Key Determinant Research Articles

Socioeconomic and ethnic disparities in preterm births in an English maternity setting: a population-based study of 1.3 million births

BackgroundPreterm birth is a major cause of infant mortality and morbidity and accounts for 7–8% of births in the UK. It is more common in women from socially deprived areas and from minority ethnic groups, but the reasons for this disparity are poorly understood. To inform interventions to improve child survival and their quality of life, this study examined the socioeconomic and ethnic inequalities in preterm births (< 37 weeks of gestation at birth) within Health Trusts in England.MethodsThis study investigated socioeconomic and ethnic inequalities in preterm birth rates across the National Health Service (NHS) in England. The NHS in England can be split into different units known as Trusts. We visualised between-Trust differences in preterm birth rates. Health Trusts were classified into five groups based on their standard deviation (SD) variation from the average national preterm birth rate. We used modified Poisson regression to compute risk ratios (RR) and 95% confidence intervals (95% CI) with generalised estimating equations.ResultsThe preterm birth rate ranged from 6.8/100 births for women living in the least deprived areas to 8.8/100 births for those living in the most deprived areas. Similarly, the preterm birth rate ranged from 7.8/100 births for white women, up to 8.6/100 births for black women. Some Health Trusts had lower than average preterm birth rates in white women whilst concurrently having higher than average preterm birth rates in black and Asian women. The risk of preterm birth was higher for women living in the most deprived areas and ethnicity (Asian).ConclusionsThere was evidence of variation in rates of preterm birth by ethnic group, with some Trusts reporting below average rates in white ethnic groups whilst concurrently reporting well above average rates for women from Asian or black ethnic groups. The risk of preterm birth varied substantially at the intersectionality of maternal ethnicity and the level of socioeconomic deprivation of their residency. In the absence of other explanations, these findings suggest that even within the same Health Trust, maternity care may vary depending on the women’s ethnicity and/or whether she lives in an area of high socioeconomic deprivation. Thus, social factors are likely key determinants of inequality in preterm birth rather than provision of maternity care alone.

A Survey on the Effect of the Chemical Composition on the Thermal, Physical, Mechanical, and Dynamic Mechanical Thermal Analysis of Three Brazilian Wood Species.

Wood is a versatile material extensively utilized across industries due to its low density, favorable mechanical properties, and environmental benefits. However, despite considerable research, the diversity in species with varying compositions and properties remains insufficiently explored, particularly for native woods. A deeper understanding of these differences is crucial for optimizing their industrial applications. This study investigated the composition, tensile strength, flexural strength, Young's modulus, bending stiffness and elongation at break, thermal behavior, and viscoelastic properties of three Brazilian native wood species: Araucaria angustifolia (ARA), Dipterix odorata (DOD), and Tabeuia ochracea (TOC). The density of these woods showed a linear correlation with mechanical properties such as Young's modulus (0.9) and flexural modulus (0.9). The research revealed a linear correlation between the woods' density and mechanical properties, with lignin content emerging as a key determinant of thermal stability. This study highlights the importance of understanding wood species' composition and physical properties, and provides valuable insights into their behavior.

Effect of geopolitical risk on energy consumption policy: New empirical evidence from BRICS

This study investigates the impact of geopolitical risk (GPR) on energy consumption. For empirical analysis, we utilize the dataset of BRICS nations spanning 25 years from 1998 to 2022. We employ three econometric models, namely fully modified ordinary least squares (FMOLS), dynamic ordinary least squares (DOLS), and autoregressive distributed lag (ARDL), to analyze the relationships between GPR and energy consumption. Our empirical findings reveal several significant insights. Firstly, we observe a substantial negative influence of GPR on both fossil fuel energy consumption (FEC) and total energy consumption (TEC). This suggests that higher levels of GPR are associated with reduced utilization of fossil fuels and overall energy consumption within the BRICS countries. Conversely, we identify a significant positive effect of GPR on renewable energy consumption (REC). This implies that, as GPR rises, there is a corresponding increase in the adoption and usage of renewable energy sources. Furthermore, our analysis uncovers the presence of asymmetric effects pertaining to other key determinants of energy consumption, including FDI inflow, economic growth, banking sector development, and inflation rate. This study offers fresh empirical evidence on the intricate interplay between GPR and energy consumption in BRICS nations, shedding light on the significant impacts of GPR and the nuanced effects of various economic factors. These findings have important implications for policymakers and stakeholders seeking to navigate energy policy decisions in a geopolitically dynamic world.

