Knowledge-based Model Research Articles

Mechanical unfolding of RNA molecules using a knowledge-based model.

We revisit a coarse-grained model to study the dynamics of ribonucleic acid (RNA). In our model, each nucleotide is replaced by an interaction center located at the center of mass. The interaction between nucleotides is carried out by a series of effective pair potentials obtained from the statistical analysis of 501 RNA molecules of high molecular weight from the Protein Data Bank. In addition to the Watson-Crick interactions, we also include non-canonical interactions, which provide stability to the three-dimensional (3D) structure of the molecule. The resulting knowledge-based interactions for the nucleotides (KIN) model allow us to perform efficient Brownian dynamics simulations under different conditions. First, we simulate the stretch of a set of hairpins at a loading rate similar to the values employed in unfolding experiments near equilibrium using optical tweezers. Additionally, we explore unfolding a set of pseudoknots under conditions farther from equilibrium, namely, at loading rates higher than the experimental equilibrium values. The results of our simulations are compared with those obtained from experimental measurements and theoretical models intended to estimate transition states and activation energies. Our KIN model is able to reproduce the intermediate states observed during mechanical unfolding experiments. Moreover, the results of the KIN model are in good agreement with the measured data.

Assessing Scientific Text Similarity: A Novel Approach Utilizing Non-Negative Matrix Factorization and Bidirectional Encoder Representations from Transformer

The patent serves as a vital component of scientific text, and over time, escalating competition has generated a substantial demand for patent analysis encompassing areas such as company strategy and legal services, necessitating fast, accurate, and easily applicable similarity estimators. At present, conducting natural language processing(NLP) on patent content, including titles, abstracts, etc., can serve as an effective method for estimating similarity. However, the traditional NLP approach has some disadvantages, such as the requirement for a huge amount of labeled data and poor explanation of deep-learning-based model internals, exacerbated by the high compression of patent content. On the other hand, most knowledge-based deep learning models require a vast amount of additional analysis results as training variables in similarity estimation, which are limited due to human participation in the analysis part. Thus, in this research, addressing these challenges, we introduce a novel estimator to enhance the transparency of similarity estimation. This approach integrates a patent’s content with international patent classification (IPC), leveraging bidirectional encoder representations from transformers (BERT), and non-negative matrix factorization (NMF). By integrating these techniques, we aim to improve knowledge discovery transparency in NLP across various IPC dimensions and incorporate more background knowledge into context similarity estimation. The experimental results demonstrate that our model is reliable, explainable, highly accurate, and practically usable.

Enhancing Students’ Knowledge-Based Economy Skills at Sultan Qaboos University

This study examines the readiness of Sultan Qaboos University (SQU) students for the knowledge-based economy, focusing on their awareness, perceptions, and skills. As Oman transitions towards a knowledge-based economic model, understanding and enhancing students’ preparedness has become crucial. This research employs a quantitative approach, utilizing a questionnaire distributed to SQU students across various colleges and academic levels, achieving a 66.04% response rate. The key findings reveal that while many students consider knowledge economy skills very important, some express neutral awareness about these skills. Students ranked creativity and innovation (85.82%) and critical thinking and problem solving (85.11%) as the most essential skills. The study identifies significant relationships between enhancing students’ knowledge-based economy skills (ESKBE) and both awareness of the knowledge-based economy (AWS) and the impact of technology on education and employment (ITEE). Students generally view the knowledge economy positively, with 55% agreeing it will have a positive societal impact. However, they recognize challenges, including resistance to change (53.5% agreement) and limited access to education and training (49.3% agreement). The need for government involvement in addressing these challenges was strongly emphasized (54.3% agreement). Based on these findings, the study recommends that SQU enhance its curriculum to explicitly develop key skills, improve awareness of knowledge economy demands, further integrate technology into educational practices, strengthen industry partnerships, promote lifelong learning initiatives, and engage more actively with policymakers. This paper also provides a unique look at higher education’s role in the changing economy, as seen through graduates. It offers empirical evidence for the necessity of universities to change to serve the knowledge economy and, at the same time, make a case on how complex this transformation is. The results matter not only for SQU but also—in a more general sense, at least as far as knowledge-based economies are concerned—globally with respect to higher education institutions.

