Lasting Effects Research Articles

ТЕРАПИЯ БОЛИ В ПОЯСНИЧНОМ ОТДЕЛЕ ПОЗВОНОЧНИКА ПОСЛЕ СПОРТИВНОЙ ТРАВМЫ

The article discusses the treatment of pain in the lumbar spine in a patient after a sports injury. According to the results of the therapy, the pain syndrome was completely relieved. This therapy showed a lasting therapeutic effect.

Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?

The neuropsychological functioning of people with type 1 diabetes (T1D) is of key importance to the effectiveness of the therapy, which, in its complexity, requires a great deal of knowledge, attention, and commitment. Intellectual limitations make it difficult to achieve the optimal metabolic balance, and a lack of this alignment can contribute to the further deterioration of cognitive functions. The aim of this study was to provide a narrative review of the current state of knowledge regarding the influence of diabetes on brain structure and functions during childhood and also to present possible actions to optimize intellectual development in children with T1D. Scopus, PubMed, and Web of Science databases were searched for relevant literature using selected keywords. The results were summarized using a narrative synthesis. Disturbances in glucose metabolism during childhood may have a lasting negative effect on the development of the brain and related cognitive functions. To optimize intellectual development in children with diabetes, it is essential to prevent disorders of the central nervous system by maintaining peri-normal glycemic levels. Based on the performed literature review, it seems necessary to take additional actions, including repeated neuropsychological evaluation with early detection of any cognitive dysfunctions, followed by the development of individual management strategies and the training of appropriate skills, together with complex, multidirectional environmental support.

Reform of the construction of the professional skills course cluster of musicology in colleges and universities in the context of aesthetic immersion action based on the VAR model

Abstract In the context of aesthetic education infiltration action, the construction of musicology majors in colleges and universities needs to design diverse teaching contents. This paper analyzes the dynamic impact of the construction of musicology professional skill course clusters with the help of the variable impulse response function of the VAR model and explores the promotional relationship between aesthetic education and music professional literacy. Aiming at the problem that the VAR model cannot reflect the time-varying features and nonlinear features, the TVP-VAP model is used to capture the time-varying features, and at the same time, the Bayesian algorithm is used to calculate the parameters in the model to improve the operation efficiency of the model. After the design was completed and put into practical use, the professional knowledge scores of musicology majors in colleges and universities and students’ aesthetic ability scores in January-October 2023 were selected as databases to establish the TVP-VAR model. When implementing aesthetic education, the response value is 0. From the second month onwards, aesthetic education will have a lasting positive effect and level off, and the response value is around 0.003. The value of the impact effect of students’ professionalism on aesthetic education is 0, which indicates a lag, and shows a gradual upward trend in periods 1-4, with a maximum response value of 0.26. This paper provides a quantitative analysis of the effects of integrating aesthetic education and music and proposes a new direction for reforming the curriculum of the music major.

327 Amphiregulin downregulation during preeclampsia may have long lasting cardiovascular effects

327 Amphiregulin downregulation during preeclampsia may have long lasting cardiovascular effects

Investing in a leveraged world

PurposeThroughout the 21st century, US households have experienced unprecedented levels of leverage. This dynamic has been exacerbated by income shortfalls during the COVID-19 crisis. Leveraging and deleveraging decisions affect household consumption. This study investigates the effect of the dynamics of household leverage and consumption on the stock market.Design/methodology/approachThe authors explore the relation between household leverage and consumption in the context of the consumption capital asset pricing model (CCAPM). The authors test the model's implication that leverage has a negative risk premium by transforming the asset pricing restriction into an unconditional linear factor model and estimate the model using the general method of moments procedure. The authors run time-series regressions to estimate individual stocks' exposures to leverage, and cross-sectional regressions to investigate the leverage risk premium.FindingsThe authors show that shocks to household debt have strong and lasting effects on consumption growth. The authors extend the CCAPM to accommodate this effect and find, using various test assets, a negative risk premium associated with household deleveraging. Looking at individual stocks the authors show that the deleveraging risk premium is not explained by well-known risk factors.Originality/valueThis paper contributes to the literature on the role of leverage in economics and finance by establishing a relation between household leverage and spending decisions. The authors provide novel evidence that households' leveraging and deleveraging decisions can be a fundamental and influential force in determining asset prices. Further, this paper argues that household leverage might explain the small, persistent, and predictable component in consumption growth hypothesised in the long-run risk asset pricing literature.

