Large Surface Area Research Articles

Experimental Examination of Additively Manufactured Patterns on Structural Nuclear Materials for Digital Image Correlation Strain Measurements

Abstract Background There are a limited number of commercially available sensors for monitoring the deformation of materials in-situ during harsh environment applications, such as those found in the nuclear and aerospace industries. Such sensing devices, including weldable strain gauges, extensometers, and linear variable differential transformers, can be destructive to material surfaces being investigated and typically require relatively large surface areas to attach (> 10 mm in length). Digital image correlation (DIC) is a viable, non-contact alternative to in-situ strain deformation. However, it often requires implementing artificial patterns using splattering techniques, which are difficult to reproduce. Objective Additive manufacturing capabilities offer consistent patterns using programmable fabrication methods. Methods In this work, a variety of small-scale periodic patterns with different geometries were printed directly on structural nuclear materials (i.e., stainless steel and aluminum tensile specimens) using an aerosol jet printer (AJP). Unlike other additive manufacturing techniques, AJP offers the advantage of materials selection. DIC was used to track and correlate strain to alternative measurement methods during cyclic loading, and tensile tests (up to 1100 µɛ) at room temperature. Results The results confirmed AJP has better control of pattern parameters for small fields of view and facilitate the ability of DIC algorithms to adequately process patterns with periodicity. More specifically, the printed 100 μm spaced dot and 150 μm spaced line patterns provided accurate measurements with a maximum error of less than 2% and 4% on aluminum samples when compared to an extensometer and commercially available strain gauges. Conclusion Our results highlight a new pattern fabrication technique that is form factor friendly for digital image correlation in nuclear applications.

Fabrication of Fe/KB composite as sulfur host for Li-S battery.

Lithium sulfur battery is a novel kind of secondary battery which has high energy density, however its application is greatly affected by the shuttle effect of polysulfides generated in the redox reaction of cathode electrode. Metal active sites are supposed as effective catalysts which can absorb and accelerate the conversion efficiency oflithium polysulfides, thus the shuttle effect will be alleviated. In this work, we conducted a simple way to prepare a metal Fe doped ketjen black to serve as the sulfur host of lithium sulfur battery. Ketjen black has a large specific surface area and rich porous structure, while Fe nanodot is an excellent catalyst for lithium polysulfides. Because of these advantages, the Fe/KB host can effectively confine a large amount of active material and accelerate its, therefore the Fe/KB-S cathode electrode show an excellent electrochemical performance.

Inducing ferroptosis via nanomaterials: a novel and effective route in cancer therapy

Abstract The use of nanomaterials for cancer ferroptosis presents a promising avenue for research and clinical applications. The unique properties of nanomaterials, such as their small size, large surface area, and ability to be engineered for specific tasks, make them ideal candidates for ferroptosis inducing cancer therapies. Ferroptosis is a new type of cell death mechanism that is distinct from apoptosis and necrosis. It has been shown to be critical in the treatment of various tumors. The ferroptotic mechanism has been mainly linked with the regulation of iron, amino acid, glutathione, and lipid metabolism of cells. The relationship between ferroptosis mechanisms and cancer nanomedicine has attracted considerable interest in recent years. It has been reported that the combination of nanomedicine and ferroptosis can achieve high therapeutic efficacy for the treatment of different cancer types. This review will provide an overview of recent work in ferroptosis-related cancer nanomedicine. First, general information is given about the definition of ferroptosis and its differences from other cell death mechanisms. Later, studies exploring the role of ferroptosis in the cancer nanomedicine field are discussed in detail. Specific focus has been given to the use of combinatorial treatment strategies which combine ferroptosis with chemodynamic therapy, photodynamic therapy, photothermal therapy, immunotherapy and sonodynamic therapy. Considering the fact that ferroptosis inducing nanoparticles have already been introduced into clinical studies, nanoscientists can further accelerate this clinical translation as they tailor the physicochemical characteristics of nanomaterials. This review provides enlightening information for all researchers interested in the molecular characterization and relationship between ferroptosis and cancer-directed nanoparticles.