Knowledge Editing for Large Language Models: A Survey

Large Language Models (LLMs) have recently transformed both the academic and industrial landscapes due to their remarkable capacity to understand, analyze, and generate texts based on their vast knowledge and reasoning ability. Nevertheless, one major drawback of LLMs is their substantial computational cost for pre-training due to their unprecedented amounts of parameters. The disadvantage is exacerbated when new knowledge frequently needs to be introduced into the pre-trained model. Therefore, it is imperative to develop effective and efficient techniques to update pre-trained LLMs. Traditional methods encode new knowledge in pre-trained LLMs through direct fine-tuning. However, naively re-training LLMs can be computationally intensive and risks degenerating valuable pre-trained knowledge irrelevant to the update in the model. Recently, Knowledge-based Model Editing (KME), also known as Knowledge Editing or Model Editing , has attracted increasing attention, which aims to precisely modify the LLMs to incorporate specific knowledge, without negatively influencing other irrelevant knowledge. In this survey, we aim to provide a comprehensive and in-depth overview of recent advances in the field of KME. We first introduce a general formulation of KME to encompass different KME strategies. Afterward, we provide an innovative taxonomy of KME techniques based on how the new knowledge is introduced into pre-trained LLMs, and investigate existing KME strategies while analyzing key insights, advantages, and limitations of methods from each category. Moreover, representative metrics, datasets, and applications of KME are introduced accordingly. Finally, we provide an in-depth analysis regarding the practicality and remaining challenges of KME and suggest promising research directions for further advancement in this field.

Exploiting explicit item–item correlations from knowledge graphs for enhanced sequential recommendation

In recent years, the research of employing knowledge graphs (KGs) in sequential recommendation (SR) has received a lot of attention, since the side information extracted from KGs, especially the information of the correlations between items, indeed helps the SR models achieve better performance. However, many previous KG-based SR models tend to introduce some noise information when learning item embeddings, or insufficiently fuse item–item correlations into their sequential modeling, thus limiting their performance improvements. In this paper, we propose a Distance-Aware Knowledge-based Sequential Recommendation model (DAKSR), which exploits the explicit item–item correlations from KGs to achieve enhanced SR. Specifically, as one critical component in our DAKSR, the distance score matrix (DSM) is first obtained to indicate the correlations between items, and then leveraged in the following three major modules of DAKSR. First, in the Item-Set Embedding layer (ISE) all item embeddings are learned based on DSM, in which the noise information is eliminated effectively. Meanwhile, the Knowledge-Infused Transformer (KIT) incorporates DSM into its attention mechanism to improve the feature extraction. Furthermore, the Knowledge Contrastive Learning module (KCL) also leverages the item–item correlations presented in DSM to generate two credible sequence views, which are used to refine sample representations through a contrastive learning strategy, and thus improve the model’s robustness. Our extensive experiments on three SR benchmarks obviously demonstrate our DAKSR’s superior performance over the state-of-the-art (SOTA) KG-based recommendation models. The implementation of our DAKSR is available at https://github.com/Easonsi/DAKSR for reproducing our experiment results conveniently.

Prediction of multiaxial fatigue life with a data-driven knowledge transfer model

A data-driven model is presented for accurate prediction of multiaxial fatigue life based upon the principle of transfer learning (TL). The Tradaboost framework is explored to adjust the weights of training data from different sources, actuating information transfer from domain knowledge to the data-driven modeling of multiaxial fatigue life. Subsequently, extensive experimental results tested under the proportional and non-proportional circle loadings are collected for model evaluation. The results demonstrate that the proposed model is more accurate than domain knowledge-based, conventional data-driven, and comparable TL-based models, with a low data requirement, showcasing good applicability for multiaxial fatigue life assessment.

A dopaminergic basis of behavioral control.

