Kinds Of Allergens Research Articles

The impact of hand eczema severity on quality of life in workers engaged in lock making: A cross-sectional study from tertiary care hospital

Objectives: Hand eczema is a frequent condition that dermatologists commonly encounter. It leads to considerable impact on quality of life (QOL) by significant functional impairment, disruption of work, and discomfort in the working population. The symptoms range from a minor discomfort to a serious debilitating and long-term conditions. Workers engaged in lock making constitute an economically poor section of society. They are exposed to different kinds of allergens, hence are predisposed to develop hand eczema. The aim of this study was to study the impact of hand eczema on the QOL in workers engaged in lock making. Materials and Methods: A total of 65 workers engaged in lock making and suffering from hand eczema, who visited the out-patient department of dermatology for 6 months, were included in this study. Data on QOL were obtained through a questionnaire devised by Finlay et al. Hand eczema severity index (HECSI) was used to assess the severity of disease. Associations were drawn regarding Dermatology Life Quality Index (DLQI) and HECSI scores with age, sex, duration of disease, number of episodes of illness, and number of sick leaves. Results: Sixty-five patients suffering from hand eczema and engaged in lock making participated in this study, of which 52 (80%) were male and 13 (20%) were female. The commonest age group affected was 36–40 years (41.53%). The most common morphological pattern seen was hyperkeratotic palmar eczema in 50.7% (n = 33) patients followed by chronic dry fissured eczema in 35.3% (n = 23). The mean HECSI score was 19.52 (Standard deviation [SD] = 9.416) and mean DLQI score was 9.92 (SD = 2.426). A significant association of DLQI was seen with duration of disease (P = 0.011), number of episodes of eczema (P = 0.003), and number of sick leaves taken (P = 0.005). Similarly, HECSI score showed significant association with duration of disease (P = 0.002) but not with number of episodes of eczema (P = 0.056). No significant association was found between hand eczema severity and QOL. Being a OPD-based study, it may not truly reflect the community data. Patch test could not be done as workers were poor and could not afford it. Conclusion: Lock makers with hand eczema showed considerable impairment of their QOL. Further, they are more prone to absenteeism from work.

Health Disparities in Communities of Color During the COVID-19 Pandemic.

Health Disparities in Communities of Color During the COVID-19 Pandemic.

Health Disparities in Communities of Color During the COVID-19 Pandemic

[ ]of this panel discussion only 12 states were collecting data on race Part of it is lack of trust of health professionals based upon infringements in the past, and I think another part of it, (which it has not given enough attention to in my opinion), is the health-seeking behavior and risk-taking behavior in some minority subgroups of the population as it relates to their knowledge base about the importance of adopting certain habits and avoiding certain risks [ ]to that extent, we already have data collected extensively on African-American communities corroborating the notion that vitamin D levels are indeed low in the majority of that population, but it does not mean by extrapolation that the prevalence of COVID-19 is higher for that reason or that the morbidity and mortality is higher for that reason, but is certainly, if that turns out to be the case, it is something that can easily be remedied by taking adequate doses of supplemental vitamin D and spending adequate time outside getting abundant sunlight for a limited period of time Both children and adults with Cystic fibrosis seem to be protected [ ]there is an interesting immunologic question here

Analysis of serum inhaled allergens in children with adenoid hypertrophy in Yantai area

Objective:The results of the detection of the serum inhalant allergen in children with adenoid hypertrophy in Yantai were analyzed, and the common inhalant allergens and their distribution in the children with adenoid hypertrophy were found. Method:Serum inhaled allergen specific IgE（sIgE） was measured in 590 cases of adenoid hypertrophy from Nov 2017 to Oct 2018 by Symer allergen detection system, and stratified according to sex, age and visiting season. The distribution of inhaled allergens in serum of children with adenoid hypertrophy was described. Result:The positive rate of serum inhaled allergens in children with adenoid hypertrophy in Yantai area was 34.07%. Among them the most common inhaled allergens were dust mite（19.66%）, dust mite（18.98%） and the mixed mold（17.97%）. The positive degree of allergen in children with adenoid hypertrophy was mild（93 cases）, moderate（88 cases）, and severe（20 cases）. 76 cases were positive for single allergens, 79 cases were positive for 2 allergens, and 56 cases were positive for three or more allergens. Stratified study showed that there was no significant difference in the positive rate of inhaled allergens between male and female children（P>0.05）, but the positive rate of mixed mold and animal dandruff allergens in male children was higher than that in female children（P<0.05）. There was no significant difference in the positive rate of inhaled allergens between pre-school and school-age children（P>0.05）, and there was no significant difference in the positive rate of inhaled allergens in different seasons（P>0.05）. Conclusion:Dust mite, dust mite and mildew mixture were the most common inhaled allergens in children with adenoid hypertrophy in Yantai area. The positive degree of serum allergens in children with adenoid hypertrophy was mild to moderate, and most of the children were allergic to two kinds of allergens. Male children were more susceptible to mold mixing and animal dandruff. There was no significant difference in age and seasonal distribution of common inhaled allergens.

