Late Stage Research Articles

From Ponds to Pine Plantations in 9000 Years: The Environmental Archaeology of Beck Burn, Solway Moss, Cumbria

ABSTRACT This article explores the evidence for environmental change at Beck Burn, Solway Moss, on the English/Scottish border. The analysed pollen, non-pollen palynomorphs (NPP) and microscopic charcoal particles permit several palaeoenvironmental events to be interpreted, supported by radiocarbon dating. These and previously published data suggest the presence of very early Mesolithic water-edge activity, later Mesolithic woodland management, clearance and small-scale cultivation during the early Neolithic period, followed by low-level disturbance for pastoral farming in the early Bronze Age. Woodland clearance and cereal cultivation are dated to the middle Bronze Age, with significant clearance and cultivation identified during the late Iron Age or early Roman period. The medieval period is characterised by evidence for a mixed subsistence economy, with reduced activity possibly coincident with the Wars of Scottish Independence, famines and the Black Death of the fourteenth century, as well as the Little Ice Age. Renewed activity, with evidence for both arable and pastoral farming, is dated to the late medieval to early post-medieval period. Pine plantations were then created, possibly in the eighteenth century or later. The data reveal the importance of palaeoenvironmental archaeology, in the absence of significant finds or features, in creating a link with the past.

Paleozoic Equatorial Records of Melting Ice Ages (PERMIA): calibrating the pace of paleotropical environmental and ecological change during Earth's previous icehouse

Abstract. The upper Paleozoic Cutler Group of southern Utah, USA, is a key sedimentary archive for understanding the Earth-life effects of the planet's last pre-Quaternary icehouse–hothouse state change: the Carboniferous–Permian (C–P) transition, between 304 and 290 million years ago. Within the near-paleoequatorial Cutler Group, this transition corresponds to a large-scale aridification trend, loss of aquatic habitats, and ecological shifts toward more terrestrial biota as recorded by its fossil assemblages. However, fundamental questions persist. (1) Did continental drift or shorter-term changes in glacio-eustasy, potentially driven by orbital (Milankovitch) cycles, influence environmental change at near-equatorial latitudes during the C–P climatic transition? (2) What influence did the C–P climatic transition have on the evolution of terrestrial ecosystems and on the diversity and trophic structures of terrestrial vertebrate communities? The Paleozoic Equatorial Records of Melting Ice Ages (PERMIA) project seeks to resolve these issues in part by studying the Elk Ridge no. 1 (ER-1) core, complemented by outcrop studies. This legacy core, collected in 1981 within what is now Bears Ears National Monument, recovered a significant portion of the Hermosa Group and the overlying lower Cutler Group, making it an ideal archive for studying paleoenvironmental change during the C–P transition. As part of this project, the uppermost ∼ 450 m of the core were temporarily transferred from the Austin Core Repository Center to the Continental Scientific Drilling Facility at the University of Minnesota for splitting, imaging, and scanning for geophysical properties and spectrophotometry. Here we (1) review the history of this legacy core, (2) introduce recently obtained geophysical and lithologic datasets based on newly split and imaged core segments to provide a sedimentological and stratigraphic overview of the Elk Ridge no. 1 core that aligns more accurately with the currently recognized regional lithostratigraphic framework, (3) establish the position of the boundary between the lower Cutler beds and the overlying Cedar Mesa Sandstone in the core, and (4) outline our ongoing research goals for the core. In-progress work on the core aims to refine biostratigraphic and chemostratigraphic age constraints, retrieve the polarity stratigraphy, interrogate preserved cyclostratigraphy, analyze sedimentary structures and paleosol facies, investigate stable isotope geochemistry, and evaluate elemental abundance data from X-ray fluorescence (XRF) scanning. Together with outcrop studies throughout Bears Ears National Monument and its vicinity, these cores will allow the rich paleontological and paleoenvironmental archives recorded in the continental Carboniferous–Permian transition of western North America to be confidently placed in a robust chronologic context that will help test hypotheses relating ecosystem evolution to the Carboniferous rainforest collapse, initial decline of the Late Paleozoic Ice Age, and long-wavelength astronomical cycles pacing global environmental change.

