Large Field Of View Research Articles

Accuracy of photon-counting computed tomography for the measurement of bone quality in the knee

Visualization and quantification of bone microarchitecture in the human knee allows gaining insight into normal bone structure, and into the structural changes occurring in the onset and progression of bone diseases such as osteoporosis and osteoarthritis. However, current imaging modalities have limitations in capturing the intricacies of bone microarchitecture. Photon counting computed tomography (PCCT) is a promising imaging modality that presents high-resolution three-dimensional visualization of bone with a large field of view. However, the potential of PCCT in assessing trabecular microstructure has not been investigated yet. Therefore, this study aimed to evaluate the accuracy of PCCT in quantifying bone microstructure and bone mechanics in the knee. Five human cadaveric knees were scanned ex vivo using a PCCT scanner (Naetom alpha, Siemens, Germany) with an in-plane resolution of 146.5 μm and slice thickness of 100 μm. To assess accuracy, the specimens were also scanned with a high-resolution peripheral quantitative computed tomography (HR-pQCT; XtremeCT II, Scanco Medical, Switzerland) with a nominal isotropic voxel size of 60.7 μm as well as with micro-computed tomography (micro-CT; TESCAN UniTOM XL, Czech Republic) with a nominal isotropic voxel size of 25 μm which can be considered gold standards for in vivo and ex vivo scanning, respectively. The thickness and porosity of the subchondral bone and the microstructure of the underlying trabecular bone were assessed in the load bearing regions of the proximal tibia and distal femur. The apparent Young's modulus was determined by micro-finite element (μFE) analysis of subchondral trabecular bone (STB) in the load bearing regions of the proximal tibia using PCCT, HR-pQCT and micro-CT images. The correlation between PCCT measurements and micro-CT and HR-pQCT, respectively, was calculated. The coefficients of determination (R2) between PCCT and micro-CT based parameters, ranged from 0.69 to 0.87. The coefficients of determination between PCCT and HR-pQCT were slightly higher and ranged from 0.71 to 0.91. Apparent Young's modulus, assessed by μFE analysis of PCCT images, correlated well with that of micro-CT (R2 = 0.80, mean relative difference = 19 %). However, PCCT overestimated the apparent Young's modulus by 47 %, but the correlation (R2 = 0.84) remained strong when compared to HR-pQCT. The results of this study suggest that PCCT can be used to quantify bone microstructure in the knee.

Prospects for Detecting Gaps in Globular Cluster Stellar Streams in External Galaxies with the Nancy Grace Roman Space Telescope

Stellar streams form through the tidal disruption of satellite galaxies or globular clusters orbiting a host galaxy. Globular cluster streams are exciting since they are thin (dynamically cold) and therefore sensitive to perturbations from low-mass subhalos. Since the subhalo mass function differs depending on the dark matter composition, these gaps can provide unique constraints on dark matter models. However, current samples are limited to the Milky Way. With its large field of view, deep imaging sensitivity, and high angular resolution, the upcoming Nancy Grace Roman Space Telescope (Roman) presents a unique opportunity to increase the number of observed streams and gaps significantly. This paper presents a first exploration of the prospects for detecting gaps in streams in M31 and other nearby galaxies with resolved stars. We simulate the formation of gaps in a Palomar 5–like stream and generate mock observations of these gaps with background stars in M31 and foreground Milky Way stellar fields. We assess Roman's ability to detect gaps out to 10 Mpc through visual inspection and with the gap-finding tool FindTheGap. We conclude that gaps of ≈1.5 kpc in streams that are created from subhalos of masses ≥5 × 106 M ⊙ are detectable within a 2–3 Mpc volume in exposure times of 1000 s to 1 hr. This volume contains ≈150 galaxies, including ≈eight galaxies with luminosities >109 L ⊙. Large samples of stream gaps in external galaxies will open up a new era of statistical analyses of gap characteristics in stellar streams and help constrain dark matter models.