Application of Three-Dimensional Porous Aerogel as Adsorbent for Removal of Textile Dyes from Water

The textile industry is one of the most important industries in the European Union. The main environmental problems of the textile industry are the high water consumption, the generated pollution, the variety of chemicals used and the high energy demand. Recently, adsorbents with a large specific surface area and low weight, such as aerogels, have attracted great interest as promising materials for removing dyes from polluted water. Cellulose aerogels are inexpensive and non-toxic. Langmuir and Freundlich isotherms were chosen as the best method to describe the performance of the adsorbent. In this study, the adsorption efficiency of Congo red, Naphthol green B, Rhodamine B and Methylene blue were determined by using an adsorbent synthesized from paper and cardboard waste. The total organic carbon concentration was chosen as an indicator of the concentration of the dyes in the solutions. The aerogel capsules had 5% cellulose content. It was found that the adsorption capacity of the aerogel in the solutions of Congo red varied from 0.028 mg/g to 14.483 mg/g; in the solutions of Naphthol green B, from 0.013 mg/g to 7.698 mg/g; in the solutions of Rhodamine B, from 0.020 mg/g to 8.768 mg/g; and in the solutions of Methylene blue, from 0.024 mg/g to 13.538 mg/g.

Polydopamine-assisted immobilization of metallic nanoparticles confined regionally in bamboo microchannels as continuous-flow microreactors for enhanced catalysis

In contrast to conventional plant-based microreactors where the nanocatalyst is anchored on the inner walls of microchannel structures, this study presents a bamboo-based flow microreactor in which the metallic nanocatalyst is immobilized within polydopamine (PDA) region-modified bamboo microchannels. This novel design facilitates a large surface area for nanocatalyst loading, enhances mass transfer, and reduces nanocatalyst leaching. Firstly, the hierarchical PDA architecture was fabricated on the wall surface of required bamboo microchannels through an ammoniation-induced self-assembly process to serve as a nanocatalyst support layer. The thickness of PDA architectures was modulated by adjusting the flow duration. Secondly, the metallic nanoparticles (NPs), including Pd, Au, and Ag, were effectively immobilized within the hierarchical PDA architectures as highly efficient catalysts using a flow-assisted method with minimal chemical usage and low catalyst loading (Pd content: 0.011 wt%). The catalytic performances of the proposed Pd-PDA/bamboo microreactor were evaluated for the continuous hydrogenation of nitroaromatics under flow conditions, encompassing variations in Pd content, nitroaromatic concentration, and liquid flow rate. The optimized Pd-PDA/bamboo microreactor exhibited high average conversion (>97 %) of nitroaromatics during 20 days of continuous operation without any noticeable deactivation or loss in activity due to its excellent stability resulting from firm immobilization of active metallic NPs within hierarchical PDA architectures. Additionally, this bamboo microreactor demonstrated potential applicability in environmental pollution treatment through azo dye hydrogenation.

Analysis of the temporal and spatial characteristics of lunar reconnaissance orbiter’s orbit error based on multi-coverage narrow angle camera images

ABSTRACT Photogrammetric mapping of large area of the lunar surface using high-resolution orbiter images is very challenging due to increasing spatial resolution and lack of a comprehensive understanding of orbit error characteristics. The Lunar Reconnaissance Orbiter (LRO) Narrow Angle Camera (NAC) images are currently one of the highest-resolution images of the Moon available. The study of LRO orbit errors from the perspective of mapping applications is important for high accuracy mapping of large areas using NAC images. This paper proposes a method for orbit error estimation using multi-coverage NAC images. First, available NAC images covering the study regions are orthorectified using ISIS. Then, the impact crater feature matching algorithm is used to match the multi-coverage images. Finally, estimation of the orbit error is achieved through statistical analysis of a large number of homologous points obtained from the matching. The orbit error analyses of nine representative regions on the Moon show that in most cases the refined ephemeris provided by the LOLA/GRAIL team can significantly reduce the orbit error. The orbit errors show a sawtooth variation with a period of about one year, which have been stable for a long time and tend to increase slightly in recent years. There is a slight variation of the orbit error in space, which is even less obvious when using the refined ephemeris. The general tendency is for the far side to be larger than the near side at the same latitude, and for the higher latitudes to be larger than the lower latitudes. The proposed method and analysis results provide a reference for selection and processing of multi-coverage LROC NAC images for high-resolution large-area mapping.