Prevalence and burden of pain across the entire spectrum of Huntington’s disease

BackgroundPain is an important symptom in Huntington’s disease (HD), however, not systematically studied and understood. The objective of the current study is to assess the prevalence of pain, pain interference...

Geochronology, geochemistry, and geological evolution of the Troiseck-Floning and Rosskogel nappes (Eastern Alps): unraveling parallels between the Eastern Alps and Western Carpathians

The Troiseck-Floning and Rosskogel nappes are part of the Austroalpine Unit in the eastern part of the Eastern Alps. The nappes are in tectonic contact and comprise Permian to Mesozoic lower greenschist facies metamorphic metasediments, but only the Troiseck-Floning Nappe consists of a pre-Permian crystalline basement (Troiseck Complex) as well. LA-ICP-MS U–Pb zircon ages, Rb–Sr biotite ages and geochemical data unravel the geological evolution of these tectonic units from Neoproterozoic to Mesozoic times. Detrital U–Pb zircon analyses from siliciclastic metasediments of the Troiseck Complex indicate a late Ediacaran to early Cambrian deposition age of the volcanoclastic sequence. The age distribution correlates with a position along the northeastern Gondwana margin. A late Cambrian crystallization age (502.4 ± 6.8 Ma) of granitic intrusions together with evidence for Late Cambrian/Ordovician magmatism and metamorphism indicate a position at an active plate margin. Polyphase overprinting during the Variscan orogeny is recorded by Late Devonian/early Carboniferous pegmatite dikes (~ 353 Ma) that formed after an early Variscan event, while Pennsylvanian ages of overgrowth rims and inherited grains (~ 320 Ma) are evidence for late Variscan metamorphism. Rhyolitic to andesitic volcanic rocks from the Troiseck-Floning and Rosskogel nappes (271–264 Ma) concomitant with intrusions of porphyric granitoids now transformed to augen gneiss (271 Ma) yield evidence for Permian rift-related magmatism that is widely reported from the Eastern Alps and Western Carpathians. Rb–Sr biotite ages (75–74 Ma) indicate Late Cretaceous cooling below c. 300 °C. This relates to Late Cretaceous exhumation of the Troiseck-Floning Nappe following an Eo-Alpine metamorphic overprint at lower greenschist-facies metamorphic conditions. Based on the similar lithostratigraphy, analogous geological evolution and structure, the Troiseck-Floning Nappe represents the lateral extension of the Seckau Nappe. The new dataset also allows for correlations with other basement complexes that occur in the Western Carpathians.

Hikikomori and Sōshokukei-danshi: A semantic analysis of Japan’s social deviants

This study is a semantic analysis that examines the meanings of two contemporary Japanese labels, hikikomori and soushokukei-danshi. This duo has often been linked to the late marriage age, declining marriage rate, shoushika (low birth rate), and koureika (the aging society). The goal of this thesis is to define these individuals according to the perceptions of native Japanese speakers and to convey the definitions by using the reductive paraphrase methodology. Accordingly, cultural values reflected in the labels will be revealed. The Natural Semantic Metalanguage (NSM) approach and corpus analysis are the chosen methodology. NSM is a universal mini metalanguage, while corpus analysis is a tool that can analyse data from online sources. Combined, these methods support the goal of delivering explications that reflect the labels from a Japanese perspective. Results from the study show that the values of Japanese society and the duos are at odds with one another, subsequently, fuelling the negative stigma directed towards both cohorts: Hikikomori are individuals who are emotionally withdrawn and bound to the house for the most part. Furthermore, their condition is something they feel they cannot change so easily; and Soushokukei-danshi are young men who are uninterested in romance or attaining stereotypical male positions in the workforce. Moreover, they would rather invest time in their hobbies. Through this study, a better comprehension of what these words mean is acquired.