The analysis of serum allergen spectrum in 0－12 years old children with allergic diseases in Liaoning Province

Objective:To explore the distribution and characteristics of allergens in children aged 0－12 years old in liaoning province. Method:46 620 children with suspected allergic diseases were grouped according to age, sex and detection time. Then allergen detections were conducted. The distribution of allergen in different groups was analyzed. Result:Most children were sensitized to single allergen, followed by a double positive. 98.08% children showed sensitivities to up to five kinds of allergen. The allergen spectrum of patients in different age groups was slightly different. With the increase of age, the rate, degree and number of allergen positive are generally on the rise. The positive rate and degree of each allergen were statistically significant in different age groups, seasons and genders, but not the trend and degree of variation. The onset time in this region is relatively concentrated in July to September, and the incidence of allergen in summer and autumn is higher than that in winter and spring. Conclusion:In Liaoning Province, household dust mites, animal dander, egg white, milk are the main allergens in patients with allergic disease, and the onset time is relatively concentrated in summer and autumn. Clear the main allergens, the region characteristic and changing trend is conducive to the treatment of allergic disease take effective and preventive measures.

The analysis of the allergic rhinitis and chronic rhinosinusitis with nasal polyps

Objective:To study the influence of allergen,sIgE,total IgE in allergic rhinitis and chronic rhniosinusitis with nasal polyps.Method:Fifty patients with allergic rhinitis and fifty patients with both allergic rhinitis and nasal polyp were involved in this study.Average dense of sIgE and total IgE in serum were dectected. Result:The kinds of allergens between the two groups were siginificantly diffierent;there was no siginificantly diffierence on sIgE average dense(P>0.05);total IgE dense was higher in allergic rhinitis and chronic rhniosinusitis with nasal polyps patients(P>0.05).Conclusion:AR with nasal polyps in patients was high proportion of food allergies and allergic reactions strength was high than the AR.

Effect on quality of life of the mixed house dust mite/weed pollen extract immunotherapy.

BackgroundAlthough many patients with allergic rhinitis have symptoms due to sensitization to more than one kind of allergens, and mixed allergen extracts are widely used for immunotherapy, there are few published trials.ObjectiveOur study aimed to evaluate the effect of multiple-allergen immunotherapy on improving the symptoms and quality of life of allergic rhinitis patients.MethodsWe performed a 1-year single-center observation study of subcutaneous immunotherapy using house dust mite extract (n = 12), weed pollen extract (n = 21), or mixed house dust mite/weed pollen extract (n = 11) in 44 allergic rhinitis patients. All the allergens responsible for the symptom of each patient were included in his immunotherapy. Symptom score, medication score, and quality of life of the patients were evaluated before and after 1-year immunotherapy. Quality of life was evaluated with the Rhinoconjunctivitis Quality of Life Questionnaire.ResultsIn all 3 groups receiving subcutaneous immunotherapy, significant improvement of symptom score, medication score, and quality of life was found vs. baseline at 1 year, irrespective of the allergen used. In the weed pollen season, the changes of quality of life questionnaire score after 1-year treatment were not significantly different between the weed pollen group (1.55 ± 1.24) and the mixed house dust mite/weed pollen group (1.14 ± 1.01). The same happened in the nonpollen seasons, during which dust mite immunotherapy (1.23 ± 1.63) and mixed immunotherapy (0.60 ± 0.47) did not show significantly different effect on the quality of life.ConclusionThe multiple-allergen immunotherapy might be effective in polysensitized allergic rhinitis patients, and could improve their quality of life. Our result did not show significant difference between the effects of multiple-allergen immunotherapy and mono-allergen immunotherapy.

