Kemerovo Regional Research Articles

Корпус руководящих работников учебных заведений системы государственных трудовых резервов Кемеровской области: основные проблемы и их решение (1943–1959 гг.)

This article delves into the primary issues faced by the Kemerovo Regional Department of Labor Reserves when dealing with leadership personnel and the measures undertaken to overcome these challenges. Drawing primarily from unpublished archival documents such as orders and directives from the head of the Kemerovo Regional Department of Labor Reserves, as well as annual reports on the activities of vocational schools and factory training schools, the study examines the core problems related to leadership cadres in these educational institutions. Additionally, regional periodicals are utilized to shed light on various aspects of the activities of educational institutions within the labor reserve system. The author identifies key issues concerning leadership personnel in vocational schools and factory training schools, elucidates their causes, and evaluates the efforts aimed at enhancing the quality of leadership within these educational institutions. Despite these challenges, efforts to improve the quality of leadership within these educational institutions have been observed. Moving forward, continued attention to these issues will be essential to ensuring the effectiveness and success of the labor reserve system in the Kemerovo region.

Руководители системы трудовых резервов Кемеровской области (1943–1959 гг.)

The article touches upon the issue of three heads of the Kemerovo Regional Department of Labor Reserves: M.G. Brondspitz, N.M. Korenev, P.I. Bushlanov. The major part of the sources used in the preparation of the work are unpublished archival documents: department head’s personnel files, kept in the fonds of the Party bodies, staff affairs of one of them, materials of the Regional Council of Labor Deputies and the awarding group of its executive committee. In addition, the author established the main facts of working careers of the department heads, showed the work experience and the level of qualification of each of them by the time of their appointment to this position. Conclusions dwells upon the fact that the Party-Soviet leaders evaluated the activity of one or another head of the department and how it influenced the further labor path of this employee.

Kemerovo Regional Medical Exercises Dispensary in 1949–1965

The establishment of the Kemerovo Region in 1943 marked the institutionalization of regional physical culture and sports management bodies. Regional sports competitions needed medical support and control. The Kemerovo Regional Medical Exercises Dispensary appeared in 1949 as an important structural component of the system of medical control and medical support of physical culture and sports in the Kemerovo Region. The archives of the Regional Health Department and the Kemerovo Regional Medical Exercises Dispensary made it possible to determine the advantages and shortcomings of the new institution. The author relied on the principles of historicism and objectivity, as well as on the methods of problem chronology and historical system, to describe the role of the Dispensary in the new system of medical support of physical culture and sports in the postwar years. In the mid-1950s, the Kemerovo Region developed an elaborated network of institutions of medical and physical therapy service, and the Dispensary became a core institution that organized its work. The early 1960s saw a steady increase in the number of medical control and physical therapy services. The Dispensary acquired new functions but suffered from poor facilities and staffing until the mid-1960s, which restrained its developmental potential. The state used the positive experience gained during World War II to improve the network of medical and physical therapy institutions. In 1949–1965, the Kemerovo Region introduced a fundamentally new system of medical support for physical culture and sports.

Health status of coal industry workers

Health status of coal industry workers

“Accept Costs as an Exception”: Social Costs in Soviet Land Management with Reference to Conflicts around the Reconstruction of the Bachatsky Surface Mine in the Late 1960s — 1970s

This article uses the concept of social costs to analyse the features of Soviet land use in the 1960s–1970s. This concept is based on the study of the mechanisms of modern economies, in which shifting costs to society becomes the most important way to increase profits for producers. Resources depletion and environmental pollution are inevitable costs of any economic activity, but they are usually borne not by the manufacturer, but by third parties and society. The concept of social costs makes it possible to carry out a comprehensive analysis and highlight the complex picture of the actors involved in nature management: those who are the source of social costs, who bear them, and who becomes an agent of redistribution. The empirical material in the article is the conflicts around the reconstruction of the Bachatsky surface coal mine. Its expansion and transformation into one of the largest enterprises of the Soviet coal mining in the late 1960s required withdrawal of significant land plots from nearby farms. The study of conflicts around land allotment, reclamation and compensation demonstrates the following dynamics. In different contexts, the coal industry at all its institutional levels acted as a source of social costs: the ministry, the Kuzbasskarierugol trust, and the Bachatsky mine itself. The Ministry of Agriculture and farms, which directly incurred costs due to the expansion of the mine, did not participate in conflicts on their own behalf. Other actors acted as agents of redistribution: first of all, the Kemerovo Regional Executive Committee, as well as regional Soviet authorities and the State Planning Committee of the USSR. At the same time, each of these bodies had its own vision of the volumes and forms in which coal miners had to compensate social costs.

