In order to improve the utilization and development of bamboo resources and promote its application in the engineering field, the effects of different lattice cores and processing methods on the bending performance of laminated bamboo sandwich panels were discussed in this study. These structures featured distinct lattice cores, namely triangular lattice, square lattice, and Kagome lattice. The manufacturing process included using laminated bamboo as the raw material and adopting the interlocking method and partition method. Four-point bending tests were carried out on laminated bamboo sandwich panels with different lattice cores, and the bending performance of sandwich panels was discussed. The failure mechanism of sandwich panels under bending load, as well as the variation law of mid-span deflection, bending stiffness and ultimate bearing capacity, are analyzed, and the specific stiffness and specific strength of laminated bamboo sandwich panels with four different core layers were compared. At the same time, a four-point bending test model of laminated bamboo sandwich panels was established by using finite element software ABAQUS, and numerical simulation was carried out. Three kinds of sandwich panels with different lattice core processed by the interlocking method all show shear failure during the bending loading, among which the triangular lattice sandwich panel has the best bearing capacity, while the specific strength of the laminated bamboo sandwich panel with triangular lattice is also the largest. The failure mode of the laminated bamboo sandwich panel with square lattice processed by partition method is that the upper layer yields under compression and the lower layer is damaged in tension. Its bearing capacity and specific strength are better than those of the three sandwich panels processed by interlocking method, which are 21.6 % and 43.6 % higher than those of the triangular lattice interlocking sandwich panel respectively. The error between the simulation results and the experimental results is less than 5 %, which has good consistency and can effectively predict the bending performance of the laminated bamboo sandwich panels. The laminated bamboo square lattice sandwich panel processing by partition method has excellent bending performance among the four kinds of sandwich panels, which can better present the lightweight and high-strength advantages of laminated bamboo. The research results can provide an effective structural form and theoretical basis for the application of bamboo in the engineering field.