Clinical significance of immune mechanisms in food allergy

The immune mechanisms of food allergy relate to allergen and immunologic response.Different kind of allergens and different immunologic response will impact on the clinical features, diagnoses and management of food allergy.It is benefiting for clinical practice to insight the immune mechanisms of food allergy. Key words: Food allergy; Immune mechanism; Diagnosis; Treatment

Analysis of German cockroach (Blattella germanica) expressed sequence tags

Cockroaches are known to act not only as vectors for parasites and pathogenic microorganisms but also as intermediate hosts for parasite development and allergens. It is necessary to understand genomic information to obtain ecological knowledge of the cockroach as well as to more effectively engineer genetic cockroach control, in addition to developing allergy medications and analyzing the allergen. We constructed a cDNA library of German cockroach Blattella germanica (Orthoptera: Blattellidae) and generated 5,466 clones expressed by EST sequences analysis. A total of 3,937 sequences were identified by a BLAST search against the NCBI nr database under an E-value of <1e−5 using BLASTX programs. The database of Clusters of Orthologous Groups of proteins was used to attempt a functional study with an E-value of <1e−10, which resulted in 2,833 significant sequence matches. We identified several kinds of allergens, proteases, serine proteases, serine protease inhibitors, stress-related proteins, immune response-related proteins, and a variety of other genes. This genomic data can provide essential information about cockroaches, including data on metamorphosis, metabolism, and intracellular signaling. This genomic information of the German cockroach can also supply knowledge for cockroach control and allergen analysis as well as genome comparison among similar species.

Distribution characteristics and clinical significance of specific immunoglobulin E in asthmatic and allergic rhinitis children with multiple sensitization factors

Objective To evaluate the distribution characteristics of the positive ratio of serum allergen speci-fic IgE(sIgE) in asthmatic and allergic rhinitis children with multiple sensitization factors, which may be beneficial for recommendations on the avoidance of allergen and assessment of atopic disease. Methods A total of 128 children with asthma and allergic rhinitis were enrolled(93 male, 35 female, aged from 1.5 to 16.1 years old, and the average age was 7 years and 8 months). All of the patients were presented as positive allergic screening test results for 2 or more kinds of allergen when evaluated.Eighty-seven patients were diagnosed as asthma combined with allergic rhinitis, while 38 cases with allergic rhinitis and 3 cases with asthma.The serum sIgE levels to 29 kinds of inhalant allergens and food allergens for each patients were detected by the UniCAP250 quantified IgE measurement system. Results The positive ra-tios of each inhalant allergen for all the patients were as follows: 67% for House dust, 61% for Dermatophagoides pteronyssinus, 59% for Dermatophagoides farinae, 50% for Alternaria alternata, 42% for Blomia tropicalis, 29% for Cat dander, 23% for Dog dander, 11% for Cockroach, 32% for Artemisia vulgaris, 29% for Humulus scandens, 28% for White ash, 26% for Ambrosia elatior, 24% for Willow, 24% for Mountain juniper, 24% for London plane, 24% for Humulus scandens, 22% for Chenopodium album and 20% for Common silver birch; the positive ratios of each food allergen were as follows: 25% for Milk, 25% for Egg white, 7% for Shrimp, 6% for Crab, 6% for Egg yolk, 4% for Chicken, 2% for Fish, 31% for Wheat, 20% for Peanut, 17% for Soybean, 27% for Peach and 21% for Tomato.Sixty-five patients with positive results to food allergens were divided into food allergen sensitization group while the other 53 patients for food allergen non-sensitization group.The positive ratios of different inhalant allergens such as Dog dander, Alternaria alternate, Common silver birch, Mountain juniper, London plane, Willow, White ash, Ambrosia elatior, Artemisia vulgaris, Chenopodium album, Humulus scandens of children in the food allergen sensitization group were 35.4%, 60.0%, 39.7%, 41.5%, 43.1%, 43.1%, 46.2%, 43.1%, 55.4%, 40.0%, 44.6%, which were higher than those in the food allergen non-sensitization group(11.1%, 39.7%, 1.6%, 6.3%, 4.8%, 4.8%, 9.5%, 7.9%, 7.9%, 3.2%, 3.2%, respectively, all P<0.05). The positive ratios of Dermatophagoides pteronyssinus, Dermatophagoides farinae and House dust in the food allergen non-sensitization group were 69.8%, 69.8%, 76.2%, respectively, which were higher than those in the food allergen sensitization group (52.3%, 49.2%, 58.5%, respectively, all P<0.05). Eighty-two point eight percent of the children with asthma combined with allergic rhinitis and 73.7% of the children with allergic rhinitis were sensitive to 3 or more kinds of inhalant allergens. Conclusions Inhalant allergens such as house dust, mites and molds were the main sensitization allergen for asthmatic and allergic rhinitis children with multiple sensitization factors.The asthmatic and allergic rhinitis children with food allergens sensitization often presented sensitive to animal dander, molds and outdoor inhalant allergens, while those without food allergens sensitization were more commonly sensitive to indoor allergens. Key words: Asthma; Allergic rhinitis; Specific immunoglobulin E; Allergen