Soil management practice and smallholder agricultural productivity in Nigeria

This study investigates how various soil management practices can enhance soil fertility and pest control, ultimately increasing crop yields among farming households in Nigeria. Utilizing descriptive statistics, logit regression and propensity score matching on data from the 2019 Living Standard Measurement Study, the findings reveal that households using herbicides experience higher agricultural productivity. The use of pesticides and certified crops also positively influences productivity. Key determinants of soil technology access include cooperative membership and the age of household heads, both of which significantly affect access to herbicides, pesticides, organic fertilizers, and certified crops. Education plays a vital role, positively impacting the use of organic and inorganic fertilizers as well as certified crops. Additionally, larger farm sizes correlate with better access to these resources. Conversely, the gender of the household head negatively affects access to certified crops. The study emphasizes the importance of capacity building and knowledge transfer to encourage the adoption of effective soil technology practices among farmers, thereby enhancing agricultural productivity and addressing food security issues.

HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice

With age, metabolic perturbations accumulate to elevate our obesity burden. While age-onset obesity is mostly driven by a sedentary lifestyle and high calorie intake, genetic and epigenetic factors also play a role. Among these, members of the large histone deacetylase (HDAC) family are of particular importance as key metabolic determinants for healthy ageing, or metabolic dysfunction. Here, we aimed to interrogate the role of class 2 family member HDAC5 in controlling systemic metabolism and age-related obesity under non-obesogenic conditions. Starting at 6 months of age, we observed adult-onset obesity in chow-fed male global HDAC5-KO mice, that was accompanied by marked reductions in adrenergic-stimulated ATP-consuming futile cycles, including BAT activity and UCP1 levels, WAT-lipolysis, skeletal muscle, WAT and liver futile creatine and calcium cycles, and ultimately energy expenditure. Female mice did not differ between genotypes. The lower peripheral sympathetic nervous system (SNS) activity in mature male KO mice was linked to higher dopaminergic neuronal activity within the dorsomedial arcuate nucleus (dmARC) and elevated hypothalamic dopamine levels. Mechanistically, we reveal that hypothalamic HDAC5 acts as co-repressor of STAT5b over the control of Tyrosine hydroxylase (TH) gene transactivation, which ultimately orchestrates the activity of dmARH dopaminergic neurons and energy metabolism in male mice under non-obesogenic conditions.

Anthocyanin Accumulation in Grape Berry Skin Promoted by Endophytic Microbacterium sp. che218 Isolated from Wine Grape Shoot Xylem.

Grape berry skin coloration is a key determinant of the commercial value of red wines. Global warming caused by climate change has inhibited anthocyanin biosynthesis in berry skins, leading to poor coloration. Through two-year field experiments, the endophyte che218 isolated from grape shoot xylem promoted anthocyanin accumulation in berry skins. The che218 enhanced anthocyanin biosynthesis in grapevine cultured cells. In the 2022 growing season, applying che218 to grape bunches enhanced anthocyanin accumulation in berry skins on day 20 post-treatment. However, the anthocyanin accumulation enhancing effect of che218 became negligible at harvest. In the 2023 growing season, che218 enhanced anthocyanin accumulation in berry skins on day 15 post-treatment and at harvest (day 30 post-treatment) and also upregulated the transcription of mybA1 and UFGT, two genes that regulate anthocyanin biosynthesis in berry skins. Whole genome sequencing demonstrated that che218 is an unidentified Microbacterium species. However, it remains unknown how che218 is involved in the biosynthesis of anthocyanin in berry skins. This study provides insights into the development of an eco-friendly endophyte-mediated technique for improving grape berry skin coloration, thereby mitigating the effects of global warming on berry skin coloration.

Determinants of household livelihood diversification in the uplands: The case of cassava production areas in central highlands of Vietnam

ABSTRACT The livelihoods of upland communities in Vietnam are rapidly transforming due to socio-economic and environmental changes. As a result, livelihood diversification has emerged as an adaptive strategy to these pressures, while agricultural commercialization demands greater production specialization. This study explored livelihood and crop diversification in the central highlands using survey data from 364 households and 22 in-depth interviews. The Simpson Diversity Index and Herfindahl-Hirschman Indexe were used to measure diversification levels, and regression analysis identified key determinants. Findings revealed moderate-low livelihood diversification toward non-farm activities and moderate-high crop diversification, with a trend toward industrial cassava specialization. Household-head age, education, perception of climate risks, and transportation accessibility were key factors influencing livelihood diversification. The study recommends policies to enhance young laborers’ capacity in agriculture and promote the development of non-farm livelihood activities, leveraging local resources for sustainable upland development.