Geographic origin, ancestry, and death circumstances at the Cornaux/Les Sauges Iron Age bridge, Switzerland

Cornaux/Les Sauges (Switzerland, Late Iron Age) revealed remnants of a wooden bridge, artifacts, and human and animal skeletal remains. The relationship between the collapsed structure and the skeletal material, whether it indicates a potential accident or cultural practices, remains elusive. We evaluate the most plausible scenario for Cornaux based on osteological, taphonomic, isotopic, and paleogenomic analysis of the recovered individuals. The latter amount to at least 20 individuals, mostly adult males. Perimortem lesions include only blunt force traumas. Radiocarbon data fall between the 3rd and 1st c. BCE, although in some cases predating available dendrochronological estimates from the bridge. Isotopic data highlight five to eight nonlocals. No close genetic relatedness links the analyzed skeletons. Paleogenomic results, the first for Iron Age Switzerland, point to a genetic affinity with other Central and Western European Iron Age groups. The type of skeletal lesions supports an accidental event as the more plausible explanation. Radiocarbon data and the demographic structure of the sample may suggest a sequence of different events possibly including executions and/or sacrifices. Isotopic and paleogenomic data, while not favoring one scenario over the other, do support earlier interpretations of the last centuries BCE in Europe as a dynamic period from a biocultural perspective.

Results of petrographic analysis of stone assemblage from the Kosa Mesolithic sites (Northern Kama region)

In this paper, the results of petrographic analysis of stone materials from the Mesolithic sites of Kosa 1–3 in the northern Kama River area (Perm Region) are discussed. The sites of Kosa 1 and 2 are located on the second terraces of the Lolog and Kosa Rivers, and Kosa 3 — on the first terrace of the Kosa River. Kosa 1 and 2 are considered chronologically similar and belong to the Late Mesolithic period. The site of Kosa 3 is younger, and it marks the transition from the Mesolithic to the Neolithic. For the analysis, aimed at determining the ancient raw material strategies, selected were five stone artifacts from Kosa 1, five stone artifacts from Kosa 2, and eight samples from Kosa 3. Polarised microscopy was used for the petrographic study of stones in thin sections. This method allows the precise diagnosis of minerals and rocks based on their optical characteristics. The results indi-cate that flint and jasper were applied as main raw materials at all analysed sites. The choice of material for the stone industry at the sites was limited. Sandstone and siltstone were used for production of stone macro tools. The difference in raw source materials was determined for the Kosa 1 and Kosa 2 sites on one hand, and Kosa 3 on another — the main raw sources at the Mesolithic sites were flint and jasper, while at the Kosa 3 transitional site coloured pebbly flint was used. The comparison of the results with petrographic data from other Mesolithic sites of this region demonstrates similarity in the main principles of the strategy of raw source choices such as using flint and jasper. Furthermore, a larger variety of source raw materials has been determined for the sites of the Middle Kama River basin. The comparison with the results from the Late Stone Age sites also revealed a greater variety in the materials used in comparison with the Kosinsk sites (platy flints, cherts, tuffs, gabbro, and others). All raw materials were of local origin such as alluvial deposits of the Lolog and Kosa Rivers. The results of the petrographic analysis suggest the situational choice of materials for the manufacture of tools by the local population, with the main factor being their easy accessibility.

A distinct manganese deposit on a Middle Permian carbonate platform in South China