Effect of humic substances on the fraction of heavy metal and microbial response

Contamination of soils by Molybdenum (Mo) has raised increasing concern worldwide. Both fulvic acid (FA) and humic acid (HA) possess numerous positive properties, such as large specific surface areas and microporous structure that facilitates the immobilization of the heavy metal in soils. Despite these characteristics, there have been few studies on the microbiology effects of FA and HA. Therefore, this study aimed to assess the Mo immobilization effects of FA and HA, as well as the associated changes in microbial community in Mo-contaminated soils (with application rates of 0%, 0.5% and 1.0%). The result of the incubation demonstrated a decrease in soil pH (from 8.23 ~ 8.94 to 8.05 ~ 8.77). Importantly, both FA and HA reduced the exchangeable fraction and reducible fraction of Mo in the soil, thereby transforming Mo into a more stable form. Furthermore, the application of FA and HA led to an increase in the relative abundance of Actinobacteriota and Firmicutes, resulting in alterations to the microbial community structure. However, it is worth noting that due to the differing structures and properties of FA and HA, these outcomes were not entirely consistent. In summary, the aging of FA and HA in soil enhanced their capacity to immobilization Mo as a soil amendment. This suggests that they have the potential to serve as effective amendments for the remediation of Mo-contaminated soils.

Preparation and Evaluation of FeMnTi Monolithic Catalysts for High‐Efficiency CO Oxidation

AbstractA comprehensive study was conducted on the synthesis of FeMnTi monolithic catalysts using plasma electrolytic oxidation (PEO) process combined with hydrothermal method followed by depositing active nanostructures. As synthesized catalysts were characterized using a series of techniques for morphology, structure and surface chemical state investigations. Meanwhile, the CO light‐off curves demonstrate that they possess excellent low‐temperature catalytic performance compared with TiO2 based single transition oxides. Specifically, FeMnTi(0.10, 4) can achieve 100 % conversion at 201 °C, which is due to the homogeneous elements distribution, large surface area and high surface activity. The supersaturation of the deposited solution and deposition time determine the growth of MnOx and the FeMnTi(0.10, 4) has the most suitable Fe/Mn atom ratio of 2.5. Furthermore, the electron transfer between Fe (Fe2+ and Fe3+) and Mn (Mn2+, Mn3+ and Mn4+) ensures the excellent redox properties. The synthetic strategy proposed in this work has general applicability for synthesizing multiple transition oxides monolithic catalysts not only for CO oxidation.

Mesoporous silica nanoparticles as a drug delivery mechanism.

Research in intelligent drug delivery systems within the field of biomedicine promises to enhance drug efficacy at disease sites and reduce associated side effects. Mesoporous silica nanoparticles (MSNs), characterized by their large specific surface area, appropriate pore size, and excellent biocompatibility, have garnered significant attention as one of the most effective carriers for drug delivery. The hydroxyl groups on their surface are active functional groups, facilitating easy functionalization. The installation of controllable molecular machines on the surface of mesoporous silica to construct nanovalves represents a crucial advancement in developing intelligent drug delivery systems (DDSs) and addressing the issue of premature drug release. In this review, we compile several notable and illustrative examples of MSNs and discuss their varied applications in DDSs. These applications span regulated and progressive drug release mechanisms. MSNs hold the potential to enhance drug solubility, improve drug stability, and mitigate drug toxicity, attributable to their ease of functionalization. Furthermore, intelligent hybrid nanomaterials are being developed, featuring programmable properties that react to a broad spectrum of stimuli, including light, pH, enzymes, and redox triggers, through the use of molecular and supramolecular switches.

Hydrogen bond-modulated copper nanocluster-aggregation-induced enhanced ECL with layered double hydroxides-sensing interface for miRNA-135b detection in colorectal cancer

Herein, we developed a novel electrochemiluminescence (ECL) sensing interface based on Mg/Fe layered double hydroxides nanosheets (LDHs) for miRNA-135b detection in human colorectal cancer tissues. The LDHs nanosheet with large specific surface area and abundant active sites can work as the electrode sensing interface to effectively catalyze the electrochemical reactions. Furthermore, the formation of hydrogen bonds between 4-carboxyphenylboronic acid (CBPA) on the copper nanoclusters (Cu NCs) and fluorine ions limited the intramolecular vibration and accelerated electron transfer, greatly improving the luminescence signal. Due to the catalysis of LDH and the aggregation-induced enhanced electrochemiluminescence (AIECL) effect, the ECL quantum yield of Cu NCs has been significantly amplified. The Mg/Fe LDH-based sensing system for miRNA-135b detection had a linear detection range of 10 fM to 10 μM with a detection limit of 3.5 fM. Finally, the cancer tissue extracted from colorectal cancer patients have been successfully detected. The result indicated that the Mg/Fe LDHs sensing interface provided a new and reliable pathway for ECL analysis performance.

