Brain mapping performance (BMP) is an innovative assessment designed by psychosocial occupational therapists to createtalent engagement across lifespan. However, work readiness seems to be challenging assessment for anyone who has notbeen accepted on why and how to develop their upskilling. This preliminary study aimed to examine the validity andreliability of the BMP assessment. Six case studies were voluntarily participated as talented leaders of one corporate. Fourassociations of soft skills were outcomes, i.e., creativity, flexibility, empathy, and leadership, in the consecutive assessmentof resting and voice-recording.This special formulation displays healthy brain performance, significantly associated inbetween empathy and leadership (Sr = 0.880-0.943); creativity and flexibility (Sr = 0.886); eustress engagement and growthmindset (Sr = 0.943); flexibility and positive thinking (Sr = 0.926). The BMP can individually explain how well of intrinsicbrain capacity for leadership talent. This is a transformative strategy to optimize human-centered performances.