During the Middle Permian, Earth experienced a period of profound environmental changes, including the final stages of the Late Paleozoic Ice Age (LPIA), global seawater regression, the Guadalupian mass extinction event, and the eruption of the Emeishan Large Igneous Province (ELIP) in South China. These events collectively induced significant shifts in both the environment and biosphere, yielding several geochemical anomalies, including deposition of manganese (Mn) deposits. The link between Middle Permian Mn deposits and the prevailing environmental conditions, however, remains unclear. Here, four sections spanning the Middle Permian Maokou Formation to the Late Permian Longtan Formation in the Zunyi area of northern Guizhou, South China are investigated. Through sedimentological and geochemical analyses, this work aims to elucidate the evolution of sedimentary environments over the Middle to Late Permian. During this period, a transition from a shallow-water carbonate platform in the 1st Member of the Maokou Formation to a deeper, siliceous deposit in its 2nd Member was recorded. This shift results in a pronounced paleogeographic differentiation in the 3rd Member, juxtaposing the shallow-water carbonate platform against a deeper Mn-enriched basin. A number of geochemical proxies indicate a strong hydrothermal signal in the Mn deposits. Combined with positive Eu anomalies and low Sr isotopes, the data underscore the profound influence of hydrothermal input linked with early subaqueous eruptions from the ELIP on the nearby marine environment. A detailed examination of carbon isotope profiles from the Maokou Formation indicates that volcanic influences, shifts in marine ecosystems, and changes in primary production caused the fluctuations of δ13Ccarb and δ13Corg. Moreover, the formation of Mn carbonate in deeper waters effectively sequestered organic C. Collectively, our new data demonstrate that the essential conditions for the development of the carbonate-hosted Mn deposits include drowning of the carbonate platform through an increase in sea level, the availability of a sufficient Mn source, and the presence of a redox-stratified water column.

N-Carbamylglutamate in ovo feeding improves carcass yield, muscle fiber development, and meat quality in broiler chickens.

Insufficient endogenous nutrients in the broiler embryo can lead to muscle gluconeogenesis, which ultimately affects the post-hatching performance of chicks. This study investigated the effects of in ovo feeding (IOF) of N-carbamylglutamate (NCG) on the growth hormones, carcass yield, and meat quality in broilers. Fertile eggs from a 30-week-old Ross 308 breeder flock were divided into three treatment groups: NC (non-injection), SC (100 μL saline-injection), and NCG (2 mg NCG injection). Each group had six replicates, with 70 eggs per replicate during incubation. Injections were administered on the 17.5th day of embryonic development. After hatching, 270 chicks were selected for 42-day rearing for further sampling. Chicks in the NCG group had significantly higher body weight (BW) and average daily gain (ADG) at the growing phase, increased growth and testosterone hormone in both feeding phases (21 and 42 days), and improved average daily gain (ADG) and food conversion ratio (FCR) in both grower and entire feeding phases (P < 0.05). Triiodothyronine (T3) and tetraiodothyronine (T4) levels, carcass yield, dressing, drum weight, breast muscle weight, drumstick weights, thighs, pectoralis major, and their part percentage of carcass were improved in the NCG group (P < 0.05), these effects were varied along feeding phases. Moreover, IOF of the NCG also improved pectoralis breast muscle color values at 24 h post mortem (P < 0.05). These results suggest that NCG injection at the late embryonic age of broiler enhances growth performance and meat quality throughout the lifespan and this can probably be attributed to an increase in thyroid and testosterone hormones, indicating potential involvement in metabolic and nutrient partitioning pathway regulation. © 2024 Society of Chemical Industry.

New paleofloristic and geochronological U–Pb zircon data in late Paleozoic deposits of the Matzitzi formation in southern Mexico

The fossil flora of the Matzitzi Formation, is a fluvial unit of late Paleozoic age exposed in southern Mexico, has been studied since the last century; however, the discovery of new plant elements during the last decade imposes a reevaluation of two aspects that have always been the subject of debate: the depositional age of the unit and the taxonomy of its paleoflora. The objective of the present work is to report new paleofloral records from two areas of the Matzitzi Formation as well as their chronological implications. The study sites are named Carretera and Coatepec. Nineteen genera and 11 species have been identified in beds from the Carretera site, whereas 23 genera and 16 species in beds from the Coatepec site. The analysis of floral assemblages of both sites shows that they share 49% of taxa. Ovopteris, Lesleya, Lobatopteris, and Trigonocarpus are unique to the Carretera site, while Coatepec is characterized by the presence of cf. Bjuvia, Schizoneura, and Velascophyllum. When analyzing the greatest ranges of the paleoflora awareness for the Carretera site indicates that deposition of these beds took place in a time interval that may span between Pennsylvanian and lower Permian. On the other side, the floral assemblage recovered from the Coatepec site indicates that the hosting beds were deposited in upper Permian time. U–Pb detrital zircon geochronology indicates that the maximum depositional age of the fossiliferous beds at the Carretera and Coatepec sites are of 276 ± 15 Ma and 254 ± 11 Ma, respectively. The integration of the paleontological and geochronological data obtained in this work suggests that the analyzed floral assemblage recovered from the Carretera site is of Kungurian age, whereas the one from the Coatepec site is of Lopingian age. Alternatively, we explore the possibility that deposits that are presently grouped within the Matzitzi Formation could be the vestiges of different fluvial cycles associated with different tectonic settings. Finally, the work on this unit has not finished, since there are still localities where its flora and age are still unknown.

