Neural networks (NNs) with large scales of artificial neurons are increasingly used in recognition and classification tasks. In power-constrained scenarios, the tradeoff between performance and hardware consumptions must be carefully evaluated before silicon tape-out. In this paper, we proposed a systematic approach to design ultra-low power NN system. This work is motivated by the facts that NNs are resilient to approximation in many of the computations and NNs are outputting statistical tensors which are acceptable to less-than-perfect results. We resort to the front-back end approach with a twofold aim: (1) a fast and accurate design approach is proposed by estimating the computing quality of low-power approximate adder arrays, and it is adopted to evaluate the neural network system; (2) a quality configurable engine with different approximation degrees while processing NNs is implemented. The proposed work is demonstrated with a comprehensive keyword spotting (KWS) system as an ultra-low power NN engine. The experimental environment is setup with ten keywords from the google speech command dataset (GSCD) using an industrial 22-nm ultra-low-leakage (ULL) process. Comparing to the state-of-the-art KWS processors, the proposed approximate NN engine can demonstrate over 60% improvement in power efficiency and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1.1\times $ </tex-math></inline-formula> area efficiency while achieving similar recognition accuracy.