Elektroliza rzęs – trwała metoda leczenia pacjentów z nieprawidłowo rosnącymi rzęsami

Eyelashes constitute a protective apparatus for our eyes, which is why their improper growth negatively affects the aesthetics and condition of the ocular surface. Electrolysis of eyelashes is one of the methods used to treat this condition. This paper focuses on discussing the procedure, mechanism of action, and achieved results of eyelash electrolysis. The presented conclusions aim to broaden knowledge about this method and emphasize its potential in improving the quality of life for patients with issues related to abnormal eyelash growth. To conduct a literature review, relevant scientific publications on eyelash electrolysis were identified through database searches. Additionally, the study presents a photographic representation of the course of the electrolysis procedure. Electrolysis, also known as galvanization, is based on the chemical breakdown of tissues under the influence of direct current. In the hair follicle, electrolysis reactions lead to the generation of gases that interact with the hair tissue. The procedure can be an effective option for patients with trichiasis or distichiasis. The effectiveness of electrolysis depends on close contact with stem cells, and results suggest a lasting effect for the majority of patients. Patient age and operator experience impact efficacy. Electrolysis appears to be more efficient than lash ablation or thermolysis and is associated with a lower likelihood of complications. The literature review has yielded essential conclusions for the ophthalmologist’s practice, aiding in more efficient diagnosis and patient management. Given the limited number of available studies, the reisencouragement to further explore the topic of eyelash electrolysis, document cases, and foster collaborative scientific efforts to find the optimal treatment method for patients with abnormal eyelash growth.

Pengukuran dan Penilaian Status Gizi Anak Sekolah Dasar Negeri 100 Kendari Menggunakan Indeks Massa Tubuh Menurut Umur

<p><em>The growth and development of school-age children are linked to their nutritional status. It is necessary to monitor the nutritional well-being of these children, as issues during this crucial period can have lasting effects on their future and impact the overall quality of human resources. This research was performed to measure and assess the nutritional status of elementary school children at State Elementary School 100 Kendari based on the Body Mass Index for Age (BMI/A). The participants were pre-adolescents aged between 10-12 years old at the fourth, fifth, and sixth grade totaling to 63 students. The anthropometric measurements of weight and height was used as the primary method for assessment. Nutritional status was determined through the BMI/A. The results indicate that in the fourth grade, 12 students (57%) were classified as underweight, 8 students (38%) as normal, and 1 student (5%) as overweight. Similarly, in the fifth grade, 10 students (48%) were under weight, 8 students (38%) were normal, and 3 students (14%) were overweight. In the sixth grade, 9 students (43%) were under weight, 9 students (43%) had a normal nutritional status, and 3 students (14%) were overweight. Regular monitoring of nutritional status is emphasized as a preventive measure against nutritional problems in school-age children. </em></p>

The Impacts of Sugar Intake on The Body and The Feasibility of Anti-Sugar Diet

In today's society, people are increasingly mindful of their daily dietary habits, with particular attention given to sugar consumption. While sugar provides a quick source of energy, excessive intake can lead to oxidative stress and have detrimental health effects. It has been linked to a number of illnesses, including obesity, type 2 diabetes, dental problems, and even cancer. Additionally, sugar can have lasting effects on skin health through a process known as antiglycation. Hence, the call to reduce or combat sugar intake is gaining traction. The anti-sugar movement advocates for a reduction or complete elimination of added sugars from diets, so emphasizing the importance of following proper guidelines is needed. This article aims to conduct a thorough examination of the mechanisms related to sugar consumption and explore the repercussions of adjusting sugar intake. It will also delve into the distinctions and similarities among three prevalent dietary patterns: high-sugar, low-carb, and ketogenic diets. Furthermore, it will explore the relevance of these dietary patterns in the context of anti-glycation efforts. By providing comprehensive insights into these dietary choices, this article seeks to empower individuals to make informed and objective decisions about sugar intake, rather than making hasty decisions that may adversely affect their health.

