Lavender Essential Oil Research Articles

The Effect of Aromatherapy with Lavender Essential Oil on the Sleep and Fatigue Level of Patients with Multiple Sclerosis in Turkey: A Randomized Controlled Trial.

Fatigue is a common problem in patients with multiple sclerosis (MS) and is one of the most serious symptoms of the disease. Although many factors play a role in the etiology of fatigue in patients with MS, it has been reported that fatigue is caused by irregular or disrupted sleep patterns. The purpose of the study was to examine the effects of lavender oil aromatherapy on the sleep and fatigue of MS patients. The study was designed as a randomized controlled trial and was conducted in Turkey. The data of the study were collected using the Patient Description Form, Fatigue Severity Scale, and Pittsburgh Sleep Quality Index. The mean FSS score in the experimental group was 6.86 ± 0.94 before the procedure and 3.42 ± 0.85 after the procedure, the mean PSQI score was 9.45 ± 1.23 before the procedure and 6.68 ± 2.87 after the procedure, and the difference in the mean scores between the two groups was found to be statistically significant (P < 0.001). The results showed that aromatherapy with lavender essential oil has significant impacts on fatigue and sleep in MS patients. Lavender essential oil aromatherapy can be used by nurses as an independent nursing practice. It is an inexpensive, noninvasive, and reliable technique to manage fatigue in individuals with MS.

Enhancing the nitric oxide inhibitory activity using a combination of plant essential oils and mixture design approach

The synergistic effects of essential oils (EOs) from three aromatic plant species, Foeniculum vulgare subsp. piperitum (C.Presl) Bég. (FV), Origanum heracleoticum L. (OH) and Lavandula austroapennina N.G.Passal., Tundis & Upson. (LA), were evaluated for their inhibitory properties on nitric oxide production in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS). We utilized a Design of Experiments (DoE) methodology to optimize a formulation by combining three Essential Oils (EOs), while simultaneously taking into account two response variables, maximization of NO inhibition with minimum cytotoxicity. The optimal blend of components was predicted, and the statistical outcome's efficacy was experimentally verified. The combination corresponding to 87.7 % FV, 12.3 % LA and 0.0 % OH showed high inhibitory effect (76.3 %) with negligible cytotoxicity (4.5 %). This research provides new information on the interactions among fennel, oregano and lavender essential oils and shows how they can synergistically inhibit in vitro LPS-induced NO production.

Stability and Retention of Nanoemulsion Formulations Incorporating Lavender Essential Oil

Lavender essential oil (LEO) is applied topically for its soothing properties, serving not only as an antiseptic in wound care but also as an insect repellent. This study investigates the impact of carrier systems on LEO encapsulation, stability, and release kinetics for potential skincare applications. The LEO carrier impact on skin hydration and barrier function was also evaluated. Conventional emulsions (CEs) and nanoemulsions (NEs) with (CELs and NELs, respectively) and without LEO incorporation were analyzed for physicochemical properties, stability, and release mechanisms. The droplet size distribution and ζ-potential remained consistent in both CE and CEL, showing the minimal influence of LEO on those parameters. NE and NEL exhibited enhanced stability and higher LEO retention compared to CE and CEL (37.38 mg/mL ± 0.48 mg/mL and 50.96 mg/mL ± 2.00 mg/mL, respectively, p &lt; 0.05), suggesting NE as a superior carrier system for LEO delivery. NEL retained LEO over 60 days at 4 °C without a significant reduction while CEL showed a notable reduction of 94.93% ± 0.08%. Release kinetics analysis showed zero-order release kinetics of LEO from both CEL and NEL (R2: 0.973 and 0.952, respectively), revealing a diffusion-based mechanism, particularly evident in NE formulations, supporting the controlled and sustained release of LEO constituents. NEL also promoted quicker skin barrier repair and enhanced skin hydration, sustaining effects for up to 120 min post application, surpassing CEL’s performance. These findings contribute to understanding the carrier system effects on LEO delivery and underscore NE as a promising vehicle for skincare applications. Further research should explore underlying mechanisms and conduct long-term safety and efficacy studies to fully exploit the therapeutic potential of NE in dermatological applications.

