Case presentation 1: A 45-year-old man with a history of obesity, hypertension, dyslipidemia, deep vein thrombosis (DVT) complicated by pulmonary embolism (PE) 12 years earlier, and non–ST-elevation myocardial infarction treated with angioplasty and stenting of the left anterior descending coronary artery 4 years earlier presented to the emergency department with sudden onset of substernal chest pain. His ECG showed anterolateral ST-segment elevation, and emergent coronary angiography demonstrated in-stent thrombosis of his left anterior descending coronary artery (Figure 1A). Figure 1. Coronary angiography of the left coronary system, anterior-posterior cranial view. Total occlusion of the left anterior descending artery (arrow) was observed at the origin of the previously stented midsegment and was consistent with in-stent thrombosis (A). The occlusion was treated successfully with angioplasty and stenting (B). Case Presentation 2 : A 39-year-old man with a history of cigarette smoking, hypertension, dyslipidemia, and non–ST-elevation myocardial infarction 3 years earlier presented with progressive dyspnea and several hours of chest pressure. His ECG was unchanged, but his cardiac troponin I was elevated at 1.33 ng/mL (normal <0.1 ng/mL). Contrast-enhanced chest computed tomography demonstrated a large saddle PE (Figure 2). Figure 2. Contrast-enhanced chest computed tomography demonstrating a large saddle PE straddling the bifurcation of the main pulmonary artery and extending into the right main pulmonary artery and lobar branches (A). Extensive thrombus (arrows) occluding the left main pulmonary artery and distal right pulmonary artery branches was observed (B). Venous thromboembolism (VTE), including DVT and PE, is the third most common cardiovascular disorder after coronary artery disease and stroke. Furthermore, patients with acute coronary syndromes or stroke have an increased risk of VTE as a complication of hospitalization.1 Many risk factors for VTE, such as obesity, hypertension, dyslipidemia, diabetes, and smoking, overlap with those for atherothrombosis. Data from registry analyses and clinical …