Objective To investigate the short-term clinical efficacy of arthroscopic reconstruction of posterior cruciate ligament (PCL) via double posteromedial portals. Methods A retrospective case series study was performed on the clinical data of 29 patients with PCL injury from January 2013 to January 2018 admitted to Xuancheng People's Hospital of Anhui province. There were 15 males and 14 females, with an average age of 49.6 years (range, 27-61 years). There were 13 patients with left knee injury and 16 patients with right knee injury. The combined injuries included five patients with medial meniscus tear, seven patients with lateral meniscus tear, one patient with medial collateral ligament injury, and two patients with lateral medial collateral ligament injury. The average duration from injury to surgery was 14.1 days ( range, 5-97 days). All patients received arthroscopic PCL reconstruction surgery using double posteromedial portals. The operation time and intraoperative blood loss were recorded. The posterior drawer test, reverse Lachman test, posterior translation, and Lysholm knee score scale were used to evaluate knee function preoperatively and 6 months after operation. The complications were recorded. Results All patients were followed up for 6-22 months (mean, 12 months). The operation time was (63.3±9.5) minutes, and the intraoperative blood loss was (48.9±22.8)ml. The posterior drawer tests and reverse Lachman tests of all patients turned to be negative 6 months after surgery. Preoperatively, the posterior translation and Lysholm score were (11.2±3.3)mm and (42.7±12.2)points, respectively. At 6 months postoperatively, the posterior translation and Lysholm score were (2.2±0.5)mm and (86.3±9.0)points, respectively (P<0.05). No complication such as infection and neurovascular injury occured. Conclusion The technique of arthroscopic PCL reconstruction surgery using double posteromedial portals has the advantages of good knee joint stability, less tibial posterior translation, and fast function recovery with satisfactory short-term efficacy. Key words: Knee injuries; Arthroscopy; Posterior cruciate ligament; Reconstruction