Junta De Andalucia Research Articles

La inmatriculación de la Mezquita-Catedral de Córdoba: tutela del patrimonio y relevancia constitucional

En este trabajo, partiendo del caso de la Mezquita-Catedral de Córdoba se exponen sucintamente los argumentos en los que basar una posible inconstitucionalidad del artículo 206 de la Ley Hipotecaria, referidos a la violación de los principios constitucionales de aconfesionalidad del Estado y de igualdad, con referencias a la Sentencia del Tribunal Europeo de Derechos Humanos «Sociedad Anónima del Ucieza contra España», que tiene una relevancia específica para el objeto de nuestro estudio. Finalmente se analiza el deber de tutela del patrimonio histórico y cultural de la Comunidad Autónoma de Andalucía y el posible uso de la cuestión de constitucionalidad como vía de actuación de la Junta de Andalucía en relación a la inscripción registral de la Mezquita-Catedral.

Part 4: Interaction between unproven cellular therapies and global medicinal product approval regulatory frameworks

NantKwest, Inc, Culver City, California, USA. ISCT Past Co-Chair, NA LRA Committee 2011–2014, St Jude Children’s Research Hospital, Memphis,Tennessee, USA. ISCT Past Co-Chair, NA LRA Committee 2011–2014. ISCT North America, RegionalVice-President 2014–2016, Department of Pathology, University of Melbourne, Cell Therapies Pty Ltd, East Melbourne,Australia, ISCT Australia & New Zealand, Past RegionalVice President 2012– 2014 and Chair, ISCT ANZ LRA Committee 2014–2016, Andalusian Initiative for Advanced Therapies, Junta de Andalucia, Sevilla, Spain. Chair, ISCT EU LRA Committee 2014–2016, and Moffitt Cancer Center and Research Institute,Tampa, Florida, USA. Chair, ISCT NA LRA Committee 2014–2016. Co-Editor of the Telegraft

Part 1: Defining unproven cellular therapies

Center for Stem Cell Research (a unit of inStem, Bengaluru), Department of Hematology, Christian Medical College, Vellore, India. Member at large of the ISCT Presidential Task Force on the Use of Unproven Cellular Therapies, Advanced Centre for Biochemical Engineering, University College London, London, United Kingdom. Member at large of the ISCT Presidential Task Force on the Use of Unproven Cellular Therapies, Voorburg, Netherlands. ISCT Europe, RegionalVice President 2014–2016, Andalusian Initiative for Advanced Therapies, Junta de Andalucia, Sevilla, Spain. Chair, ISCT EU LRA Committee, 2014–2016, Department of Medicine, University ofVermont, Burlington,Vermont, USA. ISCT Chief Scientific Officer 2014–2016. Chair, ISCT Pulmonary Committee 2013–2015, Division of Hematology/Oncology/BMT, Nationwide Children’s Hospital, Departments of Pediatrics and Medicine,The Ohio State University College of Medicine, Columbus, Ohio, USA. ISCT Past President 2010–2012, and Division of Oncology, Laboratory of Cellular Therapy, University of Modena & Reggio Emilia, Modena, Italy. ISCT President 2014–2016. Chair, ISCT Presidential Task Force on the Use of Unproven Cellular Therapies

Like the machete the snake: Integration of topic and vehicle in poetry comprehension reveals meaning construction processes.

This research was funded by the following grants: The European Commission (Marie Curie IOF: NARLYR 235129) to C.P.; Junta de Andalucia and ERDF (P09-SEJ-4772) to J.V. and J.S.; Spanish Ministry of Economy and Competitiveness (PSI2012-32464) to J.S.; Leverhulme fellowship (VP1-2012-032) to J.S.

Limited Evidence Suggests High Risk of Implant Failure Rates Among People With Generalized Aggressive Periodontitis

Generalized aggressive periodontitis as a risk factor for dental implant failure: a systematic review and meta-analysis. Monje A, Alcoforado G, Padial-Molina M, Suarez F, Lin GH, Wang HL.J Periodontol 2014;85(10):1398-1407. Ahmed Yaseen Alqutaibi, BDS, MDSc, PhD(c), Radhwan saleh Algabri, BDS, MDSc, PhD(c) In patients with dental implants, what are the differences in implant survival rate (SR), and marginal bone loss (MBL) between people with or without generalized aggressive periodontitis (AgP)? University of Michigan Periodontal Graduate Student Research Fund and the Talentia Scholarship Program, Junta de Andalucia, Spain Systematic review and meta-analysis Level 2: Limited-quality, patient-oriented evidence Grade B: Inconsistent, limited quality patient-oriented evidence.