U-Pb geochronology reveals that hydrothermal dolomitization was coeval to the deposition of the Burgess Shale lagerstätte

Fault-controlled, hydrothermal dolomitization often occurs at margins between shallow-water carbonate platforms and deep-water sedimentary basins. In western Canada, for example, the platform margin between the Cathedral Formation and the Burgess Shale Formation has been dolomitized at temperatures up to ~200 °C, with local magnesite, talc, and clinochlore mineralization. At the same time, the Burgess Shale Formation includes exceptional fossils that provide key evidence of the radiation of the animal phyla during the Cambrian Period (541 to 485.4 Ma). This lagerstätte and Mg-rich minerals within the adjacent and underlying strata, however, have been critically understudied. Here we show, using carbonate U-Pb geochronology, that western Canada was tectonically active and subject to hydrothermal dolomitization during the Middle Cambrian (Miaolingian Epoch) to Middle Ordovician (488.1 ± 18.8 Ma). These results extend the latest stages of rifting along the western margin of Laurentia into the Paleozoic, while also suggesting that the dolomitization of the Cathedral Formation occurred at the same time as the deposition of the Burgess Shale lagerstätte.

Taxonomic review, palaeoecological, and palaeobiogeographical significances of Campanian Tethyan oysters from the North Eastern Desert, Egypt

The Late Cretaceous was a time of high eustatic sea level that enabled extensive epicontinental seaways and carbonate platforms across the Tethyan Realm, providing favorable habitats for oyster communities to flourish. This study focuses on the Campanian Tethyan oysters from the North Eastern Desert of Egypt regarding taxonomy, palaeoecology, and palaeobiogeography. Three oyster species, Nicaisolopha nicaisei (Coquand, 1862), Pycnodonte (Phygraea) vesicularis (Lamarck, 1806), and Ambigostrea bretoni (Thomas and Peron, 1891), were identified from the Campanian succession in two studied sections. The sampled specimens of the genus Nicaisolopha have undergone a systematic palaeontological revision. As a result, N. tissoti (Thomas and Peron, 1891) is considered herein a junior synonym of N. nicaisei (Coquand, 1862). Palaeobiogeographically, the likely primary migration pattern of the studied oysters suggests an east–west trend along the Southern Tethys margin. All identified oysters in this study exhibit a Tethyan affinity and are primarily abundant in two main provinces: the Southern Tethys and the Western Tethys. The macrofaunal contents are categorized into two fossil associations: the Nicaisolopha nicaisei association of the middle-late Campanian age and the Pycnodonte vesicularis association of the late Campanian age. These macrofaunal associations indicate a deepening trend during the middle-late Campanian age, suggesting a transition from shallow inner neritic to middle neritic environments. Additionally, it is observed that Pycnodonteinae tend to grow larger under eutrophic conditions, low-energy environments, and nutrient-rich waters with high carbonate contents.