АНДРОНОВСКИЕ ПОГРЕБЕНИЯ НА МОГИЛЬНИКЕ КЫТМАНОВО (ПО МАТЕРИАЛАМ РАСКОПОК В.И. КАЦА В 1961 Г.)

The article presents the previously unpublished results of V.I. Katz’s archaeological excavations at the Kytmanovo burial ground, discovered by him in 1961 during routine surveys. The site was located on the left bank of the Chumysh River in the Kytmanovsky District of the Altai Territory in the area of a brick factory. Information from the authors’ correspondence with V.I. Katz, as well as materials of his report and the collection stored in the Kemerovo Regional Museum of Local Lore is given. The researcher recorded nine burials belonging to the Andronovo archaeological culture of the Bronze Age. This is evidenced by the peculiarities of the burial rites (orientation and position of the dead people, the presence of wooden intra-burial structures, etc.) and the peculiarities of the discovered inventory, the basis of which are ceramic vessels. The presented characteristics and illustrations of the obtained archaeological material find numerous analogies in the Andronovo sites of the Upper Priobie and adjacent territories.

Результаты хирургического лечения гнойной язвы роговицы у пациентов с ВИЧ-инфекцией

Purulent corneal ulcers – severe inflammatory disease, often with unfavourable outcome. Therapeutic keratoplasty of this disease is the main treatment way. The total number of HIV cases in Russia and throughout the world is permanently increasing. 75 % of HIV-infected have ophthalmology manifestations, among all of them only 5 % is infection corneal lesions. The information about patients initial immune status could contribute to the successful surgical results. Results of surgical treatment of corneal ulcer in HIV-patients was analysed. Period of operations was from 2018 to 2022 years and the clinical base was Kemerovo Regional Clinical Ophthalmological Hospital. Among patients were 2 females and 4 males, the age was from 36 to 72 years old. Penetrating keratoplasty for emergency reasons with tectonic or organ preservation aims was made for all of them. Retrospective analysis showed that transparent engraftment of the transplant was better after the only operation. The secondary keratoplasty was needed in 50 % cases. Corneal leucoma after the keratoplasty and the previous infection was in patients with 10 years HIV-infection in the anamnesis regardless of the number of keratoplasty and young ages of patients. Transparent condition of transplant was for the period from 4 months to 2 years and there were only uveitis after keratoplasty, there were not any cases of endophthalmitis. Keywords: purulent corneal ulcer; HIV-infection; keratoplasty

Study of relationships between HLA-G gene polymorphism, intrauterine infection and recurrent miscarriage in women

The relationship between the HLA-G gene polymorphism (rs41551813, rs12722477, rs41557518), intrauterine infection and recurrent miscarriage (RM) in women were studied. The case group consisted of 180 patients with RM, defined as two or more consecutive miscarriages (min = 2; max = 8) at up to 20 weeks of gestation, and with clinically confirmed pregnancies and non-viable fetuses. At the time of examination. the women were enrolled from the Genetic Counseling Center at the Kemerovo Regional Clinical Hospital, Kemerovo, Russia, and were not pregnant. Each patient underwent a gynecological examination. We excluded women with a history of medical abortion, birth, and ectopic pregnancies. In addition, we excluded women with endocrine (e.g. diabetes) disorders. To exclude other known causes of spontaneous abortion, the following tests were performed: ultrasound examination of pelvic organs, and karyotyping in women and men. The women’s mean age in the RM group, was 29.6±4.8 (SD) years. The control group comprised 408 fertile women. These women didn’t have a history of spontaneous abortion, or a family history of congenital malformations. They have born, at least, 1-2 healthy children. Women’s mean age at birth of last child was 26.8±5.2 (SD) years. Influence of the intrauterine infection was analyzed on the basis of laboratory tests. Diagnostics of bacterial vaginosis and vulvo-vaginal candidiasis by microscopic examination was conducted. Viral agent infections (herpes simplex virus type 2, cytomegalovirus, human papilloma virus type 16/18), Chlamydia trachomatis, Mycoplasma hominis, Ureaplasma urealyticum, Gardnerella vaginalis and Trichomonas vaginalis were detected by enzyme-linked immunoassay and polymerase chain reaction (PCR). The data were obtained from the medical cards of the surveyed women. All the women gave a written informed consent before participating in the study. Typing of polymorphisms of Thr31Ser (rs41551813, HLA-G*01:03) in exon 2, Leu110Ile (rs12722477, HLA-G*01:04) and 1597 delС (rs41557518, HLA-G*01:05N) in exon 3 HLA-G genes were performed by realtime PCR followed by melting analysis. The study showed that the intrauterine infection was not a risk factor for RM (p = 0.30) in the examined women. It was found that the 110 Ile allele (HLA-G *01:04) was a risk factor for RM both in women with intrauterine infection [ORa = 4.50 (2.41-8.38), p = 2.09e-06], and in women without infection [ORa = 2.46 (1.44-4.21), p = 0.0009]. The cooperative influence of genetic and infections factors with the risk of RM in women was revealed [ORa+f = 3.50 (2.01-6.09), p = 8.78e-06]. Our results will be useful in understanding the molecular mechanisms of immune disorders in fetomaternal interface, and for choosing the strategy of management and treatment in women with RM.

