The Tabei Uplift in the Tarim Basin of NW China represents an area with significant hydrocarbon exploration potential. This paper describes the effects of multi-phase faults on structural and hydrocarbon systems in the Tabei Uplift utilizing high-quality 3-D seismic, geological outcrops and drilling and production data. The interpretation and analysis of 10 fault systems from the Cambrian through the Cretaceous, shows that the deep, middle and shallow faults developed in four stages: the Early Caledonian, Mid-Late Caledonian, Hercynian and Himalayan. Specifically, the Early Caledonian fault system is favorable for the hydrocarbon expulsion of Cambrian source rocks, while Mid-Late Caledonian strike-slip faults facilitate hydrocarbon migration and accumulation. Hercynian and Himalayan strike-slip faults were formed as a result of the reactivation of the Mid-Late Caledonian strike-slip faults and have a destructive effect on the older oil reservoirs. Similarly, Permian volcanic activity also caused varying degrees of damage to Ordovician reservoirs. Oil production along fault zones more than 100 km show that the complex fracture-vuggy (FV) structure is more likely to trap oil and gas when it is damaged than the simple FV structure. Fault-controlled, fracture-vuggy carbonate reservoirs (FVCRs) were classified into six grades, which correlate to the productivity of oil wells in the region. Using this classification system, several drilling locations were selected and resulted in 80% success rate. This classification provides a novel approach for assessing the interplay between fault activity and reservoir formation, enhancing the prediction of hydrocarbon potential in varying strike-slip fault zones. This analysis not only refines our understanding of the region's geodynamic history but also aids in optimizing exploration and development strategies.