The tailing in a large lead-zinc-iron-sulfur multi-metallic mine has rich reservation in variety of metallic minerals. It has been difficult to recover because of all kinds of reasons. The challenges faced by lead-zinc ore beneficiation are, low grade and recovery of lead and zinc concentrate for fine disseminated grain size, high oxidation rate and close intergrowth. This paper presents a Pulp Potential Control Flotation by stages technique to improve the flotation performance of the lead-zinc ores. In the electrochemical potential controlling flotation processing, using DDTC as collector, the separation potential range of galena and sphalerite with pyrrhotite can be achieved. Flotation circuit of lead-zinc-silver tailing ore was achieved.