Introduction: Children are known to receive antibiotics more often than any other type of drug, as they are frequent subjects of infections of various etiologies. The improper use of antibiotics is the most important cause of the modern expansion of antibiotic resistance. The development of antibiotic resistance, with its clinical and economic consequences. Increased bacterial resistance is threatening the therapeutic effectiveness of antibiotics. High level of antibiotic use is probably the main factor driving the emergence of resistant. Objectives of the Study: To determine the level of awareness of antibiotic use in Benghazi 2021 among parents of children and to identify factors associated with parent’s decision regarding use of antibiotics. Materials and Methods: A convenient sample of 2000 questionnaires was distributed among parents of their children aged from 6moths to 6 years. By direct an interview to the parents at Benghazi city during the period from September to December –2021 who agreed for an interview survey. The questionnaire was developed by the researcher, and the data collected by well- trained interviewer team (the researcher and his colleagues, including doctors, medical students and pharmacists). The questionnaire contains were focused on the knowledge and attitude and practice of parents including the general knowledge on antibiotics, side effects of antibiotics use, the ideal mechanism of action of antibiotics and if antibiotics can cause allergy. If the parents use antibiotics to their children without a doctor's prescription, the reasons for use antibiotics without doctor's prescription. A score technique was chosen as suitable method to identify the level of awareness among parents regarding antibiotics use. A Scoring for questions knowledge five questions, every question gives 2 marks. We Categorize Score as: Deficient (poor), intermediate (average), Optimum (good) marks. The participants responded to the questionnaire without any .......