Comparative biotoxicity study for identifying better alternative insecticide especially green nano-emulsion which used as mosquitocides

This research work was planned to test biosafety of different nanomaterials on the different animals models. These nanoparticles were previously used as potential insecticides of mosquito larvae. The biosafety of these nanoproducts were evaluated on certain organs of non target animals that associated with mosquito breeding sites in Egypt. Animal organs such as the kidneys of rats, toads, and the fish’s spleen were used as models to study the biological toxicity of these nanomaterials. After 30 days of the animals receiving the nanomaterials in their water supply, different cell mediated immune cells were assessed in these tissues. Both TNF-α and BAX immuno-expression were also used as immunohistochemical markers. Histopathology was conducted to detect the effect of the tested nanoproducts at the tissue level of the liver and kidneys of both the rats and toads. Green nanoemulsion of the lavender essential oil was relatively more effective, safe, and biodegradable to be used as insecticides against mosquito larvae than the metal-based nanomaterials.

Programming and validation of a novel green procedure for the production of essential oil from Lavandula angustifolia

Lavandula angustifolia (lavender) essential oil (LEO) is extremely popular and beneficial. In the present study, LEO was extracted with green ultrasound-assisted supercritical CO2 (UscCO2) and other classical methodologies. The highest yield of LEO (5.32 % (w/w)) was achieved with the UscCO2 process, followed by hexane extraction (4.32%), scCO2 extraction (3.94 %) and hydrodistillation (HD; 3.69 %). The contents of two dominant aromatic ingredients, linalool (29.93 %) and linalyl acetate (35.08 %), obtained by the UscCO2 procedure were also the highest. Remarkably, the linalyl acetate content in UscCO2-derived LEO was nearly triple that in LEO extracted via HD (12.33 %). The novel UscCO2 technique not only provided the highest LEO quality but also revealed the highest extraction efficiency under mild extraction parameters. The dynamic solubility of LEO in the UscCO2 and scCO2 procedures was further determined to confirm the kinetic efficacy. The dynamic solubility was simulated with three density-based models, which provided excellent agreement with the experimental results. The approximate heat of vaporization, total heat of solution and heat of solvation obtained from UscCO2 dynamic extraction of LEO were significantly lower than those obtained from the scCO2 procedure. The kinetic and thermal effects of ultrasonic energy substantially contributed to the excellent performance of UscCO2.

Toxicological, biological, and biochemical impacts of the egyptian lavender (Lavandula multifida L.) essential oil on two lepidopteran pests

The use of essential oils as an eco-friendly tool in pest management stems from their natural origin and the presence of bioactive compounds that exhibit pesticidal properties, offering a sustainable alternative to synthetic chemical pesticides. This study explores the toxicity of Lavandula multifida (lavender) essential oil (EO), as a botanical pesticide against two widespread and destructive Noctuidae pests, Spodoptera littoralis (Boisd.) and Agrotis ipsilon (Hufnagel). GC-MS was employed to characterize 23 compounds in the EO, with 1,3,3-trimethyl-2-oxabicyclo [2.2.2] octane (eucalyptol) (39.84%), being the primary component. The leaf dipping technique was utilized to assess the toxicity of the EO to both insects. At 96 hours post-treatment, the LC50 of lavender EO to S. littoralis and A. ipsilon larvae were 2.350 and 2.991 mg · ml–1, respectively. Concerning its biological effect, both concentrations of the EO (LC15 and LC50) significantly shortened the duration of the larval (to 15.24 and 14.23 days) and pupal (to 11.19 and 10.55 days) stages of S. littoralis. Biochemical assays revealed that the LC50 of lavender EO significantly inhibited α-esterase activity in S. littoralis at 72- and 96 hours post-treatment (0.031 and 0.063 mmol · min–1 · mg–1), and A. ipsilon at 96 hours post-treatment (0.129 mmol · min–1 · mg–1 protein). Given its significant toxicological, biological, and biochemical effects on S. littoralis, it is suggested that lavender EO could be considered for use in integrated pest management strategies while ensuring its safe application to protect non-target organisms.