COVID-19 Convalescent Plasma Therapy: Long-term Implications.

The long-term effect of coronavirus disease 2019 (COVID-19) acute treatments on postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) is unknown. The CONTAIN-Extend study explores the long-term impact of COVID-19 convalescent plasma (CCP) therapy on postacute sequelae of SARS-CoV-2 infection (PASC) symptoms and general health 18 months following hospitalization. The CONTAIN-Extend study examined 281 participants from the original CONTAIN COVID-19 trial (CONTAIN-RCT, NCT04364737) at 18 months post-hospitalization for acute COVID-19. Symptom surveys, global health assessments, and biospecimen collection were performed from November 2021 to October 2022. Multivariable logistic and linear regression estimated associations between the randomization arms and self-reported symptoms and Patient-Reported Outcomes Measurement Information System (PROMIS) scores and adjusted for covariables, including age, sex, race/ethnicity, disease severity, and CONTAIN enrollment quarter and sites. There were no differences in symptoms or PROMIS scores between CCP and placebo (adjusted odds ratio [aOR] of general symptoms, 0.95; 95% CI, 0.54-1.67). However, females (aOR, 3.01; 95% CI, 1.73-5.34), those 45-64 years (aOR, 2.55; 95% CI, 1.14-6.23), and April-June 2020 enrollees (aOR, 2.39; 95% CI, 1.10-5.19) were more likely to report general symptoms and have poorer PROMIS physical health scores than their respective reference groups. Hispanic participants (difference, -3.05; 95% CI, -5.82 to -0.27) and Black participants (-4.48; 95% CI, -7.94 to -1.02) had poorer PROMIS physical health than White participants. CCP demonstrated no lasting effect on PASC symptoms or overall health in comparison to the placebo. This study underscores the significance of demographic factors, including sex, age, and timing of acute infection, in influencing symptom reporting 18 months after acute hypoxic COVID-19 hospitalization.

The death of an adult child and trajectories of parental depressive symptoms: A gender-based longitudinal analysis

RationaleDespite the existing body of research on the impact of child bereavement, little is known about whether time to the death of an adult child is longitudinally associated with changes in depressive symptoms among older parents. ObjectiveThis study examines (a) trajectories of depressive symptoms before and after the loss of an adult child and (b) whether these trajectories differ across parent-child gender dyads (father-son, father-daughter, mother-son, and mother-daughter). MethodsUsing eight waves of the Korean Longitudinal Study of Ageing (KLoSA), this study employs fixed effects models to mitigate potential bias due to unobserved individual-level heterogeneity. Gender-stratified fixed effects models were estimated to investigate potential heterogeneity in the trajectories of depressive symptoms by parent-child gender dyads. ResultsThe result of this study revealed that depressive symptoms increased within the first year following the loss of an adult child among bereaved parents. Within a year of the loss of a child, both mothers and fathers experienced an increase in depressive symptoms. However, only fathers experienced lasting effects for up to two years. Different patterns in psychological adjustment to bereavement were observed across different parent-child gender dyads. Among daughter-bereaved fathers, depressive symptoms surged within the first year and persisted even beyond the fourth year of loss. In contrast, for other dyads, only an immediate rise in depressive symptoms within the first year of loss was observed. ConclusionsThe loss of an adult child increases the depressive symptoms of parents. This study highlights the importance of considering the different trajectories of psychological adjustment to bereavement, particularly based on parent-child gender dyads, when formulating policies for providing psychological support to older parents who have experienced the loss of their child.

EXPLORING THE INTERCONNECTEDNESS OF INTERNAL COLONIZATION AND MIMICRY IN GEORGE ORWELL’S ANIMAL FARM: A POST-COLONIAL ANALYSIS

In Animal Farm, George Orwell introduces mimicry and internal colonisation. Mimicry, a basic notion in human imitation, is used to study Napoleon and his porcine companions. Homi K. Bhabha's ambivalence and “same but not quite” theory examines mimicry. The pigs' behaviour is explained by these post-colonial theories. This study also shows how internal colonisation underlies narrative mimicry. This study claims that the story's copying indicates colonization's lasting effects and is a strategy for internal colonisation. Old Major's clear speech inspires Animal Farm residents to imitate humans, making them feel inadequate. This study reveals how internal or external colonisation divides colonised people. In this approach, people may adopt the conquering entity's cultural norms and values as superior. Another group may be indigenous. Internal colonisation by another party or associated group could result through imitation rivalry. This level requires imitation to demonstrate power. Animal Farm exemplifies colonised people imitating colonisers. This detailed analysis of Animal Farm by George Orwell shows how imitation and internal colonisation are interconnected.

