This special issue of the IEEE Transactions on Circuits and Systems—Part II: Express Briefs (TCAS-II) includes papers presented at the International Symposium on Integrated Circuits and Systems (ISICAS), held in Taormina, Italy, on 2–3 September 2018. This is the first edition of this symposium and a new initiative of the IEEE Circuits and Systems Society (CASS), which includes a selection of original works in very diverse areas of integrated circuits and systems, describing integrated implementations with experimental results. In contrast to conventional symposia and conferences, ISICAS is a Journal Track Symposium which does not produce proceedings. Instead, the works presented at the conference are published in two journal special issues. One of them is the issue that you are holding and the other one is a special issue of the IEEE Transactions on Circuits and Systems—Part I: Regular Papers (TCAS-I). The technical program of the conference is therefore made up of those papers which has been accepted for publication in these special issues of TCAS-I and TCAS-II.