In this study, we proposed a practical scheme for the challenging robotic cable insertion task. In general, the applied architecture is based on two YOLOs, vision-based pose estimation and admittance control. A precise and effective method was developed to estimate the pose of a manipulated connector. Our method uses a deep convolutional neural network to detect the relevant regions in the image. The characteristics of these relevant regions along with the pins’ layout manifold are combined to conduct the estimation. Practical problems such as error examination and time efficiency were considered in the proposed method for real applications. An admittance controller is introduced to experimentally validate the performance of pose estimation and provide compliant insertion by the proposed architecture. Our method is only based on less prior layout knowledge and does not require a precise model, which facilitates modeling and deployment. In addition, our method is robust to image quality and has low computational complexity, which makes it highly suitable for online manipulation. Besides, our method can handle multiple connector types which can cover most cases in aeronautical manufacturing and guide the design of connectors in the production process. The advantages of our method were demonstrated by extensive testing using both synthetic data and experiments. We also designed an insertion controller and realized a complete insertion task using a PC with a 12 GB RTX 3060 GPU and 32 GB RAM. These experimental results show that our method can achieve precise and reliable estimation with mean absolute errors less than 0.44 deg and 0.36 mm, an estimation accuracy of over 99%, and a successful manipulation rate of over 94%. This reveals that the proposed method displays potential for the challenging robotic cable insertion task.