The Hindukush and Himalaya regions of Pakistan are chronically prone to several geological hazards such as landslides. Studying landslides in these regions is crucial for risk assessment and disaster management, as well as for determining the effects of adverse climatic conditions, infrastructure management, and increasing anthropogenic activities. High-relief mountains in these regions face severe challenges because of frequently occurring landslides and other natural hazards, especially during intensive rainfall seasons and seismic activity, which destroy infrastructure and cause injuries and deaths. Landslides in the Alpuri Valley (Hindukush) and the Neelum Valley (Himalaya) have been activated through high magnitude earthquakes, intensive rainfalls, snowfall, floods, and man-made activities. Landslide susceptibility mapping in these areas is essential for sustainable development as it enables proactive risk management, up-to-date decision-making, and effective responses to landslide hazards, ultimately safeguarding human lives, property, and the environment. In this study, the relative effect method was applied for landslide susceptibility modeling in both study areas to determine the capability to reduce the effects of landslides, and to improve the prediction accuracy of the method. The relative effect is a statistical model that has only been used for very limited time for landslide susceptibility with effective results. A total of 368 (Neelum Valley) and 89 (Alpuri Valley) landslide locations were identified, which were utilized to prepare the reliable landslide inventory using GIS. In order to evaluate the areas at risk for future landslides activities and determine their spatial relationship with landslide occurrences, the landslide inventory was developed with 17 landslide causative factors. These factors include slope gradient, slope aspect, geology, plan curvature, general curvature, profile curvature, elevation, stream power index, drainage density, terrain roughness index, distance from the roads, distance from the streams, distance from fault lines, normalized difference wetness index, land-use/land-cover, rainfall, and normalized difference vegetation index. Finally, the performance of the relative effect method was validated using the success and prediction curve rate. The AUC-validated result of the success rate curve in the Alpuri Valley is 74.75%, and 82.15% in the Neelum Valley, whereas, the AUC-validated result of the prediction rate curve of the model is 87.87% in the Alpuri Valley and 82.73% in the Neelum Valley. These results indicate the reliability of the model to produce a landslide susceptibility map, and apply it to other landslide areas. The model demonstrated a more effective result in the Alpuri Valley, having a smaller area. However, the results are also desirable and favorable in Neelum Valley, with it being a large area. It will assist in general landslide hazard management and mitigation, and further research studies related to future landslide susceptibility assessments in other parts of the region.