Learning Approach Research Articles

Optimizing Distributed Energy Resources in Microgrid SCUC through Seq2Seq Scheduling Algorithms

In order to optimize Distributed Energy Resources (DERs) inside a microgrid's Security-Constrained Unit Commitment framework, this study investigates the use of Seq2Seq (Sequence-to-Sequence) scheduling methods (SCUC). There is a growing consensus that microgrids are an important part of the future of the electric grid because of the advantages they provide in terms of reliability, renewable energy integration, and overall efficiency. In the context of complicated SCUC issues, efficient scheduling and optimization of DERs are essential for realizing their full potential. Seq2Seq models, a kind of deep learning approach, have shown impressive performance in several applications requiring sequence prediction. Uncertainty in renewable energy production, energy demand forecasts, and security limitations are all addressed in this work as Seq2Seq algorithms are applied to microgrid SCUC. Significant gains in economic efficiency, ecological viability, and compliance with security constraints have been shown. This study lays the way for the development of more effective, sustainable, and resilient energy infrastructure by contributing to the advancement of the area of microgrid optimization.

US federal resource allocations are inconsistent with concentrations of energy poverty.

Recent data from the US Energy Information Administration reveals that nearly one in three households in the United States report experiencing energy poverty, and this number is only expected to rise. Federal assistance programs exist, but allocations across states have been nearly static since 1984, while the distribution of energy poverty is dynamic in location and time. We implement a LASSO-based machine learning approach using sociodemographic and geographical information to estimate energy burden in each US census tract for 2015 and 2020. We then compare the allocation to states from the Low Income Home Energy Assistance Program to an optimized allocation. We allocate funds to the most burdened households, providing them with enough assistance to reduce their energy expenditures so that their household energy burden is equal to a new maximum allowable energy burden. This markedly shifts funds from the northern cold-weather states to the southern warm-weather states.

Machine Learning Approaches in Multi-Cancer Early Detection

Cancer is a prominent global cause of mortality, primarily due to delayed detection leading to limited treatment options. Current screening methods are mostly invasive and involve complex lengthy processes with high costs. Moreover, each screening typically focuses on a single type of cancer. This imposes a growing need for innovative, precise, and minimally invasive methods for early cancer detection. With the current advances in assay technologies and data science, multi-cancer early detection (MCED) tests are gaining increased interest in the research community as they offer potential for earlier diagnosis and improved patient outcomes. Different approaches are followed for MCED, and multiple machine learning methods are considered. In this paper, we systematically explore various MCED studies and their applied machine learning (ML) models for different types of biomarker data. We discuss the strengths and limitations of different study designs and compare their performance. Future directions are proposed, emphasizing the importance of integrating multi-omics data, enhancing model transparency, and fostering collaborative efforts to develop robust, cost effective and clinically applicable MCED tools.

DeepIndel: An Interpretable Deep Learning Approach for Predicting CRISPR/Cas9-Mediated Editing Outcomes

DeepIndel: An Interpretable Deep Learning Approach for Predicting CRISPR/Cas9-Mediated Editing Outcomes

Enhancing health assessments with large language models: A methodological approach.

Health assessments have long been a significant research topic within the field of health psychology. By analyzing the results of subject scales, these assessments effectively evaluate physical and mental health status. Traditional methods, based on statistical analysis, are limited in accuracy due to their reliance on linear scoring methods. Meanwhile, machine learning approaches, despite their potential, have not been widely adopted due to their poor interpretability and dependence on large amounts of training data. Recently, large language models (LLMs) have gained widespread attention for their powerful natural language understanding capabilities, offering a viable solution to these issues. This study investigates the application of LLMs in enhancing physical and mental health assessments, introducing ScaleLLM. ScaleLLM employs language and knowledge alignment to turn LLMs into expert evaluators for health psychology scales. Experimental results indicate that ScaleLLM can improve the accuracy and interpretability of health assessments.

Comparative study of machine learning approaches integrated with genetic algorithm for IVF success prediction.

