PurposeThe purpose of this study is to investigate structure parameters that influence the mixing process of droplets-gas in underwater depth-adjustable launcher cooling chamber and help engineers who design the launcher to distinguish the most important factor that impacts mixing performance in the cooling chamber.Design/methodology/approachEuler–Lagrangian droplet tracking method was used to simulate droplets-gas mixing process in the cooling chamber. The SST k-w model was adopted to simulate turbulence. Droplet breakup was described by KHRT hybrid model using modified contains which are more fit to the supersonic main flow condition.FindingsThe results show the counter-rotating vortex pairs which caused by injected liquid accelerate the mixing process. High-pressure supersonic freestream makes the liquid jet break into more small droplets due to the high momentum of the main stream. Axial injection angle has the greatest influence on Sauter mean diameter (SMD). Penetration height, SMD and total pressure loss slightly change in different tangential injection conditions. However, mixedness decreases with reduction of tangential injection angle due to a more limited space for spray developing. Enlarging orifice diameter raises penetration and mixedness greatly, while SMD and total pressure loss increase slightly.Originality/valueThe findings of this study confirm the key structure parameter to improve mixing performance in the cooling chamber. Engineers who design the underwater depth-adjustable launcher can refer the findings in this study to make control of launching power more accurate.