Anstrengungsinduzierte Anaphylaxie

Exercise-induced anaphylaxis is a mast cell dependent reaction, which is induced by allergen exposure in combination with physical activity. Typically, the reaction occurs within 2 hours after allergen exposure followed by physical activity. Not only food allergens but all kinds of allergens including drugs can induce this form of anaphylaxis. The clinical symptoms of exercise-induced anaphylaxis are the same as in any other type of anaphylaxis. Thus not only the skin and mucosa but also other organ systems like the lungs, cardiovascular system and gastrointestinal tract can be affected. The diagnostic work up should cover a detailed clinical history including the assessment of symptoms and possible trigger factors including suspected allergens. Besides classical allergy diagnostics like skin prick tests and specific IgE determination, tryptase should be measured for the differential diagnosis to exclude mast cell dependent diseases. The diagnosis of exercise-induced anaphylaxis is made by the means of a double-blind placebo-controlled provocation test. Both, a sufficient amount of allergen and of physical activity must be achieved for a valid test. After the diagnosis is made, patients should be extensively counseled and provided with an emergency kit including an epinephrine auto injector.

THE FIRST BULGARIAN STANDARDIZED SERIES FOR EPICUTANEOUS PATCH TESTING FOR ALLERGIES TO DENTAL MATERIALS AND ALLOYS

SUMMARY The teeth and teeth rows restoration in the maxillofacial area is the last stage of the ongoing patient treatment and a basic purpose for the dental doctors. For this purpose a different set of modern and classic contemporary dental materials is used. The choice of each material during the treatment of every patient with proven allergy to different kind of allergens is very specific and strictly individual. In the everyday oral diagnostics a standardized set of allergens for diagnostics is used for proving the allergy to dental materials. The set has been developed on the base of all existing and permitted by the Bulgarian authorities dental materials, as well as professional series. The difference between the developed and standardized allergens for diagnostics used in our country and the existing ready-for-use series is that the first are made of the final product (material) in the form introduced to the oral cavity and persisting there for a different period of time, sometimes for tenths of years. This enables the possibility for early or late contact allergic reactions with symptoms in the oral cavity and on the skin, maxillofacial area, head and neck, as well as the entire organism. The current article introduces the readers to the results obtained by the realization of the research project No.28/2011 “Research on the type of sensibilisation to contemporary dental materials and development of set of allergens for its diagnosing through epicutaneous patch testing” funded by the Committee of Medical science of MU Sofia (CMC). Through the project became possible the creation and the initial research of the first Bulgarian series for epicutaneous testing whose aim is to prove the allergenic potential of the most frequently used by the dental doctors dental materials.

1P1-V08 アレルゲンタンパク質定量チップのためのELISA法を用いた試薬供給部の開発(ナノ・マイクロ流体システム)

We report that the regent supply system using the ELISA method for the allergen detection chip. For the medical treatment regarding an allergy disease, it is important to detect and eliminate causative allergens from several hundred kind of allergen. The final goal of our research is to develop the allergy detection device that enables us to detect causative allergens from a few drops of human's blood. The prototype of the allergy detection chip has been developed. As the next step, the regent supply system using the ELISA method was proposed. The design of the micro channel that is able to supply 5 kinds of the reagent properly was verified. The experimental results showed its effectiveness.

Is there any correlation between allergy and adenotonsillar tissue hypertrophy?