Both goal-directed and automatic processes shape human behavior, but these processes often conflict. Behavioral control is the decision about which process guides behavior. Despite the importance of behavioral control for adaptive decision-making, its neural mechanisms remain unclear. Critically, it is unknown if there are mechanisms for behavioral control that are distinct from those supporting the formation of goal-relevant knowledge. We performed deep phenotyping of individual dopamine system function by combining multiple PET scans, fMRI, and dopaminergic drug administration in a within-subject, double-blind, placebo-controlled design. Subjects performed a rule-based response time task, with goal-directed and automatic decision-making operationalized as model-based and model-free influences on behavior. We found a double dissociation between two aspects of ventral striatal dopamine physiology: D2/3 receptor availability and dopamine synthesis capacity. Convergent and causal evidence indicated that D2/3 receptors regulate behavioral control by enhancing model-based and blunting model-free influences on behavior but do not affect model-based knowledge formation. In contrast, dopamine synthesis capacity was linked to the formation of model-based knowledge but not behavioral control. D2/3 receptors also modulated frontostriatal functional connectivity, suggesting they regulate behavioral control by gating prefrontal inputs to the striatum. These results identify central mechanisms underlying individual and state differences in behavioral control and point to striatal D2/3 receptors as targets for interventions for improving goal-directed behavior.

Towards cleaner energy: An innovative model to minimize NOx emissions in chemical looping and CO2 capture technologies

The urgent global challenges of climate change and environmental issues have catalyzed the development of CO2-capture-ready technologies incorporating fluidization, such as fluidized bed (FB) and circulating fluidized bed (CFB) combustion under oxy-fuel conditions, chemical looping combustion (CLC), chemical looping with oxygen uncoupling (CLOU), in-situ gasification chemical looping combustion (iG-CLC), and calcium (or carbonate) looping (CaL) systems. While these technologies have the potential to reduce CO2 emissions significantly, the persistent presence of nitrogen oxides (NOx = NO + NO2) as pollutants remains a critical environmental concern.This paper introduces a comprehensive fuzzy logic-based model for predicting NOx emissions (FuzzyNOx model) from solid fuel combustion in fluidized beds of chemical looping systems. This innovative model takes into account a wide range of operating parameters, including fuel type, fuel particle size, fuel moisture content, air/fuel ratio, and temperature. It also explores advanced coal and biomass combustion modes, including air-firing, oxyfuel, iG-CLC, and CLOU. Furthermore, it delves into the intricacies of two distinct facilities: the 5 kWth dual-fluidized bed Chemical-Looping-Combustion of Solid-Fuels (DFB-CLC-SF) facility at Czestochowa University of Technology, Poland, and the calcium looping dual-fluidized bed (CaL DFB) facility at Niigata University, Japan.Bituminous coal, semi-anthracite, and wood chips are utilized as fuels. Moreover, three various oxygen carriers (OCs) for chemical looping combustion were employed, namely ilmenite, copper oxide (60 % wt.) supported by carbonate waste from ore flotation, and copper oxide (60 % wt.) supported by ilmenite (20 % wt.) and fly ash. Bituminous coal, semi-anthracite, and wood chips are utilized as fuels.The developed knowledge-based fuzzyNOx model allows the optimization of operating parameters to reduce NOx emissions from CO2 capture technologies.

People-centered knowledge management systems and supply chain performance in SMEs