ВЛИЯНИЕ УРОВНЯ ЗАЛЕСЁННОСТИ НА ИЗМЕНЕНИЕ ЧИСЛЕННОСТИ ЛОСЯ В НЕКОТОРЫХ РАЙОНАХ КУЗБАССА

Forests are a unique environmental phenomenon, since their space serves as the fundamental basis for the life of an innumerable number of biological species. Significant integral limited territories of forests are important ecosystems of our planet and have a significant impact on climate and biological processes. Mixed or single-breed, mountain or plain, dense or well-groomed, the forest as a self-regulating system with its life cycle is directly related to the natural balance. Currently, fragmentation, degradation and loss of natural habitats of animals are recognized as serious threats to the conservation of wildlife around the world. First of all, these changes are anthropogenic in nature and directly affect forests as a sphere of existence of the animal world. This issue is updated in the works of modern domestic and foreign scientists. Fragmentation, deterioration, and destruction of natural animal habitats are major threats to global wildlife conservation. The article introduces some results of monitoring the existing data on the layout chart, exportation, and protection of hunting grounds on the territory of the Kemerovo region (Kuzbass). The data were provided by the Kemerovo Regional Department of Wildlife Protection. The article focuses on the population of large game species, e.g. elks. The research covered two municipalities, namely Krapivinsky and Topkinsky municipal districts. The study proved that monitoring data analysis can provide reliable initial assessment of the changes that happen to the hunting grounds and the local biodiversity as a result of natural and man-induced processes. A comparative analysis of game population in several economic zones of the Kemerovo region revealed a strong connection between the uneven growth and / or decrease in the animal population on the hunting grounds and the level of forest coverage. Based on the study of monitoring data, analysis of comparative material on the number of hunting species in different economic zones of the Kemerovo region revealed the existence of natural connections between uneven growth and/or reducing the number of animals on the hunting grounds, and’s forest coverage rate. The study confirms and complements the research of Russian and foreign researchers on the complex influence of anthropogenic and biological factors on changes in the parameters of the population of hunting species (elk). The obtained results contribute to modern research on the mechanisms of population regulation. To improve the efficiency of hunting resources use, it is necessary to conduct on-farm management with the introduction of new methods of land quality assessment based on forest management materials in geoinformation systems. These points fit into the prospects of our further research.

