Abstract A high prevalence of diseases and parasites is one of the major constraints in the small-ruminant industry in the Southeast because of its warm and humid climate, and poor management practices. Drug resistance developing in pathogens, and the lack of access of producers to and affordability for veterinarians practicing in small ruminants warranted us to look for integrated preventive approaches. To promote integrated approaches for preventing diseases and parasites in small ruminants, a team of scientists and professionals from five institutions (Tuskegee University, Fort Valley State University, USDA-ARS Booneville, University of Arkansas, and the University of Maryland Eastern-Shore) worked together with an objective to develop curricula (training handbook) and train the trainers (educators) and small-ruminant producers in the Southeast. The Training Handbook consisted of nine chapters authored by project collaborators and invited experts. Relevant aspects of keeping small ruminants healthy and preventing possible diseases and parasites, including basic facilities and health care, suitable sites, grazing systems and management, biosecurity, selection and breeding, nutrition, and economics have been presented and discussed in the Handbook. After the handbook was developed, a 3-day train-the-trainers training was conducted at Tuskegee University. County agents, specialists, and technical-service providers working at various land-grant universities and other institutions working with small-ruminant producers or their educators were invited to participate in the training. Additionally, selected lead producers raising small ruminants from Alabama and graduate students working on small-ruminant research and outreach were invited to the training. Twelve professionals from four different states (Alabama, Georgia, Mississippi, and North Carolina) six farmers, and four graduate students attended the training. Training included indoor sessions with presentations, discussions, and question-answer sessions. Outdoor sessions included demonstrations, hands-on activities, and tours of the small-ruminant production sites and facilities. Evaluations by participants were conducted before adjournment on the same day or at the beginning on the next day. Most participants expressed that presented topics, hands-on activities, demonstration, and tours were extremely useful (71-85%) or very useful (13-23%). They stated that they were extremely likely (73-89%) or very likely (11-23%) to apply what was learned from the training. Similarly, most participants reported that the ultimate condition of small-ruminant health would be improved if the learned knowledge and skills are applied on the farms (producers) or on education endeavors (professionals) with most improvements (64-83%) or reasonable improvements (15-21%). Evaluations by participants showed that the training handbook and the overall training could be very useful to improve health of small ruminants significantly.