Advantages of the Utilization of Wide-Field OCT and Wide-Field OCT Angiography in Clinical Practice

Wide-field (WF) retinal imaging is becoming a standard diagnostic tool for diseases involving the peripheral retina. Technological progress elicited the advent of wide-field optical coherence tomography (WF-OCT) and WF-OCT angiography (WF-OCTA) examinations. This review presents the results of studies that analyzed the implementation of these procedures in clinical practice and refers to them as traditional and ultra-wide-field fluorescein angiography (UWF-FA). A PUBMED search was performed using the terms WF-OCT OR WF-OCTA OR UWF-FA AND the specific clinical entity, and another search for diabetic retinopathy (DR), retinal vein occlusion (RVO), Coats disease, peripheral retinal telangiectasia, peripheral retinal degeneration, lattice degeneration, and posterior vitreous detachment. The analysis only included the studies in which the analyzed field of view for the OCT or OCTA exam was larger than 55 degrees. The evaluation of the extracted studies indicates that WF imaging with OCT and OCTA provides substantial information on retinal disorders involving the peripheral retina. Vascular diseases, such as DR or RVO, can be reliably evaluated using WF-OCTA with results superior to standard-field fluorescein angiography. Nevertheless, UWF-FA provides a larger field of view and still has advantages over WF-OCTA concerning the evaluation of areas of non-perfusion and peripheral neovascularization. Detailed information on the vascular morphology of peripheral changes should be obtained via WF-OCTA and not angiographic examinations. WF-OCT can serve as a valuable tool for the detection and evaluation of vitreoretinal traction, posterior vitreous detachment, and peripheral retinal degeneration, and guide therapeutic decisions on a patient’s eligibility for surgical procedures.

Cooperative correction method for distortion and dispersion of deflected field of view in Risley-prism bionic-human-eye imaging systems.

The Risley-prism imaging system (RPIS) is a powerful way to achieve bionic human eye imaging with great advantages on large field of view (FOV) and variable resolution imaging owing to the autonomous controlled deflection of light. But the imaging dispersion originating from nonlinear and uneven light deflection results in limited imaging wavelength that seriously hinders its application. The existing solutions for imaging dispersion mainly rely on the hardware, which generally has bulky structure and limited improvement on image. Besides, the existing image evaluation methods for dispersion are not suitable for RPIS due to inhomogeneous dispersion. Herein, this paper systematically analyzes the mechanism and characteristics of dispersion in the RPIS, and proposes a cooperative correction method for image distortion and dispersion of multiple-color imaging, achieving the elimination of distortion and dispersion simultaneously without changing the optical structure. A dispersion evaluation index based on Pearson's correlation coefficient (PCC) is also established, and the objectivity and validity of the index are proved by experiments. Furthermore, a kind of compact RPIS based on an RGB camera is built, and both indoor and outdoor experiments are conducted. The experimental results demonstrate that proposed algorithm has strong universality and robustness for various scenes and targets.

A case study of an early galaxy cluster with the Athena X-IFU

Context. Observations of the hot gas in distant clusters of galaxies, though challenging, are key to understanding the role of intense galaxy activity, supermassive black hole feedback, and chemical enrichment in the process of massive halo assembly. Aims. Using X-ray hyperspectral data alone, we assess the feasibility of retrieving the thermodynamical hot gas properties and chemical abundances of a z = 2 galaxy cluster of mass M500 = 7 × 1013 M⊙, extracted from the Hydrangea hydrodynamical simulations. Methods. We created mock X-ray observations of the future X-ray Integral Field Unit (X-IFU) on board the Athena mission. By forward-modelling the measured 0.4 − 1 keV surface brightness, the projected gas temperature and abundance profiles, we reconstructed the three-dimensional distribution for the gas density, pressure, temperature, and entropy. Results. Thanks to its large field of view, high throughput, and exquisite spectral resolution, one X-IFU exposure lasting 100 ks enabled the reconstruction of density and pressure profiles with 20% precision out to a characteristic radius of R500, accounting for each quantity’s intrinsic dispersion in the Hydrangea simulations. Reconstruction of abundance profiles requires both higher signal-to-noise ratios and specific binning schemes. We assess the enhancement brought by longer exposures and by observing the same object at later evolutionary stages (at z = 1 and 1.5). Conclusions. Our analysis highlights the importance of scatter in the radially binned gas properties, which induces significant effects on the observed projected quantities. The fidelity of the reconstruction of gas profiles is sensitive to the degree of mixing of the gas components along the line of sight. Future analyses should aim to involve dedicated hyper-spectral models and fitting methods that are able to grasp the complexity of such three-dimensional, multi-phase, diffuse gas structures.

