility criteria. Quantitative self-report measures examining emotion regulation, mindfulness, adaptive and maladaptive coping responses including substance misuse, and qualitative feedback from participants were collected. Quantitative data were summarised by their mean and standard deviation and multilevel linear mixed effects models were used to estimate the mean change from baseline to post-intervention and the 6-month follow-up period. Thematic analysis was used to analyse the qualitative data.ResultsQuantitative results indicated reductions in binge drinking and use of Class A, B and C drug use from pre-intervention (T1) to the 6-month follow-up (T3). Additionally, significant improvements were noted for mindfulness practice and DBT skills use from T1 to T3 (p < 0.001). There were also significant reductions in dysfunctional coping and emotional dysregulation from T1 to T3 (p < 0.001). Significant differences were identified from pre to post intervention in reported substance use, p = 0.002. However, there were no significant differences between pre-intervention and 6-month follow up reports of substance use or at post-intervention to 6 month follow up. Qualitative findings indicated three superordinate themes in relation to participants’ experiences of a DBT skills training programme, adapted from standard DBT: (1) new lease of life; (2) need for continued formal aftercare and (3) programme improvements. Participants described reductions in substance misuse, while having increased confidence to use the DBT skills they had learned in the programme to deal with difficult emotions and life stressors.ConclusionsThis DBT skills training programme, adapted from standard DBT, showed positive results for participants and appears effective in treating people with co-occurring disorders. Qualitative results of this mixed methods study corroborate the quantitative results indicating that the experiences of participants have been positive. The study indicates that a DBT skills programme may provide a useful therapeutic approach to managing co-occurring symptoms.

A former ALMA prototype antenna has a new lease of life in the harsh conditions of Greenland, where it will play a key role in very-long-baseline interferometry observations of supermassive black holes, explain Nimesh Patel and Paul Ho.

The photoessay Healing The Wounds From the Drug War was the trail of people’s lives that have been disrupted by this brutal campaign in the Philippines. It was about what happens to those people left behind after the killings. Some who survive end up in decrepit jails. The families of the dead, mostly from the poor who get by in hand-to-mouth existence, end up buried in debt only to have their loved ones get a burial. But it also a story of hope for those given a new lease of life by organisations willing to assist in the rehabilitation of drug addicts.

ABSTRACTThis article challenges the historiographical narrative that modernity saw a transition from shame to guilt. I argue not only that these two concepts overlapped, but that, if anything, a shift occurred in the opposite direction: from guilt to shame. I identify two concepts of shame: guilt-shame, focused on sinfulness and caused by mere introspection, and reputation-shame, focused on social norms and caused by the (albeit imagined) gaze of others. Looking primarily at English texts, straying often into the European republic of letters, I argue that in the seventeenth century, as Biblicist fervour gave way to natural religion and a naturalistic turn in moral philosophy, and as burgeoning public spheres needed governing, reputation-shame experienced a new lease of life. This argument, in turn, questions the characterisation of the modern self as private, insulated and autonomous, gesturing instead at open, social minds that were nonetheless deeply, passionately, interiorised. In picking apart these interwoven strands in the history of the concept of shame, I hope to make the methodological point that one cannot be essentialist about concepts. There is no concept of shame that can be analysed abstracted from time and space, only particular uses of the concept in particular utterances.

Europe is a continent of extraordinary variety and diversity geographically, ethnically, nationally, culturally, economically and politically. Yet at the same time all its parts are and always have been so deeply linked by their destiny that this continent can accurately be described as a single albeit complex political entity. Anything crucial in any area of human endeavour occurring anywhere in Europe always has had both direct and indirect consequences for our continent as a whole. The history of Europe is, in fact, the history of a constant searching and reshaping of its internal structures and the relationship of its parts. Today, if we talk about a single European civilization or about common European values, history, traditions, and destiny, what we are referring to is more the fruit of this tendency toward integration than its cause.

Scientists who step back from full-time work can find plenty of ways to remain active in their research field. Scientists who step back from full-time work can find plenty of ways to remain active in their research field.