Inquiring Life span Impact of Mild and Moderate Hearing Impairment on Diverse Aspects of Development

The current study was particularly designed to endeavor the effects of hearing impairment on the developmental dimensionsof persons with hearing impairment. Mild and moderate hearing impairment was assumed to be as independent factor having mild and moderate levels of losses. Multidimensional developmental dimensionsof persons with hearing impairment were taken to be as dependent variables such as cognition, physical, moral, social as well as economicdevelopments. The parents as well as relatives of the persons with hearing impairment from Faisalabad, Jhang and Chiniot citieswere chosen as the population of the study while sample was comprised ofn=208 participantschosen through purposive sampling technique. Effects were stronger among older n=51 with mean ages 69 years (65-74 years) than youngern=72 with mean ages 36 years (20-44 years) and middle aged n=77 with mean ages 58 years (45-64 years) manifesting long lasting effects of independent variable (hearing impairment) on dependent variables (developmental dimensions) of persons with mild and moderate hearing losses. The results of the study revealed monotonically increasing function of developmental dimensions that is affected by the level of disability as in the case of hearing impairment, the effects of disability on the person’s developmental dimensions always increase or remain constant and never decrease in any case or in any circumstances at any stage of life.

Behavioral and inflammatory changes in rats induced by a three-hit stress model: Implications for psychiatric disorders

Many aspects of the impact of childhood trauma remain unknown, such as the age at which individuals are most vulnerable to trauma, whether traumatic experiences have more severe and lasting effects when experienced early in life, and whether early life trauma causes psychiatric conditions such as anxiety and major depressive disorder (MDD) that persist over time or evolve into other disorders. Thus, this study aimed to investigate the impact of traumatic experiences in childhood on susceptibility to mood disorders in adulthood, particularly MDD. Animal models were used to address these questions, and different stressor protocols at various stages of the offspring's life were used. Three-hit starting with injections of Poly: IC was performed on the 9th day of gestation and then considered the first stressor. After birth, the animals were exposed to the maternal deprivation (MD) protocol, which separated the pups from the mother 3 h a day during the first ten days of life. From the 60th day of life, the animals were divided to receive the chronic mild stress (CMS) protocol over 21 days. The stressors can induce anxiety-like behaviors, such as increased locomotor activity through a maternal immune activation protocol using Poly: IC and demonstrating depressive-like behaviors through the MD and CMS protocols. It also showed changes in brain structures for pro-inflammatory parameters, IL-1β and TNF-α, and alterations in anti-inflammatory parameters, IL-4 and IL-10, at different ages of life. The study also found that regulating pro- and anti-inflammatory cytokines is necessary for appropriate neuronal behavior, and stress responses can be both friendly and enemy, with costs and benefits balanced to provide the best-fit result. In conclusion, phenotypic characteristics of animals' life history are shaped by signals transmitted directly or indirectly to developing animals, known as “predictive adaptive responses."

Insights into Meniscal Injuries Among Young Football Athletes: A Scoping Review

This comprehensive literature review delves into the prevalence, risk factors, management strategies, and outcomes related to meniscal injuries, particularly focusing on young football athletes. Drawing from eight scholarly articles, it covers various aspects of meniscal injuries, including incidence rates, treatment options, rehabilitation techniques, and long-term implications. Meniscal injuries are highlighted as significant in sports, notably in high-mobility activities like football, where sudden movements and twisting motions increase the likelihood of such injuries. The review explores common treatment methods such as meniscal repair, transplantation, and partial meniscectomy, along with tailored rehabilitation approaches aimed at facilitating athletes' return to play. Research indicates that while meniscal injuries are common among athletes, particularly in contact sports like football, early detection and proper treatment are crucial to mitigate lasting effects. Understanding knee joint anatomy and biomechanics is emphasized, along with the implementation of effective rehabilitation protocols to enhance joint stability and prevent re-injury. In summary, this literature review offers valuable insights into the multifaceted nature of meniscal injuries among young football athletes. By synthesizing evidence from diverse sources, it contributes to a deeper understanding of the epidemiology, management, and rehabilitation of meniscal injuries, informing clinical practices and guiding future research in sports medicine

Nitrogen Deposition Amplifies the Legacy Effects of Plant Invasion.