MICROPHOTOGRAPHY- A REVIEW

Microphotographs are useful biology teaching aids. In laboratory activities that require microscope slide preparation, they are an effective tool for pre- and post-lab discussions. They are also useful mechanisms to enhance lectures that deal with the microscopic world.1Microphography is useful to generate high quality micrographs with high resolution with a larger field of view, that enable to view the crucial ultrastructure relevant for pathological diagnosis. Incorporation into correlation and multi-modal microscopy workflows will assist with solving problems not only in research but also in specific fields of pathology and medical diagnosis.2

Feasibility of frozen soft tissues to simulate fresh soft tissue conditions in cone beam CT scans.

To evaluate the feasibility of frozen soft tissues in simulating fresh soft tissues of pig mandibles using cone beam CT (CBCT). Two fresh pig mandibles with soft tissues containing 2 tubes filled with a radiopaque homogeneous solution were scanned using 4 CBCT units and 2 field-of-view (FOV) sizes each. The pig mandibles were deep-frozen and scanned again. Three cross-sections were exported from each CBCT volume and grouped into pairs, with one cross-section representing a fresh and one a frozen mandible. Three radiologists compared the pairs and attributed a score to assess the relative image quality using a 5-point scale. Mean grey values and standard deviation were obtained from homogeneous areas in the tubes, compared using the Wilcoxon matched-pair signed-rank test and subjected to Pearson correlation analysis between fresh and frozen physical states (α = .05). Subjective evaluation revealed similarity of the CBCT image quality between fresh and frozen states. The distribution of mean grey values was similar between fresh and frozen states. Mean grey values of the frozen state in the small FOV were significantly greater than those of the fresh state (P = .037), and noise values of the frozen state in the large FOV were significantly greater than those of the fresh state (P = 0.007). Both mean grey values and noise exhibited significant and positive correlations between fresh and frozen states (P < 0.01). The freezing of pig mandibles with soft tissues may serve as a method to prolong their usability and working time when CBCT imaging is planned.

A Deep Learning Approach for Improving Two-Photon Vascular Imaging Speeds.

A potential method for tracking neurovascular disease progression over time in preclinical models is multiphoton fluorescence microscopy (MPM), which can image cerebral vasculature with capillary-level resolution. However, obtaining high-quality, three-dimensional images with traditional point scanning MPM is time-consuming and limits sample sizes for chronic studies. Here, we present a convolutional neural network-based (PSSR Res-U-Net architecture) algorithm for fast upscaling of low-resolution or sparsely sampled images and combine it with a segmentation-less vectorization process for 3D reconstruction and statistical analysis of vascular network structure. In doing so, we also demonstrate that the use of semi-synthetic training data can replace the expensive and arduous process of acquiring low- and high-resolution training pairs without compromising vectorization outcomes, and thus open the possibility of utilizing such approaches for other MPM tasks where collecting training data is challenging. We applied our approach to images with large fields of view from a mouse model and show that our method generalizes across imaging depths, disease states and other differences in neurovasculature. Our pretrained models and lightweight architecture can be used to reduce MPM imaging time by up to fourfold without any changes in underlying hardware, thereby enabling deployability across a range of settings.

Application of Regularization Methods in the Sky Map Reconstruction of the Tianlai Cylinder Pathfinder Array

The Tianlai cylinder pathfinder is a radio interferometer array to test 21 cm intensity mapping techniques in the post-reionization era. It works in passive drift scan mode to survey the sky visible in the northern hemisphere. To deal with the large instantaneous field of view and the spherical sky, we decompose the drift scan data into m-modes, which are linearly related to the sky intensity. The sky map is reconstructed by solving the linear interferometer equations. Due to incomplete uv coverage of the interferometer baselines, this inverse problem is usually ill-posed, and regularization method is needed for its solution. In this paper, we use simulation to investigate two frequently used regularization methods, the Truncated Singular Value Decomposition (TSVD), and the Tikhonov regularization techniques. Choosing the regularization parameter is very important for its application. We employ the generalized cross validation method and the L-curve method to determine the optimal value. We compare the resulting maps obtained with the different regularization methods, and for the different parameters derived using the different criteria. While both methods can yield good maps for a range of regularization parameters, in the Tikhonov method the suppression of noisy modes are more gradually applied, produce more smooth maps which avoids some visual artefacts in the maps generated with the TSVD method.

Integrated Point-of-Care Immune Cell Analyzer with Rapid Blood Sample Reaction and Wide Field-of-View Detection.