Multiple-center study of laparoscopic and open treatment of duodenal atresia

To summarize data of a multiple-center study of the treatment of duodenal atresia in 3 children's hospitals of the Siberian Federal District. We analyzed postoperative outcomes in 211 patients with duodenal atresia. All patients underwent surgery at various hospitals of the Siberian Federal District: Ivano-Matreninsky Children's Clinical Hospital in Irkutsk (expert hospital) - 120 patients; Center for Maternal and Child Welfare in Krasnoyarsk (learning hospital No. 1) - 51 patients; Kemerovo Regional Children's Clinical Hospital (learning hospital No. 2) - 40 patients. The study has been carried out for 15 years (from January 2005 and to December 2019). Patients were divided into 2 cohorts: group I - 88 patients (laparoscopic formation of duodenal anastomosis); group II - 123 patients (surgery via laparotomy). Demographic data, intra- and postoperative parameters and complications were analyzed. Preoperative parameters were similar in both groups. Significant between-group differences were found for surgery time (70 vs. 90 min; p<0.001). Initiation of feeding and complete enteral nutrition occurred significantly earlier after laparoscopy (3 vs. 7 days, p<0.001 and 8 vs. 12 days, p<0.001). Incidence of anastomotic leakage significantly differed in both groups (1 patient after laparoscopy and 9 patients after laparotomy, p=0.038). Mortality was absent in the laparoscopy group. In the laparotomy group, this value was 4.9% (p=0.036) and caused by concomitant conditions (prematurity, sepsis, heart defects). Late postoperative complications (adhesive intestinal obstruction, ventral hernias) were absent after laparoscopy and occurred in 5.7% of patients after laparotomy (p=0.023). Laparoscopic correction of duodenal atresia can be safely performed by experienced endoscopic surgeons from different centers united by the same ideology of endoscopic surgery. Laparoscopy ensures less duration of surgery, faster postoperative recovery, less mortality, incidence of early and late postoperative complications.

Album “The Kemerovo Regional Museum of Fine Arts”

In 2019, as part of the events dedicated to the 50th anniversary of the Museum, the album "The Kemerovo Regional Museum of Fine arts" (now the Kuzbass Museum of Fine Arts) was published. This is the first publication about the Kuzbass Museum of Fine Arts — a regional cultural institution of the Kemerovo region, opened in 1969. The album is based on research that reveals the history of the Museum in its fundamental aspects: the origins, the ascetics, the buildings that housed the Museum, and the art collection. В 2019 году в рамках мероприятий, посвященных 50-летию музея, издан альбом «Кемеровский областной музей изобразительных искусств» (ныне Музей изобразительных искусств Кузбасса). Это первое издание о Музее изобразительных искусств Кузбасса (МИИК) — областном учреждении культуры Кемеровской области, открытом в 1969 году. Основой альбома является исследование, раскрывающее историю музея в ее фундаментальных аспектах: истоки, подвижники, здания, в которых размещался и размещается музей, и художественная коллекция.

Pregnancy course and birth outcomes in young women

Aim. To study the features of pregnancy and birth outcomes in young women.Materials and Methods. We retrospectively analyzed birth histories of 400 women admitted to Regional Perinatal Center of Belyaev Kemerovo Regional Clinical Hospital during 2015-2018. All patients were stratified according to their age (&lt; 18 years and 20-25 years of age, n = 200 per group).Results. Pregnant women &lt; 18 years of age had earlier menarche and sexual intercourse as well as less frequent use of contraceptives as compared with those 20-25 years of age; the proportion of married pregnant women was 13.0% and 86.0% in the former and latter group, respectively. The vast majority (96.0%) of women &lt; 18 years of age were primiparous, in comparison with 64.0% in those aged 20-25. First visit to the prenatal care center was registered at 23 and 7 weeks in younger and older age group, respectively. The prevalence of extragenital pathology in patients &lt; 18 years of age was 9.0%. No significant differences in pregnancy complications (gestational hypertension or preeclampsia) and placental insufficiency were found. Most of the patients in both groups had full-term labor, yet premature births and caesarean section were significantly more common in those &lt; 18 years of age. There were no significant differences in weight, height, and Apgar scores among the newborns in regards to maternal age.Conclusion. Despite pregnant adolescents are characterised by an earlier menarche, sexual intercourse, less frequent use of contraceptives and higher need in assisted delivery in comparison with parturient women of 20-25 years; however, age does not impact pregnancy course and birth outcomes.

