Journal Of Pharmacology Research Articles

Abstract C167: Understanding the effect of single nucleotide polymorphism rs2292596 on the interaction of aryl hydrocarbon receptor repressor and aryl hydrocarbon receptor nuclear translocator

Abstract Lung cancer is the leading cause of cancer death in America. Additionally, the incident rates among Black/African American (B/AA) men and women are significantly higher than those of their white counterparts, despite B/AA’s lower exposure to cigarette smoke (Berg et al, 2010. Journal of Pharmacology and Experimental Therapeutics, Vol. 332, p202). One factor that may increase the risk of lung adenocarcinoma in B/AA individuals is a single nucleotide polymorphism (SNP) found in the aryl hydrocarbon receptor repressor (AHRR) gene. To date, this SNP has been poorly studied, particularly in B/AA individuals. As its name suggests, AHRR represses the detoxification of tobacco smoke induced by aryl hydrocarbon receptor (AHR). Upon exposure to tobacco smoke, AHR enters the nucleus where it dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT) and binds to xenobiotic response elements (XREs), thereby inducing the genes mediating the detoxification process. Simultaneously, AHRR is turned on as part of a negative feedback loop. AHRR down-regulates the detoxification process by binding to ARNT, forming a negative regulatory complex that binds to XREs. Within the region of AHRR that encodes for the ARNT interaction domain, a single nucleotide polymorphism (SNP) is found in exon 6. SNP rs2292596 encodes a proline or alanine, with 63% of the White subjects having proline while 89% of the B/AA subjects have proline (Single Nucleotide Polymorphism Database, NCBI). As proline is a turn-inducing amino acid, this change, residing in one of the AHRR loops that encircles ARNT, may affect the kinetics of AHRR/ARNT complex association and/or dissociation, thereby potentially affecting the regulatory balance of detoxification. We are currently synthesizing recombinant AHRR protein containing the two different amino acids, along with ARNT. To assess how these changes in the amino acid sequence affect the interaction of AHRR and ARNT, we will measure the association and dissociation rates using a SwitchSense DRX2 instrument. If the SNP affects the kinetics of AHRR/ARNT heterodimer formation, it may affect detoxification and thereby lung cancer risk. If so, in the future the accuracy of lung cancer detection may be improved by increased screening for individuals carrying the risk allele. Furthermore, if the presence of the risk allele implicates a higher risk for lung cancer, this may strengthen lung cancer prevention within the B/AA community. Funding: This research is supported by R21CA290319 from National Institute of Health (NIH)/National Cancer Institute (NCI), the Norris Comprehensive Cancer Center core grant, award number P30CA014089 from the NIH/NCI, and by the Undergraduate Research Associates Program supported by the USC Provost. Citation Format: Shiori Fukutome, Matthew A. Gladstone, Chunli Yan, Diego A. Velarde, Nicholas Mancuso, Ite Offringa. Understanding the effect of single nucleotide polymorphism rs2292596 on the interaction of aryl hydrocarbon receptor repressor and aryl hydrocarbon receptor nuclear translocator [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C167.

Prevalence and characteristics of graphical abstracts in a specialist pharmacology journal

Prevalence and characteristics of graphical abstracts in a specialist pharmacology journal

Natural product pharmacology: the British Journal of Pharmacology perspective.

Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development. Recent technological advancements have revitalised natural products research as evidenced by increased publications in this field. In this editorial review, we highlight key points from the 2020 British Journal of Pharmacology (BJP) practical guide, which outlines standards for natural products research reports, and provide papers published in BJP between years 2020 to 2023 that demonstrate adherence to these guidelines. Looking ahead, we discuss the potential of chemical proteomics approaches to elucidate natural products mechanisms of action and identify therapeutic targets for future research. By fostering innovation, we aim to advance natural products research and contribute to the development of novel therapeutics that will have a significant impact on healthcare.

Impact of mitochondrial damage on tumor microenvironment and immune response: a comprehensive bibliometric analysis.