Multiple distinct evolutionary mechanisms govern the dynamics of selfish mitochondrial genomes in Caenorhabditis elegans

Cells possess multiple mitochondrial DNA (mtDNA) copies, which undergo semi-autonomous replication and stochastic inheritance. This enables mutant mtDNA variants to arise and selfishly compete with cooperative (wildtype) mtDNA. Selfish mitochondrial genomes are subject to selection at different levels: they compete against wildtype mtDNA directly within hosts and indirectly through organism-level selection. However, determining the relative contributions of selection at different levels has proven challenging. We overcome this challenge by combining mathematical modeling with experiments designed to isolate the levels of selection. Applying this approach to many selfish mitochondrial genotypes in Caenorhabditis elegans reveals an unexpected diversity of evolutionary mechanisms. Some mutant genomes persist at high frequency for many generations, despite a host fitness cost, by aggressively outcompeting cooperative genomes within hosts. Conversely, some mutant genomes persist by evading inter-organismal selection. Strikingly, the mutant genomes vary dramatically in their susceptibility to genetic drift. Although different mechanisms can cause high frequency of selfish mtDNA, we show how they give rise to characteristically different distributions of mutant frequency among individuals. Given that heteroplasmic frequency represents a key determinant of phenotypic severity, this work outlines an evolutionary theoretic framework for predicting the distribution of phenotypic consequences among individuals carrying a selfish mitochondrial genome.

Appropriate Use of Antibiotics in Acute Pancreatitis: A Scoping Review.

While selective use of antibiotics for infected pancreatic necrosis (IPN) in acute pancreatitis (AP) is recommended, studies indicate a high rate of inadequate treatment. A search of PubMed, Scopus, and Cochrane databases was conducted, focusing on primary research and meta-analyses. Data were categorized based on core concepts, and a narrative synthesis was performed. The search identified a total of 1016 publications. After evaluating 203 full texts and additional sources from the grey literature, 80 studies were included in the review. The answers obtained were: (1) Preventive treatment does not decrease the incidence of IPN or mortality. Given the risks of bacterial resistance and fungal infections, antibiotics should be reserved for highly suspected or confirmed IPN; (2) The diagnosis of IPN does not always require microbiological samples, as clinical suspicion or computed tomography signs can suffice. Early diagnosis and treatment may be improved by using biomarkers such as procalcitonin and novel microbiological methods; (3) When indicated, early initiation of antibiotics is a key determinant in reducing mortality associated with IPN; (4) Antibiotics with good penetration into pancreatic tissue covering Gram-negative and Gram-positive bacteria should be used. Routine antifungal therapy is not recommended; (5) The step-up approach, including antibiotics, is the standard for IPN management; (6) Antibiotic duration should be kept to a minimum and should be based on the quality of source control and patient condition. Early antibiotic therapy is essential for the treatment of IPN, but prophylactic antibiotics are not recommended in AP. High-quality randomized controlled trials are required to better understand the role of antibiotics and antifungals in AP management.

The enhanced neutral process with decreasing cell size: a study on phytoplankton metacommunities from the glacier-fed river of Qinghai-Xizang Plateau.

The cell size of phytoplankton is a key life-history trait and key determinant, and phytoplankton of different cell sizes are differentially affected by ecological processes. However, the study of the assembly patterns and drivers of phytoplankton metacommunities with different cell sizes has not been widely carried out. We provide an in-depth analysis of phytoplankton community diversity across three cell sizes in the glacier-fed river, describing how the pattern of phytoplankton communities differs across cell sizes in response to geochemical gradients. The results show that the smaller phytoplankton (picophytoplankton) are relatively more influenced by dispersal-based stochastic processes, whereas larger ones (microphytoplankton and nanophytoplankton) are more structured by selection-based deterministic processes.