The course of pregnancy and the outcomes of labor in the combination of oligoamnion with a flattened shape of the fetal bladder

Aim. To study pregnancy and the outcomes of labor in women with oligohydramnios and flattened fetal bladder. Materials and Methods . We retrospectively analysed childbirth histories of 100 women admitted to Belyaev Kemerovo Regional Clinical Hospital either diagnosed with oligohydramnios combined with a flattened fetal bladder or having normal pregnancy course (n = 50 per group). Results. Patients with oligohydramnios and a flattened fetal bladder more frequently had past medical history of pelvic inflammatory disease (60% versus 30% in healthy women, p = 0.001) as well as dilation and curettage (32% versus 10% in healthy women, p = 0.003). Such patients had higher rate of a urinary tract infections during pregnancy (26.0% versus 4.0% in healthy women, p = 0.001). Childbirth in this patient group was more frequently complicated by a discoordinated labor (40.0% versus 0% in healthy women, p = 0.001). Pathology examination of the placenta confirmed the high frequency of chronic inflammatory process and chorioamnionitis in patients with oligohydramnios and a flattened fetal bladder. Conclusion. Patients with oligohydramnios and a flattened fetal bladder are a risk group of urinary tract infections during pregnancy and chorioamnionitis.

Medical and social characteristics of tuberculosis patients who died in in-patient units in 2017-2018 (based on data from Kemerovo Region)

The objective of the study : to analyze the medical and social characteristics of tuberculosis cases died in hospitals of Kemerovo Region in 2017-2018 including those with HIV infection Subjects and methods . Clinical, radiological and morphological data of 372 patients who died in in-patient units of Kemerovo Regional Clinical Phthisiopulmonary Medical Center in 2017-2018 were studied. Results. HIV infection was the major cause of death in tuberculosis patients in Kemerovo Region - in 74.7% (278 patients). Only 21.7% died of tuberculosis, and 3.6% - died of other diseases. The main clinical form of tuberculosis in patients with TB/HIV co-infection was a generalized form with lesions in multiple organs, of them, lesions of intrathoracic lymph nodes, spleen, liver, kidneys, pleura, and central nervous system were the most frequent. In patients who died of tuberculosis, the leading clinical form was fibrous cavernous tuberculosis, mainly complicated by caseous pneumonia.

Pregnancy and severe anemia: problems in diagnosis and treatment

Aim. To determine features, course, complications, and outcomes of pregnancy in women with severe anemia.Materials and Methods. We retrospectively analysed 39 case histories of women with severe anemia during pregnancy who delivered in Reshetova Kemerovo Regional Perinatal Center during 2017-2018.Results. Average age of women was 30 ± 5 years (average age of sexual debut 17 ± 1 years). The proportions of primiparous and smoking women were 28% and 56%, respectively. More than two-thirds (69%) of women suffered from chronic anemia before the pregnancy, and 21% were HIVinfected. Average first visit to the obstetrician was registered during the second trimester (at 14 ± 6 weeks of gestation), and 13% did not receive the medical care during the pregnancy. The prevalence of preterm and emergency childbirth was 31% and 69%, respectively; 80% of patients required a Cesarean section, and the average birth weight was 2,820 ± 805 g. Intrauterine growth restriction was observed in 28% of cases. Average values of hemoglobin at the first visit, at hospital admission, and at the time of blood transfusion were 103 ± 13 g/L, 74 ± 8 g/L, and 65 ± 4 g/L, respectively; average serum iron at the first visit and at hospital admission was 11 ± 5 µmol/L and 8 ± 3 µmol/L, respectively. Iron replacement therapy was inefficient in 84% of women who received it (90%).Conclusion. In the majority of cases, severe anemia developed from chronic anemia which had occurred before pregnancy and could not be corrected by means of iron replacement therapy. Pregnant women with severe anemia often require Cesarean section due to pre-eclampsia.

Predictors of Progressive Course of Multifocal Atherosclerosis in Patients With Myocardial Infarction

