Large Magnitude Research Articles

Can we rely on EUV emission to identify coronal waveguides?

Context. Traditional models of coronal oscillations rely on a modelling of the coronal structures that support them as compact cylindrical waveguides. An alternative model of the structure of the corona has recently been proposed, in which the thin strand-like coronal loops, that are observed in the extreme-UV (EUV) emission are the result of the line-of-sight integration of warps in more complex coronal structures. This is referred to as the coronal veil model. Aims. We extend the implications of the coronal veil model of the solar corona to models of coronal oscillations. Methods. Using convection-zone-to-corona simulations with the radiation-magnetohydrodynamics (rMHD) code Bifrost, we analysed the structure of the self-consistently formed simulated corona. We focused on the spatial variability of the volumetric emissivity of the Fe IX 171.073 Å EUV line and on the variability of the Alfvén speed, which captures the density and magnetic structuring of the simulated corona. We traced features associated with large magnitudes of the Alfvén speed gradient, which trap MHD waves and act as coronal waveguides. We searched for the correspondence with emitting regions, which appear as strand-like loops in the line-of-sight-integrated EUV emission. Results. We find that the cross sections of the waveguides bounded by large Alfvén speed gradients become less circular and more distorted with increasing height in the solar atmosphere. The waveguide filling factors corresponding to the fraction of the waveguides filled with plasma that emits in the given EUV wavelength range from 0.09–0.44. This suggests that we can only observe a small fraction of the waveguide. Similarly, the projected waveguide widths in the plane of the sky are several times larger than the widths of the apparent loops that are observed in the EUV. Conclusions. We conclude that the coronal veil structure is independent of the model. As a result, we find a lack of straightforward correspondence between peaks in the integrated emission profile that constitute apparent coronal loops and regions of plasma bound by a large Alfvén speed gradient that act as waveguides. Coronal waveguides cannot be reliably identified based on emission in a single EUV wavelength is not reliable in the simulated corona formed in convection-zone-to-corona models.

Local adaptation can cause both peaks and troughs in nucleotide diversity within populations.

The amount of standing variation present within populations is a fundamental quantity of interest in population genetics, commonly represented by calculating the average number of differences between pairs of nucleotide sequences (nucleotide diversity, π). It is well understood that both background and positive selection can cause reductions in nucleotide diversity, but less clear how local adaptation affects it. Depending on the assumptions and parameters, some theoretical studies have emphasized how local adaptation can reduce nucleotide diversity, while others have shown that it can increase it. Here, we explore how local adaptation shapes genome-wide patterns in within-population nucleotide diversity, extending previous work to study the effects of polygenic adaptation, genotypic redundancy, and population structure. We show that local adaptation produces two very different patterns depending on the relative strengths of migration and selection, either markedly decreasing or increasing within-population diversity at linked sites at equilibrium. At low migration, regions of depleted diversity can extend large distances from the causal locus, with substantially more diversity eroded than expected with background selection. With higher migration, peaks occur over much smaller genomic distances but with much larger magnitude changes in diversity. Across spatially extended environmental gradients, both patterns can be found within a single species, with increases in diversity at the center of the range and decreases towards the periphery. Our results demonstrate that there is no universal diagnostic signature of local adaptation based on within-population nucleotide diversity, so it will not be broadly useful for explaining increased FST. However, given that neither background nor positive selection inflate diversity, when peaks are found they suggest local adaptation may be acting on a causal allele in the region.

The Effects of High-Intensity, Short-Duration and Low-Intensity, Long-Duration Hamstrings Static Stretching on Contralateral Limb Performance.

