Abstract
Cutaneous nociceptors are specialized primary afferents responding to noxious or injurious stimulation of the skin. Unmyelinated (C-fiber) nociceptors mediate the burning pain from noxious heat stimuli and pain from prolonged mechanical stimuli. Myelinated (A-fiber) nociceptors mediate the sharp, pricking pain associated with application of intense heat or sharp objects. The enhanced pain sensation at the site of skin injury (primary hyperalgesia) is thought to result from an enhanced responsiveness (sensitization) of cutaneous nociceptors. Hyperalgesia in a large area of uninjured skin surrounding the injury site (secondary hyperalgesia) is most likely due to sensitization of neurons in the central nervous system.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of the American Dental Association and the Dental Cosmos
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
