LA-ICP-MS zircon U–Pb ages and geochemical data are presented for the Mesozoic volcanic rocks in northeast China, with the aim of determining the tectonic settings of the volcanism and constraining the timing of the overprinting and transformations between the Paleo-Asian Ocean, Mongol–Okhotsk, and circum-Pacific tectonic regimes. The new ages, together with other available age data from the literature, indicate that Mesozoic volcanism in NE China can be subdivided into six episodes: Late Triassic (228–201Ma), Early–Middle Jurassic (190–173Ma), Middle–Late Jurassic (166–155Ma), early Early Cretaceous (145–138Ma), late Early Cretaceous (133–106Ma), and Late Cretaceous (97–88Ma). The Late Triassic volcanic rocks occur in the Lesser Xing’an–Zhangguangcai Ranges, where the volcanic rocks are bimodal, and in the eastern Heilongjiang–Jilin provinces where the volcanics are A-type rhyolites, implying that they formed in an extensional environment after the final closure of the Paleo-Asian Ocean. The Early–Middle Jurassic (190–173Ma) volcanic rocks, both in the Erguna Massif and the eastern Heilongjiang–Jilin provinces, belong chemically to the calc-alkaline series, implying an active continental margin setting. The volcanics in the Erguna Massif are related to the subduction of the Mongol–Okhotsk oceanic plate beneath the Massif, and those in the eastern Jilin–Heilongjiang provinces are related to the subduction of the Paleo-Pacific Plate beneath the Eurasian continent. The coeval bimodal volcanic rocks in the Lesser Xing’an–Zhangguangcai Ranges were probably formed under an extensional environment similar to a backarc setting of double-direction subduction. Volcanic rocks of Middle–Late Jurassic (155–166Ma) and early Early Cretaceous (145–138Ma) age only occur in the Great Xing’an Range and the northern Hebei and western Liaoning provinces (limited to the west of the Songliao Basin), and they belong chemically to high-K calc-alkaline series and A-type rhyolites, respectively. Combined with the regional unconformity and thrust structures in the northern Hebei and western Liaoning provinces, we conclude that these volcanics formed during a collapse or delamination of a thickened continental crust related to the evolution of the Mongol–Okhotsk suture belt. The late Early Cretaceous volcanic rocks, widely distributed in NE China, belong chemically to a low- to medium-K calc-alkaline series in the eastern Heilongjiang–Jilin provinces (i.e., the Eurasian continental margin), and to a bimodal volcanic rock association within both the Songliao Basin and the Great Xing’an Range. The volcanics in the eastern Heilongjiang–Jilin provinces formed in an active continental margin setting related to the subduction of the Paleo-Pacific Plate beneath the Eurasian continent, and the bimodal volcanics formed under an extensional environment related either to a backarc setting or to delamination of a thickened crust, or both. Late Cretaceous volcanics, limited to the eastern Heilongjiang–Jilin provinces and the eastern North China Craton (NCC), consist of calc-alkaline rocks in the eastern Heilongjiang–Jilin provinces and alkaline basalts in the eastern NCC, suggesting that the former originated during subduction of the Paleo-Pacific Plate beneath the Eurasian continent, whereas the latter formed in an extensional environment similar to a backarc setting. Taking all this into account, we conclude that (1) the transformation from the Paleo-Asian Ocean regime to the circum-Pacific tectonic regime happened during the Late Triassic to Early Jurassic; (2) the effect of the Mongol–Okhotsk suture belt on NE China was mainly in the Early Jurassic, Middle–Late Jurassic, and early Early Cretaceous; and (3) the late Early Cretaceous and Late Cretaceous volcanics can be attributed to the subduction of the Paleo-Pacific Plate beneath the Eurasian continent.