The legacy effects of invasive plant species can hinder the recovery of native communities, especially under nitrogen deposition conditions, where invasive species show growth advantages and trigger secondary invasions in controlled areas. Therefore, it is crucial to thoroughly investigate the effects of nitrogen deposition on the legacy effects of plant invasions and their mechanisms. The hypotheses of this study are as follows: (1) Nitrogen deposition amplifies the legacy effects of plant invasion. This phenomenon was investigated by analysing four potential mechanisms covering community system structure, nitrogen metabolism, geochemical cycles, and microbial mechanisms. The results suggest that microorganisms drive plant-soil feedback processes, even regulating or limiting other factors. (2) The impact of nitrogen deposition on the legacy effects of plant invasions may be intensified primarily through enhanced nitrogen metabolism via microbial anaerobes bacteria. Essential insights into invasion ecology and ecological management have been provided by analysing how nitrogen-fixing bacteria improve nitrogen metabolism and establish sustainable methods for controlling invasive plant species. This in-depth study contributes to our better understanding of the lasting effects of plant invasions on ecosystems and provides valuable guidance for future ecological management.

THE PAID AND FAMILY DEMENTIA WORKFORCE IN THE COVID-19 PANDEMIC ERA

Abstract The COVID-19 pandemic has had a disproportionate impact on persons living with dementia and their carers. The early period of the pandemic led to drastic changes in dementia care at home, in healthcare services, community programs, and institutional care settings, with lasting effects (Capstick et al., 2022; Giebel et al., 2022). This symposium describes the impact of the COVID-19 pandemic on a variety of individuals providing care for persons living with dementia through different stages of the pandemic. Our work will be presented within a translational framework and include a discussion of ways of leveraging findings to improve resources for individuals and caregivers living with dementia in the COVID-19 era. Karen Donelan will provide an overview of the dementia workforce and describe study procedures. Michael Vetter will describe findings from a survey study of self-efficacy of dementia caregiving for family caregivers of individuals in community and assisted living facilities (ALF). Inga Antonsdottir will describe survey data on family caregivers in community and ALF – focus on newer experiential members; how lives changed, how COVID impacted them. Esteban Barreto will present findings describing the impact of the COVID-19 pandemic on frontline staff. Finally, Sarah Bannon will present findings from a qualitative study identifying family caregivers’ impressions of their psychosocial stressors and enacted coping strategies in the post-vaccine era of the COVID-19 pandemic.

HEALTH AND WELL-BEING ACROSS ECOLOGICAL SYSTEMS AND TIME IN MID LIFE AND LATE ADULTHOOD

Abstract Health and well-being are shaped by peoples’ experiences and ecological contexts (Bronfenbrenner, 2005), reflecting the influence of complex person-context relationships. For example, experiences (e.g., daily stressors, early childhood adversity) occur within microlevel (e.g., marital relationships, neighborhoods) and macrolevel (e.g., societal inequalities) contexts, impacting both daily well-being and healthy aging. Further, a robust literature highlights the significance of naturally occurring everyday experiences for a range of health outcomes, underscoring how daily experiences have immediate and lasting effects on individual physical and cognitive health and psychological well-being. Drawing on Bronfenbrenner’s Ecological Model, the current symposium features novel research examining health and well-being outcomes across diverse ecological systems and time scales across midlife and old age, with the goal of articulating how innovative approaches for studying person-context interactions can be leveraged to understand both proximal and long-term health and well-being. Polenick and colleagues will examine associations between daily negative and positive events and well-being among heterosexual married couples living with early-stage dementia. Cichy et al. will examine gender differences in the prospective effects of daily stress processes on long-term chronic disease risk in midlife and later life. Next, Turner and Mogle will examine how positive and negative affect mediate the associations between daily memory lapses and psychological well-being. Finally, Choi, Munoz, Scott, and Sliwinski will examine whether current positive (i.e., neighborhood cohesion) and negative (i.e., neighborhood violence) neighborhood contexts moderate the effect of childhood stress exposure on cognitive function in adulthood. Robert Stawski will synthesize the presentations and offer insights for future research.