Consultant engineers give endoscopy facilities a new lease of life

We study the evolution of ideas related to creation of asset-backed currencies over the last 200 years and argue that recent developments related to distributed ledger technologies and blockchains give asset-backed currencies a new lease of life. We propose a practical mechanism combining novel technological breakthroughs with well-established hedging techniques for building an asset-backed transactional oriented cryptocurrency, which we call the digital trade coin (DTC). We show that in its mature state, the DTC can serve as a much-needed counterpoint to fiat reserve currencies of today.

The Boeing 787's troubled service entry and new engine technology have given the Airbus A330 a new lease of life

Both Antiquity and archaeology have changed immeasurably since O.G.S. Crawford penned this journal's first editorial in 1927. The discipline has grown in size and sophistication, and has achieved professional status and public recognition. What was novel at that time, such as aerial photography and the use of ethnographic parallels, both flagged in that first editorial, have now long been integral to archaeological theory and practice. Antiquity has documented—and often driven—these developments, itself evolving along the way. Nine decades after its foundation, Antiquity publishes more content, on more varied periods and places, and authored by an ever-more international cast of contributors. It has also changed in terms of its audience. Part of Crawford's original vision was to communicate archaeology more effectively to the general public, not least with the intention of debunking the misleading, sensationalist and downright incorrect fare peddled in the bestsellers and newspapers of the day. The content of Antiquity today is aimed at a more professional readership, what one previous editor, Martin Carver, called “the extended archaeological family” of academics and field archaeologists, and the many associated specialists in cognate disciplines with whom we work. All these developments notwithstanding, it is striking that many of Crawford's concerns and interests still continue to resonate. The disciplinary imperative to communicate with the public is stronger than ever, finding new opportunities in social media, blogs and TV programmes, and under pressure from funding bodies to demonstrate public benefit or ‘impact’. The analytical, and aesthetic, importance of aerial photography that Crawford worked hard to promote has too taken on a new lease of life through satellite imagery, LiDAR and, most recently, photography using drones or unmanned aerial vehicles (see Frontispiece 1).

Every day thousands of family photographs get abandoned in second hand bookshops, at flea markets, and internet auctions, losing their past and having their stories erased. Conversely, the same images get found, reappropriated, and assigned with new meanings. It is this process of giving the found photograph a new lease of life that I explore in this article. As I argue here, photographs continue to act as potent narrative tools even if we no longer have access to their subjects or producers. Not only do I show how anonymous photographs can be read and interpreted but also how they function as material objects that are collected, loved, treasured, and inevitably integrated into the lives of their new adopted families. I show, in particular, how both the content and the materiality of photographs makes them carriers of family history and private memory, as well as intersecting with other categories such as class and identity.

Currently, in view of the increasing garbage crisis, the notion of a “new lease of life” for waste becomes even more relevant. Waste recycling makes it possible not only to solve obvious environmental problems, but also to offer new resource opportunities for industries. Among the obvious economic, social and environmental advantages, however, waste recycling meets various problems. These problems and solutions for them, as well as the problems of economic efficiency improvement and recycling activities’ appeal for industrial companies in Leningrad region, are discussed in the present study.

Cpf1 nucleases were recently reported to be highly specific and programmable nucleases with efficiencies comparable to those of SpCas9. AsCpf1 and LbCpf1 require a single crRNA and recognize a 5′-TTTN-3′ protospacer adjacent motif (PAM) at the 5′ end of the protospacer for genome editing. For widespread application in precision site-specific human genome editing, the range of sequences that AsCpf1 and LbCpf1 can recognize is limited due to the size of this PAM. To address this limitation, we sought to identify a novel Cpf1 nuclease with simpler PAM requirements. Specifically, here we sought to test and engineer FnCpf1, one reported Cpf1 nuclease (FnCpf1) only requires 5′-TTN-3′ as a PAM but does not exhibit detectable levels of nuclease-induced indels at certain locus in human cells. Surprisingly, we found that FnCpf1 possesses DNA cleavage activity in human cells at multiple loci. We also comprehensively and quantitatively examined various FnCpf1 parameters in human cells, including spacer sequence, direct repeat sequence and the PAM sequence. Our study identifies FnCpf1 as a new member of the Cpf1 family for human genome editing with distinctive characteristics, which shows promise as a genome editing tool with the potential for both research and therapeutic applications.

