Large Sample Of Participants Research Articles

To imprison or not to imprison: an analytics model for drug courts

Despite all the promises of analytics, its complexity, multidimensionality, and multidisciplinary nature can sometimes disserve its efficacy. What can further aggravate the problem is the need to deal with human behavior and social interactions as inherent qualities of the application domain. One such area is the drug court; an alternative for traditional criminal courts that attempts to transform the traditional punitive jurisprudence to a therapeutic one. Under this new philosophy, the eligible offenders are considered as individuals in need of rehabilitative treatments and are persuaded to undergo a regimen that seeks to return them back to the community, rather than sending them to prison. This initiative, if performed properly, has proven to be effective in lowering the costs and improving the social outcomes. While many researchers have studied this initiative from the perspective of its factors, requirements, and tradeoffs, there currently is a lack of a comprehensive analytics model that can accurately predict who would (or would not) graduate from these programs. To fill this gap, and to enable better management of resources and improvement of outcomes, this study develops an analytics model to describe a large real-world sample of drug court participants; to predict who would or would not graduate from these courts; and to prescribe a set of guidelines (presented as characteristics of the offenders) that can help jurisdictions and drug court administrators to make more effective and efficient decisions.

Direct Structural Connections between Auditory and Visual Motion-Selective Regions in Humans.

In humans, the occipital middle-temporal region (hMT+/V5) specializes in the processing of visual motion, while the planum temporale (hPT) specializes in auditory motion processing. It has been hypothesized that these regions might communicate directly to achieve fast and optimal exchange of multisensory motion information. Here we investigated, for the first time in humans (male and female), the presence of direct white matter connections between visual and auditory motion-selective regions using a combined fMRI and diffusion MRI approach. We found evidence supporting the potential existence of direct white matter connections between individually and functionally defined hMT+/V5 and hPT. We show that projections between hMT+/V5 and hPT do not overlap with large white matter bundles, such as the inferior longitudinal fasciculus and the inferior frontal occipital fasciculus. Moreover, we did not find evidence suggesting the presence of projections between the fusiform face area and hPT, supporting the functional specificity of hMT+/V5-hPT connections. Finally, the potential presence of hMT+/V5-hPT connections was corroborated in a large sample of participants (n = 114) from the human connectome project. Together, this study provides a first indication for potential direct occipitotemporal projections between hMT+/V5 and hPT, which may support the exchange of motion information between functionally specialized auditory and visual regions.SIGNIFICANCE STATEMENT Perceiving and integrating moving signal across the senses is arguably one of the most important perceptual skills for the survival of living organisms. In order to create a unified representation of movement, the brain must therefore integrate motion information from separate senses. Our study provides support for the potential existence of direct connections between motion-selective regions in the occipital/visual (hMT+/V5) and temporal/auditory (hPT) cortices in humans. This connection could represent the structural scaffolding for the rapid and optimal exchange and integration of multisensory motion information. These findings suggest the existence of computationally specific pathways that allow information flow between areas that share a similar computational goal.

Exploring the use of models as a written corrective feedback technique among EFL children

The language learning potential of models, a form of written feedback consisting of native-like texts that students compare with their original composition, has been under-represented in studies on EFL child SLA. In particular, there is a need to gather data from larger samples of participants and to use delayed post-tests to assess whether potential positive effects of models are sustained over time. The aim of the present study is to analyze what EFL primary school children notice and incorporate during a four-stage collaborative writing task. The participants in the study were 38 11-12-year-old children divided into a treatment group (TG, n = 18), which received a model, and a control group (CG, n = 20), which self-edited their texts. The children’s pair talk was analyzed for evidence of any content and linguistic problems they noticed during the composition or comparison stages. The findings show that children in the TG noticed significantly more lexical and content-related features at the comparison stage. Moreover, the TG incorporated significantly more mechanics- and discourse-related features than the CG into the rewriting stage, and also a significantly higher number of formal and discursive aspects into the post-test. Our findings point to the apparent benefits of models with this population.

