Hospital Management Systems (HMS) represent a key advancement in healthcare technology designed to revolutionize operational efficiency, raise standards of patient care and ensure compliance with regulatory protocols. This paper explores the multifaceted functions of HMS, highlighting its role in automating administrative tasks, supporting real-time access to patient data, and facilitating seamless communication between healthcare professionals. Drawing on current research and practical implementations, we delve into the transformative potential of HMS, particularly in the context of recent innovations in telemedicine, data analytics, and remote monitoring systems. In our research, we present SIMRS, a robust hospital management information system developed using the waterfall method, strategically focused on the systematic improvement of hospital operations. By automating key processes such as patient registration, appointment scheduling, payment and inventory management, SIMRS optimizes hospital workflows and ultimately improves patient care delivery. In addition, we examine the empirical evidence that shows the significant impact of management systems and leadership traits on the quality of care in hospital settings, and highlight the indispensable role of effective leadership and management frameworks. Next, we discuss the technical foundations of HMS and highlight the integration of various programming languages and database management systems such as HTML, CSS, JavaScript, PHP, MySQL, and MongoDB. This cross-disciplinary approach underscores the synergy between technological innovation and healthcare management, paving the way for a more efficient patient- centered healthcare ecosystem. In summary, this research illuminates the transformative potential of HMS to revolutionize healthcare operations, improve patient outcomes and optimize resource allocation, advocating for its widespread adoption to shape the future of healthcare delivery. Key Words: JavaScript, MySql, HMS, Electronic Health Records, Telehealth