Increases in contralateral range of motion (ROM) have been shown following acute high-intensity and high-duration static stretching (SS) with no significant change in contralateral force, power, and muscle activation. There are currently no studies comparing the effects of a high-intensity, short-duration (HISD) or low-intensity, long-duration (LILD) SS on contralateral performance. The aim of this study was to examine how HISD and LILD SS of the dominant leg hamstrings influence contralateral limb performance. Sixteen trained participants (eight females, eight males) completed three SS interventions of the dominant leg hamstrings; (1) HISD (6 × 10 s at maximal point of discomfort), (2) LILD (6 × 30 s at initial point of discomfort), and (3) control. Dominant and non-dominant ROM, maximal voluntary isometric contraction (MVIC) forces, muscle activation (electromyography (EMG)), and unilateral CMJ and DJ heights were recorded pre-test and 1 min post-test. There were no significant contralateral ROM or performance changes. Following the HISD condition, the post-test ROM for the stretched leg (110.6 ± 12.6°) exceeded the pre-test (106.0 ± 9.0°) by a small magnitude effect of 4.2% (p = 0.008, d = 0.42). With LILD, the stretched leg post-test (112.2 ± 16.5°) exceeded (2.6%, p = 0.06, d = 0.18) the pre-test ROM (109.3 ± 16.2°) by a non-significant, trivial magnitude. There were large magnitude impairments, evidenced by main effects for testing time for force, instantaneous strength, and associated EMG. A significant ROM interaction (p = 0.02) showed that with LILD, the stretched leg significantly (p = 0.05) exceeded the contralateral leg by 13.4% post-test. The results showing no significant increase in contralateral ROM with either HISD or LILD SS, suggesting the interventions may not have been effective in promoting crossover effects.

Abstract C054: Clinicogenomic determinants of response to FOLFIRINOX versus gemcitabine plus nab-paclitaxel as first-line systemic therapy for pancreatic cancer

Abstract Background: FOLFIRINOX (FFX) and gemcitabine plus nab-paclitaxel (GA) are two recommended first-line systemic options for pancreatic cancer; however, there is limited evidence to support a particular regimen or provide guidance for treatment selection. We sought to compare outcomes for FFX versus GA across disease stages, and test whether there was an association between clinicogenomic features, treatment response, and survival. Methods: For this retrospective analysis, we utilized AACR’s GENIE PANC v1.2 database, the first large-scale pancreatic cancer dataset that combines genomic data with clinical annotations. The clinicogenomic profiles of patients were stratified and compared by stage: resectable/borderline resectable (R/BR), locally advanced (LA), or metastatic (MET). Patients who received FFX or GA as first-line therapy were compared across stages, with a focus on MET patients. We evaluated OS and PFS as survival outcomes and performed an adjusted analysis using Cox proportional hazards modeling. Treatment responses were further evaluated by change in serum CA 19-9. To test for features associated with treatment response, the genomic profiles of best and worst responders were compared. Results: Of 987 patients with complete genomic data, there were 452 R/BR, 82 LA, and 453 MET. While there was no difference in KRAS status, patients with later-stage disease accumulated greater common co-alterations: CDKN2A (19%, 23%, 35%), SMAD4 (26%, 29%, 30%), TP53 (72%, 73%, 77%), and ARID1A (6%, 6%, 11). Within MET patients, there was no significant difference in PFS between those treated with FFX (n=239) and GA (n=82), but patients treated with FFX had significantly longer OS, even after multivariable adjustment (median 1.14 vs. 0.854 years, p < 0.01; HR: 0.66, 95% CI: 0.49- 0.89, p < 0.01). Despite improved OS in FFX patients, GA patients had a greater reduction in CA 19-9 (median 50.0 vs. 69.0 U/mL). In addition, when comparing the genomic profiles of best/worst responders for MET patients treated with FFX and GA, there was no clear signal that one regimen should be favored over another in a specific context. Exploratory analyses in the R/BR and LA groups indicated no significant survival differences between first-line FFX vs. GA patients, nor in first-line treatment among patients who developed metastases post- diagnosis. Conclusion: Common co-alterations appear to accumulate in later-stage disease, and outcomes in patients undergoing systemic therapy is worse generally in patients with more complex genomic profiles. However, we did not observe any specific genomic features suggestive of a particular response to FFX vs. GA. Of note, we found that Met GA patients had a larger magnitude in CA 19-9 response, even though Met FFX was associated with improved OS. This provokes important questions regarding how biochemical response should be gauged in patients treated with these regimens. Citation Format: Kunling Tong, Elishama Kanu, Ethan Agritelley, Jiayin Bao, Peter J Allen, Daniel P Nussbaum. Clinicogenomic determinants of response to FOLFIRINOX versus gemcitabine plus nab-paclitaxel as first-line systemic therapy for pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research; 2024 Sep 15-18; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl_2):Abstract nr C054.