On the existence of orders in semisimple Hopf algebras

The first author was supported by the projects MTM2011-27090 from MICINN and FEDER and by the research group FQM0211 from Junta de Andalucia. The second author was supported by the Danish National Research Foundation (DNRF) through the Centre for Symmetry and Deformation. The authors would like to thank Dmitriy Rumynin and Martin Lorenz for bring- ing to their attention the notion of weak order, Cesar Galindo for pointing out that these examples were already discussed in [8], and Yevgenia Kashina and Sonia Na-tale for useful discussions on the classification of low dimensional semisimple Hopf algebras.

Biometrical analysis reveals major differences between the two subspecies of the European rabbit

This study was partially funded by Projects PAI06-170, VP-0119-07,POII09-0099-2557, CGL2009-11665, 2012-30E060, CGL2013-43197, CGL2013-43197-R, FCT research project (PTDC/BIA-EVF/111368/2009), and ‘Genomics Applied to Genetic Resources’ co-funded by North Portugal Regional Operational Programme 2007/2013 (ON.2 – O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). C.F. was supported by a PhD grant (Ref. SFRH/BD/22084/2005) and a postdoctoral grant (Ref. SFRH/BPD/88643/2012), and J.B.-A. by a postdoctoral grant (Ref. SFRH/BPD/65464/2009) all from the Fundacao para a Ciencia e Tecnologia of the Ministerio da Ciencia, Tecnologia e Ensino Superior, Portuguese government. C.F. is currently supported by a Marie Curie Out going International Fellowship for Career Development (PIOF-GA-2013-621571) within the 7th Framework Programme of the European Union. M.D.-M. is currently funded by Consejeria de Economia, Innovacion, Ciencia y Empleo of Junta de Andalucia, and the European Union’s SeventhFramework Programme for research, technological development and demonstration under grant agreement 267226. C.A.R.-S. was supported by a doctoral grant from the National Council of Science and Technology of Mexico (CONACyT). P.C.A. was supportedby an FCT sabbatical grant (SFRH/BSAB/1278/2012) and by FLAD (Luso-American Foundation).

Ground-based search for lightning in Jupiter with GTC/OSIRIS fast photometry and tunable filters

A.L. and F.J.G.V. were supported by the Spanish Ministry of Economy and Competitiveness (MINECO) under projects AYA2011-29936-C05-02 and ESP2013-48032-C5-5-R and by the Junta de Andalucia, Proyecto de Excelencia FQM-5965. E.P. was supported by the MINECO ESP2013-48391-C4-2-R grant

Prediabetes and type 2 diabetes implication in central proliferation and neurogenesis

Type 2 diabetes (T2D) is an important risk factor for developing dementias, including Alzheimer's disease (AD). Hyperinsulinemia and glucose intolerance, as features of T2D, might increase the neurodegeneration process, synaptic loss and brain atrophy, leading to cognitive impairment observed in AD. Also, adult neurogenesis seems to be impaired in AD models. Therefore, we have studied morphological alterations, cell proliferation and neurogenesis in the central nervous system (CNS) from a classical model of T2D, the db/db mouse, and in a prediabetes insulin-resistant model, obtained after long-term high fat diet (HFD) administration to C57Bl/6 mice. Db/db mice showed an age-dependent cortical and hippocampal atrophy, whereas in HFD mice cortex and hippocampus were preserved. Neurogenesis and cell proliferation were increased in young db/db mice, when compared with control mice, whereas no differences were detected in the prediabetic model. We also detected significant correlations between metabolic parameters and central atrophy, altered proliferation and neurogenesis in the central nervous system. Altogether these data support that glycaemia control in elderly patients, could help to control central alterations and improve dementia prognosis.

Pleiotrophin fights Brd2 for neuronal differentiation.

Work in M G-D lab is supported by Ministry of Economy and Competitiveness, Spain (MINECO), grant number BFU2012-37304, and by Junta de Andalucia, Spain, grant number P12-CTS-2064.