Three‐dimensional electrically conductive–hydrophobic layer for stable Zn metal anodes

AbstractThe interrelated side reactions and dendrites growth severely destabilize the electrode/electrolyte interfaces, resulting in the difficult application of aqueous Zn ion batteries (AZIBs). Hydrophobic protective layer possesses natural inhibition ability for side reactions. However, the conventional protective layer with plane structure is difficult to attain joint regulation of side reaction and Zn nucleation. Herein, a novel three‐dimensional (3D) electrically conductive and hydrophobic (3DECH) interface is elaborated to enable stable Zn anode. The as‐prepared 3DECH interface presents a uniform 3D morphology with hydrophobic property, large specific surface area, abundant zincophilic sites, and excellent electroconductivity. Therefore, the 3DECH interface achieves uniform nucleation and dendrite‐free deposition from synergetic benefits: (1) increased nucleation sites and reduced local current density through the special 3D structure and (2) uniform electric potential distribution and rapid Zn2+ transport due to the electroconductive alloy chemistry, thus coupling the hydrophobic property to obtain a highly reversible Zn anode. Consequently, the modified anode achieves a superior coulombic efficiency of 99.88% over 3500 cycles, and the pouch cells using modified anode and LiMn2O4 (LMO) cathode retain a capacity of 84 mAh g−1 after 700 cycles at a reasonable depth discharge of 36%, without dendrite piercing and “dead Zn.”

N‐Doped Carbon Nanofibers and Carbon Nanotubes‐Encapsulated CoNi Alloy as Highly Active Oxygen Reduction Catalysts for Direct Methanol Fuel Cells

The slow oxygen reduction kinetics of direct methanol fuel cell (DMFCs) are one of the limiting factors affecting its application. Therefore, exploring nonprecious catalysts with high activity and methanol resistance is urgently needed. Herein, zeolitic imidazolate framework‐8 particles are first blended with different proportions of metal salts (Ni as well as Co) and further electrospun to obtain a nanofiber precursor. After pyrolysis treatment, a composite catalyst (CoNi@N‐CNFs) with a highly dispersed CoNi alloy phase supported by porous N‐doped carbon nanofiber and carbon nanotube is prepared. The surface electronic structure can be reasonably adjusted by optimizing the doping ratio of Ni and Co. The CoNi@N‐CNFs shows high oxygen reduction activity and methanol resistance. Half‐wave potential and the onset potential of Co1Ni1@N‐CNFs (Co: Ni mole ratio = 1:1) are 0.79 and 0.87 V. Additionally, Co1Ni1@N‐CNF‐modified DMFC endows a high power density (24.07 mW cm−2), which is close to Pt/C‐based DMFC (27.59 mW cm−2). Rich active sites, large specific surface area, and synergy between CoNi alloy and N configuration of CoNi@N‐CNFs effectively accelerate electron transfer, resulting in the superior catalytic activity. This work provides a new strategy to design effective 1D oxygen reduction reaction catalysts in fuel cells.

Pectin Supercapacitor Applications

In today’s energy wars, the decrease in fossil fuels and the increase in pollution reuses the question of energy and clean merit production. For this reason, supercapacitor electrodes are available for supercapacitor applications, which are synthesized using biodegradable materials or hybrids by taking nature as an example. In synthesizing our example electrode pectin, we will examine the methods of obtaining pectin, which is abundant in nature and can be used effectively in terms of its physicochemical properties, by purification or synthesis methods. Supercapacitors are essential in storing energy with their fast charge/discharge properties. This includes using pectin and other materials in energy storage systems. We will present other materials preferred in supercapacitor applications and modified compilations of these applications. In conclusion; a porous material such as pectin has a large surface area. Materials with large surface areas are very suitable electrodes for charge storage in supercapacitor applications. If some problems in pectin production and electrical conductivity can be resolved, it will be a very suitable natural electrode material for supercapacitors.

Gd and Ni co-doped BiFeO3 ferrite/r-GO nanocomposite for photocatalytic environmental remediation applications