ObjectivesTonsil and adenoid are part of waldeyers ring;the basic function of which are antibody formation,which later react against a grat variety of antigens,The Adenotonsillectomy is the most common operation in small children but the exact reasons of adenotonsillar hypertrophy remains unknown,some researches have shown that allergy may be at risk factor for adenotonsillar hypertrophy. MethodsThorough one year two separated groups of children at the ENT and allergy ward of childrens hospital was enrolled in the study.The study group consisted of 117 children between 1 and 14 years old(with average of 6) who had adenotonsillar hypertrophy.The control group consisted of 100 children in the similar age that had not adenotonsillar hypertrophy.both groups were examined for the incidence of allergic disease,results of skin prick test, serum IgE levels and close contact to smoke. ResultsIn the study group .70.3% of children with adenotonsillar hypertrophy had positive skin prick test.But only 10% of children in control group had positive skin prick test.Increased serum total IgE level was confirmed in 48% of children with positive skin prick test in study group were in close contact with smoker parents. ConclusionAllergy and sensitivity to different kinds of allergens are important risk factors for adenotonsillar hypertrophy in children.Allergy control may have role in reducing the rate of adenotonsillectomy in children suffering allergic reactions with adenotonsillar hypertrophy.

Detection of serum allergen specific IgE in the child with recurrent auergic purpura

Objective To investigate the role of allergen specific IgE in the child with recurrent auergic purpura,and to detect the relation between all kinds of allergen and the disease.Methods The serum specific IgE of allergen detected by ELISA in 100 cases of the child with recurrent auergic purpura.Results 81 cases of serum allergen-specific IgE were over than 50ku/L(81%).52 cases(52%)were positive reaction to more than two kinds of allergens and 29 cases(29%)were positive reaction to one kind of allergen.Several familiar aeroallergen mixed molds (19/100),dermatophagoides(12/100)and mugwort pollens(9/100).The most familiar food fish(28/100).shrimpand crab(22/100),milk(18/100).protein(11/100).Conclusion It suggests that aeroallergens,fish,shrimp and crab play an important role in the pathogenesis of repeating child anaphy lactic purpura.Mixed molds and protein foods are important pathogens to the disease.To detect the serum specific IgE could help screen allergens,and have important role to prevent disease. Key words: Purpura; allergic; Immunoglobulin E; Allergens

Oral Administration of Heat-Killed Lactobacillus brevis SBC8803 Ameliorates the Development of Dermatitis and Inhibits Immunoglobulin E Production in Atopic Dermatitis Model NC/Nga Mice

We have previously shown that the oral administration of heat-killed Lactobacillus brevis (L. brevis) SBC8803 strain inhibits IgE production in ovalbumin (OVA)-sensitized BALB/c mice through improvement of the type-1 helper T (Th1)/Th2 balance toward Th1 dominance. Atopic dermatitis is one of the most common skin diseases and is frequently associated with elevated immunoglobulin E (IgE) antibodies against many kinds of allergens. In this study, we investigated the inhibitory effect of oral administration of L. brevis SBC8803 on the development of dermatitis and IgE elevation using the NC/Nga atopic dermatitis model mice. Male 8-week-old NC/Nga mice were sensitized by the topical application of picryl chloride to foot pads and shaved abdomen. These mice were boosted with picryl chloride by topical application onto the ears once a week for 9 weeks. The mice (n=10 per group) were fed a diet containing 0%, 0.05% or 0.5% of heat-killed L. brevis SBC8803 from 2 weeks before the first sensitization to the end of the study. Total IgE concentration in serum, clinical score, and ear thickness were periodically examined throughout the study. Finally, cytokine (interleukin (IL)-4, IL-5, IL-6, IL-10, IL-12, IFN-gamma and transforming growth factor (TGF)-beta) productions from splenocytes and Peyer's patch (PP) cells of mice were measured. Oral administration of L. brevis SBC8803 significantly inhibited IgE production and ear swelling, and suppressed the development of dermatitis in a dose-dependent manner. Immunosuppressive cytokines such as IL-10 and TGF-beta production from PP cells significantly increased in the 0.5% group compared to the control group although Th1-type and Th2-type cytokines production was not affected.