Sorption-Desorption Tests on the Performance of Non-Hazardous Industrial Wastes in Decreasing Leachability of Trace Metals on Contaminated Lands

Soil stabilization by addition of industrial solid wastes in order to increase trace metals retention and (a minor secondary effect) to dilute their concentrations is an environmentally friendly and attractive soil remediation process that attenuates trace metals impact. In this study, non-hazardous industrial by-products (sugar foam, gypsum, zeolitic materials and fly ashes) were tested using laboratory scale experiments to assess their performance on the remediation of acidic soil that has been affected by a pyritic source of contamination at Aljaraque, Spain. In this soil, the concentration of metals in the Aqua Regia and soil-water extracts confirmed the extent of the soil contamination since all seven trace metals (Cu, Cd, As, Pb, Zn, Co and Sb) analyzed from the Aqua Regia extracts and nine trace metals (Cu, As, Cd, Zn, Pb, Co, Sb, Ni and Cr) analyzed in soil-water extract were found above the intervention limits specified in the Junta de Andalucia (Spain) and Germany National Standard (DIN) respectively for both Agriculture and Industrial activities. Metal sorption and desorption capacity of the industrial wastes were estimated in a soil water extract medium. Fly ashes and zeolitic material were found to be the best candidate materials for soil remediation due to their ability to increase soil pH, exhibiting greater solid-liquid distribution coefficient (Kd), lower sorption reversibility (Kd, des) and lower desorption yields to almost all trace metals analyzed. Key words: - amendment materials, contaminated soil, trace metals, soil remediation, leachability

Isolation and characterization of microsatellite loci in the carnivorous subshrub Drosophyllum lusitanicum (Drosophyllaceae)

Funding was provided by projects BREATHAL (CGL2011-28759/BOS; Spanish Ministerio de Ciencia e Innovacion-MICINN) and project P07-RNM-02869 (Junta de Andalucia, Spain). M.P. and M.J.G.-L. were supported by an FPI and FPU Ph.D. grants, respectively, from MICINN. J.G.S.-M. was supported by a ‘Ramon y Cajal’ (MICINN-RYC, Spain) postdoctoral contract.

M16 D1R and A2AR Blockade Normalises PKA Activity and Improves Hippocampal-dependent Cognitive Dysfunction but not Motor Deficits in Huntington's Disease

Background Stimulation of dopamine D1 receptor (D1R) and adenosine A2Areceptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. Increased PKA activity contributes to hippocampal-dependent cognitive impairment in R6 mouse models of Huntington’s disease (HD), whereas D1R and A2AR signalling is known to be increased in the striatum. Aims To analyse whether mutant huntingtin amplifies D1R and/or A2AR signalling in the hippocampus and the impact of their blockade on cognitive and motor dysfunction. Methods/techniques D1R and A2AR functional efficiency and density were analysed by ELISA and binding assays in hippocampal nerve terminals. Mice were chronically injected with D1R and A2AR antagonists (SCH23390 and SCH58261, respectively). Cognitive function was assessed by the novel object recognition, T-maze spontaneous alternation and passive avoidance tests, and motor function by rotarod test. PKA activity was assessed by western blot against phospho-PKA catalytic subunit and phospho-PKA substrates. Results We found that D1R and A2AR density and functional efficiency were increased in hippocampal nerve terminals from R6/1 mice, which accounts for increased cAMP levels and PKA signalling. In this line, chronic, but not acute, combined treatment with SCH23390 plus SCH58261 normalised PKA activity in the hippocampus, ameliorated hippocampal-dependent cognitive deficits and facilitated long-term potentiation in behaving R6/1 mice. In contrast, chronic treatment with D1R plus A2AR antagonist normalised striatal PKA activity, but did not improve motor deficits in R6/1 mice. Conclusions Parallel alterations in dopaminergic and adenosinergic signalling in the hippocampus contribute to increased PKA activity and to hippocampal-dependent cognitive deficits, but not to motor dysfunction in HD. Targeting D1R and A2AR might be a novel therapeutic strategy to manage early cognitive impairment in HD. Funding This work was supported by Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain (PI10/01072 to E. Perez-Navarro, and RETICS: RD06/0010/0006), Ministerio de Economia y Competitividad, Spain (BFU2011–29286 to A. Gruart, BFU2011–29089 to J. M. Delgado-Garcia and SAF2011–29507 to J. Alberch), Generalitat de Catalunya, Spain (2009SGR-00326 to J. Alberch), Junta de Andalucia, Spain (BIO122 and CVI7222 to J.M. Delgado-Garcia and A. Gruart), DARPA (09–68-ESR-FP-010 to R.A. Cunha), and FCT (PTDC/SAU-TOX/122005/2010 to R.A. Cunha). S. Tyebji is a fellow of Generalitat de Catalunya (AGAUR ST06914) and A. Saavedra was supported by Ministerio de Economia y Competitividad, Juan de la Cierva subprograme, Spain (JCI-2010-08207).