Synergistic effects of the co-doping of rare earth and transition metals on the structural, electrical and optical, in multi-ferroic BiFeO3 nanoferrites (NFs) combined with reduced graphene oxide (r-GO) nanosheets, photocatalytic degradation properties can be boosted. In this current study gadolinium and nickel-co-doped Bi1-xGdxFe1-yNiyO3 were synthesised via the tartaric acid-assisted sol-gel method and their composite Bi1-xGdxFe1-yNiyO3/r-GO with 10 % reduced graphene oxide (r-GO) via the ultra-sonication route. Phase and structural investigation were carried out using x-ray diffraction (P-XRD), Raman scattering, and Fourier transform infrared (FTIR) analysis, which confirms the successful fabrication of co-doping in the rhombohedral geometry of the perovskite-type Bi1-xGdxFe1-yNiyO3. Electrical conductivity of the fabricated composite material was observed to increase because of the co-doping and the addition of r-GO. Photoluminescence (PL) spectra of co-doped and r-GO composite material exhibited a decline in PL intensity because optical bandgap energies exhibited narrowing of 1.99 eV and 1.91 eV respectively, which indicates the excellent separation and stabilization of photo-excited charge pairs. Special conduction properties of r-GO nanosheets improved electrical and optical properties, a well-porous nature, large surface area, lower bandgap, and increased dye degradation in the Bi1-xGdxFe1-yNiyO3/r-GO photocatalyst showing excellent photo-degradation of cationic malachite green (M.G.) dye, achieving a degradation efficiency of 96.4 % under natural solar light. Hence, the photocatalyst shows excellent stability where quenching of radicals using selective scavengers shows that OH* radicals and e−/h+ pairs are primarily involved in the mechanism of photo-degradation in a basic pH medium, making the as-fabricated material a potential material for photo-catalytic environmental remediation.

Preparation of solution blow spinning nanofibers and its application in the food field: a review

Abstract Solution blow spinning is a technology that uses high-pressure gas to prepare spinning solution into nanofibers. It has the advantages of high production efficiency and easy operation, and the prepared nanofibers have a large specific surface area, high porosity, and flexible surface functionalization. Therefore, solution blow spinning has received more and more attention in the food field. This paper first introduces the principle of solution blow spinning, the influence of spinning liquid properties, process parameters, and environmental factors on the spinning process. Secondly, it introduces the materials and ways of applying solution blow-spun nanofibers in the food field, such as bacteriostatic food packaging, slow-release food packaging, and intelligent sensors. Finally, the application of solution blow spinning technology in food is summarized and prospected. This paper provides a reference for further research and application of solution blow spinning in the food field at a later stage.

Heterointerface-Rich Ni3N/WO3 Hierarchical Nanoarrays for Efficient Glycerol Oxidation-Assisted Alkaline Hydrogen Evolution.

Glycerol oxidation-assisted water electrolysis has emerged as a cost-effective way of co-producing green hydrogen and HCOOH. Still, preparing highly selective and stable nickel-based metal electrocatalysts remains a challenge. Herein, heterostructure Ni3N/WO3 nanosheet arrays of bifunctional catalysts with large specific surface areas loaded on nickel foam (denoted as Ni3N/WO3/NF) were synthesized. This catalyst was for glycerol oxidation reaction (GOR) and hydrogen evolution reaction (HER) with excellent catalytic performance, a voltage saving of 267 mV compared to oxygen evolution reaction (OER), and a HER overpotential of 104 mV at 100 mA cm-2. The cell voltage in the assembled GOR//HER hybrid electrolysis system reaches 100 mA cm-2 at 1.50 V, 296 mV lower than the potential required for overall water splitting. This work demonstrates that replacing GOR with OER using a cost-effective and highly active Ni-based bifunctional electrocatalyst can make hybrid water electrolysis an energy-efficient, sustainable, and green strategy for hydrogen production.

Nanocomposites with polyurethane polymer matrix/ particulate material

The environment is currently considered one of the main concerns of the industrial sector and society. In the particular case of the oil industry, one of the biggest environmental catastrophes that can happen are large oil spills, where to reduce or minimize the environmental damage caused, various cleaning methods are used. Thus, nanocomposites aim to change the mechanical, physical and chemical properties of polymer matrices. The main focus of modifying Polyurethanes has been directed to materials science, the objective of which is to obtain particulate materials, allowing surfaces to be differentiated, reducing surface energy and increasing interlayer spacing for polymer intercalation. This particulate material, produced and modified, interspersed with the Polymer, allows us to absorb crude oil, as it is hydrophobic and, consequently, organophilic. The factors that define the degree of sorption of organic compounds are: hydrophobicity, porosity, molecular structure and volume, and the volume of the surface area of the sorbent material. Therefore, the sorbent must be wettable by the hydrophobic compound and non-wettable or slightly wettable by water. Sorbent materials must have characteristics such as a large surface area, high porosity, good oleophilic character, as well as good oil retention capacity and ease of application. Polyurethane presents several of these characteristics, making it an interesting sorbent for the oil sector. The present work studies the obtaining of these nanocomposites, using a particulate material to combat leaks or spills of hydrocarbons.