Key Determinants to Drive Motor Insurance Customer Acquisition in Western Province, Sri Lanka: A Focus on the Marketing Mix

Purpose: There is a significant need for a comprehensive insurance policy for all vehicle owners, especially considering the growing emphasis on health and safety, and public protection. The substantial preference for 3rd party insurance over comprehensive policy covers has created a hurdle for insurance companies, both in terms of acquiring new customers and retaining existing ones. This prevailing trend has presented a significant challenge to the growth potential of general insurance firms in the market. The main purpose of this study is to investigate how factors such as product, price, promotion, and distribution network influence the customer purchase intention towards motor insurance. Design/methodology/approach: This was a cross-sectional study using a deductive research approach. Data were gathered from 412 policy holders in Sri Lanka using a self-administered structured questionnaire. Multiple regression analysis was used to determine the most influencing factor among product, price, promotion and distribution network influencing customer purchase intention towards motor insurance. Findings: Based on the analysis, the insurance service [product], insurance premium [price], promotion and distribution network have a significant relationship with the customer purchase intention towards motor insurance policies in Sri Lanka. Among the factors tested, distribution network and insurance service have the most significant impact on customer purchase intention with reference to motor insurance segment. Originality: This study provides a unique contribution by highlighting the critical role of the distribution network, particularly the combination of Place and People elements, in driving motor insurance customer acquisition in Sri Lanka. Unlike prior studies that emphasize price and promotional strategies, this research focuses on the integrated influence of accessibility and personalized service. The findings demonstrate that a well-established distribution network outweighs traditional marketing factors in influencing purchase decisions, offering a new perspective on consumer behavior in the Sri Lankan motor insurance industry. Implications: The findings of this study will pave the way for a paradigm shift where, insurance firms could understand and develop relevant strategies to improve services provided to the existing and potential motor insurance customers. By analyzing what truly matters to Sri Lankan drivers, both insurance service providers as well as regulatory authorities can ally and develop a holistic insurance policy that comprehensively covers all aspects of vehicle ownership, filling the void in the current market. According to the findings, it can be advised that the insurance corporations should focus more on providing a product with more unique features and invest in creating a solid network of branches across the country which are fortified with skilled and service-oriented personnel who could persuade the customers in buying comprehensive insurance covers. Future researchers can also focus on income and educational level as moderators since both of which have an impact on consumer behavior as suggested in prior literature. Also, there is a possibility of widening their scopes by considering other types of insurance products and expand the geographical area as well.

Transdifferentiation occurs without resetting development-specific DNA methylation, a key determinant of full-function cell identity

A number of studies have demonstrated that it is possible to directly convert one cell type to another by factor-mediated transdifferentiation, but in the vast majority of cases, the resulting reprogrammed cells are unable to maintain their new cell identity for prolonged culture times and have a phenotype only partially similar to their endogenous counterparts. To better understand this phenomenon, we developed an analytical approach for better characterizing trans-differentiation-associated changes in DNA methylation, a major determinant of long-term cell identity. By examining various models of transdifferentiation both in vitro and in vivo, our studies indicate that despite convincing expression changes, transdifferentiated cells seem unable to alter their original developmentally mandated methylation patterns. We propose that this blockage is due to basic developmental limitations built into the regulatory sequences that govern epigenetic programming of cell identity. These results shed light on the molecular rules necessary to achieve complete somatic cell reprogramming.

Research on Child-Friendly Evaluation and Optimization Strategies for Rural Public Spaces

Public spaces are essential for the implementation of child-friendly principles and the development of child-friendly cities, with positive and healthy environments playing a crucial role in supporting children’s well-being and development. However, existing research on child-friendly public spaces predominantly targets economically developed urban areas with robust public service infrastructure, often neglecting rural areas with less advanced facilities. This study utilizes grounded theory and qualitative analysis to propose a child-friendly public space evaluation framework specifically for rural settings. The framework includes four primary indicators—safety, accessibility, comfort, and multifunctionality—and 19 secondary indicators, such as facility safety and plant safety. An empirical investigation was conducted in Baishoupu Town, a child-friendly pilot area within Changsha, China, which is designated as a United Nations Child-Friendly City, and the study encompassed an analysis of 11 rural villages within this area. The findings reveal that while Baishoupu Town demonstrates a relatively high level of child-friendly development, there is significant disparity among individual villages. Key determinants affecting the child-friendliness of rural public spaces include the type of rural industry, per capita income levels, and the degree of policy support. Specifically, the advancement of public service infrastructure and the tourism sector significantly influence the primary indicators. Moreover, while rural road infrastructure is positively correlated with accessibility, the presence of through traffic adversely affects safety indicators. Based on these insights, this study recommends enhancing child-friendliness in rural public spaces through strategic village planning, spatial design improvements, and ensuring child participation. This research provides valuable insights for government policy development and implementation and offers a replicable framework for child-friendly public space development in rural areas globally.