PurposeThe study explores the impact of people-centered Knowledge Management Systems (KMS) on Supply Chain Performance (SCP). It also aims to reinforce the importance of people in an organization’s survival, particularly from a knowledge-based perspective, by empirically assessing the mediating effect of knowledge sharing on people-centered KMS and SCP. The model being assessed incorporates people-centered KMS that promote knowledge sharing and therefore improve SCP within Small and Medium sized Enterprises (SME) in developing countries, leading to their extended life span.Design/methodology/approachThe study developed a knowledge-based SCP model using people-centered KMS as a predictor variable and knowledge sharing as a mediating variable, with SCP as the outcome variable. The data were collected from a sample of 580 SME owners from across Zimbabwe via a questionnaire developed based on validated constructs available in literature that was vetted through a pilot survey before distribution. The dataset was subsequently tested for validity of constructs and scales and analyzed using multiple regression.FindingsThe results of the study showed significant influence of three people-centered KMS, namely, Communities of Practice (CoP), Innovation Management (IM) and Organizational Culture (OC), on knowledge sharing but not from Social Capital. Thereafter, significant influence was also found of knowledge sharing on three process-based measures of SCP, namely, Time-Related Performance (TRP), Cost-Related Performance (CRP) and Responsiveness-Related Performance (RRP), but not on Operational Quality-Related Performance (OQRP). Thus overall, it was confirmed that people-centered KMS has a salutary impact on process-based SCP, with knowledge sharing serving as a significant mediator.Research limitations/implicationsThe study makes a novel contribution to the extant literature by providing insight into how people-centered KMS impacts SCP through knowledge sharing. Additionally, the geographical scope of the study also makes it among the few that have studied supply chain management within the context of developing economies, especially those that face significant economic pressures, such as Zimbabwe. Finally, given the criticality of SMEs to the economic growth in developing economies juxtaposed with the low survival rates of SMEs therein, the study reveals a relatively low-cost strategy of knowledge sharing among supply chain partners as a valid strategy to improve the SCP of these SMEs in an effort to enhance their survival rates. The primary limitation of the study relates to potential difficulty in the generalizability of findings because data were collected from a single country.Originality/valueThe original contributions of the study include: utilizing a people-centered knowledge management perspective, an establishment of the relationship between KMS on SCP and demonstrating the salience of knowledge sharing as a mediator; addressing the dearth of literature on supply chain management in developing economies, especially those with stressed economies; demonstrating the usefulness of knowledge sharing as a relatively low-cost but effective strategy to improve the performance of SMEs in a developing economy and thus lead to higher survival rates, thus providing a tool that can be used by the public and the private sector in developing countries to build structures for successful economic development.

Synergizing Data-Driven and Knowledge-Based Hybrid Models for Ionic Separations

Synergizing Data-Driven and Knowledge-Based Hybrid Models for Ionic Separations

Knowledge-based model generation for aircraft cabin noise prediction from pre-design data

The climate targets set out in the “European Green Deal” call for the consideration and implementation of climate-friendly propulsion concepts and sustainable fuels in future aircraft configurations. This puts the use of very efficient propeller engines into the focus of aircraft design. However, these pose major challenges, especially to cabin acoustics, due to high, tonal sound pressure levels on the fuselage. The design of noise control measures requires the competence to predict the resulting interior noise as early as possible in the design process of the vehicle. This requires a high level of geometric and structural detail regarding the fuselage structure and cabin components. With increasing frequency range, the necessary structural details also increase, which have to be resolved in the simulation models due to the associated decreasing structural wavelength. Especially in the context of aircraft pre-design, there is usually not enough information available for a detailed vibro-acoustic modeling of the fuselage and cabin components, which allows a meaningful prediction of the vibrations and thus the cabin noise. Therefore, the knowledge-based tool Fuselage Geometry Assembler (FUGA) is developed for the targeted enrichment of preliminary design data with knowledge for detailed numerical analyses. This paper describes the knowledge-based geometry and model generation in FUGA, which can consider the necessary (increasing) level of detail for the vibro-acoustic prediction already in the preliminary design. For this purpose, aircraft data sets in the preliminary design data format Common Parametric Aircraft Configuration Schema (CPACS) form the modeling basis. Originating from the aircraft preliminary design, these initially describe the outer shell of the vehicle and are extended by detailed structural information that defines the geometric boundary conditions for component placement in cabin design. For the cabin components, the open-source geometry kernel Open Cascade Technology (OCCT) is used to provide geometries at the level of detail required for subsequent analyses. The geometry models are then discretized in open source (e.g. Gmsh) or commercial meshers and further used for numerical analysis. Finally, the prediction of cabin noise is demonstrated as a Proof of Concept using the example of a short-haul propeller-driven aircraft and the feasibility of the proposed method is indicated by investigating the sensitivity of resulting simulation models to the fuselage skin thickness.