Assessment and correction of local antimicrobial protection factors in women with chronic recurrent vulvovaginal candidiasis and type 2 diabetes mellitus

Aim. Evaluation and correction of local antimicrobial protection factors in women with type 2 diabetes mellitus (DM 2) and chronic recurrent vulvovaginal candidiasis (rVVC). Materials and methods. The study involved 100 women undergoing outpatient follow-up at the age of 40.9±5.8 years, with a body mass index of 29.8±3.5. The period was 2022–2023. The examination included anamnesis, collection of anthropometric data, calculation of body weight, microscopic examination of smears from the cervical canal and vagina, Gram-stained before treatment, in the 1st and 3rd months after its completion, identification pathogenic microorganisms using PCR, colposcopy, ultrasound of the pelvic organs. Indicators of glycosylated hemoglobin in the subjects at the control points of the study: at 1 month the average values were 5.9±2.9%, at 3 months – 5.9±3.0%, the average value was 5.9±3.1%. Candida species were identified by the bacteriological method using Sabouraud dextrose agar (growth of colonies of fungi of the genus Candida in an amount of more than 103 CFU/ml). Immunological methods for studying antimicrobial protection factors included studying the number of neutrophil granulocytes (NG) on the surface of the mucous membranes of the vulva and vagina, their phagocytic and NBT-reducing activity in a latex test. Randomization of patients into groups: group 1 included 50 (50%) women with DM 2 who, as part of complex therapy for rVVC received the drug Genferon® 1 intravaginal suppository of 500 thousand units 2 times a day for 10 days and fluconazole 150 mg orally three times with an interval of 72 hours at the first stage of treatment; group 2 included 50 (50%) women who received therapy with fluconazole 150 mg three times with an interval of 72 hours. The maintenance anti-relapse course therapy in both groups included the use of fluconazole 150 mg once a week for 6 months. In group 1st anti-relapse therapy was supplemented by the administration of the drug Genferon® 1 intravaginal suppository of 500 thousand units at night 3 times a week for 3 months, after which the vaginal microbiota was corrected for 2 weeks using vaginal suppositories, containing Lactobacillus acidophilus in an amount of at least 108 CFU. In group 2nd, basic anti-relapse antimycotic therapy was not accompanied by the prescription of any immunomodulatory or probiotic drugs. Results. The etiological agents of rVVC in women of late reproductive age in 79% (n=79) и 28% (n=28), respectively, were C. albicans and C. glabrata, which during the period of acute of the disease were detected by culture in the vaginal discharge at more than 104 CFU/ml. Chronic recurrent course of vulvovaginal candidiasis in women with DM 2 was characterized by exacerbations 4 or more times a year, accompanied by the corresponding clinical picture: white or yellowish-white cheesy discharge from the genital tract, itching or burning in the anogenital area, discomfort in the external genital area, dyspareunia, dysuria, decreased phagocytic activity of NG in vaginal secretions by 25.8%, impairment of their spontaneous and latex-induced NBT-reducing activity by 35.2%, functional reserve by 23.0% relative to reference values. The use of the drug Genferon® as part of complex therapy for rVVC contributed to a decrease in the number of Candida spp. in 1st and 3d months of observation after completion of anti-relapse therapy, normalization of cellular factors of innate immunity of the mucous membranes, faster resolution of the clinical manifestations of an episode of the disease. The decrease in the number of relapses over a 12-month observation period compared to the control group was also facilitated by an increase in the protective properties of the vaginal mucosa due to the restoration of the vaginal microbiota with the help of lactobacilli acidophilus. Conclusion. The etiological agents of rVVC in women of late reproductive age are C. albicans and C. glabrata. Subcompensated DM 2 is a risk factor for rVVC, which requires additional monitoring of microbiological parameters of the vaginal microbiota. rVVC in women with DM 2 is associated with an increase in the number of NG in the vaginal secretion, a decrease in their phagocytic activity and functional reserve compared to the reference values. Combination therapy of rVVC with topical recombinant interferon α2b, benzocaine and taurine in the formulation of Genferon® (suppositories) is an effective method to improve the clinical and immunological efficacy of therapy.