Chitosan-incorporated Bioceramic-based Nanomaterials for Localized Release of Therapeutics and Bone Regeneration: An Overview of Recent Advances and Progresses

Abstract: The usage of nanoparticles in tissue engineering applications has increased significantly in the last several years. Functional tissues are developed by regulating cell proliferation, differentiation, and migration on nanostructured scaffolds containing cells. These scaffolds provide an environment that is more structurally supportive than the microarchitecture of natural bone. Given its exceptional properties, such as its osteogenic potential, biocompatibility, and biodegradability, chitosan is a good and promising biomaterial. Unfortunately, chitosan's low mechanical strength makes it unsuitable for load-bearing applications. By mixing chitosan with other biomaterials, this drawback might be mitigated. Bone tissue engineering uses both bioresorbable materials like tricalcium phosphate and bioactive materials like hydroxyapatite and bioglass. Alumina and titanium are examples of bioinert materials that are part of these bioceramics. When produced at nanoscale scales, these materials have a larger surface area and better cell adhesion. This review paper will go into great detail on the bioinert, bioresorbable, and bioactive nanoceramics-reinforced chitosan scaffolds for bone tissue engineering.

Pore Fractal Characteristics between Marine and Marine–Continental Transitional Black Shales: A Case Study of Niutitang Formation and Longtan Formation

Marine shales from the Niutitang Formation and marine–continental transitional shales from the Longtan Formation are two sets of extremely important hydrocarbon source rocks in South China. In order to quantitatively compare the pore complexity characteristics between marine and marine–continental transitional shales, the shale and kerogen of the Niutitang Formation and the Longtan Formation are taken as our research subjects. Based on organic petrology, geochemistry, and low-temperature gas adsorption analyses, the fractal dimension of their pores is calculated by the Frenkel–Halsey–Hill (FHH) and Sierpinski models, and the influences of total organic carbon (TOC), vitrinite reflectance (Ro), and mineral composition on the pore fractals of the shale and kerogen are discussed. Our results show the following: (1) Marine shale predominantly has wedge-shaped and slit pores, while marine–continental transitional shale has inkpot-shaped and slit pores. (2) Cylindrical pores are common in organic matter of both shale types, with marine shale having a greater gas storage space (CRV) from organic matter pores, while marine–continental transitional shale relies more on inorganic pores, especially interlayer clay mineral pores, for gas storage due to their large specific surface area and high adsorption capacity (CRA). (3) The fractal characteristics of marine and marine–continental transitional shale pores are influenced differently. In marine shale, TOC positively correlates with fractal dimensions, while in marine–continental shale, Ro and clay minerals have a stronger influence. Ro is the primary factor affecting organic matter pore complexity. (4) Our two pore fractal models show that the complexity of the shale in the Longtan Formation surpasses that of the shale in the Niutitang Formation, and type I kerogen has more complex organic matter pores than type III, aiding in evaluating pore connectivity and flow effectiveness in shale reservoirs.

Non-Enzymatic Glucose Detection by Fe2O3 Nanorods-Reduced Graphene under Physiological pH

Background: Non-enzymatic detection has become a research hotspot because of its alternativity in solving problems compared to enzymatic biosensors, but most of those sensors require a strong basic pH environment (higher than 10) to active their surface, restricting their use in clinical detection because the pH of body fluid is around 7.4. Furthermore, metal oxide sensors with specific morphologies are reported to have a fast electrocatalytic response. Therefore, Fe2O3 nanocomposites with porous structure are selected for glucose detection research in a physiological pH environment. Objective: The study aimed to assess the potential use of porous reduced graphene oxide-Fe2O3 nanorods in glucose detection in a physiological pH environment. Method: Hydrothermal method was used to prepare porous Fe2O3-rGO NRs (Nanorods) and hollow Fe2O3/C nanoparticles. Cyclic voltammetry and electrochemical impedance spectroscopy were used to evaluate the performance of our materials. Results: Porous-reduced graphene oxide-Fe2O3 nanorods have exhibited better performance than hollow carbon-Fe2O3 core-shell nanoparticles for glucose detection in a physiological pH environment. Conclusion: Non-enzymatic glucose sensing based upon cavity Fe2O3-rGO NRs under a physiological pH environment has been successfully realized, attributing to their high electron mobility and large specific surface area. Furthermore, the results of this work indicate that the glucose sensor prepared here has shown good repeatability and stability, which suggests its potential use in clinical detection.