Can one imagine language without proverbs? Do we really need these somewhat cliched adages like An apple a day keeps a doctor away, Once bitten, twice shy, or Crime doesn’t pay? Are they still influential, or perhaps modern society should give them a new lease of life? This paper aims to reveal the “painful truth” behind traditional proverbs and especially their modified versions. Leading paremiologists (Wolfgang Mieder, Nihada Delibegovic Džanic, Anna Litovkina) introduce a number of terms in reference to the latter, and so this study discusses the etymology and the semantic import of such labels as anti-proverbs, twisted proverbs, quasi-proverbs, and pseudo-proverbs. However, its basic aim is to propose a classification of modified proverbs based on a number of examples, such as Man proposes, mother-in-law opposes; A good beginning is half the bottle; Crime pays – be a lawyer; A new broom sweeps clean, but the old one knows the corners, and many others. Finally, based on Ronald Langacker’s conception of the profile-base distinction, deriving from the figure-ground alignment, this paper makes an attempt to prove the necessary link between traditional proverbs and their innovative modifications.

Abstract Today, technological development has given a new lease of life in language learning and teaching field. Particularly in terms of evaluation, some schools in Indonesia conduct national examination using computer-based test. Traditionally, testing in a class involves paper-based test which is familiar to students. A substantial number of studies have been conducted to compare both of the tests. The researcher investigated what activities were performed by the students throughout the tests, what kind of multiple choice tests the students prefer to do, and what the positive and negative side of those tests. This study presents a wonder share quiz creator (WSQC) program to facilitate the teachers to design a test. The data was collected by questionnaire, interview, observation, and quiz. In this study, the authors concluded that students in senior high school of Kendari prefer paper-based test for national examination.

Reforestation in Algeria has been recognized as a priority in different programs for the development and enhancement of forest heritage. Degradation factors of forest and soil contribute significantly to the decline in land values. The Algerian forests in the past, during the colonial period suffered considerable degradation. The degraded forest heritage has been undertaken with serious programs since independence. Several programs for the development of the forest sector through reforestation have been carried out. Unfortunately, the achievements were still below expectations. The launch of the National Reforestation Plan in 2000 has given the forestry sector a new lease of life with a vision that incorporates the productive aspect of reforestation, the industrial aspect, and the recreational aspect. Before the end of the NRP timeline, significant reforestation projects are completed. In a future projection, reforestation is integrated into the land use planning within the framework of the National Plan of Land Use Planning.

A new lease of life for a controversial wonder-drug? The latest on statins

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REE N°1/2017 47 In order to continue safe operation of its nu- clear fleet, EDF has launched a programme of investment entitled “Grand Carenage” (in other words, a fleet upgrade programme). The term – which is a maritime expression – suggests a ship which, after years at sea, undergoes a retrofit to get a new lease of life. This programme aims to extend the operating lifetime of the French fleet’s reactors beyond 40 years, and to do so in complete safety. The “Grand Carenage”, which represents a real industrial and financial challenge, relies on the entire nuclear industry, the third largest French industrial sector, comprising 220,000 employees, a network of regional companies of all sizes, numerous and varied professions, all being drivers of innovation. Lastly, the “Grand Carenage” helps lay the foundations for a mix of nuclear and renewable energies, and gua- rantees the sustainable generation of safe, clean and competitive electricity. ABSTRACT Afin de poursuivre l’exploitation de son parc nucleaire en toute surete, EDF a en- gage un programme d’investissements baptise « Grand Carenage ». Ce terme, emprunte au monde maritime, evoque un