Mitochondrial damage contributes to apoptosis, oxidative stress, and inflammation, which collectively impact the immune system's function and the tumor microenvironment (TME). These processes, in turn, influence tumor cell growth, migration, and response to treatment. We conducted a bibliometric analysis to elucidate the complex interactions between mitochondrial damage, the immune system, and the TME. Data were sourced from the Science Citation Index Core Collection (WoSCC) and analyzed using advanced tools like VOSviewer and Citespace. Our focus was on literature published between 1999 and 2023 concerning the interactions between mitochondrial damage and the TME, as well as immune responses to tumors. The analysis included regional contributions, journal influence, institutional collaborations, authorship, co-cited authors, and keyword citation bursts. Our research encompassed 2,039 publications, revealing an increasing trend in annual output exploring the relationship between mitochondrial damage, TME dynamics, and immune responses. China, the United States, and South Korea emerged as the leading contributors. Prominent institutions included Institut National de la Santé et de la Recherche Médicale, University of Texas System, China Medical University, and Sun Yat-sen University. Key journals in this field are the International Journal of Molecular Sciences, Mitochondrion, and the European Journal of Pharmacology. Liang H and Wallace DC were identified as the most productive and co-cited authors, respectively. Keyword analysis highlighted the critical roles of inflammatory responses, oxidative stress, and the immune system in recent research. This bibliometric analysis provides a comprehensive overview of historical and current research trends, underscoring the pivotal role of mitochondrial damage in the TME and immune system.

Clarifying middle authorship contributions to reduce abuses in science publishing and assessment of top-ranked SJR biochemistry and pharmacology journals' authorship criteria.

So-called "middle authors," being neither the first, last, nor corresponding author of an academic paper, have made increasing relative contributions to academic scholarship over recent decades. No work has specifically and explicitly addressed the roles, rights, and responsibilities of middle authors, an authorship position which we believe is particularly vulnerable to abuse via growing phenomena such as paper mills. Responsible middle authorship requires transparent declarations of intellectual and other scientific contributions that journals can and should require of co-authors and established guidelines and criteria to achieve this already exist (ICMJE/CRediT). Although publishers, editors, and authors need to collectively uphold a situation of shared responsibility for appropriate co-authorship, current models have failed science since verification of authorship is impossible, except through blind trust in authors' statements. During the retraction of a paper, while the opinion of individual co-authors might be noted in a retraction notice, the retraction itself practically erases the relevance of co-author contributions and position/status (first, leading, senior, last, co-corresponding, etc.). Paper mills may have successfully proliferated because individual authors' roles and responsibilities are not tangibly verifiable and are thus indiscernible. We draw on a historical example of manipulated research to argue that authors and editors should publish publicly available, traceable contributions to the intellectual content of an article-both classical authorship or technical contributions-to maximize both visibility of individual contributions and accountability. To make our article practically more relevant to this journal's readership, we reviewed the top 50 Q1 journals in the fields of biochemistry and pharmacology, as ranked by the SJR, to appreciate which journals adopted the ICMJE or CRediT schools of authorship contribution, finding significant variation in adhesion to ICMJE guidelines nor the CRediT criteria and wording of author guidelines.

Trends in clinical pharmacology as represented by international and specialized journals

Relevance. Clinical pharmacology is a rapidly evolving field of medicine. The advent of modern technologies has led. The continued evolution of clinical pharmacology, as reflected in publications in specialized medical journals.The aim of this study was to determine how new trends in clinical pharmacology were reflected in the publications of the leading clinical pharmacology journals in Russia during the period from 2015-2021, to conduct a comparative analysis of trends with international journals from 2015-2021.Materials and methods. Original articles published in leading Russian journals were analyzed and categorized into relevant key areas of interest, drug modalities, and therapeutic areas based on the content of the publications independently by three authors. Publications in which authors expressed divergent opinions were discussed until consensus was reached using a modified Delphi method. A comparative analysis was then performed with the results of a similar analysis published in journal “Clinical Pharmacology and Therapeutics”.Results. Most Russian journals and publications have focused on real-world data. The topics most frequently covered in international journals were pharmacometrics, machine learning, and pharmacogenetics. In third place were real-world data. The leading therapeutic areas represented in publications in both Russian and international journals were cardiology, oncology, and infectious diseases. Most publications have focused on various aspects of small molecule use.Conclusions. The novel trends in clinical pharmacology are reflected in the scientific articles published in specialized journals. The principal trends observed in Russian publications are consistent with international tendencies.