Aromatherapy in the Care of an Atypical Child with ADHD and Atopic Dermatitis

Introduction: This study was a practical intervention aimed at analyzing and demonstrating the effects of aromatherapy in a case of Atopic Dermatitis. One male child, aged 5, participated in this study with the following inclusion criteria: having a diagnosis and undergoing medical follow-up, engaging in necessary behavioral therapies, availability to participate in the study, undergoing therapeutic practice in a clinic weekly and at home daily. The skin is our boundary with the world, our body limit, the organ that allows us to feel, making exchanges and contact with the environment and people around us; it signals our emotions and affective needs. Materials and Methods: The treatment was carried out by a single professional. The sessions were held once a week, totaling 10 sessions of 45 minutes each. The following oils were used: Grape Seed Vegetable Oil: Anti-inflammatory, antimicrobial action, promotes wound healing, inhibits histamine production (assists in dermatitis treatment), and increases skin flexibility. Rosehip Vegetable Oil: Revitalizing action aiding in healing. Regenerating, recommended for wound care, eczema, skin lesions. Sweet Orange Essential Oil: Balance, comfort, and safety, anxiolytic, soothing, sedative, for colds and flu. Lemongrass Essential Oil: Strengthens family bonds, reduces stress and anxiety, and calms. Copaiba Essential Oil: Stress reducer, emotional soother, anti-inflammatory, healing, expectorant, anti-allergic, immune system booster. Lavender Essential Oil: Bactericidal, sedative action, recommended for stress and nervousness, dermatitis, healing, respiratory system, decongestant, bronchitis, colds. Protocol Description: An initial assessment was conducted, followed by the selection of oils to be used and the protocol definition. According to information provided by the mother, the child exhibited concentration and focus difficulties, sensory changes, respiratory issues like bronchitis and rhinitis, low immunity, and pruriginous, eczematous, scaly, and fissured cutaneous changes in the cubital fold, knee, and perioral regions, intensified after the birth of a sibling. Protocol Steps: Maternal-infant-family integration (essential oils of lemongrass and sweet orange were used olfactorily for 2 weeks); Cutaneous lesions (blend of copaiba and lavender essential oils diluted in grape seed and rosehip vegetable oils at 1.5%, for home and clinic use); Agitation and immunity (copaiba and lavender essential oils in an environmental diffuser once a day, for home and clinic use). Results: The results showed a decrease in motor and mental agitation, improved maternal/paternal-infant-family bonding, and significant improvement in dermatological conditions, with reduced eczema, itching, scaling, and dryness. Discussion and Conclusion: The application of aromatherapy requires technical and scientific knowledge, as well as the choice of oils. Aromatherapy is a complementary technique that adds to the existing behavioral and conservative treatments, enhancing their results and broadening the treatment possibilities in these cases. It works in conjunction with the medical and paramedical team, providing interdisciplinary quality care and can be considered an efficient health prevention strategy.

Clinical Case Report: Use of Essential Oils in Chronic Dermal Wound

Currently, there is a trend towards adopting treatments with more natural alternative products over synthetic ones. Essential oils are known for their numerous medicinal properties (from physical to emotional issues) and have been used by the population for millennia. They contain volatile compounds that have therapeutic properties. Their complex chemical composition provides plants with adaptive advantages in their environment and can be used as important active principles in products intended for human treatment. Essential oils also have antioxidant properties, preventing cellular damage and premature aging (such as lemon, lavender, and sweet orange essential oils, for example). Regarding antimicrobial properties, various essential oils have shown activity against bacteria, fungi, and viruses. For example, tea tree oil has been effective against various bacteria and fungi, including methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans. Additionally, essential oils are widely used for analgesic purposes, such as peppermint, lavender, eucalyptus, and clove, or essential oils that can reduce anxiety, improve mood, and promote relaxation like lavender, sweet orange, bergamot, and ylang-ylang. Another interesting oil is used in important ingredients in incenses and perfumes, the extract from gum resins obtained from the Burseraceae family trees (Boswellia sp.) that have anti-inflammatory and antineoplastic effects. Chemical components like linalool, linalyl acetate, terpinen-4-ol, 1,8 cineole, pinenes, γ-terpinene, borneol, limonene, α-thujene, and menthol are some of the main components found in various essential oils. The most abundant phenol in oregano essential oil is a potent antibacterial agent. The aim was to report an individual clinical case, in home care, requested by a physical educator, of a female patient, leucoderma, 74 years old, residing in the State of São Paulo, presenting a chronic wound in the posteroinferior region of the right leg that was not responding to conventional methods (antibiotics, anti-inflammatories, analgesics, in addition to laser therapy) for more than two months. She also faced respiratory problems, sleep difficulties, mild depression, and reduced mobility. She reported being a controlled diabetic, hypertensive, and having occupational asthma. As a requested choice, aromatherapy was the sought treatment, and a protocol was established considering both physical and emotional aspects, recommending topical and aromatic use of essential oils of oregano, lavender, tea tree, frankincense, in addition to fractionated coconut and rosehip vegetable oils as diluents. After 47 days, the wound had healed, and the patient showed optimism and improved sleep quality. Aromatherapy offers a holistic and gentle approach to treating various conditions, and this case is an inspiring example of how essential oils can make a difference in people's lives. However, more clinical studies with a larger population are necessary to investigate the treatment's efficacy and safety.

