This Special Issue of the IEEE Transactions on Circuits and Systems—I: Regular Papers (TCAS-I) includes papers presented at the International Symposium on Integrated Circuits and Systems (ISICAS) 2022, held on October 20–21, 2022, at Bordeaux, France. This is the fifth edition of this journal track symposium as part of the initiative of the IEEE Circuits and Systems Society (CASS), started in 2018. The Symposium welcomes high-quality original research papers in the areas of integrated circuits and systems, including but not limited to analog, digital, power, energy, biomedical, sensor interfaces, and communication systems. A reader will notice that all the papers presented in this Special Issue and at the conference describe integrated circuit and implementations in CMOS, hybrid, SiP or SoC forms with experimental results—this is a mandatory requirement of the Symposium.