Knowledge-based machine learning for predicting and understanding the androgen receptor (AR)-mediated reproductive toxicity in zebrafish

Traditional methods for identifying endocrine-disrupting chemicals (EDCs) that activate androgen receptors (AR) are costly, time-consuming, and low-throughput. This study developed a knowledge-based deep neural network model (AR-DNN) to predict AR-mediated adverse outcomes on female zebrafish fertility. This model started with chemical fingerprints as the input layer and was implemented through a five-layer virtual AR-induced adverse outcome pathway (AOP). Results indicated that the AR-DNN effectively and accurately screens new reproductive toxicants (AUC = 0.94, accuracy = 0.85), providing potential toxicity pathways. Furthermore, 1477 and 2448 chemicals that could lead to infertility were identified in the plastic additives list (PLASTICMAP, n = 7112) and the Inventory of Existing Chemical Substances in China (IECSC, n = 17741), respectively. Colourants containing steroid-like structures are the major active plastic additives that might lower female zebrafish fertility through AR binding, DNA binding, and transcriptional activation. While active IECSC chemicals primarily have the same fragments, such as benzonitrile, nitrobenzene, and quinolone. The predicted toxicity pathways were consistent with existing fish evidence, demonstrating the model’s applicability. This knowledge-based approach offers a promising computational toxicology strategy for predicting and characterising the endocrine-disrupting effects and toxic mechanisms of organic chemicals, potentially leading to more efficient and cost-effective screening of EDCs.

Acupuncture indication knowledge bases: meridian entity recognition and classification based on ACUBERT.

In acupuncture diagnosis and treatment, non-quantitative clinical descriptions have limited the development of standardized treatment methods. This study explores the effectiveness and the reasons for discrepancies in the entity recognition and classification of meridians in acupuncture indication using the Acupuncture Bidirectional Encoder Representations from Transformers (ACUBERT) model. During the research process, we selected 54 593 different entities from 82 acupuncture medical books as the pretraining corpus for medical literature, conducting classification research on Chinese medical literature using the BERT model. Additionally, we employed the support vector machine and Random Forest models as comparative benchmarks and optimized them through parameter tuning, ultimately leading to the development of the ACUBERT model. The results show that the ACUBERT model outperforms other baseline models in classification effectiveness, achieving the best performance at Epoch = 5. The model's "precision," "recall," and F1 scores reached above 0.8. Moreover, our study has a unique feature: it trains the meridian differentiation model based on the eight principles of differentiation and zang-fu differentiation as foundational labels. It establishes an acupuncture-indication knowledge base (ACU-IKD) and ACUBERT model with traditional Chinese medicine characteristics. In summary, the ACUBERT model significantly enhances the classification effectiveness of meridian attribution in the acupuncture indication database and also demonstrates the classification advantages of deep learning methods based on BERT in multi-category, large-scale training sets. Database URL: http://acuai.njucm.edu.cn:8081/#/user/login?tenantUrl=default.

Explicit-implicit priori knowledge-based diffusion model for generative medical image segmentation

The diffusion probabilistic model (DPM) has achieved unparalleled results in current image generation tasks, and some recent research works employed it in several computer vision tasks, such as image super-resolution, object detection, etc. Thanks to DPM's superior ability to generate fine-grained details, these research efforts have yielded significant successes. In this paper, we propose a new DPM-based generative medical image segmentation method, named EIDiffuSeg. Specifically, we first construct an explicit-implicit aggregation priori knowledge with directional supervision ability by mining the semantic distribution pattern in the frequency and spatial domains. Then, the explicit-implicit aggregation priori knowledge is integrated into the different encoding stages of the denoising backbone network using a novel unsupervised priori knowledge induction strategy, which can guide the model to generate a segmentation mask of the region of interest directionally from a random inference process. We evaluate our method on three medical image segmentation benchmark datasets with different modalities and achieve the best segmentation results compared to state-of-the-art methods. Especially, compared to several current diffusion-based image segmentation methods, we achieved a 9% Dice improvement in the polyp segmentation benchmark. Our code will be available at https://github.com/Notmezhan/EIDiffuSeg.

In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.