The development of affordable, reliable, and rapid diagnostic devices is crucial for monitoring immunological responses using a drop of blood. However, conventional automated diagnostic devices typically involve expensive and impractical robotic fluid-handling approaches. Herein, we developed an integrated cell analyzer comprising a cylindrical sample cartridge connected to a direct current motor and a compact fluorescence imaging module. Sample mixing and loading are performed automatically by a programmable sequence of single motor rotation controlled by an Android application. Two distinct stained immune cell samples can be identified by using two types of fluorescence imaging modes. The effectiveness of mixing performance in antigen-antibody (Ag-Ab) reactions was assessed through a compound objective lens that collects weak fluorescence emitted by the cell membrane. Active mixing with bidirectional rotation of the cartridge in a confined space shortened the Ag-Ab reaction time by a factor of 3.3 and achieved cell counting with higher accuracy while reducing reagent consumption by 4 times compared to the conventional incubation method. High-intensity fluorescence images of cells labeled with a nucleic acid stain were acquired through a single-lens-based fluorescence imaging module with a large field of view (FOV) in an unconventional detection chamber with a curved substrate. Compared with a flat chamber, the curved detection chamber reduces the effects of field curvature and provides aberration-free wide-FOV images, even with a simple lens. Our integrated cell analyzer thus offers a practical and cost-effective solution for monitoring patient immune responses in point-of-care settings.

Mirrorless MEMS imaging: a nonlinear vibrational approach utilizing aerosol-jetted PZT-actuated fiber MEMS scanner for microscale illumination.

This study introduces a novel image capture and lighting techniques using a cutting-edge hybrid MEMS scanner system designed for compact microscopic imaging. The scanner comprises a tapered optical fiber waveguide and innovative aerosol-jet printed PZT (lead zirconate titanate) bimorph push-pull actuators on a stainless-steel substrate, effectively addressing issues that are commonly associated with PZT on silicon substrates such as fracture and layer separation. By leveraging nonlinear vibration, the scanner achieves a spiral scan pattern from a single signal input, in addition to the expected two-dimensional scanning and target illumination from two phase-shifted inputs. This capability is further enhanced by a novel process to taper the optical fiber, which reduces illumination scattering and tunes the fiber to the resonant frequencies of the scanner. The precisely tapered tip enables large fields of view while maintaining independent 2-axis scanning through one-degree-of-freedom actuation. Experimental validation showcases the successful generation of a spiral scan pattern with a 60 μm diameter scan area and a 10 Hz frame rate, effectively reconstructing scanned images of 5 μm lines, cross patterns (15 μm in length with a 5 μm gap), and structures of a Psychodidae wing.

Square beams for optimal tiling in transmission electron microscopy

Imaging large fields of view at a high magnification requires tiling. Transmission electron microscopes typically have round beam profiles; therefore, tiling across a large area is either imperfect or results in uneven exposures, a problem for dose-sensitive samples. Here, we introduce a square electron beam that can easily be retrofitted in existing microscopes, and demonstrate its application, showing that it can tile nearly perfectly and deliver cryo-electron microscopy imaging with a resolution comparable to conventional set-ups.

High-precision analysis of aberration contribution of Zernike freeform surface terms for non-zero field of view.

Clarifying the aberrations arising from freeform surfaces is of great significance for maximizing the potential of freeform surfaces in the design of optical systems. However, the current precision in calculating aberration contribution of freeform surface terms for non-zero field of view is insufficient, impeding the development of freeform imaging systems with larger field of view. This paper proposes a high-precision analysis of aberration contribution of freeform surface terms based on nodal aberration theory, particularly for non-zero field points. Accurate calculation formulas of aberrations generated by Zernike terms on freeform surface are presented. Design examples illustrate that the calculation error of the provided formulas is 78% less than that of conventional theoretical values. Building upon high-precision analysis, we propose an optimization method for off-axis freeform surface systems and illustrate its effectiveness through the optimization of an off-axis three-mirror system. This research extends the applicability of nodal aberration theory in aberration analysis, offering valuable insights for the optimal design and alignment of optical freeform systems.

Development and evaluation of MWIR imaging spectrometer for multi-dimensional detection

For the detection of moving target in complex background, in order to increase the identification ability, the sensor needs the ability of multi-dimensional detection, not only image and spectrum, but also motion features. We propose a multi-slit imaging spectrometer, in which multiple slits instead of the single slit are arranged along the track on the focal plane of the fore-optics. Thus, the moving target is imaged with spectral resolution multiple times in one scanning period, which obtains the time resolution. We have developed a prototype with three slits covering spectrum between 3 µm and 5 µm. The prototype utilizes a reflective triple optics and a prism yielding a compact spectrometer design, which makes it much easier to realize the large field of view, the fast optical speed, the high optical transmission efficiency, the compact volume, and cooled opto-mechanics. Results of the laboratory tests verify the satisfaction of the imaging quality and spectral characters. The flight test shows this type of imaging spectrometers with multiple slits is feasible in the multi-dimensional detection of moving targets. It deserves the expected value in satellites and airborne applications in the future.