Understanding the Anomalous Thermoelectric Behavior of Fe-V-W-Al-Based Thin Films.

We investigated the thermoelectric and thermal behavior of Fe-V-W-Al-based thin films prepared using the radio frequency magnetron sputtering technique at different oxygen pressures (0.1-1.0 × 10-2 Pa) and on different substrates (n, p, and undoped Si). Interestingly, at lower oxygen pressure, formation of a bcc-type Heusler structure was observed in deposited samples, whereas at higher oxygen pressure, we have noted the development of an amorphous structure in these samples. Our findings indicate that the moderately oxidized Fe-V-W-Al amorphous thin film deposited on the n-Si substrate possesses a large magnitude of S ∼ -1098 ± 100 μV K-1 near room temperature, which is almost double the previously reported value for thin films. Additionally, the power factor (PF) indicated an enormously large value of ∼33.9 mW m-1 K-2 near 320 K. The thermal conductivity of the amorphous thin film is also found to be 2.75 Wm-1 K-1, which is quite lower compared to bulk alloys. As a result, the maximum figure of merit is estimated to be extremely high, i.e., ∼3.9 near 320 K, which is among one of the highest reported values so far. The anomalously large value of Seebeck coefficient and PF has been ascribed to the unusual composite effect of the metallic amorphous oxide phase and insulating substrate possessing a large Seebeck coefficient.

Fossil Groups analysis using weak gravitational lensing

Abstract The overall objective of this study is to investigate claims found in the literature that fossil groups, characterized by a large magnitude gap between their two brightest galaxies, are darker, i.e. exhibit higher mass-to-light ratios (M/L), compared to regular groups. Specifically, we aim to measure the mass of these systems using the weak gravitational lensing technique. To achieve this, we obtained deep images of four fossil systems with the CFHT telescope in the r and g bands. Through a careful process of weak gravitational shear measurement, including corrections for the point spread function (PSF) and contamination from group and foreground galaxies, we fit NFW models and obtained mass measurements as a result. Similarly, we quantified the light distribution produced by these groups, taking into account relevant data gaps in the images due to the presence of bright stars, as well as contamination from foreground and background galaxies. We obtained masses and M/L ratios that are consistent with previous results where mass was estimated from galaxy dynamics. Indeed, the four fossil systems studied here exhibit high M/L ratios compared to the general population of systems. Drawing more generalizable conclusions from a sample of only four systems is challenging. However, the procedure outlined in this study can be applied to large image surveys, allowing for a revisiting of this question with significantly reduced statistical uncertainties. This will enable a more homogeneous comparison between fossil groups and clusters and the overall population.

Exploring seismic fragility and strengthening of masonry built heritage in Lisbon (Portugal) via the Applied Element Method

Although mainland Portugal has been spared from large magnitude earthquakes in recent years, it faces a threat due to the presence of several active fault systems. In such a framework, Portuguese pre-code masonry construction is believed to be the most vulnerable in the existing building stock. Given the lack of information on earthquake damage to this stock, the use of detailed numerical models is a viable strategy to comprehend its seismic behavior. This paper provides an updated fragility characterization of Lisbon pre-code masonry buildings based on their seismic assessment through the Applied Element Method. To limit the computational time, a promising pushover strategy, known as Incremental Ground Acceleration, was adopted. After the characterization of the current fragility, two retrofit layouts based on piers strengthening were modeled and assessed for the building stock whose seismic capacity does not meet expected demand. The aim of the paper is to derive updated fragility curves for the Lisbon region to support risk analysis incorporating the latest hazard studies and to offer insights into potential retrofit interventions.