Inclisiran, an siRNA targeting hepatic PCSK9 mRNA, administered twice-yearly (after initial and 3-month doses), substantially and sustainably reduced LDL-cholesterol (LDL-C) in Phase III trials. Whether lowering LDL-C with inclisiran translates into a reduced risk of major adverse cardiovascular events (MACE) is not yet established. In-silico trials applying a disease computational model to virtual patients receiving new treatments allow to emulate large scale long term clinical trials. The SIRIUS in-silico trial programme aims to predict the efficacy of inclisiran on CV events in individuals with established atherosclerotic cardiovascular disease (ASCVD). A knowledge-based mechanistic model of ASCVD was built, calibrated, and validated to conduct the SIRIUS programme (NCT05974345) aiming to predict the effect of inclisiran on CV outcomes.The SIRIUS Virtual Population included patients with established ASCVD (previous myocardial infarction (MI), previous ischemic stroke (IS), previous symptomatic lower limb peripheral arterial disease (PAD) defined as either intermittent claudication with ankle-brachial index <0.85, prior peripheral arterial revascularization procedure, or vascular amputation) and fasting LDL-C ≥ 70 mg/dL, despite stable (≥ 4 weeks) well-tolerated lipid lowering therapies.SIRIUS is an in-silico multi-arm trial programme. It follows an idealized crossover design where each virtual patient is its own control, comparing inclisiran to 1) placebo as adjunct to high-intensity statin therapy with or without ezetimibe, 2) ezetimibe as adjunct to high-intensity statin therapy, 3) evolocumab as adjunct to high-intensity statin therapy and ezetimibe.The co-primary efficacy outcomes are based on time to the first occurrence of any component of 3P-MACE (composite of CV death, nonfatal MI or nonfatal IS) and time to occurrence of CV death over 5 years. The SIRIUS in-silico trial programme will provide early insights regarding a potential effect of inclisiran on MACE in ASCVD patients, several years before the availability of the results from ongoing CV outcomes trials (ORION-4 and VICTORION-2-P).

ATC-SD Net: Radiotelephone Communications Speaker Diarization Network

This study addresses the challenges that high-noise environments and complex multi-speaker scenarios present in civil aviation radio communications. A novel radiotelephone communications speaker diffraction network is developed specifically for these circumstances. To improve the precision of the speaker diarization network, three core modules are designed: voice activity detection (VAD), end-to-end speaker separation for air–ground communication (EESS), and probabilistic knowledge-based text clustering (PKTC). First, the VAD module uses attention mechanisms to separate silence from irrelevant noise, resulting in pure dialogue commands. Subsequently, the EESS module distinguishes between controllers and pilots by levying voice print differences, resulting in effective speaker segmentation. Finally, the PKTC module addresses the issue of pilot voice print ambiguity using text clustering, introducing a novel flight prior knowledge-based text-related clustering model. To achieve robust speaker diarization in multi-pilot scenarios, this model uses prior knowledge-based graph construction, radar data-based graph correction, and probabilistic optimization. This study also includes the development of the specialized ATCSPEECH dataset, which demonstrates significant performance improvements over both the AMI and ATCO2 PROJECT datasets.

Evaluation of knowledge-based planning models for male pelvic CBCT-based online adaptive radiotherapy on conventional linear accelerators.

To assess the practicality of employing a commercial knowledge-based planning tool (RapidPlan) to generate adapted intact prostate and prostate bed volumetric modulated arc therapy (VMAT) plans on iterative cone-beam computed tomography (iCBCT) datasets. Intact prostate and prostate bed RapidPlan models were trained utilizing planning data from 50 and 44 clinical cases, respectively. To ensure that refined models were capable of producing adequate clinical plans with a single optimization, models were tested with 50 clinical planning CT datasets by comparing dose-volume histogram (DVH) and plan quality metric (PQM) values between clinical and RapidPlan-generated plans. The RapidPlan tool was then used to retrospectively generate adapted VMAT plans on daily iCBCT images for 20 intact prostate and 15 prostate bed cases. As before, DVH and PQM metrics were utilized to dosimetrically compare scheduled (iCBCT Verify) and adapted (iCBCT RapidPlan) plans. Timing data was collected to further evaluate the feasibility of integrating this approach within an online adaptive radiotherapy workflow. Model testing results confirmed the models were capable of producing VMAT plans within a single optimization that were overall improved upon or dosimetrically comparable to original clinical plans. Direct application of RapidPlan on iCBCT datasets produced satisfactory intact prostate and prostate bed plans with generally improved target volume coverage/conformality and rectal sparing relative to iCBCT Verify plans as indicated by DVH values, though bladder metrics were marginally increased on average. Average PQM values for iCBCT RapidPlans were significantly improved compared to iCBCT Verify plans. The average time required [in mm:ss] to generate adapted plans was 06:09±02:06 (intact) and 07:12±01:04 (bed). This study demonstrated the feasibility of leveraging RapidPlan to expeditiously generate adapted VMAT intact prostate and prostate bed plans on iCBCT datasets. In general, adapted plans were dosimetrically improved relative to scheduled plans, emphasizing the practicality of the proposed approach.

