s S103 mRNA was significantly increased 31.7 fold in RM placentas compared to control placentas. Conlusion: Il-15 is a growth factor of NK cells and mainly responsible for the cytolytic potential of NK cells. There is evidence, that patients with RM or infertility have an increased NK cell activity in the pre-and post-conceptional period. 22 Transvaginal 3D multislice saline infusion sonohysterography A. Jurǐsic1, E. Garalejic1, Z. Jurǐsic2, B. Arsic3, J. Rudic3, M. Hadzovic3 1University of Belgrade Medical School, Serbia, 2OB/GYN Polyclinic “Jurǐsic”, Belgrade, Serbia, 3OB/GYN University Clinic Narodni Front, Belgrade, Serbia Objective: To evaluate 3D multislice SIS in analysis of endometrial pathology. Methods: Twenty patients with suspected endometrial changes on transvaginal sonography were included into this study. Investigation was performed on the Accuvix XQ, with transvaginal 3D probe. Transvaginal 3D multislice volumes of the uterus were obtainded after introduction of SIS catheter to confirm the correct position. After vizualization of the catheter in the uterine cavity, SIS procedure was performed. Another sagital and transversal volume scans of the uterus were done after injection of saline infusion and distension of uterine walls. Volumes were stored and offline 3D and 3D multislice analysis of endometrium and uterine cavity in coronary plane was performed. Results: In one patient 3D multislice SIS revealed normal endometrium and uterine cavity. In 12 patients single endometrial polyp was confirmed (polyp size was 5 30mm). In 4 patients multiple endometrial polyposis was found. One patient had large pedunculated polyps up to 40mm in diameter and submucous myomas up to 20mm in size. In two patients endometrial adhesions were confirmed on SIS. One of the patients with adhesions had only partial obliteration of the uterine cavity with secondary amenorrhoea. Hystopathological evaluation after D&C or hysteroscopical extirpation of endometrial changes confirmed endometrial polyps and in two cases submucous myomas. Endometrial cancer was not found in this study in any of the cases. Conclusion: 3D multislice saline infusion sonohysterography represents very reliable method for the analysis of endometrial changes and the uterine cavity. With 3D multislice analysis of the endometrium and uterine cavity changes can be easily distinguished between endometrial polyps or submucous myomas. 3D multislice SIS also enables precize location of endometrial changes and also correct measurement of the size of diagnosed polyps. After offline analysis of uterine cavity changes, patients can be selected either for D&C or hysteroscopic treatment. 23 Varicocele repair and fertility: a huge controversy