Las competencias municipales en Andalucía

Se analiza el Decreto-ley 7/2014, de 20 de mayo, mediante el cual el Consejo de Gobierno de la Junta de Andalucía establece determinadas medidas para llevar a cabo la reforma local introducida por la Ley 27/2013, de 27 de diciembre de racionalización y sostenibilidad de la administración local. Se pone de relieve el peculiar sistema de fuentes del régimen local andaluz a partir del Estatuto de Autonomía aprobado por Ley orgánica 2/2007, de 19 de marzo y a partir de ahí se analiza la incidencia de la reforma en el mismo y las medidas que la Junta de Andalucía ha establecido para el ejercicio de las nuevas competencias distintas de las propias y de las atribuidas por delegación, así como el régimen de adaptación de determinados instrumentos de cooperación financiera.

La interculturalidad en el contexto universitario a través de las voces de estudiantes inmigrantes

This article aims to highlight some nuances of a study carried out in the Faculty of Sciences of the Education of the University of Malaga, where we intended to make visible the voices of women immigrants from a perspective of interculturality and inclusion. Indeed, while it is true that the phenomenon of immigration on school is a matter treated comprehensively in recent years in our country, as a result of the conceptual development of intercultural education, it seems that it will stay in the formal field of school organization, and in particular, in the educational levels of non-university education. For all these reasons, and in the light of the development of the research project entitled Management of diversity in community contexts, financed by the DG of migratory policies of the Departament of Employment and Immigration of the Junta de Andalucia, we tried to go and focus our gaze to the study of the process of building identity of immigrant women University as well as studying how to develop interculturality in the university context. The results of this study indicate the need for a greater awareness about cultural interbreeding and the culture of diversity in the university context, as well as the creation of spaces and creative instruments where interculturality can develop in a practical way in the university classroom.

In situ Fourier transform infrared reflection absortion spectroscopy study of adenine adsorption on gold electrodes in basic media

Financial support from the Spanish Ministry of Science and Technology (CTQ2010-19823and a FPU-grant to JAM), from the Junta de Andalucia (PAI FQM202) and University of Alicante.

Development of sensitive molecular markers for detecting the genotoxicity induced by two pyrethroids insecticides, Cypermethrin and permethrin, to the Meditnerranean sole, Solea senegalensis (Kaup 1858)

This study was partly supported by grants Proyecto de Excelencia PO7-RNM-02843 (Junta de Andalucia, Andalucia Governerate, Spain) to JMM.

Structure-function relationship in viral RNA genomes: The case of hepatitis C virus

Spanish Ministry of Economy and Competitiveness, No. BFU2012-31213; Junta de Andalucia, No. CVI-7430; and FEDER funds from the EU

Genetic diversity, genetic structure and phylogeography of the Iberian endemicGypsophila struthium(Caryophyllaceae) as revealed by AFLP and plastid DNA sequences: connecting habitat fragmentation and diversification

Financial support was provided by a project from the Consejeria de Economia, Innovacion y Ciencia (Regional Government of Andalusia) and E.R.D.F. (European Regional Development Fund): ‘Proyecto de excelencia P07-RNM03217’. MIM-N was supported by a Junta de Andalucia PhD grant. JGS-M was supported by a Ramon y Cajal postdoctoral contract from the Ministerio de Ciencia e Innovacion of Spain.

La cuestión territorial en el debate de investidura de la presidenta de la Junta

Frente a cuarenta y ocho votos contrarios, cincuenta y ocho parlamentarios otorgaron la confianza de la Cámara a la candidata a la presidencia de la Junta de Andalucía, Susana Díaz Pacheco, en la sesión plenaria celebrada los días 4 y 5 de septiembre de 2013. Y como destacaría la generalidad de los medios de comunicación, en esta ocasión el acto de investidura presentaba novedades palpables en comparación con la de los anteriores Presidentes. Novedades que serían destacadas por el portavoz del Grupo Parlamentario Socialista, hasta el punto de no dudar en atribuir “carácter histórico” a la sesión.