Bibliometric Analysis of Multiple Sclerosis Studies in Pharmacology Journals

Multiple sclerosis (MS) is a prevalent neurological disease with a global impact on patients' lives. Our study aimed to conduct a bibliometric analysis of research published in the field of pharmacology over the past decade. We retrieved original articles on MS from pharmacology journals in the last ten years through the Scopus database. The collected data underwent analysis using VOSViewer software, examining relationships between studies based on parameters such as citation, authorship, and organizations. In our country-based analysis, the United States emerged with the highest document count, totaling 350, followed by Germany with 210 documents. Claudio Viegas holds the top position with four publications in the last decade. The most prolific organization identified was associated with the Biogen-Cambridge-MA-United States group. However, Chulalongkorn University in Bangkok, Thailand, specifically the Department of Psychiatry, received the most citations. The most cited document was "Therapeutic Advances in Neurological Disorders," while the study with the highest citations was Ferreria-Vieira et al.'s (2016) work published in Current Neuropharmacology. Research efforts on MS treatment are evidently growing, with diverse research groups contributing worldwide. We anticipate that our study will provide valuable guidance to researchers in the field by shedding light on significant research and their interconnections in recent years.

Research Trend in The Inhibition of Transient Receptor Potential Vanilloid 1 (TRPV1): Bibliometric Analysis and Visualization

This study aimed to provide a comprehensive overview of the research trend in transient receptor potential vanilloid 1 (TRPV1) inhibition and modulation. A bibliometric analysis of peer-reviewed articles and reviews published from 2003 until 2022 in the Scopus database was conducted. A total of 7,470 publications were retrieved and distributed over 140 countries and published by 23,875 authors. The number of publications was increasing over the determined period, indicating a steady upward trend. Approximately 80% of the total extracted publications were research articles. The leading country in this research field is the United States of America. The top publishing journal was the British Journal of Pharmacology. The most frequent keywords included TRPV1, pain, and capsaicin. Analysis of authors-keywords pointed to the role of TRPV1 inhibition in numerous conditions including cancer, inflammation, oxidative stress, pruritus, osteoarthritis, migraine, the endocannabinoid system, nitric oxide, and endothelium relaxation. This study revealed most of the research was focused on the role of TRPV1 channels in pain. However, TRPV1 has been implicated in different pathological conditions. This implication should be translated into the development of therapeutic strategy, and efforts should be expanded into new clinical indications and novel drug discovery.

Retraction: 'Curcumin inhibits the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathway', by Jingzhe Yang, Chengli Wang, Zhijie Zhang, Xiaojun Chen, Yusen Jia, Bin Wang, Tao Kong, APMIS. 2017; 125: 134-140: The above article, published online on 24 January 2017 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10.1111/apm.12650) has been retracted by agreement between the journal Editors in Chief,

The retraction has been agreed due to unattributed overlap between this article and the following article: 'Curcumin inhibits cell survival and migration by suppression of Notch-1 activity in prostate cancer cells' by Tao Kong, Yongxing Wang, Li Xiao and Limin Liao; African Journal of Pharmacy and Pharmacology, Vol.7(27), pp. 1911-1916, 2013, https://doi.org/10.5897/AJPP2012.1526. The authors were not available for a final confirmation of the retraction.

Trends in gender disparity in the field of Helicobacter pylori research from 2000 to 2020: A cross-sectional study.

