Abstract: Ahiputana (napkin rash) is one of the commonest diseases of balaawstha (mainly infantile age) which is discussed by various Ayurvedic Acharyas in their respective literature. Acharya Sushruta described Ahiputana in Ksudra roga. According to Acharya Vagbhatta, either due to malaoplepa (coating of faeces) or sweda (by excess of sweat), rashes develops in perianal region due to rakta and kapha doshas, which is tamravrana (copper coloured), with itching and later on associated with many complication. Diaper rash is a disease which occurs in infantile group having similar causative factors, sign/symptoms, pathogenesis as described in Ahiputna. It is more common in artificially fed infants and those with poor perineal hygiene. It is usually caused by skin irritation from prolonged contact with urine and faeces. It is usually seen around the groin and inside the folds of the upper thighs and buttocks. Various Ayurvedic medicines have been described in treatment of Ahiputana Keywords: Ayurveda, Ahiputana, Diaper Rash.