It is highly desirable that surface coatings such as kitchen furniture coatings, hospital wall, furniture coatings and many other coatings used in public areas possess antibacterial properties. Although many antibacterial coatings have already been developed and are now commercially available for some time, effective antibacterial properties often require the addition of antibacterial agents in large amount which deteriorate the mechanical properties of the coatings and hence limit their wide-spread uses. Herein we show the fabrication of a robust and wear-resistant polyurethane-based coatings via addition of fluoro-containing quaternary ammonium compounds (QACF) modified silica nanoparticles. The nanoparticles are obtained from a classical Stöber process with a thin layer of thiol groups on the particle surface and the QACF is then further linked to particle surface through double bond and thiol group reaction. QACF and its modified silica nanoparticles both show high levels of antibacterial properties toward Gram positive and Gram negative bacteria. Addition of the nanoparticles in as less as 10 wt% in the formulation recipe would be enough to produce an antibacterial coating with excellent anti-wear resistance due to the self-migration of the modified silica nanoparticles to the surface layer of the coating. We have used XPS and confocal microscopy to show the particle migration to the top of the coatings enables us to clarify the mechanism. Compared to coatings with added pure antibacterial reagents, our coating shows enhanced anti-wear property at relatively low particle additions.