Listener impressions of alaryngeal communication modalities

Purpose: Following a total laryngectomy in which the larynx is completely removed, individuals in the USA have three primary options for alaryngeal verbal communication including tracheoesophageal speech (TES), oesophageal speech (ES) and electrolarynx (EL). Using a large sample of participants from across the USA, this study investigated listener impressions of each primary type of alaryngeal communication. As these are the individuals more likely to be participating in social interactions and in positions of hiring for employment, the general public’s impressions of TES, ES and EL may be a vital consideration during the treatment process. Method: A total of 381 individuals rated eight speech samples, including samples from speakers of each alaryngeal communication modality as well samples from age and sex matched laryngeal speakers, with regards to three outcome measures: intelligence, likability and employability. Result: Listener impressions of alaryngeal speech samples were modulated by the type of communication mode. Further, the patterns of results differed by speaker sex, with ES speech rated consistently more favourable for female speakers across all outcome measures and TES rated consistently more favourable for male speakers across all outcome measures. Conclusion: An overall preference for laryngeal speech was noted, particularly with male speakers. The female ES stimuli, interestingly, was the highest rated alaryngeal communication modality. Regardless of speaker sex, all alaryngeal modes greatly affected impressions of employability relative to impressions of likeability and intelligence.

Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort.

OBJECTIVEWhereas insulin resistance is expressed as reduced glucose uptake in peripheral tissues, the relationship between insulin resistance and brain glucose metabolism remains controversial. Our aim was to examine the association of insulin resistance and brain glucose uptake (BGU) during a euglycemic hyperinsulinemic clamp in a large sample of study participants across a wide range of age and insulin sensitivity.RESEARCH DESIGN AND METHODS[18F]-fluorodeoxyglucose positron emission tomography (PET) data from 194 participants scanned under clamp conditions were compiled from a single-center cohort. BGU was quantified by the fractional uptake rate. We examined the association of age, sex, M value from the clamp, steady-state insulin and free fatty acid levels, C-reactive protein levels, HbA1c, and presence of type 2 diabetes with BGU using Bayesian hierarchical modeling.RESULTSInsulin sensitivity, indexed by the M value, was associated negatively with BGU in all brain regions, confirming that in insulin-resistant participants BGU was enhanced during euglycemic hyperinsulinemia. In addition, the presence of type 2 diabetes was associated with additional increase in BGU. On the contrary, age was negatively related to BGU. Steady-state insulin levels, C-reactive protein and free fatty acid levels, sex, and HbA1c were not associated with BGU.CONCLUSIONSIn this large cohort of participants of either sex across a wide range of age and insulin sensitivity, insulin sensitivity was the best predictor of BGU.

Continued Exercise among the Elderly and the Relevant Support Strategies: A Qualitative Study in Taiwan

This study explores factors that contribute to elderly participants continued exercise. A qualitative approach utilizing the method of phenomenology was adopted, and semi-structured interviews were conducted to collect data on the perspectives of 21 elderly participants and 2 sports instructors. The study yielded the following findings: (a) the primary motivation behind the elderly participants’ continued exercise is the referral and encouragement of doctors. (b) the main reason for elderly participants’ continued exercise was the support strategies provided by the gym. These support strategies included suitable exercise equipment and a friendly climate, customized and professional training packages offered by staff, and regular examinations. (c) after continuing their exercise, the elderly participants experienced positive changes such as improved physical function, a renewed concept of exercise, ability to engage in exercise on their own initiative, and broadened interpersonal networks. (d) the five steps for promoting exercise among the elderly, include patient referral, fitness testing, customized training, providing support and assessment. For future study, we recommend use larger samples of participants in order to more fully understand the factors and support strategies that result in older people to form the habit of participating in exercise continuously.