The Effects of Breast-milk Feeding on Severe Atopic Dermatitis In Korean Infant and Toddler

RATIONALE: This study is designed to evaluate the effect of breast-milk feeding among the severe atopic dermatitis having multiple food allergen sensitization in Korean children. METHODS: This study subjects were recruited from the Pediatric Allergy Clinic at Inha University hospital from April 2005 to March 2006. The subjects above 56 SCORAD score and under 24 months old were selected. Parents or guardians were interviewed. The specific IgE test(MAST) for 20 foods was done. The MAST above 2 class is thought to be positive sensitization. RESULTS: The number of subjects is 24 (18 boy, 6 girl). The mean age is 11 months old(4-20 months). The patients who ate breast-milk till 4 months after birth are 19 (79.2%), who till 2 weeks are 2 (8.3%), and who never breast-milk are 3 (12.5%). The patients with frequent wheezing are 11 (45.8%). The average of positive MAST allergens are 7.5 kinds of allergens(3-19 allergens). The all patients are positive for egg white and 22 patients (91.7%) for milk. Parents allergy history shows 8 allergic rhinitis, 1 asthma, 1 allergic rhinitis and asthma, 3 atopic dermatitis, 1 food allergy, and 10 nothing of allergic disorders. CONCLUSIONS: In this study, breast-milk feeding till 4 months after birth did not give the prevention effects on the patients of severe atopic dermatitis under 24 months old from atopic or non atopic parents. The research to identify the certain antibodies or allergens from breast-milk to develop and aggravate the atopic dermatitis is needed.

The allergen analysis and nursing of abnormal rhinitis

目的 了解深圳地区变应性鼻炎的常见变应原.方法对855例疑似变应性鼻炎的患者进行皮肤点刺试验,测定致敏变应原.结果 855例疑似变应性鼻炎患者中578例(67.6%)有阳性反应,单一变应原阳性51例,2种以上变应原阳性527例.以吸入性变应原为主,其中65例有哮喘病史.578例阳性病例中屋尘螨阳性率最高,为520例(90%),其次是粉尘螨488例(84.4%).结论应针对深圳地区变应性鼻炎的常见变应原(屋尘螨、粉尘螨),做好变应原检测工作,提高检测准确率。

Specific IgE estimations by RAST in Japanese asthmatics compared with skin, passive transfer and bronchial provocation tests

198 asthmatics and twenty healthy persons were studied by RAST and in vivo tests with four common inhalant allergens. (a) Higher RAST classes were elicited with mite (Dermatophagoides farinae) extract and lower classes with other allergens. The agreement between positive RAST and skin or P-K tests was highest with the mite extract. RAST sensitivity was dependent on the kinds of allergens and was most sensitive to mite extract. Positive RAST was most closely related to the prick test reactions. (b) RASTs to house dust and mite extract were examined in terms of the threshold dosage of house dust and also the types of bronchial response (early, dual and late) induced by a certain amount of house dust; higher RAST classes were found in subjects with bronchial response to the dual or early type, elicited by a threshold dosage of diluted extract, while lower RAST classes were found in cases of the late-type response elicited by the threshold dosage of concentrated extract. (c) Changes in IgE antibodies to house dust and mite extract were estimated in patients with positive house dust provocation. A greater increase occurred in cases of dual or early response, a smaller increase in those with a late response. Despite discordances in skin tests and RAST between house dust and mite extracts, the increases in IgE antibodies to mite extracts as well as house dust were observed in all cases, presumably caused by an allergenic identity between the allergens.

STUDIES OF LATE CUTANEOUS ALLERGIC RESPONSES

In order to clarify the induction mechanism of the late cutaneous allergic respose (LCAR), the following were studied : 1) intracutaneous test with various kinds of allergens, 2) reversed type allergic resposes using anti-human IgE rabbit serum (aIgE), 3) P-K tests with several antigen-anti-body systems. Histopathological study of skin sites showing positive LCAR was performed. The following results were obtained : 1) The frequency of LCAR varied with the kind of allergen used. The type of LCAR (isolated or dual type ; immediate and late) depended on the kind of allergen.2) Intracutaneous injection of aIgE also induced LCAR. There was no significant difference in the frequency of the response asthmatic patients and healthy volunteers.3) LCAR was often detected 4-8hours after the immediate reaction in P-K tests. However, in some cases LCAR was observed in negative P-K tests.4) Histological findings of LCAR showed edema in dermis, swollen collagen fibers and invasion of lymphcytes and polymorphnuclear leucocytes around blood vessels.5) No correlation between the frequency of LCAR and IgE levels in the blood of the asthmatic patients was observed.