A detailed study of long-term variability of winds using 30 years of data from the European Centre for Medium-range Weather Forecasts global reanalysis (ERA-Interim) over the Indian Ocean has been carried out by partitioning the Indian Ocean into six zones based on local wind extrema. The trend of mean annual wind speed averaged over each zone shows a significant increase in the equatorial region, the Southern Ocean, and the southern part of the trade winds. This indicates that the Southern Ocean winds and the southeast trade winds are becoming stronger. However, the trend for the Bay of Bengal is negative, which might be caused by a weakening of the monsoon winds and northeast trade winds. Maximum interannual variability occurs in the Arabian Sea due to monsoon activity; a minimum is observed in the subtropical region because of the divergence of winds. Wind speed variations in all zones are weakly correlated with the Dipole Mode Index (DMI). However, the equatorial Indian Ocean, the southern part of the trade winds, and subtropical zones show a relatively strong positive correlation with the Southern Oscillation Index (SOI), indicating that the SOI has a zonal influence on wind speed in the Indian Ocean. Monsoon winds have a decreasing trend in the northern Indian Ocean, indicating monsoon weakening, and an increasing trend in the equatorial region because of enhancement of the westerlies. The negative trend observed during the non-monsoon period could be a result of weakening of the northeast trade winds over the past few decades. The mean flux of kinetic energy of wind (FKEW) reaches a minimum of about 100 W m−2 in the equatorial region and a maximum of about 1500 W m−2 in the Southern Ocean. The seasonal variability of FKEW is large, about 1600 W m−2, along the coast of Somalia in the northern Indian Ocean. The maximum monthly variability of the FKEW field averaged over each zone occurs during boreal summer. During the onset and withdrawal of monsoon, FKEW is as low as 50 W m−2. The Southern Ocean has a large variation of about 1280 W m−2 because of strong westerlies throughout the year.