Cortical neuroanatomical changes related to specific neuropsychological deficits in subcortical vascular cognitive impairment

ObjectiveNeuropsychological test-specific neural substrates in subcortical vascular cognitive impairment (SVCI) are expected to differ from those in Alzheimer’s disease-related cognitive impairment (ADCI) but the details are unclear. To determine neural substrates related to cerebral small vessel disease, we investigated the correlations between cognitive dysfunctions measured by standardized neuropsychological tests and cortical thickness in a large sample of participants with amyloid negative (Aβ (−)) SVCI. MethodsOne hundred ninety-eight participants with Aβ (−) SVCI were recruited from the memory clinic between November 2007 to August 2018. To acquire neural substrates, we performed linear regression using the scores of each neuropsychological test as a predictor, cortical thickness as an outcome, and age, sex, education years, intracranial volume and white matter hyperintensity (WMH) as confounders. ResultsPoor performances in each neuropsychological test were associated with cortical atrophy in certain brain regions regardless of WMH. Especially, not the medial temporal but the frontal and posterior cingulate regions with cortical atrophy were mainly associated with memory impairment. Poor performance in animal fluency was more likely to be associated with cortical atrophy in the left hemisphere, while poor performance in the visuospatial memory test was more likely to be associated with cortical atrophy in the right hemisphere. ConclusionsOur findings suggested that cortical atrophy was an important factor of cognitive impairment in Aβ (−) SVCI regardless of WMH. Furthermore, our findings might give clinicians a better understanding of specific neural substrates of neuropsychological deficits in patients with SVCI.

Do Women Give Up Competing More Easily? Evidence from Speedcubers

We analyze a large sample of participants in mixed-gender Rubik's Cube competitions. Focusing on participants who barely made or missed the cut for the second round in a competition, we examine their likelihood of joining another competition in the future. We find a significant gender difference: Whereas boys are slightly discouraged by failing to qualify for the second round, girls are affected more and are more likely to give up forever. Furthermore, we find that this gender difference is most significant in countries with larger gender gaps in labor market outcomes.

Handedness measures for the Human Connectome Project: Implications for data analysis

ABSTRACT Open data initiatives such as the UK Biobank and Human Connectome Project provide researchers with access to neuroimaging, genetic, and other data for large samples of left-and right-handed participants, allowing for more robust investigations of handedness than ever before. Handedness inventories are universal tools for assessing participant handedness in these large-scale neuroimaging contexts. These self-report measures are typically used to screen and recruit subjects, but they are also widely used as variables in statistical analyses of fMRI and other data. Recent investigations into the validity of handedness inventories, however, suggest that self-report data from these inventories might not reflect hand preference/performance as faithfully as previously thought. Using data from the Human Connectome Project, we assessed correspondence between three handedness measures – the Edinburgh Handedness Inventory (EHI), the Rolyan 9-hole pegboard, and grip strength – in 1179 healthy subjects. We show poor association between the different handedness measures, with roughly 10% of the sample having at least one behavioural measure which indicates hand-performance bias opposite to the EHI score, and over 65% of left-handers having one or more mismatched handedness scores. We discuss implications for future work, urging researchers to critically consider direction, degree, and consistency of handedness in their data.

How often were you traumatized? Reconceptualizing adverse childhood experiences for sexual and gender minorities

Introduction: The manifold consequences of adverse childhood experiences (ACEs) are well-documented. Recent research has demonstrated that sexual and gender minorities (SGMs) typically encounter ACEs more often than cisgender heterosexual individuals. Given the higher exposure rate, the measurement of frequency of exposure to traumatic events may be relevant for SGMs. Methods: We changed the response options of the ACEs index from dichotomous to a five-point Likert scale that described frequency of exposure. As part of a larger community-based participatory research study, the Likert ACEs measure was distributed to a large and diverse sample of SGM participants in San Antonio. Results: A cross-validation design demonstrated that the Likert ACEs scores outperformed the traditional ACEs index in predicting self-reported anxiety and post-traumatic stress disorder. Half of the SGMs in this sample experienced 3 or more ACEs, compared to only 10% of Americans in a nationally representative sample. Limitations: These analyses were based on retrospective self-report data instead of structured clinical interviews. Since only the Likert ACEs was administered, we had to assume that any response other than “never” on Likert ACEs corresponded to “yes” on the ACEs Index. Conclusions: Future research may assess the utility of the Likert ACEs approach with other minoritized or intersectional populations. For clinical practitioners, these results suggest that a better way to measure ACEs for SGMs is to ask them how often they were exposed, rather than asking whether they were exposed.

