The current research is based on the impact of thermal and solutal slip in the boundary layer nanofluid flow through a moving accelerating wedge. The present investigation is considered with the influence of Brownian motion and thermophoresis. Thermal insulation, geothermal engineering, crude oil extraction, and heat exchangers are very important applications of nanofluid movement over a wedge surface with thermal and concentration slip. The suggested mathematical analysis is expressed in terms of partial differential equations (PDEs). These PDEs are transformed into ordinary differential equations via similarity transformation. The Keller Box technique is used to integrate the resultant non-similar equations. The set of discretized and first order differential equations is formed with the help of central difference and the Newton–Raphson technique. The graphical and numerical results are extracted with the help of MATLAB. The numerical results with the influence of the Prandtl factor (Pr), constant moving factor (λ), thermal slip factor (S2), and concentration slip parameter (S2) are interpreted visually and numerically. Graphical representations of velocity, thermal, and mass concentration profiles are analyzed in depth. The solution for skin friction coefficient, heat transport rate, and mass transport rate is calculated. The moving velocity function increases as Pr increases. The rate of slip temperature and slip concentration rate is enhanced for a lower Prandtl factor. The maximum slip behavior in temperature function and fluid concentration slip is deduced for each value of thermal-slip and concentration-slip factors. For high Prandtl and Brownian motion factors, the rate of Nusselt number is enhanced significantly.