IVF is a widely-used assisted reproductive technology with a consistent success rate of around 30%, and improving this rate is crucial due to emotional, financial, and health-related implications for infertile couples. This study aimed to develop a model for predicting IVF outcome by comparing five machine-learning techniques. The research approached five prominent machine learning algorithms, including Random Forest, Artificial Neural Network (ANN), Support Vector Machine (SVM), Recursive Partitioning and Regression Trees (RPART), and AdaBoost, in the context of IVF success prediction. The study also incorporated GA as a feature selection method to enhance the predictive models' robustness. Findings demonstrate that AdaBoost, particularly when combined with GA feature selection, achieved the highest accuracy rate of 89.8%. Using GA, Random Forest also demonstrated strong performance, achieving an accuracy rate of 87.4%. Genetic Algorithm significantly improved the performance of all classifiers, emphasizing the importance of feature selection. Ten crucial features, including female age, AMH, endometrial thickness, sperm count, and various indicators of oocyte and embryo quality, were identified as key determinants of IVF success. These findings underscore the potential of machine learning and feature selection techniques to assist IVF clinicians in providing more accurate predictions, enabling tailored treatment plans for each patient. Future research and validation can further enhance the practicality and reliability of these predictive models in clinical IVF practice.

Countering Social Media Cybercrime Using Deep Learning: Instagram Fake Accounts Detection

An online social media platform such as Instagram has become a popular communication channel that millions of people are using today. However, this media also becomes an avenue where fake accounts are used to inflate the number of followers on a targeted account. Fake accounts tend to alter the concepts of popularity and influence on the Instagram media platform and significantly impact the economy, politics, and society, which is considered cybercrime. This paper proposes a framework to classify fake and real accounts on Instagram based on a deep learning approach called the Long Short-Term Memory (LSTM) network. Experiments and comparisons with existing machine and deep learning frameworks demonstrate considerable improvement in the proposed framework. It achieved a detection accuracy of 97.42% and 94.21% on two publicly available Instagram datasets, with F-measure scores of 92.17% and 89.55%, respectively. Further experiments on the Twitter dataset reveal the effectiveness of the proposed framework by achieving an impressive accuracy rate of 99.42%.

Deciphering Cathepsin K inhibitors: a combined QSAR, docking and MD simulation based machine learning approaches for drug design

ABSTRACT Cathepsin K (CatK), a lysosomal cysteine protease, contributes to skeletal abnormalities, heart diseases, lung inflammation, and central nervous system and immune disorders. Currently, CatK inhibitors are associated with severe adverse effects, therefore limiting their clinical utility. This study focuses on exploring quantitative structure–activity relationships (QSAR) on a dataset of CatK inhibitors (1804) compiled from the ChEMBL database to predict the inhibitory activities. After data cleaning and pre-processing, a total of 1568 structures were selected for exploratory data analysis which revealed physicochemical properties, distributions and statistical significance between the two groups of inhibitors. PubChem fingerprinting with 11 different machine-learning classification models was computed. The comparative analysis showed the ET model performed well with accuracy values for the training set (0.999), cross-validation (0.970) and test set (0.977) in line with OECD guidelines. Moreover, to gain structural insights on the origin of CatK inhibition, 15 diverse molecules were selected for molecular docking. The CatK inhibitors (1 and 2) exhibited strong binding energies of −8.3 and −7.2 kcal/mol, respectively. MD simulation (300 ns) showed strong structural stability, flexibility and interactions in selected complexes. This synergy between QSAR, docking, MD simulation and machine learning models strengthen our evidence for developing novel and resilient CatK inhibitors.

Predictive Understanding of Stream Salinization in a Developed Watershed Using Machine Learning.

Stream salinization is a global issue, yet few models can provide reliable salinity estimates for unmonitored locations at the time scales required for ecological exposure assessments. Machine learning approaches are presented that use spatially limited high-frequency monitoring and spatially distributed discrete samples to estimate the daily stream-specific conductance across a watershed. We compare the predictive performance of space- and time-unaware Random Forest models and space- and time-aware Recurrent Graph Convolution Neural Network models (KGE: 0.67 and 0.64, respectively) and use explainable artificial intelligence methods to interpret model predictions and understand salinization drivers. These models are applied to the Delaware River Basin, a developed watershed with diverse land uses that experiences anthropogenic salinization from winter deicer applications. These models capture seasonality for the winter first flush of deicers, and the streams with elevated predictions correspond well with indicators of deicer application. This result suggests that these models can be used to identify potential salinity-impaired streams for winter best management practices. Daily salinity predictions are driven primarily by land cover (urbanization) trends that may represent anthropogenic salinization processes and weather at time scales up to three months. Such modeling approaches are likely transferable to other watersheds and can be applied to further understand salinization risks and drivers.