Determination of clinical and instrumental predictors of progressive course of multifocal atherosclerosis (MFA) in patients one year after myocardial infarction (MI), initially having hemodynamically insignificant stenoses of carotid arteries. From database of patients with acute coronary syndrome treated in the Kemerovo Regional Clinical Cardiac Dispensary in 2009-2010 we selected for this study 141 patients with verified diagnosis of MI and hemodynamically insignificant lesions in the internal carotid artery (ICA) (stenosis up ≤ 55 %). All patients had coronary atherosclerosis verified on coronary angiography at admission because of MI. A multivariate analysis of possible predictors of the progressive course of multifocal atherosclerosis was made based on assessment of the development of cardiovascular complications (CVC) (death, MI, stroke and transient cerebral circulatory attacks [TIA]), as well as revascularizations and negative dynamics of parameters of color duplex scanning (CDS) of ICA during one year after MI. One year after MI the overall incidence of CVC was 16.3 % (n=23). Structure of registered events was as follows: death from MI 7.1 % (n=10), deaths from stroke 2.1 % (n=3) and other causes 2.1 % (n=3), non-fatal MI 5.0 % (n=7), non-fatal stroke / TIA 2.1 % (n=3), carotid revascularization 2.8 % (n=4), coronary revascularization 14.9 % (n=21). CDC of ICAs was repeated in 125 patients. There were 17 (13.6 %) cases of progression of carotid atherosclerosis in the form of de novo bilateral stenoses in 14 (11.2 %) patients, stenoses in the left and right ICA 1 patient and 2 patients, respectively. The following predictors of progression of atherosclerosis of cerebral arteries were identified: family history of cardiovascular diseases (CVD),ICA stenosis ≥45 %, baseline circular atherosclerotic plaque (ASP). Predictors of high risk of stroke were family history of CVD, history of stroke,ICA stenosis ≥45 %, heterogeneous hypoechoic ASP. As predictors of lethal outcome, we identified history of MI, high functional class of angina preceding the index MI, severe coronary vascular bed involvement (SYNTAX score &gt;23), presence of any bilateral atherosclerotic lesion in ICAs, and heterogeneous hypoechoic ASP. Assessment of the contribution of adherence to therapy in the prognosis 1 year after hospital discharge was fulfilled in 125 alive patients. It allowed to conclude that patients with progression of atherosclerosis and nonfatal CVC were characterized by insufficient adherence to standard therapy. Predictors of the progressive course of multifocal atherosclerosis during one year after MI were identified in this study. It is necessary to strengthen therapeutic and preventive measures aimed at minimization of the impact of these factors in this category of patients.

DIFFICULTIES IN DIAGNOSING ATYPICAL HEMOLYTIC UREMIC SYNDROME

The paper presents the case of clinical observation of a patient with atypical hemolytic-uremic syndrome (aHUS). aHUS is a disease characterized by an unfavorable prognosis (severe or catastrophic course with rapid development of terminal renal or multi-organ failure). The aim of the study is to evaluate the approaches to differential diagnosis of aHUS in clinical practice. Material and methods. The study was conducted on the basis of the Nephrology Department of Kemerovo Regional Clinical Hospital n.a. S.V Belyaev. The clinical observation of patient D., aged 26 years old, is discussed. Results and discussion. Diagnosing aHUS requires: 1) diagnosing thrombotic microangiopathy (TMA: thrombocytopenia or decrease in platelet count by more than 25 % of original, visceral damage (kidneys, CNS, gastrointestinal tract, heart, lungs)); 2) ruling out HUS associated with Shiga toxin-producing Escherichia coli (STEC-HUS; negative for Shiga-toxin in blood and stool), thrombotic thrombocytopenic purpura (TTP), systemic connective tissue disease, catastrophic antiphospholipid syndrome, HIV infection; 3) assessing the activity of ADAMTS13 (decrease confirms the aHUS diagnosis); 4) proving normal content of complement components C3 and C4 as an additional argument in favor of aHUS diagnosis. At the first stage, the patient was diagnosed with TMA (platelet content 37 x 10 9 / l , hemoglobin content 59 g/l), LDH up to 824 E/l), liver damage (AST, ALT and LDH activity 55, 60 and 824 U/l, respectively), kidney damage (acute renal damage), lungs, heart, and brain damage. At the second stage the following diagnoses were ruled out: STEC-HUS (Shiga toxin in blood and stool was not detected), TTP (ADAMTS13 activity level was 66 %, whereas reference values are 93-113 %, in TTP - below 5-10 %); systemic connective tissue diseases catastrophic antiphospholipid syndrome, HIV infection sepsis. Normal values of C3 (0.9 g/l) and C4 (0.23 g/l) complement components did not rule out the diagnosis of aHUS.