Change management in Higher Education: a New Perspective

Universities need to operate a transition from the common ‘traditional’ settings towards an education that contributes to a sustainable social change by preparing students to be change agents who care for others and for the well-being of society. We designed an interpretative qualitative approach using the unique case study of a Jesuit University, based on interviews with leaders of and participants to volunteering initiatives driven by that university. The objective of the study was to identify the drivers of change of the outreach model in higher education and analyze if the Jesuit way of doing things, or Jesuit tradition, is an effective tool to drive the change in universities. Five key drivers of change were identified (communication, participation, sharing, empathy and reflexivity), all in line with the characteristics of the Jesuit tradition. Both empathy and reflexivity are drivers of change, which were not cited in previous works on change management and may be considered as the study’s added value to the conceptual framework. The results of this study need to be confirmed on a larger sample of participants and would be enriched by a benchmarking work on Jesuit-led outreach bodies.

Attitudes to ageing and quality of life in young and old older adults: an international cross-sectional analysis

Purpose Although quality of life and attitudes to ageing have been explored in the context of mental and physical health problems in older adults, the interplay between these variables has received little attention. The purpose of this study is to explore how attitudes to ageing relate to and predict quality of life in an international sample of older people those of age 57 to 79 (youngest-old) and those over 80 years old (oldest-old). Design/methodology/approach A large international sample (n = 4,616) of participants recruited from 20 different countries completed a set of measures assessing several demographic variables, attitudes to ageing, older adult specific quality of life, general quality of life and depression. Findings Correlational and regression analysis showed that more positive attitudes to ageing were associated with and predicted better quality of life in older adults beyond demographic and depression variables. Those in the oldest-old group had significantly more negative attitudes to ageing and a poorer quality of life. However, positive attitudes to ageing remained a significant predictor of better quality of life in both the youngest-old and oldest-old age groups. Originality/value Attitudes to ageing play an important part in quality of life in older adults; however, the impact of these attitudes might be different according to age group. These results suggest that attitudes to ageing could be a possible clinical target in interventions aiming at improving quality of life in older adults.

Psychometric Properties of the 15-Item Five Facet Mindfulness Questionnaire in a Large Sample of Spanish Pilgrims

There is burgeoning interest in studying the effectiveness of mindfulness-based and traditional contemplative practices, and brief yet suitably and comprehensive measures of mindfulness are needed to assess related changes. There is preliminary evidence that pilgrimage may share some aspects with contemplative practices. This study examined the psychometric properties of the Spanish version of the 15-item Five Facets Mindfulness Questionnaire (FFMQ-15) in a large sample of pilgrims and explored the effects of pilgrimage on mindfulness. The FFMQ-15 along with distress and wellbeing measures were administered via online to a large sample of participants undertaking a pilgrimage (i.e., the Way of Saint James) in Spain (baseline: n = 800; pre-post analyses: n = 314). Confirmatory factor analyses were computed to find the best-fitting model of the FFMQ-15; reliability and construct validity analyses were also performed. The four-facet bifactor structure (mindfulness plus four specific facets, excluding observing) was the best-fitting model for the FFMQ-15 (CFI = .956; TLI = .931; RMSEA = .058 [.048–.068]; SRMR = .046). Overall, we found satisfactory reliability (Cronbach’s α ranged from .56 to .85) and small to moderate correlations with distress and wellbeing measures. The FFMQ-15 showed a four-facet bifactor structure and an overall satisfactory internal consistency and construct validity despite its shortness. We observed that mindfulness can be cultivated by pilgrimage, but further studies including long-term assessments and control groups are warranted before firm conclusions can be drawn.

