Abstract In order to control cloud cavitation, the bio-inspired leading-edge tubercles are implemented on a NACA0015 hydrofoil. The cavitation experiments in a water tunnel are conducted to elaborate on the dynamic behaviors and control mechanisms. As observed, the cavitation with a mean length of 0.38 times chord length on baseline hydrofoil performs three-dimensional features and multiple shedding by the re-entrant jet impingements. Under the equivalent cavitation condition on LET hydrofoil, the cavities with a frothy appearance are produced and confined within the troughs, and the large-scale shedding and re-entrant jet are not identified. The proper orthogonal decomposition (POD) based on cavitation images is carried out to extract the dominant shedding structures. The leading modes of POD on baseline hydrofoil dictate the main shedding of cloud cavitation. The lateral cavities on the LET hydrofoil are well separated by the spanwise periodic tubercles and then the dominant POD modes appear as small-scale vortex pairs. The leading-edge tubercles could depress the three-dimensional cloud cavitation and the re-entrant jets, which is a promising method to control cavitation unsteadiness in hydraulic machinery.