A hybrid decomposition-based Machine Learning approach for predicting subsurface temperature in the Arabian Sea

A hybrid decomposition-based Machine Learning approach for predicting subsurface temperature in the Arabian Sea

Data-driven investigation of thickness variations in multilayer thin film coatings

Abstract Design and fabrication of multilayer thin film coatings for photonics applications require careful consideration of various parameters such as layer thickness, refractive indices and number of stacks. A growing trend uses machine learning for efficient navigation in the complex parameter space of photonics applications to efficiently extract valuable insights from the extensive datasets and to predict the optical performance. We developed an approach that combines Monte-Carlo and Finite-Difference Time-Domain (FDTD) simulations to model multilayer thin films. After conducting 95,200 runs, the data were analyzed using Neural Network (NN) fitting to explore how thickness variations influence the optical performance. An experiment validation on magnetron sputtered coated samples demonstrates the high accuracy of our method in predicting the optical performance of the thin film stacks (R2>0.99), contributing to the understanding and enhancement of photonics stack properties for diverse optical applications using machine learning approaches.

Improving Predictive Efficacy for Drug Resistance in Novel HIV-1 Protease Inhibitors through Transfer Learning Mechanisms.

The human immunodeficiency virus presents a significant global health challenge due to its rapid mutation and the development of resistance mechanisms against antiretroviral drugs. Recent studies demonstrate the impressive performance of machine learning (ML) and deep learning (DL) models in predicting the drug resistance profile of specific FDA-approved inhibitors. However, generalizing ML and DL models to learn not only from isolates but also from inhibitor representations remains challenging for HIV-1 infection. We propose a novel drug-isolate-fold change (DIF) model framework that aims to predict drug resistance score directly from the protein sequence and inhibitor representation. Various ML and DL models, inhibitor representations, and protein representations were analyzed through realistic validation mechanisms. To enhance the molecular learning capacity of DIF models, we employ a transfer learning approach by pretraining a graph neural network (GNN) model for activity prediction on a data set of 4855 HIV-1 protease inhibitors (PIs). By performing various realistic validation strategies on internal and external genotype-phenotype data sets, we statistically show that the learned representations of inhibitors improve the predictive ability of DIF-based ML and DL models. We achieved an accuracy of 0.802, AUROC of 0.874, and r of 0.727 for the unseen external PIs. By comparing the DIF-based models with a null model consisting of isolate-fold change (IF) architecture, it is observed that the DIF models significantly benefit from molecular representations. Combined results from various testing strategies and statistical tests confirm the effectiveness of DIF models in testing novel PIs for drug resistance in the presence of an isolate.

Ensemble and Gossip Learning-Based Framework for Intrusion Detection System in Vehicle-to-Everything Communication Environment

Autonomous vehicles are revolutionizing the future of intelligent transportation systems by integrating smart and intelligent onboard units (OBUs) that minimize human intervention. These vehicles can communicate with their environment and one another, sharing critical information such as emergency alerts or media content. However, this communication infrastructure is susceptible to cyber-attacks, necessitating robust mechanisms for detection and defense. Among these, the most critical threat is the denial-of-service (DoS) attack, which can target any entity within the system that communicates with autonomous vehicles, including roadside units (RSUs), or other autonomous vehicles. Such attacks can lead to devastating consequences, including the disruption or complete cessation of service provision by the infrastructure or the autonomous vehicle itself. In this paper, we propose a system capable of detecting DoS attacks in autonomous vehicles across two scenarios: an infrastructure-based scenario and an infrastructureless scenario, corresponding to vehicle-to-everything communication (V2X) Mode 3 and Mode 4, respectively. For Mode 3, we propose an ensemble learning (EL) approach, while for the Mode 4 environment, we introduce a gossip learning (GL)-based approach. The gossip and ensemble learning approaches demonstrate remarkable achievements in detecting DoS attacks on the UNSW-NB15 dataset, with efficiencies of 98.82% and 99.16%, respectively. Moreover, these methods exhibit superior performance compared to existing schemes.