Considering the APOE locus in Alzheimer\u2019s disease polygenic scores in the Health and Retirement Study: a longitudinal panel study

BackgroundPolygenic scores are a strategy to aggregate the small, additive effects of single nucleotide polymorphisms across the genome. With phenotypes like Alzheimer’s disease, which have a strong and well-established genomic locus (APOE), the cumulative effect of genetic variants outside of this area has not been well established in a population-representative sample.MethodsHere we examine the association between polygenic scores for Alzheimer’s disease both with and without the APOE region (chr19: 45,384,477 to 45,432,606, build 37/hg 19) at different P value thresholds and dementia. We also investigate the addition of APOE-ε4 carrier status and its effect on the polygenic score—dementia association in the Health and Retirement Study using generalized linear models accounting for repeated measures by individual and use a binomial distribution, logit link, and unstructured correlation structure.ResultsIn a large sample of European ancestry participants of the Health and Retirement Study (n = 9872) with an average of 5.2 (standard deviation 1.8) visit spaced two years apart, we found that including the APOE region through weighted variants in a polygenic score was insufficient to capture the large amount of risk attributed to this region. We also found that a polygenic score with a P value threshold of 0.01 had the strongest association with the odds of dementia in this sample (odds ratio = 1.10 95%CI 1.0 to 1.2).ConclusionWe recommend removing the APOE region from polygenic score calculation and treating the APOE locus as an independent covariate when modeling dementia. We also recommend using a moderately conservative P value threshold (e.g. 0.01) when creating polygenic scores for Alzheimer’s disease on dementia. These recommendations may help elucidate relationships between polygenic scores and regions of strong significance for phenotypes similar to Alzheimer’s disease.

Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease

Preclinical models of Alzheimer's disease (AD) suggest that volumetric reductions in medial temporal lobe (MTL) structures manifest before clinical onset. AD polygenic risk scores (PRSs) are further linked to reduced MTL volumes (the hippocampus/amygdala); however, the relationship between the PRS and specific subregions remains unclear. We determine the relationship between the AD-PRSs and MTL subregions in a large sample of young participants (N = 730, aged 22–35 years) using a multimodal (T1w/T2w) approach. We first demonstrate that the PRSs for the hippocampus/amygdala predict their respective volumes and specific hippocampal subregions (pFDR < 0.05). We further observe negative relationships between the AD-PRSs and whole hippocampal/amygdala volumes. Critically, we demonstrate novel associations between the AD-PRSs and specific hippocampal subfields such as CA1 (β = −0.096, pFDR = 0.045) and the fissure (β = −0.101, pFDR = 0.041). We provide evidence that the AD-PRS is linked to specific MTL subfields decades before AD onset. This may help inform preclinical models of AD risk, providing additional specificity for intervention and further insight into mechanisms by which common AD variants confer susceptibility.

Association of Sodium with Obstructive Sleep Apnea. The ELSA-Brasil Study.