DIFFERENCES IN ADHERENCE BEHAVIOUR PATTERNS IN PATIENTS WITH PRIMARY AND RECURRENT MYOCARDIAL INFARCTION

Aim.To compare adherence behavior patterns in patients with primary and recurrent myocardial infarction before hospital discharge.Methods.145 patients with myocardial infarction admitted to the Kemerovo Regional Clinical in the period from November to December 2016 were included in a single-centre, nonrandomized, prospective study. All the patients were interviewed using the original adherence questionnaire. All the patients were divided into 2 groups: patients with primary myocardial infarction (n = 74) and recurrent (n = 71) myocardial infarction.Results.Both, patients with primary and recurrent myocardial infarction, had low adherence to treatment and healthy lifestyle, poor disease awareness which appeared to be a signifcant factor worsening their long-term prognosis. Recurrent myocardial infarction was associated with increased readiness to adhere the treatment regimen more strictly (62%), but it was not accompanied by any improvements in patients’ awareness on the causes of the disease (36.6%), their health status (30.9%) and secondary prevention (63.3%). The great number of subjective factors affecting patients’ adherence to the long-term therapy prescribed by a healthcare professional requires the implementation of additional information management for patients with any type of myocardial infarction about the importance of subsequent therapy, special education programs, and group psychotherapy.Conclusion.Poor adherence in patients with any myocardial infarction to the prescribed therapy after discharge (less than 80%) requires a preventive use of educational and psychological programs improving medical and social awareness and readiness to adhere to treatment prescribed by the healthcare professional.

ACCIDENTAL ARCHAEOLOGICAL FINDS IN THE SOUTH AREAS OF THE LOWER TOM’ RIVER VALLEY

The article introduces for scientific use and achaeological interpretation the items from the collection of the Kemerovo Regional Local History Museum, Museum-Preserve "Tomskaya Pisanitsa", the Archaeology, Ethnography and Ecology of Siberia museum (Kemerovo State University Museum) and the Museum of Archaeology and Ethnography (Tomsk State University). The methodology of the research is based on the definition of the term «incidental find» for particular cases of incidental finding of an archaeological site which allows one to use this type of sources for historical and cultural reconstructions in that region for the first time. The research applies the methods of mapping and landscape-geomorphological analysis, comparative and typological method, periodization method. The article determines the main meaning of accidental finds for updating the archaeological map of the least researched Tom region areas connected to the territory of Kemerovo and watershed areas of the right bank of the River Tom. The work outlines the chronological group of the items and presents some conclusions about the possible connection of the stone tools with those from Izylinka, Irbinsko-Novo Kuskovo or Krokhalevo Neolithic-Early period of the Developed Bronze Age settlements; about the accidentally found knives and diggers confirming Irmen cultural domination in Late Bronze period and exchanges with cross-border cultural groups; about typological proximity of a number of Scythian period accidental finds with the same period complex in the Middle Yenissey area, Achinsk-Mariinsk forest-steppe and Tomsk Ob River area; about the association of the Kulay and Post-Kulay period findings with ritual practices at cult places.

Polymorphisms of GSTM1, GSTT1, GSTP1 genes and chromosomal aberrations in lung cancer patients.

To study the potential links between genetic polymorphisms in the GSTT1, GSTM1, GSTP1 genes and the frequency of chromosomal aberrations (CAs) in lung cancer patients and healthy residents in Russian Federation. 200 cells in well-spread metaphase with 46 chromosomes were examined for 353 newly diagnosed lung cancer patients (males) whoreceived medical treatment in the Kemerovo Regional Oncology Center (Kemerovo, Russian Federation), and 300 healthy males from Kemerovo, Russian Federation. The polymorphisms of the GSTM1 del and GSTT1 del genes were analysed by multiplex PCR. Genotyping of the polymorphic variants in the GSTP1 (A313G, T341C) gene was performed using Real-time PCR with competing TaqMan probes complementary to the polymorphic DNA sites. The data analysis was performed using software STATISTICA 8.0 (StatSoft Inc., USA). We discovered that a GSTM1 del polymorphism increases the frequency of chromosomal damage in smoking patients with lung cancer, a general group of lung cancer patients, donors with non-small cell lung cancer and patients in the latest stages of the malignant process. The synergetic effects of occupational exposure and the malignant process can induce some modifications in the cytogenetic status in lung cancer patients harbouring the GSTM1 del polymorphism. CAs in peripheral blood lymphocytes can be used as biomarkers of the early biological effects of exposure to genotoxic carcinogens and may predict future cancer incidence in several epidemiologic studies. Genetic changes in genes encoding phase II detoxification enzymes are linked to decreases in the metabolic detoxification of environmentally derived genotoxic carcinogens.