Stimulation beliefs, parental reading involvement, and social inequalities in children's language development

Objective: This study investigates whether greater identification of mothers and fathers in different-sex couples with the stimulation dimension of intensive parenting promoted both parents' involvement in reading and benefited children's language development between ages 3 and 5 in the UK. In addition, we explore social class variations. Background: Our study tests the frequently assumed relationship of parenting beliefs about stimulation with language development, and contributes to our understanding of parenting practices and their implications for child development. Method: We draw on a large representative sample of young children from the UK Millennium Cohort Study (N = 8,071) and apply path analyses in the framework of structural equation models. Results: For mothers and fathers, stimulation beliefs partially mediated the relation between parental education and reading frequency. Mothers' and fathers' stimulation beliefs had positive effects on children’s language abilities, but their impact was small compared to the direct associations with parental education. Conclusion: While parental education emerges as a key determinant of children's language development, our study reveals the nuanced role of beliefs about stimulation within intensive parenting, prompting further investigation into the multifaceted nature of parental involvement.

Empowering Online Teaching: A System Review of Online Instructors’ Professional Development in Higher Education

This paper begins with the introduction of online education development in U.S. higher education. It examines the challenges of online learning, highlighting that online education often yields poorer outcomes, with lower completion rates and fewer educational learning outcomes. It identifies key determinants impacting online learning outcomes: student agency, the level of interaction within online courses, and digital literacy. The study emphasizes the importance of professional development (PD) for online instructors, especially in community colleges. Critical pedagogy serves as the conceptual framework for the PD, advocating for educational systems that empower students and teachers to challenge oppressive structures and to contribute to educational equity. It stresses the need for instructors to be facilitators of learning, promoting active dialogue and collaborative knowledge construction. The paper discusses scaffolding strategies, promoting student agency, enhancing interaction, and integrating technology-enhanced learning (TEL) as essential components of PD for online instructors. The paper concludes by arguing for the necessity of humanizing online education, aligning it with the principles of critical pedagogy to create more inclusive and empathetic online classrooms. It suggests that as online education evolves, there is a responsibility to ensure that PD programs reflect these humanizing principles, contributing to a more equitable and reflective education system.

Emotional Perceptions of Thermal Comfort for People Exposed to Green Spaces Characterized Using Streetscapes in Urban Parks

Thermal comfort is a key determinant ruling the quality of urban park visits that is mainly evaluated by equivalent meteorological factors and lacks evidence about its relationship with emotional perception. Exposure to green space was believed to be an available approach to increase thermal comfort, but this argument still needs verification to confirm its reliability. In this study, about ~15,000 streetscapes were photographed at stops along sidewalks and evaluated for green view index (GVI) and plant diversity index in five urban parks of Changchun, Northeast China. The faces of visitors were captured to analyze happy, sad, and neutral scores as well as two net positive emotion estimates. Meteorological factors of temperature, relative humidity, and wind velocity were measured at the same time for evaluating thermal comfort using equivalent variables of discomfort index (DI), temperature and humidity index (THI), and cooling power index (CP). At stops with higher GVI, lower temperature (slope: from −0.1058 to −0.0871) and wind velocity (slope: from −0.1273 to −0.0524) were found, as well as higher relative humidity (slope: from 0.0871 to 0.8812), which resulted in positive relationships between GVI and thermal comfort evaluated as DI (R2 = 0.3598, p &lt; 0.0001) or CP (R2 = 0.3179, p &lt; 0.0001). Sad score was positively correlated with THI (R2 = 0.0908, p = 0.0332) and negatively correlated with CP (R2 = 0.0929, p = 0.0294). At stops with high GVI, more positive emotions were shown on visitors’ faces (happy minus sad scores, 0.31 ± 0.10). Plant diversity had varied relationships with GVI in parks depending on age. Overall, our study demonstrated that using imagery data extracted from streetscapes can be useful for evaluating thermal comfort. It is recommended to plan a large amount of touchable nature provided by vegetation in urban parks so as to mitigate micro-climates towards a trend with more thermal comfort that evokes more positive emotions.