Rationale: Excessive sodium may have a role in the pathogenesis of obstructive sleep apnea (OSA) for patients with hypervolemic conditions, but it is unclear whether this is valid for all patients with OSA, including those with no significant comorbidities.Objectives: To test the association of urinary sodium and OSA in a large sample of participants from the ELSA-Brasil (Estudo Longitudinal de Saúde do Adulto-Brasil) Study. In addition, we stratified the analysis participants according to the presence of hypertension.Methods: In this cross-sectional study, OSA was defined by an apnea-hypopnea index ≥15 events/h. A validated 12-hour urine collection as representative of the 24-hour period was obtained from all participants to measure sodium excretion. We performed a logistic regression analysis to test the association of urinary sodium excretion with OSA (dependent variable) adjusting for age, sex, race and income, glomerular filtration rate, diabetes, physical activity, and antihypertensive classes related to sodium excretion. To address potential residual factors that may influence sodium excretion, we performed additional analysis replacing sodium excretion for salt intake (food frequency questionnaire) using the same models.Results: We studied 1,946 participants (age 49 ± 8 yr; 43.4% men). A third of them had OSA. Compared with those with no OSA, participants with OSA presented with higher sodium excretion (1.66 [1.19-2.29] vs. 1.99 [1.44-2.69] g/12 h; P < 0.001). After adjustments for confounding factors, we found no overall significant associations of sodium excretion with OSA (odds ratio [OR], 1.09; 95% confidence interval [CI], 0.97-1.23; P = 0.150). Regardless of the OSA status, the sodium excretion was higher in hypertensive than in normotensive participants (1.93 [1.35-2.64] vs. 1.71 [1.22-2.37] g/12 h). An independent association of sodium excretion with OSA was observed in patients with hypertension only (OR, 1.326; 95% CI, 1.067-1.648; P = 0.011), but the interaction of urinary sodium with hypertension was not significant (P = 0.37). The analysis of salt intake revealed consistent findings.Conclusions: The potential role of sodium in the pathogenesis of OSA seems to be modest and limited for those with higher salt intake and, consequently, higher fluid retention such as observed in patients with hypertension.

Performance, Cost-Effectiveness, and Representativeness of Facebook Recruitment to Suicide Prevention Research: Online Survey Study.

BackgroundResearchers are increasingly using social media advertisements to recruit participants because of their many advantages over traditional methods. Although there is growing evidence for the effectiveness and cost-effectiveness of social media recruitment in the health sciences, no studies have yet examined this in the context of suicide prevention, which remains to be a highly stigmatized and sensitive topic.ObjectiveThis study aims to recruit a general community sample to complete a survey on suicide literacy, stigma, and risk via Facebook advertisements. Specifically, we aim to establish the performance of the advertisements, cost-effectiveness, sample representativeness, and the impact of gender-specific advertising on recruiting men into the study.MethodsFrom June 2017 to March 2019, we released Facebook advertisements targeted at adults 18 years or older, residing in the New South Wales (NSW) trial or control regions, and involved in the LifeSpan suicide prevention trial. Cost-effectiveness was examined descriptively using metrics provided by Facebook. Chi-square analyses were conducted to determine demographic differences between our sample and the general NSW population as well as the impact of gender-specific advertisements on gender engagement.ResultsThe 14 Facebook advertisement campaigns reached a total of 675,199 people, yielding 25,993 link clicks and resulting in 9603 individuals initiating the survey (7487 completions) at an overall cost of Aus $2.81 (US $2.01) per participant. There was an overrepresentation of younger (P=.003), female (P=.003), highly educated (P<.001) participants and mental health conditions (P<.001) compared with the total NSW population. The use of male-specific advertisements resulted in a significantly higher proportion of men completing the survey relative to gender-neutral advertisements (38.2% vs 24.6%; P<.001).ConclusionsThis study demonstrates the potential of Facebook to be an effective, low-cost strategy for recruiting a large sample of general community participants for suicide prevention research. Strategies to improve sample representativeness warrant further investigation in future research.

Characterisation of Haemodynamic Activity in Resting State Networks by Fractal Analysis.

Intrinsic brain activity is organized into large-scale networks displaying specific structural-functional architecture, known as resting-state networks (RSNs). RSNs reflect complex neurophysiological processes and interactions, and have a central role in distinct sensory and cognitive functions, making it crucial to understand and quantify their anatomical and functional properties. Fractal dimension (FD) provides a parsimonious way of summarizing self-similarity over different spatial and temporal scales but despite its suitability for functional magnetic resonance imaging (fMRI) signal analysis its ability to characterize and investigate RSNs is poorly understood. We used FD in a large sample of healthy participants to differentiate fMRI RSNs and examine how the FD property of RSNs is linked with their functional roles. We identified two clusters of RSNs, one mainly consisting of sensory networks (C1, including auditory, sensorimotor and visual networks) and the other more related to higher cognitive (HCN) functions (C2, including dorsal default mode network and fronto-parietal networks). These clusters were defined in a completely data-driven manner using hierarchical clustering, suggesting that quantification of Blood Oxygen Level Dependent (BOLD) signal complexity with FD is able to characterize meaningful physiological and functional variability. Understanding the mechanisms underlying functional RSNs, and developing tools to study their signal properties, is essential for assessing specific brain alterations and FD could potentially be used for the early detection and treatment of neurological disorders.