Clinker-Free Cement Manufactured with Metallurgical Slags

Steel slag is a significant environmental liability generated by pyrometallurgical processes. Residue generation, such as granulated blast furnace slag and basic oxygen slag (BOF), is intrinsic in steel production. Blast furnace slag, generated in the carbothermal reduction of iron ore, is almost entirely used as a supplementary cement material in Portland cement. BOF slag, produced in the conversion of pig iron into steel in a basic oxygen converter, is still not consolidated or valued for reuse. This research proposes the reuse and valorization of BOF slag combined with blast furnace slag in clinker-free cement production. Cement formulations were produced with different slag and gypsum contents, ranging from 80 to 90% blast furnace slag, 10 to 20% gypsum, and 10 to 15% BOF slag. All formulations were evaluated for compressive strength at ages of 3, 7, 14, 28, 91, and 180 days of curing. At the initial ages, the cement formulations exhibited high resistance. On the 3rd day, the cement formulations reached up to 10 MPa, and on the 7th day, 40 MPa. At late ages, the best-performing formulation, ECO2, showed, after 28 days of hydration, a compressive strength greater than 50 MPa, and at 180 days, a compressive strength greater than 80 MPa. It was possible to understand that BOF slag acts in cement alkaline activation with pH increase, more or less actively due to the presence of lime, portlandite, and calcite.

Features of post-surgical menopause with concomitant primary hypothyroidism: A prospective single-stage clinical study

Background. In recent decades, the frequency of surgical interventions on reproductive system organs has been steadily increasing. In gynecological practice, preference is given to minimally invasive surgery and precision treatments, especially involving ovaries. Despite the modern approach, it is not always possible to preserve this endocrine organ, which leads to post-surgical menopause (PSM). The relatively high incidence of total hysterectomy-associated PSM and primary hypothyroidism in late reproductive age often leads to their combination. Clinical manifestations aggravating each other form an unfavorable vicious circle. Aim. To study the features of the PSM course with concomitant primary hypothyroidism. Materials and methods. A prospective clinical study included 130 women aged 45 to 55 years with a history of PSM. The main group consisted of 70 patients with PSM with subclinical primary hypothyroidism. A control group included 60 PSM patients without thyroid disorders. We assessed the effect of hypothyroidism on the PSM course by comparing several indicators in the main and control groups. Results. It was found that in the main group patients, severe 26.5% and moderate 38.8% menopausal syndrome prevailed, while in the control group patients, such forms were twice as common. In the women of the main group, the levels of triglycerides were higher than those in the control group by 1.3 times (2.6±0.86 mmol/L and 1.43±0.33 mmol/L, respectively). The total serum alkaline phosphatase activity in patients in the study groups was 29.8% higher than in healthy women. Conclusion. It can be concluded that the severity of menopausal disorders depends on the thyroid status, with more severe in patients of the main group with hypothyroidism. In addition, in patients of the main group with hypothyroidism, dyslipidemia is more pronounced, which predisposes them to severe diseases in the future, in particular cardiovascular disorders, the unfavorable course of metabolic syndrome, and the development of postmenopausal osteoporosis.

Morphology and ultrastructure of cicatricose spores found in an isolated sporangium-bearing structure of a schizaealean fern from the Lower Cretaceous rocks at Casal do Borracho, Torres Vedras, western Portugal

Fossil spores provide important insights into the evolutionary history of ferns, including their morphological changes and adaptations over time. The morphology and ultrastructure of trilete spores with cicatricose sculpture composed of sets of parallel or near-parallel ribs (muri) have been studied. Observations on the spores were performed using light microscopy, scanning electron microscopy, and transmission electron microscopy. The cicatricose spores were extracted from a single sporangium-bearing structure collected from Casal do Borracho mesofossil flora near Torres Vedras (Lusitanian Basin, western Portugal) from sediments belonging to the Almargem Formation, considered to be of late Barremian or early Aptian age (and possible younger than that). The sporangium-bearing structure of a schizaealean fern and in situ cicatricose spores are compared with the family Anemiaceae. On the basis of spore size and shape, laesura length, with about 20 proximal narrow ribs, oriented perpendicular to the spore sides, and three sets of distal ribs forming V-shaped patterns, the cicatricose spores in the present study are clearly assigned to the fossil-taxon Cicatricosisporites venustus. The spore ultrastructure includes a homogeneous exospore of a blechnoid type with a slight difference in the thickness in the proximal, distal, and equatorial regions. The morphology and ultrastructure of the studied spores are corresponded to Anemia type.