How Induced Earthquakes Respond to Pre‐Existing Fractures and Hydraulic Fracturing Operations? A Case Study in South China

AbstractHydraulic fracturing in shale gas production can induce felt earthquakes, making it crucial to understand and mitigate induced earthquakes. The Cen'gong shale gas block in South China offers extensive data—3D seismic, geological structure, microseismic data, and detailed stimulation operations—allowing a comprehensive investigation into induced earthquakes by hydraulic fracturing. Using a dense temporary seismic array and deep‐learning workflows, we build a high precision earthquake catalog and determine their focal mechanisms. Pre‐existing fractures are identified through the Ant Tracking attribute derived from the 3D seismic data. We analyze the distribution, frequency, magnitude, and focal mechanisms of induced earthquakes, compare them spatially with the distribution of the pre‐existing fractures, and track their temporal changes during and after hydraulic fracturing. Most induced earthquakes occurred along pre‐existing fractures, exhibiting relatively larger magnitudes and persistent trailing seismicity. The number of trailing seismicity is proportional to the response time of stimulation earthquakes. The focal mechanism solutions suggest that the rupture mechanism of the trailing seismicity remained unchanged. By analyzing four clusters of earthquakes, we found that in two of these clusters, the induced earthquakes initiated from the far side of the fractures, then linearly migrated along the pre‐existing fractures. This directional migration pattern is explained by stress rotation along the fractures. Our analysis suggests that both pre‐existing fractures and stimulation operations significantly influence induced earthquake occurrences. Therefore, this work may enhance our understanding of pre‐existing fractures, and optimizing stimulation operations can mitigate earthquake hazards in shale gas production.

Delving into CLIP latent space for Video Anomaly Recognition

We tackle the complex problem of detecting and recognising anomalies in surveillance videos at the frame level, utilising only video-level supervision. We introduce the novel method AnomalyCLIP, the first to combine Vision and Language Models (VLMs), such as CLIP, with multiple instance learning for joint video anomaly detection and classification. Our approach specifically involves manipulating the latent CLIP feature space to identify the normal event subspace, which in turn allows us to effectively learn text-driven directions for abnormal events. When anomalous frames are projected onto these directions, they exhibit a large feature magnitude if they belong to a particular class. We also leverage a computationally efficient Transformer architecture to model short- and long-term temporal dependencies between frames, ultimately producing the final anomaly score and class prediction probabilities. We compare AnomalyCLIP against state-of-the-art methods considering three major anomaly detection benchmarks, i.e. ShanghaiTech, UCF-Crime, and XD-Violence, and empirically show that it outperforms baselines in recognising video anomalies. Project website and code are available at https://lucazanella.github.io/AnomalyCLIP/.

The Effects of Static Stretching 2-Hours Prior to a Traditional Warm-Up on Performance.

Whereas prolonged static stretching (SS: >60-seconds per muscle) can increase range of motion (ROM) for up to 2-hours, it can also decrease maximal voluntary isometric contraction (MVIC) forces, countermovement (CMJ) and drop jump (DJ) heights, and muscle activation immediately after the stretching exercise. When an appropriate SS duration (<60-seconds per muscle) is incorporated into a dynamic warm-up, performance decrements are often trivial. However, there is a lack of studies that observed the effects of extensive SS (180-seconds) 2-hours prior to a dynamic warm-up. The objective was to investigate ROM and performance effects of prolonged SS, 2-hours prior to a traditional warm-up. This study investigated 9 female and 8 male healthy recreationally active, young adult participants on the effects of prolonged SS (180-seconds per muscle) of the quadriceps and hamstrings, 2-hours before a traditional warm-up compared to an active control condition on hip flexion ROM, knee extension and flexion MVIC forces, CMJ, DJ, and quadriceps and hamstrings electromyography (EMG). There were no significant changes in knee flexion/extension MVIC forces, EMG, CMJ, or DJ height. However, there was significant, small magnitude (p = 0.002) greater post-warm-up left hip flexion ROM (115.4° ± 17.2) than pre-SS (108.9° ± 17.13, Effect size [ES]: 0.28) and control post-warm-up (p = 0.05, ES: 0.31, 109.5° ± 20.55). Similarly, right hip flexion ROM (117.2° ± 16.5) also demonstrated significant small magnitude (p = 0.003) greater than the pre-SS (112.4° ± 18.4, ES: 0.22) and control post-warm-up (p = 0.046, ES: 0.33, 110.8° ± 20.5). Additionally, significant, large magnitude greater hip flexion ROM was observed with the women vs. men (ES: 1.29 - 1.34). Significant hip flexion ROM increases were not accompanied by significant changes in knee flexion/extension MVIC forces, EMG, or jump heights, suggesting that extensive SS can positively impact ROM without performance deficits when followed by a traditional warm-up, 2-hours after SS.