A hybrid machine learning approach for designing a new XY compliant mechanism to maximize fatigue life

A hybrid machine learning approach for designing a new XY compliant mechanism to maximize fatigue life

Deciphering protective genomic factors of tumor development in pediatric down syndrome via deep learning approach to whole genome and RNA sequencing

Deciphering protective genomic factors of tumor development in pediatric down syndrome via deep learning approach to whole genome and RNA sequencing

Prediction of prostate cancer recurrence after radiotherapy using a fused machine learning approach: utilizing radiomics from pretreatment T2W MRI images with clinical and pathological information

The risk of biochemical recurrence (BCR) after radiotherapy for localized prostate cancer (PCa) varies widely within standard risk groups. There is a need for low-cost tools to more robustly predict recurrence and personalize therapy. Radiomic features from pretreatment MRI show potential as noninvasive biomarkers for BCR prediction. However, previous research has not fully combined radiomics with clinical and pathological data to predict BCR in PCa patients following radiotherapy.
Purpose: This study aims to predict 5-year BCR using radiomics from pretreatment T2W MRI and clinical-pathological data in PCa patients treated with radiation therapy, and to develop a unified model compatible with both 1.5T and 3T MRI scanners.
Methods: A total of 150 T2W scans and clinical parameters were preprocessed. Of these, 120 cases were used for training and validation, and 30 for testing. Four distinct machine learning models were developed: Model 1 used radiomics, Model 2 used clinical and pathological data, and Model 3 combined these using late fusion. Model 4 integrated radiomic and clinical-pathological data using early fusion.
Results: Model 1 achieved an AUC of 0.73, while Model 2 had an AUC of 0.64 for predicting outcomes in 30 new test cases. Model 3, using late fusion, had an AUC of 0.69. Early fusion models showed strong potential, with Model 4 reaching an AUC of 0.84, highlighting the effectiveness of the early fusion model.
Conclusions: This study is the first to use a fusion technique for predicting BCR in PCa patients following radiotherapy, utilizing pre-treatment T2W MRI images and clinical-pathological data. The methodology improves predictive accuracy by fusing radiomics with clinical-pathological information, even with a relatively small dataset, and introduces the first unified model for both 1.5T and 3T MRI images.

Modeling all-type biomolecular structures with deep learning approaches

Modeling all-type biomolecular structures with deep learning approaches

A deep learning approach to calculate elementary effects of morris sensitivity analysis

A deep learning approach to calculate elementary effects of morris sensitivity analysis

Fall Risk Classification Using Trunk Movement Patterns from Inertial Measurement Units and Mini-BESTest in Community-Dwelling Older Adults: A Deep Learning Approach

Fall Risk Classification Using Trunk Movement Patterns from Inertial Measurement Units and Mini-BESTest in Community-Dwelling Older Adults: A Deep Learning Approach

EFFECT OF BLENDED LEARNING EDUCATIONAL MODEL ON SECONDARY SCHOOL STUDENTS’ MATHEMATICS CONCEPTUAL UNDERSTANDING

The study was conducted to assess the effect of a blended learning educational model on grade ten students' mathematics conceptual understanding in Ethiopia. A non-equivalent pre-test and post-test quasi-experimental design was employed. Two intact classes from different schools were randomly selected and assigned to experimental (n=38) and comparison group (n=45). From the previous semester, students’ record book revealed that both groups have almost an equivalent mathematics performance. A one-way ANOVA and paired sample t-test were used to analyze the data. Moreover, to check the equivalence of the groups, the same pre-test was developed and administered. The result indicates that both groups were equivalent. The test covers tenth-grade topics relations and functions, polynomial functions, exponential functions, and logarithmic functions. The study shows that students instructed through the blended learning approach surpassed those taught via the conventional method in their comprehension of mathematical concepts. The one-way ANOVA statistical result revealed there is a notable disparity between groups with effect size of η2 =.269, which is a large effect size. Moreover, a paired sample t-test shows the experimental group showed a substantial mean difference of 14.327 with a very large effect size (d=1.016) when compared with the comparison group. Thus, the study shows that blended learning was more effective in improving mathematical conceptual understanding when compared with a conventional method of teaching. Based on the findings, the researcher recommends blended learning in mathematics education and suggests stakeholders and policymakers incorporate the model into the curriculum. Keywords: blended learning, conceptual understanding, educational model, lab rotation model, mathematical concept