Challenges of Marrying at Late Age

Challenges of Marrying at Late Age

Continuity and Innovation in Pottery Technology: The Karst Region (North-East Italy) from Neolithic to Early Bronze Age

This paper explores the development of pottery technology in the Trieste Karst region (North-East Italy) from the Neolithic to the Early Bronze Age (EBA). It also seeks to identify cultural links with other areas by examining potentially imported vessels. Archaeometric analyses (X-ray diffraction and optical microscopy) reveal significant differences between Neolithic ceramics (Danilo–Vlaška Group) and the majority of Late Copper Age (LCA)/Early Bronze Age (EBA) pottery (primarily associated with the Ljubljana Culture and a few with the Cetina Culture). Neolithic pottery displays consistent characteristics across all vessel types, including coarse grain, prevalent sparry calcite temper, and the absence of grog. In contrast, most LCA and EBA vessels exhibit distinct features such as very fine-grained paste, no sparry calcite, notable use of grog temper, higher quartz, muscovite, and flint content. Notably, from a technological perspective, the analyzed Cetina vessels bear a strong resemblance to the majority of LCA ceramics. The differences between Neolithic and LCA/EBA vessels clearly suggest the use of new raw materials, recipes, and techniques, likely reflecting changes in cultural and social contexts and potential connections with the core area of the Ljubljana Culture.

Defining the Cimmerian orogeny in the West Pontides: geochronological and geochemical data from Permo-Triassic dykes in the İstanbul-Zonguldak Tectonic Unit

ABSTRACT Permo-Triassic intrusive rocks and back-arc basins are exposed in the İstanbul-Zonguldak Tectonic Unit in the West Pontides. Their tectono-magmatic history, thus to the evolution of the back-arc basins, is poorly understood. Here, I present on olivine-bearing basalt and andesite dykes and granite dykes and pyroxene-bearing andesite dykes of Permo-Triassic crystallization and their Pb-loss ages from the basement rocks and sedimentary rocks in the İstanbul-Zonguldak Tectonic Unit (NW Turkey). They have holocrystalline and porphyritic to vitrophyric textures. U-Pb dating of igneous zircon grains from olivine-bearing basalt and andesite dykes and granite dykes yielded Middle Permian ages of ca. 270.1 ± 1.1 to 261.4 ± 1.7 Ma (2σ), and pyroxene-bearing andesite dykes obtained Early Triassic ages of ca. 252.1 ± 2.4 to 250.1 ± 2.0 Ma (2σ). Their young ages of the dykes yielded Late Triassic ages of ca. 228 to 220 Ma (2σ). Geochemically, the Middle Permian dykes have a calc-alkaline affinity and are notable for subduction components, as indicated by the presence of distinct negative Nb anomalies. Early Triassic dykes show alkaline signatures and show within-plate character, corresponding to prominent positive Nb anomalies. Combined with data from the literature, the Middle Permian dykes are magmatic products associated with the Tethys Ocean subducting under the Pontides and the Early Triassic dykes are magmatic pulses related to the rifting of the Permo-Triassic back-arc basins. The Late Triassic young ages of the Permo-Triassic dykes in the İstanbul-Zonguldak Tectonic Unit represent a deformation event corresponding to the Cimmerian Orogeny, and this implies that the Permo-Triassic back-arc basins closed during the late Triassic.

Tuberculous spondylitis: Macromorphological and radiological studies on a skeleton from the Late Iron Age monument of Nor Armavir, Armenia

The skeleton in question derives from the Late Iron Age monument of Nor Armavir and was unearthed from burial No. 19. The deceased was buried in an unusual position. In this article, we characterize the pathological bony changes indicative of tuberculous spondylitis. The skeleton was subject to a detailed macroscopic investigation. Besides age at death estimation and sex determination, a careful palaeopathological evaluation was performed on the bone remains. In addition, volumetric (3D) computed tomography was carried out on four lumbar vertebrae (L2–5) to complement the macromorphology-based diagnosis.