DEM investigation on the dynamic characteristics of wall normal stress and particle flow during silo discharge

Violent fluctuations of wall normal stress and particle velocity during silo discharge have been frequently reported by researchers, yet a detailed particle-scale description of these phenomena is still lacking. In this work, the discharge of granular assembly from a flat-bottomed silo was investigated by performing three-dimensional (3D) Discrete Element Method (DEM) simulations. It is found that arc-shaped rupture surfaces, characterized by the lower solid volume fraction, stronger shear interaction between particles and higher particle rotating velocity, developed continuously in the bottom converging part of flowing zone. And the temporal evolution of particle velocity field in this converging part presented a swinging feature manifested by the alternate appearance of large particle velocity magnitude in the right- and left- side regions. Discrete Fourier transform results showed that the fluctuation of wall normal stress at the transition point contained two dominate frequencies. The lower frequency matched well with the dynamic evolution of the rupture surface joining the transition point, and the higher frequency was nearly the same as the fluctuating frequency of particle vertical velocity. Thus, our DEM simulation results suggested that for the silo discharge considered in this work, the periodic fluctuation of wall normal stress at the transition point was contributed by both the alternating flow pattern mechanism and the free-fall arch mechanism.

Resolving the Variability Discrepancy between Peak Ground Acceleration and Spectral Stress Drop: Insight from Double-Corner-Frequency Spectra

ABSTRACT This study addresses a challenge in ground-motion prediction, in which the observed variability of spectral stress drop Δσfc estimated from corner frequencies is significantly larger than the between-event variability of peak ground acceleration (PGA) supported by ground-motion prediction equations. To tackle this issue, we performed spectral ratio analyses on 34 crustal earthquakes with Mw 5.0–7.1 in Japan. Initially, we employed the standard spectral ratio method to estimate the corner frequencies fc and the spectral stress drops Δσfc. This method assumes the single-corner-frequency (SCF) spectral model. Next, we introduce a two-stage spectral ratio method to obtain the double-corner-frequency (DCF) spectra. This method first estimates the corner frequency of the small events in advance using further smaller events and the standard method. Then, it computes the spectra of the target event using the spectra of the small events predicted from the SCF model with the estimated corner frequency. We fit the SCF model to the observed spectra to estimate a high-frequency-fitted corner frequency fch and calculate the corresponding spectral stress drops Δσfch, called the stress parameter. Our analyses reveal that the variability of Δσfch aligns with the observed PGA variability, in contrast to the Δσfc variability, which is significantly larger and consistent with findings in previous corner-frequency studies. Thus, at least regarding the spectral ratio approach, the discrepancy between spectral stress drop and PGA variabilities primarily stems from the difference in the Δσfc and Δσfch variabilities, attributed to the diversity in source spectral shapes. This study demonstrates that although source spectra for Mw 5.0 align with the SCF model on average, deviations from the SCF model become increasingly pronounced with larger magnitudes. The results emphasize the significance of implementing the DCF model for improved ground-motion predictions.

Superior Single-Entity Electrochemistry Performance of Capping Agent-Free Gold Nanoparticles Compared to Citrate-Capped Gold Nanoparticles.