Exposure and protection protocols of dentomaxillofacial imaging applied by paediatric dentists in Europe.

Evaluate exposure and protection practices regarding dentomaxillofacial imaging among pediatric dentists in Europe and determine the effect of different clinician specific characteristics on their implementation. A cross-sectional study involving an electronic questionnaire addressed to paediatric dentists, participating in a seminar on dental radiology organized by the European Academy of Paediatric Dentistry. Participants were asked to respond to questions regarding dentomaxillofacial imaging in terms of applied radiation dose, adoption of radiation protection techniques, and different patterns of radiographic studying and exchange between patients and colleagues. Data analysis was performed and distribution of responses was tested using chi-square and Fisher's exact tests. A total of 151 paediatric dentists, 119 females and 32 males, with a mean chronological age of 42.8years (s.e. 11.3years), successfully completed the questionnaire (response rate = 82%). Regardless of the type of radiograph, majority of respondents (68%), reported that they perform the radiographs themselves, while 21% reported that they refer the patients. Half of the respondents (51%), indicated requesting a small (localized) field of view (FOV) when referring for a cone beam computed tomography (CBCT) with only a small proportion (11%) reporting a large (maxillofacial) FOV. Thyroid collars and optimizing exposure settings were the most commonly reported patient protection measures used. Lastly, paediatric dentists have adopted the latest technological capacities for the study of dental images. Dentomaxillofacial imaging protection and exposure protocols used are common among paediatric dentists with none of their specific characteristics having a significant effect.

Large-field-of-view optical-resolution optoacoustic microscopy using a stationary silicon-photonics acoustic detector.

Optical-resolution optoacoustic microscopy (OR-OAM) enables label-free imaging of the microvasculature by using optical pulse excitation and acoustic detection, commonly performed by a focused optical beam and an ultrasound transducer. One of the main challenges of OR-OAM is the need to combine the excitation and detection in a coaxial configuration, often leading to a bulky setup that requires physically scanning the ultrasound transducer to achieve a large field of view. The aim of this work is to develop an OR-OAM configuration that does not require physically scanning the ultrasound transducer or the acoustic beam path. Our OR-OAM system is based on a non-coaxial configuration in which the detection is performed by a silicon-photonics acoustic detector (SPADE) with a semi-isotropic sensitivity. The system is demonstrated in both epi- and trans-illumination configurations, where in both configurations SPADE remains stationary during the imaging procedure and only the optical excitation beam is scanned. The system is showcased for imaging resolution targets and for the in vivo visualization of the microvasculature in a mouse ear. Optoacoustic imaging with focal spots down to , lateral resolution of , and a field of view higher than 4mm in both lateral dimensions were demonstrated. We showcase a new OR-OAM design, compatible with epi-illumination configuration. This setup enables relatively large fields of view without scanning the acoustic detector or acoustic beam path. Furthermore, it offers the potential for high-speed imaging within compact, miniature probe and could potentially facilitate the clinical translation of OR-OAM technology.

Full field-of-view hexagonal lattice structured illumination microscopy based on the phase shift of electro-optic modulators.

High throughput has become an important research direction in the field of super-resolution (SR) microscopy, especially in improving the capability of dynamic observations. In this study, we present a hexagonal lattice structured illumination microscopy (hexSIM) system characterized by a large field of view (FOV), rapid imaging speed, and high power efficiency. Our approach employs spatial light interference to generate a two-dimensional hexagonal SIM pattern, and utilizes electro-optical modulators for high-speed phase shifting. This design enables the achievement of a 210-µm diameter SIM illumination FOV when using a 100×/1.49 objective lens, capturing 2048 × 2048 pixel images at an impressive 98 frames per second (fps) single frame rate. Notably, this method attains a near 100% full field-of-view and power efficiency, with the speed limited only by the camera's capabilities. Our hexSIM demonstrates a substantial 1.73-fold improvement in spatial resolution and necessitates only seven phase-shift images, thus enhancing the imaging speed compared to conventional 2D-SIM.

