Features of regulation of labor relations under the influence of measures aimed at preventing the occurrence and spread of coronavirus disease (COVID-19) are revealed. It was emphasized that the problem of regulation of labor relations during quarantine restrictions became especially acute, as it was necessary to amend the legislation in order to reduce the negative impact of the spread of coronavirus COVID-19. A set of both general and special methods of scientific cognition was used to study the problem. The main thing in this system is the general scientific dialectical method, which was used to clarify the new content of the responsibilities of the employer during the pandemic COVID-19, identify the main changes in Ukrainian legislation. Using the formal-logical method, the consequences of quarantine restrictions in the field of employment and ways to overcome them are revealed. On this methodological basis, the collection, processing and analysis of empirical material were carried out. General scientific methods are also used, such as: comparison, generalization, induction, deduction and analysis. In addition, system-structural analysis is used in the analysis of current legislation. Legislative changes are analyzed in order to reduce the negative impact of coronavirus spread. Attention is paid to the consequences of the introduction of quarantine restrictions, which affected the level of economic development of the country, social protection and employment. The economic level of Ukraine is analyzed taking into account the impact of quarantine shock, as a result of which the decline in Ukraine�s gross domestic product in 2020 was highlighted. As a result, there was a sharp reduction in jobs and loss of livelihoods of the working population. The causal links that led to a decline in employment, job cuts and rising unemployment have been identified. The main reasons for the reduction of employees in enterprises due to the difficult economic situation - the loss of a significant part of profits, reducing the number of employees to keep the company, forced sending of workers on unpaid leave, transfer to part-time work. Emphasis is placed on such a phenomenon as hidden unemployment, which is not included in official statistics. This happens when some employers send employees on unpaid long-term leave for the duration of quarantine, others transfer employees from full-time to part-time employment. Forms of hidden unemployment are highlighted. Attention is paid to the impact of quarantine restrictions imposed to prevent the spread of coronavirus disease (COVID-19) on labor migration processes and the trend of behavior of Ukrainian workers. The main reasons for the decline in migration processes, including the closure of borders for entry and exit of foreigners by most European countries, the temporary suspension of enterprises and job losses during the quarantine period, etc. are highlighted. The ways of the decision of the raised questions are offered.