This study aims to develop a systematic research method consisting of subjective and objective measurement methods to determine the effectiveness of cosmetic textiles on human skin. For this purpose, first of all, the expected properties of the cosmetic textile product were considered and the methods to be used for testing these properties were determined, and finally, a research method was created. Leggings, a cosmetic textile product, was selected to validate the method and a 28-day wear trial was carried out with female subjects to observe the effects of the product on human skin. During the wear trial, the subjects were provided to wear leggings that were designed from different knitting structures and applied cosmetic microcapsules to ensure the optimal slimming, moisturizing, and anti-cellulite properties. Dermatological and anthropometric measurements were carried out at specified periods of the study and the obtained data were statistically analyzed. According to the results, it was determined that the cosmetic textile product developed is skin-friendly and helps to increase skin moisture. Additionally, it was observed to provide a slimming effect to the wearer after a period of regular usage, however, it was suggested as a supportive product for women only with early-stage cellulite. A survey was also conducted to evaluate the cosmetic textiles by using subjective user opinions. The output of the survey has shown a high rate of satisfaction with the comfort, visual and sensory properties of the cosmetic textile product. By introducing the research method developed, it will be possible to accurately determine the effectiveness of cosmetic textiles on human skin and to design, develop and produce new cosmetic textile products with high cosmetic efficacy.