Many studies have investigated gender disparity in scientific publications, but this has been poorly studied in the field of digestive diseases. This study aimed to determine the gender difference of first and senior authors in publications related to Helicobacter pylori (H. pylori) during the past 20 years. Data were derived from original articles published in the main journals of digestive diseases (Journal of Hepatology, Gut, Gastroenterology, American Journal of Gastroenterology, Endoscopy, Gastrointestinal Endoscopy, Alimentary Pharmacology and Therapeutics, Digestive Endoscopy, Journal of Gastroenterology, Helicobacter, and Gastric Cancer) in 2000, 2005, 2010, 2015, and 2020. These original articles were classified according to the gender and nationality of the first and senior (last listed) authors. Linear-by-linear association test was used to analyze the proportion of women authors over time. Multivariable logistic regression was applied to explain the factors impacting authorship difference of first and senior authors. A total of 561 original articles on H. pylori were collected for this study, accounting for 10.70% in 2000 to 7.60% in 2020 among all articles. In these original articles, the percentage of women first authors increased from 14.60% in 2000 to 45.0% in 2020 (P < .001). The percentage of women senior authors increased from 5.60% in 2000 to 18.80% in 2020 (P < .001). Women first authors were more likely to perform research with women senior authors (18.42%) than with men senior authors (10.23%, P < .001). The proportion of women first authors from Oceania were higher than that from North and South America (P = .004), whereas there was no statistical difference regarding women senior authors. In the past 2 decades, although the percentage of women authors among both first and senior authors in the field of H. pylori research has increased significantly, women are still a minority in original research.

Artificial Intelligence-AI-and The Journal of Pediatric Pharmacology and Therapeutics.

Artificial Intelligence-AI-and The Journal of Pediatric Pharmacology and Therapeutics.

Rosalind Franklin Society Proudly Announces the 2022 Award Recipient for the Journal of Ocular Pharmacology and Therapeutics.

Rosalind Franklin Society Proudly Announces the 2022 Award Recipient for the Journal of Ocular Pharmacology and Therapeutics.

Issue Information

Pharmacotherapy: The Journal of Human Pharmacology and Drug TherapyVolume 43, Issue 6 p. 463-465 ISSUE INFORMATIONFree Access Issue Information First published: 21 June 2023 https://doi.org/10.1002/phar.2565AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume43, Issue6June 2023Pages 463-465 RelatedInformation

Dermatology journals from India: A critical appraisal of the journal metrics.

Background Bibliometrics refer to documents and citation-based measures that measure different aspects of performance of a journal, including impact, output and prestige. Objective The aim of this study was to collect bibliometric data of various Indian dermatology journals as well as Indian journals from other disciplines, in order to compare relative performances. Methods Journal metrics pertaining to various Indian journals, both from dermatology [Indian Journal of Dermatology, Venereology and Leprology (IJDVL), Indian Journal of Dermatology (IJD), Indian Dermatology Online Journal, Indian Journal of Pediatric Dermatology and International Journal of Trichology] and other disciplines [Indian Journal of Medical Research (IJMR), Indian Journal of Pediatrics (IJP), Indian Journal of Ophthalmology and Indian Journal of Pharmacology] were sought. Data pertaining to the following 8 metrics during the year 2021 was collected: Journal Impact factor, SCImago Journal Rank, h5-index, Eigenfactor score and normalized Eigenfactor Score, Journal Citation Indicator, Scimago Journal and Country Rank H-index, CiteScore and Source Normalized Impact per Paper. Results Among Indian dermatology journals, for the year 2021, IJDVL had the highest impact factor (2.217) and h-index (48). IJD led in terms of prestige metrics such as SCImago Journal Rank (0.403), Eigenfactor score (0.00231) and Source Normalized Impact per Paper (1.132). IJDVL underperformed with respect to an average dermatology journal on all three prestige metrics. Among selected journals from other disciplines, two (IJMR and IJP) had impact factor exceeding five, despite lagging behind IJDVL two years ago. Most had normalized scores exceeding 1, indicating better performance than an average journal from their respective fields. Limitations Non-inclusion of altmetrics related data Conclusion IJDVL is one of the leading Indian journals in the field of dermatology, followed closely by IJD. A rise in IJDVL influence is evident over the past decade, as evident by various metrics. However, the progress still trails behind the average of global dermatology journals as evident by the field-normalized journal metrics, indicating potential for further growth of journal influence.

