Summary and Conclusions 1. Two patients with dermatoses occurring during pregnancy are reported. Both occurred in primiparas near term and were characterized by polymorphous rash, itching, and the appearance of the rash in crops. In the first patient the lesions were primarily in the region of the genitalia, and in the second, their distribution was generalized. In the first patient, cesarean section was done because of failure of the head to engage after an adequate modified trial of labor. The postoperative course was complicated by peritonitis and wound sepsis. No special treatment was given for the skin lesions. The second patient ran a course of 206 days following delivery. The loss of serum proteins due to involvement of large skin areas necessitated treatment as a burn. Secondary infection greatly complicated the course. Grave systemic manifestations were present’ together with eosinophilia, albuminuria, hematuria, diarrhea, amenorrhea, mucous membrane, and nail bed involvement. The serum calcium was low before delivery but tetany was never demonstrated. Calcium, cod liver oil, liver extract, the serum of pregnant women, Ringer’s solution, nonspecific foreign protein, autogenous vaccine, x-rays, and ultraviolet light were all used in treatment. The disease probably ran a course uninfluenced by these measures and the most that can be said to have been accomplished was the prevention of loss of serum proteins and the control of secondary infection. 2. Impetigo herpetiformis, dermatitis herpetiformis, and pemphigus chronicus, or vulgaris, are, judging from a review of a number of case reports, similar symptom complexes. Similar manifestations are reported with all. Unfortunately, most case reports are deficient in studies of blood chemistry. The dermatoses recur with subsequent pregnancies. Amenorrhea is a frequent sequel. 3. The etiologic factors are not clear. Parathyroid dysfunction may play some part. Striking cases of impetigo herpetiformis associated with tetany have been reported. 4. Treatment probably influences the disease very little. Efforts should be directed toward maintaining the general condition of the patient and toward the prevention and control of secondary infection. In pregnancy the disease is an indication for termination and the prevention of future pregnancies. If the disease manifests itself early in pregnancy the outlook for the fetus is not good.