In observing the electrocatalytic current of nanoparticles (NPs) using single-entity electrochemistry (SEE), the surface state of the NPs significantly influences the SEE signal. This study investigates the influence of capping agents on the electrocatalytic properties of gold (Au) NPs using SEE. Two inner-sphere reactions, hydrazine oxidation and glucose oxidation, were chosen to explore the SEE characteristics of Au NPs based on the capping agent presence. The results revealed that "capping agent-free" Au NPs exhibited signal magnitudes and frequencies consistent with theoretical expectations, indicating superior stability and catalytic performance in electrolyte solutions. In contrast, citrate-capped Au NPs showed signals varying depending on the applied potential, with larger magnitudes and lower frequencies than expected, likely due to an aggregation of NPs. This study suggests that capping agents play a crucial role in the catalytic performance and stability of Au NPs in SEE. By demonstrating that minimizing capping agent presence can enhance effectiveness in SEE, it provides insights into the future applications of NPs, particularly highlighting their potential as nanocatalysts in energy conversion reactions and environmental applications.

An Approximation of the Prime Counting Function and a New Representation of the Riemann Zeta Function

Determining the exact number of primes at large magnitudes is computationally intensive, making approximation methods (e.g., the logarithmic integral, prime number theorem, Riemann zeta function, Chebyshev’s estimates, etc.) particularly valuable. These methods also offer avenues for number-theoretic exploration through analytical manipulation. In this work, we introduce a novel approximation function, ϕ(n), which adds to the existing repertoire of approximation methods and provides a fresh perspective for number-theoretic studies. Deeper analytical investigation of ϕ(n) reveals modified representations of the Chebyshev function, prime number theorem, and Riemann zeta function. Computational studies indicate that the difference between ϕ(n) and the logarithmic integral at magnitudes greater than 10100 is less than 1%.

Discontinuous Galerkin schemes for hyperbolic systems in non-conservative variables: Quasi-conservative formulation with subcell finite volume corrections

We present a novel quasi-conservative arbitrary high order accurate ADER (Arbitrary-Derivative) discontinuous Galerkin method allowing to efficiently use a non-conservative form of the considered partial differential system, so that the governing equations can be solved directly in the most physically relevant set of variables. This is particularly interesting for multi-material flows with moving interfaces and steep, large magnitude contact discontinuities, as well as in presence of highly non-linear thermodynamics. However, the non-conservative formulation of course introduces a conservation error which would normally lead to a wrong approximation of shock waves. Hence, from the theoretical point of view, we give a formal definition of the conservation defect of non-conservative schemes and we analyze this defect providing a local quasi-conservation condition, which allows us to prove a modified Lax–Wendroff theorem. Within this formalism, we also reformulate classical results concerning smooth solutions, contact discontinuities and moving interfaces. Then, to deal with shock waves in practice, we exploit the framework of the so-called a posteriori subcell finite volume (FV) limiter, so that, in troubled cells appropriately detected, we can incorporate a local conservation correction. Our corrected FV update entirely removes the local conservation defect, allowing, at least formally, to fit in the hypotheses of the proposed modified Lax–Wendroff theorem. Here, the shock-triggered troubled cells are detected by combining physical admissibility criteria, a discrete maximum principle and a shock sensor inspired by Lagrangian hydrodynamics.To prove the capabilities of our novel approach, first, we show that we are able to recover the same results given by conservative schemes on classical benchmarks for the single-fluid Euler equations. We then conclude the presentation by showing the improved reliability of our scheme on the multi-fluid Euler system on examples like the interaction of a shock with a helium bubble for which we are able to avoid the development of any spurious oscillations.

NEUTRON POINT KINETICS MODEL WITH A DISTRIBUTED-ORDER FRACTIONAL DERIVATIVE

In this paper, the solutions of an extended form of the Fractional-order Neutron Point Kinetics (FNPK) equation in terms of Caputo-time derivatives of the same order are investigated. Instead of using a Caputo derivative, a distributed-order fractional derivative in the Caputo sense was employed in the term of the FNPK equation which is multiplied by the reactivity. This term plays an important role in the description of neutron kinetics during the start-up, shutdown, and steady-state processes in nuclear reactors. The extended (DFNPK) model was solved using the beta, normal, bimodal and Dirac delta distributions to investigate their effect on the transient state solutions of the neutron density. Regardless of the distribution used, the most significant finding is that a destabilizing effect on the neutron density is induced when the mode (or the instant of application of the Dirac delta) of the distribution tends to one while maintaining the orders of the Caputo-time derivatives constant. What defines the destabilizing effect are large magnitude oscillations, a rapid decay, and an oscillation-free steady state with a monotonic increase that is parallel to but somewhat above the trend determined by the FNPK equation. The extended model is anticipated to be effective for modeling neutron density dispersion in a highly heterogeneous medium that may be described using distributed derivatives.