Issue Information

Pharmacotherapy: The Journal of Human Pharmacology and Drug TherapyVolume 43, Issue 5 p. 355-357 ISSUE INFORMATIONFree Access Issue Information First published: 15 May 2023 https://doi.org/10.1002/phar.2560AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume43, Issue5May 2023Pages 355-357 RelatedInformation

THE RELATIONSHIP OF MOTIVATION ON THE INTEREST OF THE COMMUNITY VISITING THE DENTIST DURING THE COVID-19 PANDEMIC IN SUNGAI MIAI VILLAGE

THE RELATIONSHIP OF MOTIVATION ON THE INTEREST OF THE COMMUNITY VISITING THE DENTIST DURING THE COVID-19 PANDEMIC IN SUNGAI MIAI VILLAGE

Comment on “Tacrolimus in the treatment of childhood nephrotic syndrome: Machine learning detects novel biomarkers and predicts efficacy”

Pharmacotherapy: The Journal of Human Pharmacology and Drug TherapyVolume 43, Issue 4 p. 349-350 LETTER TO THE EDITOR Comment on “Tacrolimus in the treatment of childhood nephrotic syndrome: Machine learning detects novel biomarkers and predicts efficacy” William L. Baker, Corresponding Author William L. Baker [email protected] orcid.org/0000-0003-2172-0931 Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, Connecticut, USA Correspondence William L. Baker, Department of Pharmacy Practice, University of Connecticut School of Pharmacy, 69 N Eagleville Rd, Storrs, CT 06269, USA. Email: [email protected]Search for more papers by this author William L. Baker, Corresponding Author William L. Baker [email protected] orcid.org/0000-0003-2172-0931 Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, Connecticut, USA Correspondence William L. Baker, Department of Pharmacy Practice, University of Connecticut School of Pharmacy, 69 N Eagleville Rd, Storrs, CT 06269, USA. Email: [email protected]Search for more papers by this author First published: 19 April 2023 https://doi.org/10.1002/phar.2785Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume43, Issue4April 2023Pages 349-350 RelatedInformation

Eyes on New Product Development.

Journal of Ocular Pharmacology and TherapeuticsVol. 39, No. 2 Featured ColumnEyes on New Product DevelopmentGary D. NovackGary D. NovackAddress correspondence to: Dr. Gary D. Novack, PharmaLogic Development, Inc., 17 Bridgegate Drive, San Rafael, CA 94903, USA E-mail Address: gary_novack@pharmalogic.comPharmaLogic Development, Inc., San Rafael, California, USA.Department of Ophthalmology, University of California, Davis, School of Medicine, Sacramento, California, USA.Search for more papers by this authorPublished Online:16 Mar 2023https://doi.org/10.1089/jop.2023.29101.gdnAboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View article"Eyes on New Product Development." Journal of Ocular Pharmacology and Therapeutics, 39(2), pp. 87–88FiguresReferencesRelatedDetails Volume 39Issue 2Mar 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Gary D. Novack.Eyes on New Product Development.Journal of Ocular Pharmacology and Therapeutics.Mar 2023.87-88.http://doi.org/10.1089/jop.2023.29101.gdnPublished in Volume: 39 Issue 2: March 16, 2023Online Ahead of Print:February 8, 2023PDF download

Commentary on 'Identification and characterization of select oxysterols as ligands for GPR17'.

Commentary on 'Identification and characterization of select oxysterols as ligands for GPR17'.

Assessment of risk of bias in randomized controlled trials published in Indian journals pertaining to pharmacology.

Number of trials in India shows an increasing trend. As these trials will shape clinical practice, their quality is of utmost importance. Among many tools to assess the quality of randomized control trials (RCTs), risk of bias (RoB) is most robust. To understand the quality of trials being carried out in India in terms of RoB. We aimed to assess the RoB in a set of RCTs published in Indian pharmacology of randomized trials from journals pertaining to pharmacology. We used published journal articles as source of information for randomized clinical trials and evaluated them using Cochrane RoB tool 2.0. Descriptive statistics were used. 158 trials published in seven journals were evaluated in six different domains. Overall evaluation for 97% (153) trials was "high risk," while 3% (5) were in "some concerns" category, with no trials categorized as "low risk. 74% articles showed a high risk of bias in the domain of 'selection of reported results. Nearly half articles scored "low risk" in domains of "missing data" and "deviations in assignment to intervention." The study results showed a slowly increasing trend of average RoB over the last 10 years. The study shows concerning rise in RoB in various domains RCTs published in Pharmacology journals in India.