Temporal structured illumination and vision-transformer enables large field-of-view binary snapshot ptychography.

Ptychography, a widely used computational imaging method, generates images by processing coherent interference patterns scattered from an object of interest. In order to capture scenes with large field-of-view (FoV) and high spatial resolution simultaneously in a single shot, we propose a temporal-compressive structured-light Ptychography system. A novel three-step reconstruction algorithm composed of multi-frame spectra reconstruction, phase retrieval, and multi-frame image stitching is developed, where we employ the emerging Transformer-based network in the first step. Experimental results demonstrate that our system can expand the FoV by 20× without losing spatial resolution. Our results offer huge potential for enabling lensless imaging of molecules with large FoV as well as high spatial-temporal resolutions. We also notice that due to the loss of low-intensity information caused by the compressed sensing process, our method so far is only applicable to binary targets.

Transcutaneous Imaging of Rabbit Kidney Using 3-D Acoustic Wave Sparsely Activated Localization Microscopy with a Row-Column-Addressed Array.

Super-resolution ultrasound (SRUS) imaging through localizing and tracking microbubbles, also known as ultrasound localization microscopy (ULM), can produce sub-diffraction resolution images of micro-vessels. We have recently demonstrated 3-D selective SRUS with a matrix array and phase change contrast agents (PCCAs). However, this method is limited to a small field of view (FOV) and by the complex hardware required. This study proposed 3-D acoustic wave sparsely activated localization microscopy (AWSALM) using PCCAs and a 128+128 row-column-addressed (RCA) array, which offers ultrafast acquisition with over 6 times larger FOV and 4 times reduction in hardware complexity than a 1024-element matrix array. We first validated this method on an in-vitro microflow phantom and subsequently demonstrated non-invasively on a rabbit kidney in-vivo. Our results show that 3-D AWSALM images of the phantom covering a 25×25×40 mm 3 volume can be generated under 5 seconds with an 8 times resolution improvement over the system point spread function. The full volume of the rabbit kidney can be covered to generate 3-D microvascular structure, flow speed and direction super-resolution maps under 15 seconds, combining the large FOV of RCA with the high resolution of SRUS. Additionally, 3-D AWSALM is selective and can visualize the microvasculature within the activation volume and downstream vessels in isolation. Sub-sets of the kidney microvasculature can be imaged through selective activation of PCCAs. Our study demonstrates large FOV 3-D AWSALM using an RCA probe. 3-D AWSALM offers an unique in-vivo imaging tool for fast, selective and large FOV vascular flow mapping.

Improvement to the Epoch of Reionisation power spectrum using simulations with the Central Redundant Array Mega-tile (CRAM)

Abstract Detection of the 21 cm signal from the Epoch of Reionisation (EoR) ( $z \sim 6 - 10$ ) amidst the dominant foregrounds, which are 3–4 orders of magnitude greater than the weak cosmological signal, is a challenging task for the existing 21 cm experiments. The detection is further challenged by the large Field of View (FoV) of the instrument used for observation, as it becomes necessary to excise foregrounds present within the FoV to make a successful detection. In response to the challenges faced, in our previous work, we developed and installed a new instrument – the Central Redundant Array Mega-tile (CRAM) – and integrated it within the MWA Phase II configuration. It is a larger antenna tile configuration ( $8\times 8$ dipoles) with a smaller FoV at every frequency under consideration and has multiple sidelobes of reduced response when compared with the existing Murchison Widefield Array (MWA) tiles. In this paper, we aim to demonstrate through power spectrum simulations that using the larger tile, such as the CRAM, can reduce the impact of bright radio foregrounds near the field edge. For the pedagogical approach aimed with this work, we developed a power spectrum pipeline to estimate the cylindrically averaged power spectrum. The power spectrum is estimated for MWA-MWA baselines and CRAM-MWA baselines using analytical beams, simulated diffuse sky maps and a semi-numerical 21 cm signal. Employing a drift scanning strategy, we estimate 1D and 2D power spectra for a series of two-minute observations spanning 24 hrs using the diffuse sky maps. Our simulations predict a power reduction at the edge of the EoR wedge. The reduction in foreground power is confirmed with the Fisher analysis of the expected signal-to-noise ratio (SNR) improvement, which reports a higher SNR with the power estimations from CRAM baselines when compared with the regular MWA baselines. The reduced power obtained with the CRAM baselines is consistent with the fact that the larger tile configuration has reduced the impact of foregrounds from near the horizon.