The impeller of the multi-blade centrifugal fan significantly impacts the fan's internal flow field and aerodynamic performance. To improve the axial flow distribution along the impeller and suppress the blade passage backflow at the impeller outlet of multi-blade centrifugal fans, a method of variable chord length blade design is proposed. Simultaneously, optimization models are established with static pressure and efficiency as objectives. By altering the control points of the Bezier curve, the leading-edge profile of the impeller is optimized. The results indicate that using variable chord length blades can expand the operating range of the multi-blade centrifugal fan. The maximum flow rate improvement reaches 10.6%. Significant enhancements in the aerodynamic efficiency of the multi-blade centrifugal fan are observed at low flow rates, with a maximum improvement of 4.9%. The variable chord length blade design method enables adjustment of the axial flow distribution at the impeller outlet to better match the impeller's flow requirements. This leads to increased outlet flow on both the shroud and hub sides of the impeller, consequently reducing the backflow area on both sides and improving the blade passage backflow phenomenon. Moreover, variable chord length blades facilitate a more uniform circumferential flow distribution at the impeller outlet, reducing the diversion pressure of the volute tongue, mitigating flow separation within the blade passage, weakening the interaction between the impeller and the volute tongue, and lowering energy losses in the impeller–volute tongue regions. Consequently, this enhances the aerodynamic performance of multi-blade centrifugal fans.