Lavender Essential Oil Inhalation Improves Attentional Shifting and Accuracy: Evidence from Dynamic Changes of Cognitive Flexibility and Power Spectral Density of Electroencephalogram Signals.

Cognitive flexibility, a vital component of executive function, entails the utilization of extended brain networks. Olfactory stimulation has been shown to influence various brain functions, particularly cognitive performance. To investigate aroma inhalation's effects on brain activity dynamics associated with cognitive flexibility, 20 healthy adults were recruited to complete a set-shifting task during two experimental conditions: no aroma stimuli vs. lavender essential oil inhalation. Using Thomson's multitaper approach, the normalized power spectral density (NPSD) was assessed for five frequency bands. Findings confirm that aroma inhalation significantly affects behavioral indices (i.e., reaction time (RT) and response accuracy) and electroencephalogram (EEG) signatures, especially in the frontal lobe. Participants showed a tremendous increase in theta and alpha NPSD, associated with relaxation, along with beta NPSD, associated with clear and fast thinking after inhaling the aroma. NPSD of the delta band, an indicator of the unconscious mind, significantly decreased when stimulated with lavender essential oil. Further, participants exhibited shorter RT and more accurate responses following aroma inhalation. Our findings revealed significant changes in oscillatory power and behavioral performance after aroma inhalation, providing neural evidence that olfactory stimulation with lavender essential oil may facilitate cognitive flexibility.

Effectiveness of aromatherapy with lavender compared to progressive muscle relaxation on anxiety and vital signs in patients under spinal anesthesia: A randomized clinical trial

ABSTRACT Objective: This study aimed to determine the effectiveness of aromatherapy with lavender essential oil compared to progressive muscle relaxation (PMR) on anxiety and vital signs of patients under spinal anesthesia. Materials and Methods: This clinical trial was conducted on 120 spinal anesthesia candidates who were randomly assigned into three groups of 40 including control, PMR (Jacobsen group), and aromatherapy. The state-trait anxiety inventory was completed on surgery day and 15 min after the end of the intervention by the samples of all three groups, and at the same time as completing the questionnaire, vital signs were also measured and recorded. Results: The mean score of anxiety after intervention was lower than that before the intervention in the aromatherapy group (P &lt; 0.001). The mean score of anxiety in the aromatherapy group was significantly lower than that in the Jacobsen group (P &lt; 0.001). Moreover, data analysis showed a significant decrease in the mean arterial blood pressure scores of the PMR (P = 008) and aromatherapy (P &lt; 0.001) groups and a statistically significant increase in the mean heart rate scores in the control group (P = 0.002). Conclusion: The use of aromatherapy with lavender is more effective than PMR therapy in reducing the anxiety level of patients undergoing spinal anesthesia. Due to the high level of anxiety and its serious effects on the patient’s hemodynamics, aromatherapy with lavender can be used as an easy and cheap method to reduce anxiety in operation rooms.

Can environmental nebulization of lavender essential oil (L. angustifolia) improve welfare and modulate nasal microbiota of growing pigs?

The use of phytoextracts has been proposed as a method to improve animal welfare, also in pigs, by reducing stress and anxiety and improving performances. Lavandula angustifolia (Miller) essential oil (LaEO) is an interesting calming phytoextract that could be administered by inhalation for prolonged periods of time to help pigs coping with on-farm conditions. The aim of this study was to assess the effects of daily inhalation of vaporized LaEO on pigs' welfare and health indicators, and nasal microbiota, trying to understand whether this phytoextract represents a feasible tool to improve animal welfare under intensive farming conditions. Eighty-four crossbred barrows were randomly divided into 3 experimental groups: control (C); lavender (L): 3 vaporization sessions of 10 min each of a custom made 1% solution of LaEO; sham (S): same vaporization sessions of L group but only using the solution vehicle. Experimental readouts included growth parameters, behavioural traits, tail and skin lesions, hair steroids and nasal microbiota. L group animals did not show altered growth performance and seemed calmer (increased recumbency time), with decreased amount of skin lesions also associated with lower severity class for tail lesions. They also showed decreased CORT/DHEA ratio, potentially suggesting a beneficial effect of LaEO. Inhalation of LaEO significantly affected the nasal pig microbiome by reducing its diversity. Overall, the study suggests how inhalation of Lavender essential oil may be capable of improving welfare in growing pigs, yet it is pivotal to consider the microbial modulatory capabilities of essential oils before exploiting them on larger scale.