Various Features of the X-class White-light Flares in Super Active Region NOAA 13664

Super active region NOAA 13664 produced 12 X-class flares (including the largest one so far, an occulted X8.7 flare, in solar cycle 25) during 2024 May 8–15, and 11 of them are identified as white-light flares. Here we present various features of these X-class white-light flares observed by the White-light Solar Telescope (WST) on board the Advanced Space-based Solar Observatory and the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory. It is found that both the white-light emissions at WST 3600 Å (Balmer continuum) and HMI 6173 Å (Paschen continuum) show up in different regions of the sunspot group in these flares, including outside the sunspots and within the penumbra and umbra of the sunspots. They exhibit a point-, ribbon-, loop-, or ejecta-like shape, which can come from flare ribbons (or footpoints), flare loops, and plasma ejecta depending on the perspective view. The white-light duration and relative enhancement are measured and both parameters for 3600 Å emission have greater values than those for 6173 Å emission. It is also found that these white-light emissions are cospatial well with the hard X-ray (HXR) sources in the on-disk flares but have some offsets with the HXR emissions in the off-limb flares. In addition, it is interesting that the 3600 and 6173 Å emissions show different correlations with the peak HXR fluxes, with the former one more sensitive to the HXR emission. All these greatly help us understand the white-light flares of a large magnitude from a super active region on the Sun and also provide important insights into superflares on Sun-like stars.

Application of an Auditory-Based Feedback Distortion to Modify Gait Symmetry in Healthy Individuals.

Augmenting auditory feedback through an error-augmentation paradigm could facilitate the perception and correction of gait asymmetry in stroke survivors, but how such a paradigm should be tailored to individual asymmetry profiles remains unclear. Before implementing the paradigm in rehabilitation, we need to investigate the instantaneous effects of distorted footstep sound feedback on gait symmetry in healthy young adults. Participants (n = 12) walked on a self-paced treadmill while listening to their footstep sounds, which were distorted unilaterally according to five conditions presented randomly: small delay; small advance; large delay; large advance; or unmodified (control). The primary outcomes were swing time ratio (SWR) and step length ratio (SLR). Secondary outcomes included walking speed, bilateral swing time, step length, and maximum toe height, as well as hip, knee, and ankle angle excursions. SWR (p < 0.001) but not SLR (p ≥ 0.05) was increased in all distorted feedback conditions compared to the control condition. Increased swing time on the perturbed side ipsilateral to feedback distortion was observed in the advanced conditions (p < 0.001), while swing time increased bilaterally in the delayed conditions (p < 0.001) but to a larger extent on the unperturbed side contralateral to feedback distortion. Increases in swing time were accompanied by larger maximum toe height as well as larger hip and knee joint excursions (p < 0.05 to p < 0.001). No differences in any outcomes were observed between small and large feedback distortion magnitudes. Distorted footstep sound feedback successfully elicits adaptation in temporal gait symmetry (SWR), with distinct modulation patterns for advanced vs. delayed footstep sounds. Spatial symmetry (SLR) remains unaltered, likely because auditory feedback primarily conveys temporal information. This research lays the groundwork to implement personalized augmented auditory feedback in neurorehabilitation.