Clinical decision support systems in addiction and concurrent disorders: A systematic review and meta-analysis.

This review aims to synthesise the literature on the efficacy, evolution, and challenges of implementing Clincian Decision Support Systems (CDSS) in the realm of mental health, addiction, and concurrent disorders. Following PRISMA guidelines, a systematic review and meta-analysis were performed. Searches conducted in databases such as MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science through 25 May 2023, yielded 27,344 records. After necessary exclusions, 69 records were allocated for detailed synthesis. In the examination of patient outcomes with a focus on metrics such as therapeutic efficacy, patient satisfaction, and treatment acceptance, meta-analytic techniques were employed to synthesise data from randomised controlled trials. A total of 69 studies were included, revealing a shift from knowledge-based models pre-2017 to a rise in data-driven models post-2017. The majority of models were found to be in Stage 2 or 4 of maturity. The meta-analysis showed an effect size of -0.11 for addiction-related outcomes and a stronger effect size of -0.50 for patient satisfaction and acceptance of CDSS. The results indicate a shift from knowledge-based to data-driven CDSS approaches, aligned with advances in machine learning and big data. Although the immediate impact on addiction outcomes is modest, higher patient satisfaction suggests promise for wider CDSS use. Identified challenges include alert fatigue and opaque AI models. CDSS shows promise in mental health and addiction treatment but requires a nuanced approach for effective and ethical implementation. The results emphasise the need for continued research to ensure optimised and equitable use in healthcare settings.

CGNSDE: Conditional Gaussian neural stochastic differential equation for modeling complex systems and data assimilation

A new knowledge-based and machine learning hybrid modeling approach, called conditional Gaussian neural stochastic differential equation (CGNSDE), is developed to facilitate modeling complex dynamical systems and implementing analytic formulae of the associated data assimilation (DA). In contrast to the standard neural network predictive models, the CGNSDE is designed to effectively tackle both forward prediction tasks and inverse state estimation problems. The CGNSDE starts by exploiting a systematic causal inference via information theory to build a simple knowledge-based nonlinear model that nevertheless captures as much explainable physics as possible. Then, neural networks are supplemented to the knowledge-based model in a specific way, which not only characterizes the remaining features that are challenging to model with simple forms but also advances the use of analytic formulae to efficiently compute the nonlinear DA solution. These analytic formulae are used as an additional computationally affordable loss to train the neural networks that directly improve the DA accuracy. This DA loss function promotes the CGNSDE to capture the interactions between state variables and thus advances its modeling skills. With the DA loss, the CGNSDE is more capable of estimating extreme events and quantifying the associated uncertainty. Furthermore, crucial physical properties in many complex systems, such as the translate-invariant local dependence of state variables, can significantly simplify the neural network structures and facilitate the CGNSDE to be applied to high-dimensional systems. Numerical experiments based on chaotic systems with intermittency and strong non-Gaussian features indicate that the CGNSDE outperforms knowledge-based regression models, and the DA loss further enhances the modeling skills of the CGNSDE.

Quantifying the suitability and feasibility of predictive maintenance approaches

Predictive maintenance is a promising concept for maintenance optimization which requires reliable and accurate predictions of a system’s lifetime. Despite the many studies on this topic, selecting the best approach is still a topic of debate. In general, predictive maintenance approaches can be roughly classified as knowledge-based, data analytics and physics-based models. However, this classification does not provide maintainers clear guidance on how to select the most suitable approach for a specific case. This work, therefore, presents a selection method for this process. For that purpose, a list of selection criteria was established, and six predictive maintenance approaches were analysed. The proposed selection process is based on two main groups of criteria: the suitability criteria check the match with the desired ambition level of predictive maintenance, while the feasibility criteria identify whether this can be realized, given the labour, models and data available. Finally, three case studies are presented, demonstrating that the tool effectively guides to an optimal approach.