Influence of the preparation method on selected properties of PLA nanofibers modified with lavender oil

PLA nanofibers containing 30 wt% lavender essential oil (LEO) was obtained by electrospinning (ES) and solution blow spinning (SBS) methods. The structure was assessed by scanning electron microscopy (SEM), and thermal properties were determined by thermogravimetric analysis (TGA). The ES method produced thinner nanofibers than the SBS method. The method of obtaining nanofibers did not affect their thermal properties.

Modelling of the equilibrium of supercritical CO2 + lavender essential oil with Aspen Plus®

This study describes the procedure to calculate the equilibrium data of supercritical CO2 extraction of lavender essential oil (LEO) by using the commercial Aspen Plus® simulator and RK-Aspen thermodynamic package. From the experimental and bibliographic data, properties of pure compounds and the binary interaction parameters could be determined. A plant was also designed to calculate the solubility of LEO from the model obtained and the effectiveness of this tool to predict solubility data was verified, with model values very close to those determined experimentally; the maximum value was 22.6 kg LEO/m3 CO2 at 40 ºC and 180 bar. These results allowed us to study the influence of the number of stages in the extractor as well as the ratio between solvent and raw material (S/F). The proposed model can be useful to make a preliminary study of the supercritical extraction of other oils avoiding the determination of specific equilibrium data.

Effect of Lavender Aromatherapy on Anxiety and Fatigue in Hemodialysis Patients: A Systematic Review and Meta-Analysis.

Several studies have evaluated the effects of lavender essential oil on the anxiety of hemodialysis (HD) patients, but most of them did not estimate the pooled effect size. The current systematic review and meta-analysis was conducted to evaluate the effects of lavender on anxiety and fatigue among HD patients. Eligible studies were selected based on the PRISMA steps and protocol. Literature was retrieved from PubMed, Web of Science, Scopus databases, Cochrane, ClinicalTrials.gov, and Google Scholar Search Engines until Sep 2022. The risk of bias and analysis were evaluated using version 2 of the Cochrane risk-of-bias tool and STATA v.14 software, respectively. Effect sizes were pooled using random effect models. Nine studies were included. Lavender oil significantly reduced the average anxiety of HD patients compared to the control group (SMD: -2.51, 95% CI: [-3.56, -1.45], Z=4.67, P<0.001, I2 :89.9%). Also, it significantly reduced the average fatigue compared to the control group (SMD: -1.56, 95% CI: [-2.49, -0.63], Z=3.29, P=0.001, I2:92.2%). Subgroup analysis indicated controversial results regarding session frequency and drop number of lavender oil. Using Lavender oil significantly reduced fatigue and anxiety in HD patients.

The effect of lavender on mood disorders associated with the use of combined oral contraceptives (COCs): a triple-blinded randomized controlled trial

