The conventional CMOS scaling trend faces device scaling limitations, interconnect bottleneck, and signal integrity issues due to crosstalk, which is the unwanted interference of signals between neighboring metal lines. Traditional computing circuits always try to reduce the crosstalk noise by applying various circuit and layout techniques. In contrast, Crosstalk computing is a new computing framework that can leverage this detrimental effect and convert it astutely to a useful feature. The Crosstalk is engineered into a logic computation principle by leveraging deterministic signal interference for innovative circuit implementation. In this paper, we present a comprehensive circuit framework for Crosstalk Computing and derives all the key circuit elements that can enable this computing model for large-scale design. It also performs a comparison study between Crosstalk circuits and existing CMOS-based approaches. The ability to design a wide range of logic circuits (basic and complex logics) and programmable gates compact in design and minimal in transistor count is unique to Crosstalk Computing, which leads to benefits in the circuit density, power, and performance. The circuit simulation results designed at 7 nm show 3.4x improvement density, 62% reduction in Energy-Delay-Product (EDP), and 34.5% improvement in performance compared to counterpart implementation in CMOS circuit style.