Cyber–physical systems (CPSs) are being increasingly adopted for industrial applications, yet they involve a dynamic threat landscape that requires CPSs to adapt to emerging threats during their operation. Recently, digital twin (DT) technology (which refers to a virtual representation of a product, process, or environment) has emerged as a suitable candidate to address the security challenges faced by dynamic CPSs. DT has the capability of strengthening the security of CPSs by continuously mapping the physical to twin counterparts to detect inconsistencies. The existing DT-based security solutions are constrained by untrustworthy data dissemination as well as limited data sharing among the involved stakeholders, which, in turn, limit the ability of DTs to run accurate simulations or make valid decisions. To address these challenges, this paper proposes a modular framework called TRusted and Intelligent cyber-PhysicaL systEm (TRIPLE), that leverages blockchain, DTs, and threat intelligence (TI) to secure CPSs. The blockchain-based DT components in the framework provide data integrity, traceability, and availability for trusted DTs. Furthermore, to accurately and comprehensively model system states, the framework envisions fusing process knowledge for modeling DTs from system specification-based and learning-based information and other sources, including infrastructure-as-code (IaC) and knowledge base (KB). The framework also integrates TI for future-proofing against emerging threats, such that threats can be detected either reactively by mapping the behavior of physical and virtual spaces or proactively by TI and threat hunting. We demonstrate the viability of the framework through a proof of concept. Finally, we formally verify the TRIPLE framework to demonstrate its correctness and effectiveness in enhancing CPS security.