BackgroundThe use of contraceptive methods is influenced by their effectiveness, availability, and minimal side effects. OCPs are one of the most effective and widely used methods of pregnancy prevention worldwide. This method not only prevents pregnancy but also helps prevent and treat other diseases. One of the main reasons for discontinuing this method is the emotional disturbances associated with its use. Lavender is an evergreen, fragrant plant that has gained significant attention for its anti-anxiety effects. This study was conducted to investigate the effect of lavender essential oil capsules on mood disorders during the use of COCs.MethodsThis triple-blinded clinical trial was conducted on 60 married women (aged 15–49 years old) who were consumers of COCs, referring to 26 health centers in Tabriz, Iran. The participants were randomly assigned to either the intervention (consuming one gelatin capsule containing 80 mg LEO daily) or control (consuming one placebo capsule daily) group. The intervention continued for 56 days. Scores for positive and negative were determined using the Positive and Negative Affect Schedule (PANAS) questionnaire; and for stress, depression, and anxiety were measured using the DASS-21 questionnaire on day’s 28th and 56th post-intervention. Data analysis was conducted using the t-test and ANOVA with repeated measures, and a p-value of < 0.05 was considered significant for all analyses.ResultsA statistically significant difference was observed in mood disorders, stress, and depression between women receiving LEO or placebo. The consumption of LEO increased the positive mood on day 28 [MD (95% CI): 4.5 (2.1 to 7.0), p = 0.001] and day 56 [5.9 (3.4 to 8.3), p < 0.001] while decreased the negative mood on day 28 [MD (95% CI): -3.5 (-5.3 to -1.3), p < 0.001] and day 56 [-4.3 (-6.3 to -2.2), p < 0.001], stress on day 28 [MD (95% CI): -4.9 (-7.1 to -2.8), p = 0.001] and day 56 [-5.3 (-7.6 to -3.1), p < 0. 001], and depression on day 28 [MD (95% CI): -3.0 (-4.9 to 1.1), p = 0.003] and day 56 [-3.1 (-5.0 to 1.2), p = 0.002]. There was no statistically significant difference between the two groups in terms of anxiety.ConclusionsThe consumption of LEO with COCs improved mood disorders and reduced stress and depression. The use of hormonal contraceptives and mood changes should be considered by providers. Therefore, regarding the possibility of mood changes, it is expected that appropriate counseling and education will be provided to women who consume COC., providing appropriate solutions, including the simultaneous use of LEO.

Lavandula angustifolia mill. for a suitable non-invasive treatment against fungal colonization on organic-media cultural heritage

In the context of bio-deterioration of cultural heritage, the Lavandula angustifolia Mill. plant proves to be of interest for a green approach to the preservation of art manufacts on organic media. Supercritical CO2 fluid extraction (SFE) was utilized to obtain both lavender essential oil (E2LS3) and hydrolate (E2LS3A), while ultrasound assisted maceration in n-hexane:ethanol (99:1, v:v) provided LA2/1 extract. The extracts, all chemically characterized by UHPLC-HRMS and GC–MS analyses, were screened for their antifungal capability towards six fungi isolated from the plywood support of Haim Steinbach's contemporary artwork "Un-color becomes alter ego #2" (1984). To this purpose, disk diffusion method was applied on both mycelium and conidial suspensions to unravel whether the inhibitory activity affects the growth of fungi at different life cycle stages. The micro-atmosphere method was also explored to assess the response of fungal growth in a saturated atmosphere. Data acquired highlighted that SFE-obtained lavender essential oil, whose oxygenated monoterpene part mostly accounting for terpinene-4-ol, borneol, linalool, camphor, and 1,8-cineole, proves to be a dose- and time-dependent inhibitor of fungal growth. It has also been shown that exposure to the oil vapor phase is more effective at very low dose levels. The promising results allow us to hypothesize the use of the essential oil for treating fungal colonization by exposure to its volatile components in a modified atmosphere environment, with no direct contact with the artwork.Graphical abstract

Lavender aromatherapy: Its effect on preoperative anxiety and propofol requirement for anesthesia

Background &amp; objective: Preoperative anxiety is a natural human psychology, and the physicians usually prescribe tranquillizers to allay the anxiety of their anxiety. Various other means have also been employed for this purpose. We aimed to investigate the impact of lavender aromatherapy on preoperative anxiety and propofol requirement at induction of anesthesia.&#x0D; Methodology: A total of 108 female patients were enrolled in the study, and their anxiety levels were evaluated using the Visual Analogue Scale (VAS) at three different time points. Patients were randomly divided into two groups. Group A (Lavender Group) patients were given lavender aromatherapy via a cotton strip infused with two drops of 100% pure lavender essential oil, while the patients in Group B (Control Group) had no aromatherapy.&#x0D; Results: The results showed that the lavender aromatherapy significantly reduced anxiety in Group A (P &lt; 0.001) compared to Group B, and the mean differences of VAS scores for all anxiety assessments were also significantly reduced in Group A (P &lt; 0.000). In addition, the mean total amount of propofol required was significantly less in Group A than in Group B (118.46 ± 40.01 vs 140.38 ± 35.29 mg; P = 0.003), while the mean duration to reach loss of consciousness was similar in both groups.&#x0D; Conclusion: The findings of our study suggest that lavender aromatherapy can be a simple, safe, and cost-effective way to reduce preoperative anxiety and decrease the amount of propofol required for the induction of anesthesia. Therefore, the use of lavender aromatherapy may be a valuable addition to the preoperative care of patients undergoing elective surgeries.&#x0D; Abbreviations: APAIS- Amsterdam Preoperative and Information Scale; LOC- Loss of Consciousness; OT- Operation Theatre; OR- Operating Room; STAI- State-Trait Anxiety Inventory; VAS- Visual Analogue Scale&#x0D; Key words: Aromatherapy; Benzodiazepines; Lavender; Anxiety, Preoperative; Propofol; Anxiety / therapy; Anxiety Disorders&#x0D; Citation: Rahman RA, Vasu Dewan MM, Sayed Masri SNN, Mokhtar MN, Abdullah FH, Md Nor N. Lavender aromatherapy: Its effect on preoperative anxiety and propofol requirement for anesthesia. Anaesth. pain intensive care 2024;28(1):20−25; DOI: 10.35975/apic.v28i1.2376&#x0D; Received: April 26, 2023; Reviewed: November 22, 2023; Accepted: November 22, 2023