Cross-National Comparison of Technology Innovation Capabilities in Automation and Robotics

In today’s dynamic and global economic environment, technological innovations are a key determinant of international competitiveness. In the field of automation and robotics, the development of modern technologies is of particular significance, influencing not only industrial progress but also social aspects. Automation and robotics play a crucial role in the concept of modern industry, contributing to the creation of more sustainable, flexible, and human-centric production systems. The article aims to conduct an in-depth analysis of the patent activity in automation and robotics in Europe. Patent documentation serves as a source of knowledge about the directions of research, inventive activities, and consequently, the innovative and competitive potential of the economy. The number of patents over time reflects the dynamics of a country’s technological development. The article discusses the use of patent databases to evaluate a country’s innovation in automation and robotics. The conducted analysis of data on European countries enabled the identification of trends based on the International Patent Classification and specialisation from a geographical perspective using revealed comparative technological advantage. The European countries were classified using cluster analysis, demonstrating the diversity, and identifying leaders in each group.

Macroeconomic Determinants of the Gap between Domestic and International Gold Prices in Vietnam

This research investigates the factors influencing the disparity between domestic gold prices (SJC gold and 9999 gold) and global gold prices in Vietnam from January 2011 to December 2023. Using the Autoregressive Distributed Lag (ARDL) model, we identify key macroeconomic determinants impacting this price spread, including interest rates, oil prices, and consumer demand. Our findings reveal that higher interest rates are associated with larger price spreads, suggesting that monetary policy plays a significant role in the domestic gold market. Oil prices exhibit a negative relationship with the price spread for 9999 gold, indicating that rising oil prices tend to align domestic gold prices more closely with global trends. Consumer demand notably affects the SJC_Global price spread but not the 9999_Global spread, reflecting the different market dynamics of finished goods versus raw materials. Additionally, the error correction terms in both models indicate a robust mechanism for long-term equilibrium, demonstrating the Vietnamese gold market’s resilience. These insights highlight the need for policymakers to reconsider existing regulations, such as Decree 24, to ensure a stable and efficient gold market. The study concludes that while the Vietnamese gold market exhibits sustainable practices, regulatory revisions are necessary to support both market growth and community development. Future research should consider additional macroeconomic variables and the impact of regulatory changes over time to further understand the dynamics of gold price disparities in Vietnam.

Late Colonialism and Postcolonial Development in Africa: A Comparative-Historical Analysis of Former Italian Africa

This article analyzes the development legacies of Italian colonialism in Africa. The comparative-historical analysis shows that colonial Italy pursued “settler colonialism” in areas conducive to colonial settlement and large-scale exploitation, and “plantation colonialism” in areas with fewer resource endowments and settlement opportunities. In the immediate aftermath, while settler colonialism had a positive influence and plantation colonialism exerted a negative impact on economic prosperity, both types of Italian colonialism had strong negative effects on human development. In the post-1960 period, whereas the colonial legacy of plantation colonialism led to persistent poverty in Somalia, long-run development in Eritrea and Libya was contingent on critical junctures, which variously reinforced, destabilized, and/or transformed the institutional and developmental legacies of settler colonialism. I draw on the comparative-historical tradition emphasizing national orientation of European colonizers and natural conditions in colonized areas as key determinants of European colonialism and long-run development. However, I emphasize “factor endowments” as one such condition that defined Italian colonization strategies and institutions, finding little empirical support for factor endowments per se or precolonial ethnic centralization as principal determinants.

Social Determinants of Cardiovascular Health in Asian Americans: A Scientific Statement From the American Heart Association.

To achieve cardiovascular health (CVH) equity in the United States, an understanding of the social and structural factors that contribute to differences and disparities in health is necessary. The Asian American population is the fastest-growing racial group in the United States but remains persistently underrepresented in health research. There is heterogeneity in how individual Asian American ethnic groups experience CVH and cardiovascular disease outcomes, with certain ethnic groups experiencing a higher burden of adverse social conditions, disproportionately high burden of suboptimal CVH, or excess adverse cardiovascular disease outcomes. In this scientific statement, upstream structural and social determinants that influence CVH in the Asian American population are highlighted, with particular emphasis on the role of social determinants of health across disaggregated Asian American ethnic groups. Key social determinants that operate in Asian American communities include socioeconomic position, immigration and nativity, social and physical environments, food and nutrition access, and health system-level factors. The role of underlying structural factors such as health, social, and economic policies and structural racism is also discussed in the context of CVH in Asian Americans. To improve individual-, community-, and population-level CVH and to reduce CVH disparities in Asian American ethnic subgroups, multilevel interventions that address adverse structural and social determinants are critical to achieve CVH equity for the Asian American population. Critical research gaps for the Asian American population are given, along with recommendations for strategic approaches to investigate social determinants of health and intervene to reduce health disparities in these communities.