N-Acetyl Cysteine Prevents Arterial Thrombosis in a Dose-Dependent Manner In Vitro and in Mice.

Platelet-rich thrombi occlude arteries causing fatal infarcts like heart attacks and strokes. Prevention of thrombi by current antiplatelet agents can cause major bleeding. Instead, we propose using N-acetyl cysteine (NAC) to act against the protein VWF (von Willebrand factor), and not platelets, to prevent arterial thrombi from forming. NAC was assessed for its ability to prevent arterial thrombosis by measuring platelet accumulation rate and occlusion time using a microfluidic model of arterial thrombosis with human blood. Acute clot formation, clot stability, and tail bleeding were measured in vivo with the murine modified Folts model. The effect of NAC in the murine model after 6 hours was also measured to determine any persistent effects of NAC after it has been cleared from the blood. We demonstrate reduction of thrombi formation following treatment with NAC in vitro and in vivo. Human whole blood treated with 3 or 5 mmol/L NAC showed delayed thrombus formation 2.0× and 3.7× longer than control, respectively (P<0.001). Blood treated with 10 mmol/L NAC did not form an occlusive clot, and no macroscopic platelet aggregation was visible (P<0.001). In vivo, a 400-mg/kg dose of NAC prevented occlusive clots from forming in mice without significantly affecting tail bleeding times. A lower dose of NAC significantly reduced clot stability. Mice given multiple injections showed that NAC has a lasting and cumulative effect on clot stability, even after being cleared from the blood (P<0.001). Both preclinical models demonstrate that NAC prevents thrombus formation in a dose-dependent manner without significantly affecting bleeding time. This work highlights a new pathway for preventing arterial thrombosis, different from antiplatelet agents, using an amino acid derivative as an antithrombotic therapeutic.

"Legacies of Displacement from the Iron Gates Hydroelectric Project "

Construction of the Iron Gates I hydroelectric project on the Danube River between 1966-1972 was the result of collaboration between Romania and Yugoslavia. The scale of the project resulted in the permanent displacement and relocation of several communities along the river. The aim of article is to consider how vulnerability among the displaced communities manifested and the lasting effects this has had on efforts to adapt to life in new locations. The article draws on archival research to examine the contemporaneous processes and decision-making around the construction. It presents the results of a survey of displaced residents conducted more than 40 years after relocation to identify how displacement was experienced, as well as its lasting effects. The results suggest that the different forms of vulnerability within the community that hampered adaptation continued to shape the community long after the displacement event. They also point to the aggregating nature of vulnerability, as efforts at adaptation continued to be shaped by the interaction of social, economic, and geographical factors.

An overview of attention-deficit hyperactivity disorder in the pediatrics

Attention-deficit hyperactivity disorder (ADHD), which is a disorder affecting children worldwide, has lasting effects on their behavior and cognitive functions. This review will explore the complexities of ADHD in children, including its classification, manifestations and management strategies. We will discuss the subtypes of ADHD and how they present challenges in various aspects of a child's life. From difficulties with attention to hyperactivity and impulsivity these subtypes have profiles that impact academic performance, social interactions and emotional regulation. The symptoms of ADHD intertwine inattentiveness, hyperactivity, impulsivity, emotional instability and academic struggles in patients. These symptoms significantly affect a child's functioning across areas such as schoolwork, social life and emotions. To effectively manage ADHD in children requires an approach that combines medication options with interventions, educational support systems tailored to individual needs and parental support programs that emphasize collaboration between healthcare professionals and families. This comprehensive approach seeks to address the requirements of children dealing with ADHD. Its goal is not to reduce symptoms but to improve their long-term outcomes and overall quality of life. By explaining the nature of ADHD in children, this analysis aims to provide an understanding of the disorder. It highlights the significance of customized interventions, early detection, and continuous support in order to enhance the well-being and developmental path of affected children.