Functional connectivity during smooth pursuit eye movements.

Smooth pursuit eye movements (SPEM) hold the image of a slowly moving stimulus on the fovea. The neural system underlying SPEM primarily includes visual, parietal, and frontal areas. In the present study, we investigated how these areas are functionally coupled and how these couplings are influenced by target motion frequency. To this end, healthy participants (n = 57) were instructed to follow a sinusoidal target stimulus moving horizontally at two different frequencies (0.2 Hz, 0.4 Hz). Eye movements and blood oxygen level-dependent (BOLD) activity were recorded simultaneously. Functional connectivity of the key areas of the SPEM network was investigated with a psychophysiological interaction (PPI) approach. How activity in five eye movement-related seed regions (lateral geniculate nucleus, V1, V5, posterior parietal cortex, frontal eye fields) relates to activity in other parts of the brain during SPEM was analyzed. The behavioral results showed clear deterioration of SPEM performance at higher target frequency. BOLD activity during SPEM versus fixation occurred in a geniculo-occipito-parieto-frontal network, replicating previous findings. PPI analysis yielded widespread, partially overlapping networks. In particular, frontal eye fields and posterior parietal cortex showed task-dependent connectivity to large parts of the entire cortex, whereas other seed regions demonstrated more regionally focused connectivity. Higher target frequency was associated with stronger activations in visual areas but had no effect on functional connectivity. In summary, the results confirm and extend previous knowledge regarding the neural mechanisms underlying SPEM and provide a valuable basis for further investigations such as in patients with SPEM impairments and known alterations in brain connectivity.NEW & NOTEWORTHY This study provides a comprehensive investigation of blood oxygen level-dependent (BOLD) functional connectivity during smooth pursuit eye movements. Results from a large sample of healthy participants suggest that key oculomotor regions interact closely with each other but also with regions not primarily associated with eye movements. Understanding functional connectivity during smooth pursuit is important, given its potential role as an endophenotype of psychoses.

Neuroanatomical changes associated with age-related hearing loss and listening effort

Age-related hearing loss is associated with a decrease in hearing abilities for high frequencies and therefore leads to impairments in understanding speech—in particular, under adverse listening conditions. Growing evidence suggests that age-related hearing loss is related to various neural changes, for instance, affecting auditory and frontal brain regions. How the decreased auditory input and the increased listening effort in daily life are associated with structural changes is less clear, since previous evidence is scarce and mostly involved low sample sizes. Hence, the aim of the current study was to investigate the impact of age-related untreated hearing loss and subjectively rated daily life listening effort on grey matter and white matter changes in a large sample of participants (n = 71). For that aim, we conducted anatomical MRI and diffusion tensor imaging (DTI) in elderly hard-of-hearing and age-matched normal-hearing participants. Our results showed significantly lower grey matter volume in the middle frontal cortex in hard-of-hearing compared to normal-hearing participants. Further, higher listening effort was associated with lower grey matter volume and cortical thickness in the orbitofrontal cortex and lower grey matter volume in the inferior frontal cortex. No significant relations between hearing abilities or listening effort were obtained for white matter integrity in tracts connecting auditory and prefrontal as well as visual areas. These findings provide evidence that hearing impairment as well as daily life listening effort seems to be associated with grey matter loss in prefrontal brain regions. We further conclude that alterations in cortical thickness seem to be linked to the increased listening effort rather than the hearing loss itself.