A didactic experience for educating the youngest generations about seismic risk using an escape room

Effective risk communication is crucial for enhancing societal resilience. It’s not just about scientific strategies; it’s also about ensuring that communities are informed and prepared. Educating local populations, especially younger generations, is key to improving disaster readiness. Notably, engaging younger generations assumes significance, given their role as both the future of society and conduits for educating their families. Serious Games, specifically Escape Rooms, present a compelling tool for engaging and interacting with young people. These games, designed not primarily for entertainment but for educational purposes, facilitate active participant involvement, thereby enhancing learning. In our didactic approach, comprising a frontal lesson and an Escape Room, we sought to leverage the appeal of Serious Games to educate young people. This approach was particularly timely during the COVID-19 pandemic, where virtual experiences gained positive evaluations despite the inherent challenges. Italy frequently faces large magnitude earthquakes. Yet many Italians, especially young people, have low seismic risk awareness, hindering preparedness efforts. To address this issue, the use of games and interactive experiences proves promising. By involving young people, seismic risk awareness can be effectively raised, fostering a culture of safety. Throughout the implementation of the Escape Room exercise dedicated to seismic risk, we conducted an evaluation phase both before and after the activities. The insights gained from this evaluation process provided valuable feedback on the learning experience and the effectiveness of the science communication technique. Notably, the virtual nature of the escape room experience was positively evaluated, demonstrating its adaptability during the pandemic. It is imperative to acknowledge that participants in these activities were aged between 15 and 18 years old, requiring ethical considerations in the design and execution of the educational intervention. The findings are highly promising, indicating that students viewed the protocol as beneficial for understanding fundamental concepts in seismology and enhancing their perception of risk. Moreover, the protocol positively influenced students’ interest in science and geophysics. Furthermore, an aspect that remains unexplored is the extent to which the knowledge acquired by the participants was disseminated within their families, representing a potential area for future investigation.

Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep.

Cardiovascular dysfunctions complicate 10-20% of pregnancies, increasing the risk for postpartum mortality. Various gestational insults, including preeclampsia are reported to be associated with adverse maternal cardiovascular outcomes. One such insult, gestational hyperandrogenism increases the risk for preeclampsia and other gestational morbidities but its impact on postpartum maternal health is not well known. We hypothesize that gestational hyperandrogenism such as testosterone (T) excess will adversely impact the maternal heart in the postpartum period. Pregnant ewes were injected with T propionate from day 30 to day 90 of gestation (term 147 days). Three months postpartum, echocardiograms, plasma cytokine profiles, cardiac morphometric, and molecular analysis were conducted [control (C) n = 6, T-treated (T) n = 7 number of animals]. Data were analyzed by two-tailed Student's t test and Cohen's effect size (d) analysis. There was a nonsignificant large magnitude decrease in cardiac output (7.64 ± 1.27 L/min vs. 10.19 ± 1.40, P = 0.22, d = 0.81) and fractional shortening in the T ewes compared with C (35.83 ± 2.33% vs. 41.50 ± 2.84, P = 0.15, d = 0.89). T treatment significantly increased 1) left ventricle (LV) weight-to-body weight ratio (2.82 ± 0.14 g/kg vs. 2.46 ± 0.08) and LV thickness (14.56 ± 0.52 mm vs. 12.50 ± 0.75), 2) proinflammatory marker [tumor necrosis factor-alpha (TNF-α)] in LV (1.66 ± 0.35 vs. 1.06 ± 0.18), 3) LV collagen (Masson's Trichrome stain: 3.38 ± 0.35 vs. 1.49 ± 0.15 and Picrosirius red stain: 5.50 ± 0.32 vs. 3.01 ± 0.23), 4) markers of LV apoptosis, including TUNEL (8.3 ± 1.1 vs. 0.9 ± 0.18), bcl-2-associated X protein (Bax)+-to-b-cell lymphoma 2 (Bcl2)+ ratio (0.68 ± 0.30 vs. 0.13 ± 0.02), and cleaved caspase 3 (15.4 ± 1.7 vs. 4.4 ± 0.38). These findings suggest that gestational testosterone excess adversely programs the maternal LV, leading to adverse structural and functional consequences in the postpartum period.NEW & NOTEWORTHY Using a sheep model of human translational relevance, this study provides evidence that excess gestational testosterone exposure such as that seen in hyperandrogenic disorders adversely impacts postpartum maternal hearts.