Physicochemical study of natural zeolite modified with lavender essential oil

Zeolite-containing nanocomposites as candidates for Lavender oil delivery systems were investigated. The nanocomposite samples and lavender oil delivery systems were investigated by pore size distribution and X-ray diffraction (XRD), the specific surface area with Brunauer-Emmett-Teller (BET), Fourier-transform infrared (FT-IR) spectrometer, energy-dispersive spectroscopy (EDX) analysis and Scanning Electron Microscopy (SEM). These initial results could significantly contribute to the further development of applications for lavender essential oil delivery systems based on natural zeolites as innovative bioactive products.

UJI STABILITAS FISIK LOTION ANTI NYAMUK KOMBINASI MINYAK LAVENDER (Lavandula angustifolia) DAN MINYAK ROSEMARY (Rormarinus officinalis)

Lavender essential oil 15% can be used as an anti-mosquito protection power on average 56% at 6 hours. Rosemary has a more fragrant aroma and can make mosquitoes uncomfortable and avoid it. This study aims to determine physical stability of mosquito repellent lotion. Lavender oil mosquito repellent lotion (Lavandula angustifolia) and rosemary oil (Rosmarinus officinalis) made in 3 formulas, namely F1 containing lavender oil (10%), F2 (15%), and F3 (20%), and F1 containing rosemary oil (30%), F2 (25%), and F3 (20%). Mosquito repellent lotion was tested for its physical stability using the cycling test method which included organoleptic, homogeneity, pH, adhesion, and spreadability. In this research, citronella and lavender oils can be formulated into anti-mosquito lotions. The results of physical stability (organoleptic, pH, homogeneity, spreadability and adhesion) using the cycling test method show that the anti-mosquito lotion did not change during storage and the results were in accordance with the expected specifications. It can be concluded that the difference in the concentration of lavender and rosemary essential oils does not affect the stability test of the anti-mosquito lotion preparation.

The Effectiveness of Various Essential Oils on the Market as Aedes Aegypti Mosquito Repellent

Introduction: In Indonesia, the average dengue cases are 121,191 each year with a Case Fatality Rate (CFR) of 0.69%. Mosquito control with common chemical methods will negatively impact the environment and human health and can cause mosquitoes to develop resistance. Environmentally-friendly replacement chemicals derived from plants such as citronella contains 16.27% citronella and 19.88% geraniol. In addition, lavender plants also contain 35% alcohol comprising linalool and geraniol as well as other chemicals such as borneol. Furthermore, 8-20% of camphor and borneol in rosemary can also be a natural mosquito repellent ingredient. Methods: This study is a True Experiment with The Posttest-Only Controlled Group Design. The number of Aedes aegypti mosquitoes used for each treatment was 20. The study subjects were divided into 4 groups comprising 0.4 ppm of citronella, lavender, and rosemary essential oils and aquades as control. Replication was carried out 3 times and observations were conducted for 20 minutes. Results and Discussion: The Anova Factorial test resulted in a p-value of ≤ 0.05. In addition, there was a significant difference in the number of Aedes aegypti mosquitoes expelled from humidifier vapor. Furthermore, the Least Significant Difference (LSD) test showed that citronella essential oil was most effective in repelling mosquitoes because it has a p-value of ≤ 0.05 and largest average difference between other essential oils. Conclusion: Essential oils from citronella are most effective and stable for 30 seconds to 20 minutes to repel mosquitoes compared to lavender and rosemary essential oils